Lecture Notes in Computer Science 12266

Founding Editors

Gerhard GoosKarlsruhe Institute of Technology, Karlsruhe, Germany

Juris HartmanisCornell University, Ithaca, NY, USA

Editorial Board Members

Elisa BertinoPurdue University, West Lafayette, IN, USA

Wen GaoPeking University, Beijing, China

Bernhard SteffenTU Dortmund University, Dortmund, Germany

Gerhard WoegingerRWTH Aachen, Aachen, Germany

Moti YungColumbia University, New York, NY, USA

More information about this series at http://www.springer.com/series/7412

Anne L. Martel • Purang Abolmaesumi •

Danail Stoyanov • Diana Mateus •

Maria A. Zuluaga • S. Kevin Zhou •

Daniel Racoceanu • Leo Joskowicz (Eds.)

Medical Image Computingand Computer AssistedIntervention – MICCAI 202023rd International ConferenceLima, Peru, October 4–8, 2020Proceedings, Part VI

123

EditorsAnne L. MartelUniversity of TorontoToronto, ON, Canada

Purang AbolmaesumiThe University of British ColumbiaVancouver, BC, Canada

Danail StoyanovUniversity College LondonLondon, UK

Diana MateusÉcole Centrale de NantesNantes, France

Maria A. ZuluagaEURECOMBiot, France

S. Kevin ZhouChinese Academy of SciencesBeijing, China

Daniel RacoceanuSorbonne UniversityParis, France

Leo JoskowiczThe Hebrew University of JerusalemJerusalem, Israel

ISSN 0302-9743 ISSN 1611-3349 (electronic)Lecture Notes in Computer ScienceISBN 978-3-030-59724-5 ISBN 978-3-030-59725-2 (eBook)https://doi.org/10.1007/978-3-030-59725-2

LNCS Sublibrary: SL6 – Image Processing, Computer Vision, Pattern Recognition, and Graphics

© Springer Nature Switzerland AG 2020, corrected publication 2021This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of thematerial is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,broadcasting, reproduction on microfilms or in any other physical way, and transmission or informationstorage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology nowknown or hereafter developed.The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoes not imply, even in the absence of a specific statement, that such names are exempt from the relevantprotective laws and regulations and therefore free for general use.The publisher, the authors and the editors are safe to assume that the advice and information in this book arebelieved to be true and accurate at the date of publication. Neither the publisher nor the authors or the editorsgive a warranty, expressed or implied, with respect to the material contained herein or for any errors oromissions that may have been made. The publisher remains neutral with regard to jurisdictional claims inpublished maps and institutional affiliations.

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Preface

The 23rd International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2020) was held this year under the most unusualcircumstances, due to the COVID-19 pandemic disrupting our lives in ways that wereunimaginable at the start of the new decade. MICCAI 2020 was scheduled to be held inLima, Peru, and would have been the first MICCAI meeting in Latin America.However, with the pandemic, the conference and its program had to be redesigned todeal with realities of the “new normal”, where virtual presence rather than physicalinteractions among attendees, was necessary to comply with global transmissioncontrol measures. The conference was held through a virtual conference managementplatform, consisting of the main scientific program in addition to featuring 25 work-shops, 8 tutorials, and 24 challenges during October 4–8, 2020. In order to keep a partof the original spirit of MICCAI 2020, SIPAIM 2020 was held as an adjacent LatAmconference dedicated to medical information management and imaging, held duringOctober 3–4, 2020.

The proceedings of MICCAI 2020 showcase papers contributed by the authors tothe main conference, which are organized in seven volumes of Lecture Notes inComputer Science (LNCS) books. These papers were selected after a thorough double-blind peer-review process. We followed the example set by past MICCAI meetings,using Microsoft’s Conference Managing Toolkit (CMT) for paper submission and peerreviews, with support from the Toronto Paper Matching System (TPMS) to partiallyautomate paper assignment to area chairs and reviewers.

The conference submission deadline had to be extended by two weeks to account forthe disruption COVID-19 caused on the worldwide scientific community. From 2,953original intentions to submit, 1,876 full submissions were received, which werereduced to 1,809 submissions following an initial quality check by the program chairs.Of those, 61% were self-declared by authors as Medical Image Computing (MIC), 6%as Computer Assisted Intervention (CAI), and 32% as both MIC and CAI. Following abroad call to the community for self-nomination of volunteers and a thorough reviewby the program chairs, considering criteria such as balance across research areas,geographical distribution, and gender, the MICCAI 2020 Program Committee com-prised 82 area chairs, with 46% from North America, 28% from Europe, 19% fromAsia/Pacific/Middle East, 4% from Latin America, and 1% from Australia. We investedsignificant effort in recruiting more women to the Program Committee, following theconference’s emphasis on equity, inclusion, and diversity. This resulted in 26% femalearea chairs. Each area chair was assigned about 23 manuscripts, with suggestedpotential reviewers using TPMS scoring and self-declared research areas, while domainconflicts were automatically considered by CMT. Following a final revision and pri-oritization of reviewers by area chairs in terms of their expertise related to each paper,

over 1,426 invited reviewers were asked to bid for the papers for which they had beensuggested. Final reviewer allocations via CMT took account of reviewer bidding,prioritization of area chairs, and TPMS scores, leading to allocating about 4 papers perreviewer. Following an initial double-blind review phase by reviewers, area chairsprovided a meta-review summarizing key points of reviews and a recommendation foreach paper. The program chairs then evaluated the reviews and their scores, along withthe recommendation from the area chairs, to directly accept 241 papers (13%) andreject 828 papers (46%); the remainder of the papers were sent for rebuttal by theauthors. During the rebuttal phase, two additional area chairs were assigned to eachpaper using the CMT and TPMS scores while accounting for domain conflicts. Thethree area chairs then independently scored each paper to accept or reject, based on thereviews, rebuttal, and manuscript, resulting in clear paper decisions using majorityvoting. This process resulted in the acceptance of a further 301 papers for an overallacceptance rate of 30%. A virtual Program Committee meeting was held on July 10,2020, to confirm the final results and collect feedback of the peer-review process.

For the MICCAI 2020 proceedings, 542 accepted papers have been organized intoseven volumes as follows:

• Part I, LNCS Volume 12261: Machine Learning Methodologies• Part II, LNCS Volume 12262: Image Reconstruction and Machine Learning• Part III, LNCS Volume 12263: Computer Aided Intervention, Ultrasound and

Image Registration• Part IV, LNCS Volume 12264: Segmentation and Shape Analysis• Part V, LNCS Volume 12265: Biological, Optical and Microscopic Image Analysis• Part VI, LNCS Volume 12266: Clinical Applications• Part VII, LNCS Volume 12267: Neurological Imaging and PET

For the main conference, the traditional emphasis on poster presentations wasmaintained; each author uploaded a brief pre-recorded presentation and a graphicalabstract onto a web platform and was allocated a personal virtual live session in whichthey talked directly to the attendees. It was also possible to post questions onlineallowing asynchronous conversations – essential to overcome the challenges of a globalconference spanning many time zones. The traditional oral sessions, which typicallyincluded a small proportion of the papers, were replaced with 90 “mini” sessions whereall of the authors were clustered into groups of 5 to 7 related papers; a live virtualsession allowed the authors and attendees to discuss the papers in a panel format.

We would like to sincerely thank everyone who contributed to the success ofMICCAI 2020 and the quality of its proceedings under the most unusual circumstancesof a global pandemic. First and foremost, we thank all authors for submitting andpresenting their high-quality work that made MICCAI 2020 a greatly enjoyable andsuccessful scientific meeting. We are also especially grateful to all members of theProgram Committee and reviewers for their dedicated effort and insightful feedbackthroughout the entire paper selection process. We would like to particularly thank theMICCAI society for support, insightful comments, and continuous engagement withorganizing the conference. Special thanks go to Kitty Wong, who oversaw the entire

vi Preface

process of paper submission, reviews, and preparation of conference proceedings.Without her, we would have not functioned effectively. Given the “new normal”, noneof the workshops, tutorials, and challenges would have been feasible without the trueleadership of the satellite events organizing team led by Mauricio Reyes: ErikMeijering (workshops), Carlos Alberola-López (tutorials), and Lena Maier-Hein(challenges). Behind the scenes, MICCAI secretarial personnel, Janette Wallace andJohanne Langford, kept a close eye on logistics and budgets, while Mehmet Eldegezand his team at Dekon Congress and Tourism led the professional conference orga-nization, working tightly with the virtual platform team. We also thank our sponsors forfinancial support and engagement with conference attendees through the virtual plat-form. Special thanks goes to Veronika Cheplygina for continuous engagement withvarious social media platforms before and throughout the conference to publicize theconference. We would also like to express our gratitude to Shelley Wallace for helpingus in Marketing MICCAI 2020, especially during the last phase of the virtual con-ference organization.

The selection process for Young Investigator Awards was managed by a team ofsenior MICCAI investigators, led by Julia Schnabel. In addition, MICCAI 2020 offeredfree registration to the top 50 ranked papers at the conference whose primary authorswere students. Priority was given to low-income regions and Latin American students.Further support was provided by the National Institutes of Health (support granted forMICCAI 2020) and the National Science Foundation (support granted to MICCAI2019 and continued for MICCAI 2020) which sponsored another 52 awards for USA-based students to attend the conference. We would like to thank Marius Linguraru andAntonion Porras, for their leadership in regards to the NIH sponsorship for 2020, andDinggang Shen and Tianming Liu, MICCAI 2019 general chairs, for keeping an activebridge and engagement with MICCAI 2020.

Marius Linguraru and Antonion Porras were also leading the young investigatorsearly career development program, including a very active mentorship which we dohope, will significantly catalize young and briliant careers of future leaders of ourscientific community. In link with SIPAIM (thanks to Jorge Brieva, Marius Linguraru,and Natasha Lepore for their support), we also initiated a Startup Village initiative,which, we hope, will be able to bring in promissing private initiatives in the areas ofMICCAI. As a part of SIPAIM 2020, we note also the presence of a workshop forPeruvian clinicians. We would like to thank Benjaming Castañeda and Renato Gandolfifor this initiative.

MICCAI 2020 invested significant efforts to tightly engage the industry stakeholdersin our field throughout its planning and organization. These efforts were led by ParvinMousavi, and ensured that all sponsoring industry partners could connect with theconference attendees through the conference’s virtual platform before and during themeeting. We would like to thank the sponsorship team and the contributions

Preface vii

of Gustavo Carneiro, Benjamín Castañeda, Ignacio Larrabide, Marius Linguraru,Yanwu Xu, and Kevin Zhou.

We look forward to seeing you at MICCAI 2021.

October 2020 Anne L. MartelPurang Abolmaesumi

Danail StoyanovDiana Mateus

Maria A. ZuluagaS. Kevin Zhou

Daniel RacoceanuLeo Joskowicz

viii Preface

Organization

General Chairs

Daniel Racoceanu Sorbonne Université, Brain Institute, FranceLeo Joskowicz The Hebrew University of Jerusalem, Israel

Program Committee Chairs

Anne L. Martel University of Toronto, CanadaPurang Abolmaesumi The University of British Columbia, CanadaDanail Stoyanov University College London, UKDiana Mateus Ecole Centrale de Nantes, LS2N, FranceMaria A. Zuluaga Eurecom, FranceS. Kevin Zhou Chinese Academy of Sciences, China

Keynote Speaker Chair

Rene Vidal The John Hopkins University, USA

Satellite Events Chair

Mauricio Reyes University of Bern, Switzerland

Workshop Team

Erik Meijering (Chair) The University of New South Wales, AustraliaLi Cheng University of Alberta, CanadaPamela Guevara University of Concepción, ChileBennett Landman Vanderbilt University, USATammy Riklin Raviv Ben-Gurion University of the Negev, IsraelVirginie Uhlmann EMBL, European Bioinformatics Institute, UK

Tutorial Team

Carlos Alberola-López(Chair)

Universidad de Valladolid, Spain

Clarisa Sánchez Radboud University Medical Center, The NetherlandsDemian Wassermann Inria Saclay Île-de-France, France

Challenges Team

Lena Maier-Hein (Chair) German Cancer Research Center, GermanyAnnette Kopp-Schneider German Cancer Research Center, GermanyMichal Kozubek Masaryk University, Czech RepublicAnnika Reinke German Cancer Research Center, Germany

Sponsorship Team

Parvin Mousavi (Chair) Queen’s University, CanadaMarius Linguraru Children’s National Institute, USAGustavo Carneiro The University of Adelaide, AustraliaYanwu Xu Baidu Inc., ChinaIgnacio Larrabide National Scientific and Technical Research Council,

ArgentinaS. Kevin Zhou Chinese Academy of Sciences, ChinaBenjamín Castañeda Pontifical Catholic University of Peru, Peru

Local and Regional Chairs

Benjamín Castañeda Pontifical Catholic University of Peru, PeruNatasha Lepore University of Southern California, USA

Social Media Chair

Veronika Cheplygina Eindhoven University of Technology, The Netherlands

Young Investigators Early Career Development Program Chairs

Marius Linguraru Children’s National Institute, USAAntonio Porras Children’s National Institute, USA

Student Board Liaison Chair

Gabriel Jimenez Pontifical Catholic University of Peru, Peru

Submission Platform Manager

Kitty Wong The MICCAI Society, Canada

Conference Management

DEKON GroupPathable Inc.

x Organization

Program Committee

Ehsan Adeli Stanford University, USAShadi Albarqouni ETH Zurich, SwitzerlandPablo Arbelaez Universidad de los Andes, ColombiaUlas Bagci University of Central Florida, USAAdrien Bartoli Université Clermont Auvergne, FranceHrvoje Bogunovic Medical University of Vienna, AustriaWeidong Cai The University of Sydney, AustraliaChao Chen Stony Brook University, USAElvis Chen Robarts Research Institute, CanadaStanley Durrleman Inria, FranceBoris Escalante-Ramírez National Autonomous University of Mexico, MexicoPascal Fallavollita University of Ottawa, CanadaEnzo Ferrante CONICET, Universidad Nacional del Litoral,

ArgentinaStamatia Giannarou Imperial College London, UKOrcun Goksel ETH Zurich, SwitzerlandAlberto Gomez King’s College London, UKMiguel Angel González

BallesterUniversitat Pompeu Fabra, Spain

Ilker Hacihaliloglu Rutgers University, USAYi Hong University of Georgia, USAYipeng Hu University College London, UKHeng Huang University of Pittsburgh and JD Finance America

Corporation, USAJuan Eugenio Iglesias University College London, UKMadhura Ingalhalikar Symbiosis Center for Medical Image Analysis, IndiaPierre Jannin Université de Rennes, FranceSamuel Kadoury Ecole Polytechnique de Montreal, CanadaBernhard Kainz Imperial College London, UKMarta Kersten-Oertel Concordia University, CanadaAndrew King King’s College London, UKIgnacio Larrabide CONICET, ArgentinaGang Li University of North Carolina at Chapel Hill, USAJianming Liang Arizona State University, USAHongen Liao Tsinghua University, ChinaRui Liao Siemens Healthineers, USAFeng Lin Nanyang Technological University, ChinaMingxia Liu University of North Carolina at Chapel Hill, USAJiebo Luo University of Rochester, USAXiongbiao Luo Xiamen University, ChinaAndreas Maier FAU Erlangen-Nuremberg, GermanyStephen McKenna University of Dundee, UKBjoern Menze Technische Universität München, GermanyMehdi Moradi IBM Research, USA

Organization xi

Dong Ni Shenzhen University, ChinaMarc Niethammer University of North Carolina at Chapel Hill, USAJack Noble Vanderbilt University, USAIpek Oguz Vanderbilt University, USAGemma Piella Pompeu Fabra University, SpainHedyeh Rafii-Tari Auris Health Inc., USAIslem Rekik Istanbul Technical University, TurkeyNicola Rieke NVIDIA Corporation, USATammy Riklin Raviv Ben-Gurion University of the Negev, IsraelHassan Rivaz Concordia University, CanadaHolger Roth NVIDIA Corporation, USASharmishtaa Seshamani Allen Institute, USALi Shen University of Pennsylvania, USAFeng Shi Shanghai United Imaging Intelligence Co., ChinaYonggang Shi University of Southern California, USAMichal Sofka Hyperfine Research, USAStefanie Speidel National Center for Tumor Diseases (NCT), GermanyMarius Staring Leiden University Medical Center, The NetherlandsHeung-Il Suk Korea University, South KoreaKenji Suzuki Tokyo Institute of Technology, JapanTanveer Syeda-Mahmood IBM Research, USAAmir Tahmasebi CodaMetrix, USAXiaoying Tang Southern University of Science and Technology, ChinaTolga Tasdizen The University of Utah, USAPallavi Tiwari Case Western Reserve University, USASotirios Tsaftaris The University of Edinburgh, UKArchana Venkataraman Johns Hopkins University, USASatish Viswanath Case Western Reserve University, USAHongzhi Wang IBM Almaden Research Center, USALinwei Wang Rochester Institute of Technology, USAQian Wang Shanghai Jiao Tong University, ChinaGuorong Wu University of North Carolina at Chapel Hill, USADaguang Xu NVIDIA Corporation, USAZiyue Xu NVIDIA Corporation, USAPingkun Yan Rensselaer Polytechnic Institute, USAXin Yang Huazhong University of Science and Technology,

ChinaZhaozheng Yin Stony Brook University, USATuo Zhang Northwestern Polytechnical University, ChinaGuoyan Zheng Shanghai Jiao Tong University, ChinaYefeng Zheng Tencent, ChinaLuping Zhou The University of Sydney, Australia

xii Organization

Mentorship Program (Mentors)

Ehsan Adeli Stanford University, USAStephen Aylward Kitware, USAHrvoje Bogunovic Medical University of Vienna, AustriaLi Cheng University of Alberta, CanadaMarleen de Bruijne University of Copenhagen, DenmarkCaroline Essert University of Strasbourg, FranceGabor Fichtinger Queen’s University, CanadaStamatia Giannarou Imperial College London, UKJuan Eugenio Iglesias

GonzalezUniversity College London, UK

Bernhard Kainz Imperial College London, UKShuo Li Western University, CanadaJianming Liang Arizona State University, USARui Liao Siemens Healthineers, USAFeng Lin Nanyang Technological University, ChinaMarius George Linguraru Children’s National Hospital, George Washington

University, USATianming Liu University of Georgia, USAXiongbiao Luo Xiamen University, ChinaDong Ni Shenzhen University, ChinaWiro Niessen Erasmus MC - University Medical Center Rotterdam,

The NetherlandsTerry Peters Western University, CanadaAntonio R. Porras University of Colorado, USADaniel Racoceanu Sorbonne University, FranceIslem Rekik Istanbul Technical University, TurkeyNicola Rieke NVIDIA, USAJulia Schnabel King’s College London, UKRuby Shamir Novocure, SwitzerlandStefanie Speidel National Center for Tumor Diseases Dresden, GermanyMartin Styner University of North Carolina at Chapel Hill, USAXiaoying Tang Southern University of Science and Technology, ChinaPallavi Tiwari Case Western Reserve University, USAJocelyne Troccaz CNRS, Grenoble Alpes University, FrancePierre Jannin INSERM, Université de Rennes, FranceArchana Venkataraman Johns Hopkins University, USALinwei Wang Rochester Institute of Technology, USAGuorong Wu University of North Carolina at Chapel Hill, USALi Xiao Chinese Academy of Science, ChinaZiyue Xu NVIDIA, USABochuan Zheng China West Normal University, ChinaGuoyan Zheng Shanghai Jiao Tong University, ChinaS. Kevin Zhou Chinese Academy of Sciences, ChinaMaria A. Zuluaga EURECOM, France

Organization xiii

Additional Reviewers

Alaa Eldin AbdelaalAhmed AbdulkadirClement Abi NaderMazdak AbulnagaGanesh AdluruIman AganjPriya AggarwalSahar AhmadSeyed-Ahmad AhmadiEuijoon AhnAlireza Akhondi-aslMohamed AkroutDawood Al ChantiIbraheem Al-DhamariNavid Alemi KoohbananiHanan AlghamdiHassan AlhajjHazrat AliSharib AliOmar Al-KadiMaximilian AllanFelix AmbellanMina AmiriSameer AntaniLuigi AntelmiMichela AntonelliJacob AntunesSaeed AnwarFernando ArambulaIgnacio Arganda-CarrerasMohammad Ali ArminJohn AshburnerMd AshikuzzamanShahab AslaniMehdi AstarakiAngélica AtehortúaGowtham AtluriKamran AvanakiAngelica Aviles-RiveroSuyash AwateDogu Baran AydoganQinle BaMorteza Babaie

Hyeon-Min BaeWoong BaeWenjia BaiUjjwal BaidSpyridon BakasYaël BalbastreMarcin BalickiFabian BalsigerAbhirup BanerjeeSreya BanerjeeSophia BanoShunxing BaoAdrian BarbuCher BassJohn S. H. BaxterAmirhossein BayatSharareh BayatNeslihan BayramogluBahareh BehboodiDelaram BehnamiMikhail BelyaevOualid BenkarimAicha BenTaiebCamilo BermudezGiulia BertòHadrien BertrandJulián BetancurMichael BeyelerParmeet BhatiaChetan BholeSuvrat BhooshanChitresh BhushanLei BiCheng BianGui-Bin BianSangeeta BiswasStefano B. BlumbergJanusz BobulskiSebastian BodenstedtEster BonmatiBhushan BorotikarJiri BorovecIlaria Boscolo Galazzo

xiv Organization

Alexandre BousseNicolas BoutryBehzad BozorgtabarNadia BrancatiChristopher BridgeEsther BronRupert BrooksQirong BuTim-Oliver BuchholzDuc Toan BuiQasim BukhariNinon BurgosNikolay BurlutskiyRussell ButlerMichał ByraHongmin CaiYunliang CaiSema CandemirBing CaoQing CaoShilei CaoTian CaoWeiguo CaoYankun CaoAaron CarassHeike CarolusAdrià CasamitjanaSuheyla Cetin KarayumakAhmad ChaddadKrishna ChaitanyaJayasree ChakrabortyTapabrata ChakrabortySylvie ChambonMing-Ching ChangVioleta ChangSimon ChatelinSudhanya ChatterjeeChristos ChatzichristosRizwan ChaudhryAntong ChenCameron Po-Hsuan ChenChang ChenChao ChenChen ChenCheng ChenDongdong Chen

Fang ChenGeng ChenHao ChenJianan ChenJianxu ChenJia-Wei ChenJie ChenJunxiang ChenLi ChenLiang ChenPingjun ChenQiang ChenShuai ChenTianhua ChenTingting ChenXi ChenXiaoran ChenXin ChenYuanyuan ChenYuhua ChenYukun ChenZhineng ChenZhixiang ChenErkang ChengJun ChengLi ChengXuelian ChengYuan ChengVeronika CheplyginaHyungjoo ChoJaegul ChooAritra ChowdhuryStergios ChristodoulidisAi Wern ChungPietro Antonio CicaleseÖzgün ÇiçekRobert CierniakMatthew ClarksonDana CobzasJaume Coll-FontAlessia ColonnaMarc CombaliaOlivier CommowickSonia Contreras OrtizPierre-Henri ConzeTimothy Cootes

Organization xv

Luca CorinziaTeresa CorreiaPierrick CoupéJeffrey CraleyArun C. S. KumarHui CuiJianan CuiZhiming CuiKathleen CurranHaixing DaiXiaoliang DaiKer Dai Fei ElmerAdrian DalcaAbhijit DasNeda DavoudiLaura DazaSandro De ZanetCharles DelahuntHerve DelingetteBeatrice DemirayYang DengHrishikesh DeshpandeChristian DesrosiersNeel DeyXinghao DingZhipeng DingKonstantin DmitrievJose DolzInes DominguesJuan Pedro Dominguez-MoralesHao DongMengjin DongNanqing DongQinglin DongSuyu DongSven DorkenwaldQi DouP. K. DouglasSimon DrouinKaren DrukkerNiharika D’SouzaLei DuShaoyi DuXuefeng DuDingna DuanNicolas Duchateau

James DuncanJared DunnmonLuc DuongNicha DvornekDmitry V. DylovOleh DzyubachykMehran EbrahimiPhilip EdwardsAlexander EfflandJan EggerAlma EguizabalGudmundur EinarssonAhmed ElazabMohammed S. M. ElbazShireen ElhabianAhmed EltanbolySandy EngelhardtErtunc ErdilMarius ErdtFloris ErnstMohammad EslamiNazila EsmaeiliMarco EspositoOscar EstebanJingfan FanXin FanYonghui FanChaowei FangXi FangMohsen FarziJohannes FauserAndrey FedorovHamid FehriLina FelsnerJun FengRuibin FengXinyang FengYifan FengYuan FengHenrique FernandesRicardo FerrariJean FeydyLucas FidonLukas FischerAntonio Foncubierta-RodríguezGermain Forestier

xvi Organization

Reza ForghaniNils Daniel ForkertJean-Rassaire FouefackTatiana FountoukidouAina Frau-PascualMoti FreimanSarah FriskenHuazhu FuXueyang FuWolfgang FuhlIsabel FunkePhilipp FürnstahlPedro FurtadoRyo FurukawaElies Fuster-GarciaYoussef GahiJin Kyu GahmLaurent GajnyRohan GalaHarshala GammulleYu GanCong GaoDongxu GaoFei GaoFeng GaoLinlin GaoMingchen GaoSiyuan GaoXin GaoXinpei GaoYixin GaoYue GaoZhifan GaoSara GarbarinoAlfonso Gastelum-StrozziRomane GauriauSrishti GautamBao GeRongjun GeZongyuan GeSairam GeethanathYasmeen GeorgeSamuel GerberGuido GerigNils GessertOlivier Gevaert

Muhammad Usman GhaniSandesh GhimireSayan GhosalGabriel GirardBen GlockerEvgin GoceriMichael GoetzArnold GomezKuang GongMingming GongYuanhao GongGerman GonzalezSharath GopalKarthik GopinathPietro GoriMaged GoubranSobhan GoudarziBaran GözcüBenedikt GrafMark GrahamBertrand GranadoAlejandro GranadosRobert GruppChristina GsaxnerLin GuShi GuYun GuRicardo GuerreroHoussem-Eddine GueziriDazhou GuoHengtao GuoJixiang GuoPengfei GuoYanrong GuoYi GuoYong GuoYulan GuoYuyu GuoKrati GuptaVikash GuptaPraveen Gurunath BharathiPrashnna GyawaliStathis HadjidemetriouOmid Haji MaghsoudiJustin HaldarMohammad Hamghalam

Organization xvii

Bing HanHu HanLiang HanXiaoguang HanXu HanZhi HanZhongyi HanJonny HancoxChristian HansenXiaoke HaoRabia HaqMichael HardistyStefan HarrerAdam HarrisonS. M. Kamrul HasanHoda Sadat HashemiNobuhiko HataAndreas HauptmannMohammad HavaeiHuiguang HeJunjun HeKelei HeTiancheng HeXuming HeYuting HeMattias HeinrichStefan HeldmannNicholas HellerAlessa HeringMonica HernandezEstefania Hernandez-MartinCarlos Hernandez-MatasJavier Herrera-VegaKilian HettTsung-Ying HoNico HoffmannMatthew HoldenSong HongSungmin HongYoonmi HongCorné HoogendoornAntal HorváthBelayat HossainLe HouAi-Ling HsuPo-Ya Hsu

Tai-Chiu HsungPengwei HuShunbo HuXiaoling HuXiaowei HuYan HuZhenhong HuJia-Hong HuangJunzhou HuangKevin HuangQiaoying HuangWeilin HuangXiaolei HuangYawen HuangYongxiang HuangYue HuangYufang HuangZhi HuangArnaud HuaulméHenkjan HuismanXing HuoYuankai HuoSarfaraz HusseinJana HutterKhoi HuynhSeong Jae HwangEmmanuel IarussiIlknur IckeKay IgweAlfredo IllanesAbdullah-Al-Zubaer ImranIsmail IrmakciSamra IrshadBenjamin IrvingMobarakol IslamMohammad Shafkat IslamVamsi IthapuKoichi ItoHayato ItohOleksandra IvashchenkoYuji IwahoriShruti JadonMohammad JafariMostafa JahanifarAndras JakabAmir Jamaludin

xviii Organization

Won-Dong JangVincent JaouenUditha JarayathneRonnachai JaroensriGolara JavadiRohit JenaTodd JensenWon-Ki JeongZexuan JiHaozhe JiaJue JiangTingting JiangWeixiong JiangXi JiangXiang JiangJianbo JiaoZhicheng JiaoAmelia Jiménez-SánchezDakai JinTaisong JinYueming JinZe JinBin JingYaqub JonmohamadiAnand JoshiShantanu JoshiChristoph JudFlorian JugYohan JunAlain JungoAbdolrahim KadkhodamohammadiAli Kafaei Zad TehraniDagmar KainmuellerSiva Teja KakiletiJohn KalafutKonstantinos KamnitsasMichael C. KampffmeyerQingbo KangNeerav KaraniDavood KarimiSatyananda KashyapAlexander KatzmannPrabhjot KaurAnees KaziErwan KerrienHoel Kervadec

Ashkan KhakzarFahmi KhalifaNadieh KhaliliSiavash KhallaghiFarzad KhalvatiHassan KhanBishesh KhanalPulkit KhandelwalMaksym KholiavchenkoMeenakshi KhoslaNaji KhosravanSeyed Mostafa KiaRon KikinisDaeseung KimGeena KimHak Gu KimHeejong KimHosung KimHyo-Eun KimJinman KimJinyoung KimMansu KimMinjeong KimSeong Tae KimWon Hwa KimYoung-Ho KimAtilla KiralyYoshiro KitamuraTakayuki KitasakaSabrina KletzTobias KlinderKranthi KolliSatoshi KondoBin KongJun KongTomasz KonopczynskiEnder KonukogluBongjin KooKivanc KoseAnna KreshukAnithaPriya KrishnanPavitra KrishnaswamyFrithjof KruggelAlexander KrullElizabeth KrupinskiHulin Kuang

Organization xix

Serife KucurDavid KüglerArjan KuijperJan KukackaNilima KulkarniAbhay KumarAshnil KumarKuldeep KumarNeeraj KumarNitin KumarManuela KunzHolger KunzeTahsin KurcThomas KurmannYoshihiro KurodaJin Tae KwakYongchan KwonAymen LaadhariDmitrii LachinovAlexander LadikosAlain LalandeRodney LalondeTryphon LambrouHengrong LanCatherine LaporteCarole LartizienBianca Lassen-SchmidtAndras LassoNgan LeLeo LebratChanghwan LeeEung-Joo LeeHyekyoung LeeJong-Hwan LeeJungbeom LeeMatthew LeeSangmin LeeSoochahn LeeStefan LegerÉtienne LégerBaiying LeiAndreas LeibetsederRogers Jeffrey Leo JohnJuan LeonWee Kheng LeowAnnan Li

Bo LiChongyi LiHaohan LiHongming LiHongwei LiHuiqi LiJian LiJianning LiJiayun LiJunhua LiLincan LiMengzhang LiMing LiQing LiQuanzheng LiShulong LiShuyu LiWeikai LiWenyuan LiXiang LiXiaomeng LiXiaoxiao LiXin LiXiuli LiYang Li (Beihang University)Yang Li (Northeast Electric Power

University)Yi LiYuexiang LiZeju LiZhang LiZhen LiZhiyuan LiZhjin LiZhongyu LiChunfeng LianGongbo LiangLibin LiangShanshan LiangYudong LiangHaofu LiaoRuizhi LiaoGilbert LimBaihan LinHongxiang LinHuei-Yung Lin

xx Organization

Jianyu LinC. LindnerGeert LitjensBin LiuChang LiuDongnan LiuFeng LiuHangfan LiuJianfei LiuJin LiuJingya LiuJingyu LiuKai LiuKefei LiuLihao LiuLuyan LiuMengting LiuNa LiuPeng LiuPing LiuQuande LiuQun LiuShengfeng LiuShuangjun LiuSidong LiuSiqi LiuSiyuan LiuTianrui LiuXianglong LiuXinyang LiuYan LiuYuan LiuYuhang LiuAndrea LoddoHerve LombaertMarco LorenziJian LouNicolas Loy RodasAllen LuDonghuan LuHuanxiang LuJiwen LuLe LuWeijia LuXiankai LuYao Lu

Yongyi LuYueh-Hsun LuChristian LucasOeslle LucenaImanol LuengoRonald LuiGongning LuoJie LuoMa LuoMarcel LuthiKhoa LuuBin LvJinglei LvIlwoo LyuQing LyuSharath M. S.Andy J. MaChunwei MaDa MaHua MaJingting MaKai MaLei MaWenao MaYuexin MaAmirreza MahbodSara MahdaviMohammed MahmoudGabriel MaicasKlaus H. Maier-HeinSokratis MakrogiannisBilal MalikAnand MalpaniIlja ManakovMatteo ManciniEfthymios ManeasTommaso MansiBrett MarinelliRazvan MarinescuPablo Márquez NeilaCarsten MarrYassine MarrakchiFabio MartinezAntonio Martinez-TorteyaAndre MastmeyerDimitrios Mavroeidis

Organization xxi

Jamie McClellandVerónica Medina BañuelosRaghav MehtaSachin MehtaLiye MeiRaphael MeierQier MengQingjie MengYu MengMartin MentenOdyssée MerveillePablo MesejoLiang MiShun MiaoStijn MichielseMikhail MilchenkoHyun-Seok MinZhe MinTadashi MiyamotoAryan MobinyIrina MocanuSara MocciaOmid MohareriHassan Mohy-ud-DinMuthu Rama Krishnan MookiahRodrigo MorenoLia MorraAgata MosinskaSaman MotamedMohammad Hamed MozaffariAnirban MukhopadhyayHenning MüllerBalamurali MurugesanCosmas MwikirizeAndriy MyronenkoSaad NadeemAhmed NaglahVivek NatarajanVishwesh NathRodrigo NavaFernando NavarroLydia Neary-ZajiczekPeter NeherDominik NeumannGia NgoHannes Nickisch

Dong NieJingxin NieWeizhi NieAditya NigamXia NingZhenyuan NingSijie NiuTianye NiuAlexey NovikovJorge NovoChinedu NwoyeMohammad ObeidMasahiro OdaThomas O’DonnellBenjamin OdrySteffen Oeltze-JafraAyşe OktayHugo OliveiraMarcelo OliveiraSara OliveiraArnau OliverSahin OlutJimena OlveresJohn OnofreyEliza OrasanuFelipe Orihuela-EspinaJosé OrlandoMarcos OrtegaSarah OstadabbasYoshito OtakeSebastian OtaloraCheng OuyangJiahong OuyangCristina Oyarzun LauraMichal Ozery-FlatoKrittin PachtrachaiJohannes PaetzoldJin PanYongsheng PanPrashant PandeyJoao PapaGiorgos PapanastasiouConstantin PapeNripesh ParajuliHyunjin ParkSanghyun Park

xxii Organization

Seyoun ParkAngshuman PaulChristian PayerChengtao PengJialin PengLiying PengTingying PengYifan PengTobias PenzkoferAntonio PepeOscar PerdomoJose-Antonio Pérez-CarrascoFernando Pérez-GarcíaJorge Perez-GonzalezSkand PeriLoic PeterJorg PetersJens PetersenCaroline PetitjeanMicha PfeifferDzung PhamRenzo PhellanAshish PhophaliaMark PickeringKilian PohlIulia PopescuKarteek PopuriTiziano PortenierAlison PouchArash PourtaherianPrateek PrasannaAlexander PreuhsRaphael PrevostJuan PrietoViswanath P. S.Sergi PujadesKumaradevan PunithakumarElodie PuybareauHaikun QiHuan QiXin QiBuyue QianZhen QianYan QiangYuchuan QiaoZhi Qiao

Chen QinWenjian QinYanguo QinWu QiuHui QuKha Gia QuachPrashanth R.Pradeep Reddy RaamanaJagath RajapakseKashif RajpootJhonata RamosAndrik RampunParnesh RanigaNagulan RatnarajahRichard RauMehul RavalKeerthi Sravan RaviDaniele RavìHarish RaviPrakashRohith ReddyMarkus RempflerXuhua RenYinhao RenYudan RenAnne-Marie RickmannBrandalyn RiedelLeticia RittnerRobert RobinsonJessica RodgersRobert RohlingLukasz RoszkowiakKarsten RothJosé RoucoSu RuanDaniel RueckertMirabela RusuErica RutterJaime S. CardosoMohammad SabokrouMonjoy SahaPramit SahaDushyant SahooPranjal SahuWojciech SamekJuan A. Sánchez-MargalloRobin Sandkuehler

Organization xxiii

Rodrigo Santa CruzGianmarco SantiniAnil Kumar SaoMhd Hasan SarhanDuygu SarikayaImari SatoOlivier SautMattia SavardiRamasamy SavithaFabien ScalzoNico ScherfAlexander SchlaeferPhilipp SchleerLeopold SchmettererJulia SchnabelKlaus SchoeffmannPeter SchuefflerAndreas SchuhThomas SchultzMichael SchwierMichael SdikaSuman SedaiRaghavendra SelvanSourya SenguptaYoungho SeoLama SeoudAna SequeiraSaeed SeyyediGiorgos SfikasSobhan ShafieiReuben ShamirShayan ShamsHongming ShanYeqin ShaoHarshita SharmaGregory SharpMohamed ShehataHaocheng ShenMali ShenYiqiu ShenZhengyang ShenLuyao ShiXiaoshuang ShiYemin ShiYonghong ShiSaurabh Shigwan

Hoo-Chang ShinSuprosanna ShitYucheng ShuNadya ShusharinaAlberto SignoroniCarlos A. SilvaWilson SilvaPraveer SinghRamandeep SinghRohit SinglaSumedha SinglaAyushi SinhaRajath SoansHessam SokootiJaemin SonMing SongTianyu SongYang SongYouyi SongAristeidis SotirasArcot SowmyaRachel SparksBella SpecktorWilliam SpeierZiga SpiclinDominik SpinczykChetan SrinidhiVinkle SrivastavLawrence StaibPeter SteinbachDarko SternJoshua StoughJustin StraitRobin StrandMartin StynerHai SuPan SuYun-Hsuan SuVaishnavi SubramanianGérard SubsolCarole SudreYao SuiAvan SuinesiaputraJeremias SulamShipra SumanJian Sun

xxiv Organization

Liang SunTao SunKyung SungChiranjib SurYannick SuterRaphael SznitmanSolale TabarestaniFatemeh Taheri DezakiRoger TamJosé Tamez-PeñaChaowei TanJiaxing TanHao TangSheng TangThomas TangXiongfeng TangZhenyu TangMickael TardyEu Wern TehAntonio Tejero-de-PablosPaul ThienphrapaStephen ThompsonFelix ThomsenJiang TianYun TianAleksei TiulpinHamid TizhooshMatthew ToewsOguzhan TopsakalJordina TorrentsSylvie TreuilletJocelyne TroccazEmanuele TruccoVinh Truong HoangChialing TsaiAndru Putra TwinandaNorimichi UkitaEranga UkwattaMathias UnberathTamas UngiMartin UrschlerVerena UslarFatmatulzehra UsluRégis VaillantJeya Maria Jose ValanarasuMarta Vallejo

Fons van der SommenGijs van TulderKimberlin van WijnenYogatheesan VaratharajahMarta VarelaThomas VarsavskyFrancisco VasconcelosS. Swaroop VedulaSanketh VedulaHarini VeeraraghavanGonzalo Vegas Sanchez-FerreroAnant VemuriGopalkrishna VeniRuchika VermaUjjwal VermaPedro VieiraJuan Pedro Vigueras GuillenPierre-Frederic VillardAthanasios VlontzosWolf-Dieter VoglIngmar VoigtEugene VorontsovBo WangCheng WangChengjia WangChunliang WangDadong WangGuotai WangHaifeng WangHongkai WangHongyu WangHua WangHuan WangJun WangKuanquan WangKun WangLei WangLi WangLiansheng WangManning WangRuixuan WangShanshan WangShujun WangShuo WangTianchen WangTongxin Wang

Organization xxv

Wenzhe WangXi WangXiangxue WangYalin WangYan Wang (Sichuan University)Yan Wang (Johns Hopkins University)Yaping WangYi WangYirui WangYuanjun WangYun WangZeyi WangZhangyang WangSimon WarfieldJonathan WeberJürgen WeeseDonglai WeiDongming WeiZhen WeiMartin WeigertMichael WelsJunhao WenMatthias WilmsStefan WinzeckAdam WittekMarek WodzinskiJelmer WolterinkKen C. L. WongJonghye WooChongruo WuDijia WuJi WuJian Wu (Tsinghua University)Jian Wu (Zhejiang University)Jie Ying WuJunyan WuMinjie WuPengxiang WuXi WuXia WuXiyin WuYe WuYicheng WuYifan WuZhengwang WuTobias Wuerfl

Pengcheng XiJames XiaSiyu XiaYingda XiaYong XiaLei XiangDeqiang XiaoLi Xiao (Tulane University)Li Xiao (Chinese Academy of Science)Yuting XiaoHongtao XieJianyang XieLingxi XieLong XieXueqian XieYiting XieYuan XieYutong XieFangxu XingFuyong XingTao XiongChenchu XuHongming XuJiaofeng XuKele XuLisheng XuMin XuRui XuXiaowei XuYanwu XuYongchao XuZhenghua XuCheng XueJie XueWufeng XueYuan XueFaridah YahyaChenggang YanKe YanWeizheng YanYu YanYuguang YanZhennan YanChangchun YangChao-Han Huck YangDong Yang

xxvi Organization

Fan Yang (IIAI)Fan Yang (Temple University)Feng YangGe YangGuang YangHeran YangHongxu YangHuijuan YangJiancheng YangJie YangJunlin YangLin YangXiao YangXiaohui YangXin YangYan YangYujiu YangDongren YaoJianhua YaoJiawen YaoLi YaoChuyang YeHuihui YeMenglong YeXujiong YeAndy W. K. YeungJingru YiJirong YiXin YiYi YinShihui YingYoungjin YooChenyu YouSahar YousefiHanchao YuJinhua YuKai YuLequan YuQi YuYang YuZhen YuPengyu YuanYixuan YuanPaul YushkevichGhada ZamzmiDong Zeng

Guodong ZengOliver ZettinigZhiwei ZhaiKun ZhanBaochang ZhangChaoyi ZhangDaoqiang ZhangDongqing ZhangFan Zhang (Yale University)Fan Zhang (Harvard Medical School)Guangming ZhangHan ZhangHang ZhangHaopeng ZhangHeye ZhangHuahong ZhangJianpeng ZhangJinao ZhangJingqing ZhangJinwei ZhangJiong ZhangJun ZhangLe ZhangLei ZhangLichi ZhangLin ZhangLing ZhangLu ZhangMiaomiao ZhangNing ZhangPengfei ZhangPengyue ZhangQiang ZhangRongzhao ZhangRu-Yuan ZhangShanzhuo ZhangShu ZhangTong ZhangWei ZhangWeiwei ZhangWenlu ZhangXiaoyun ZhangXin ZhangYa ZhangYanbo ZhangYanfu Zhang

Organization xxvii

Yi ZhangYifan ZhangYizhe ZhangYongqin ZhangYou ZhangYoushan ZhangYu ZhangYue ZhangYulun ZhangYunyan ZhangYuyao ZhangZijing ZhangCan ZhaoChangchen ZhaoFenqiang ZhaoGangming ZhaoHaifeng ZhaoHe ZhaoJun ZhaoLi ZhaoQingyu ZhaoRongchang ZhaoShen ZhaoTengda ZhaoTianyi ZhaoWei ZhaoXuandong ZhaoYitian ZhaoYiyuan ZhaoYu ZhaoYuan-Xing ZhaoYue ZhaoZixu ZhaoZiyuan ZhaoXingjian ZhenHao ZhengJiannan ZhengKang Zheng

Yalin ZhengYushan ZhengJia-Xing ZhongZichun ZhongHaoyin ZhouKang ZhouSanping ZhouTao ZhouWenjin ZhouXiao-Hu ZhouXiao-Yun ZhouYanning ZhouYi Zhou (IIAI)Yi Zhou (University of Utah)Yuyin ZhouZhen ZhouZongwei ZhouDajiang ZhuDongxiao ZhuHancan ZhuLei ZhuQikui ZhuWeifang ZhuWentao ZhuXiaofeng ZhuXinliang ZhuYingying ZhuYuemin ZhuZhe ZhuZhuotun ZhuXiahai ZhuangAneeq ZiaVeronika ZimmerDavid ZimmererLilla ZölleiYukai ZouGerald ZwettlerReyer Zwiggelaa

xxviii Organization

Contents – Part VI

Angiography and Vessel Analysis

Lightweight Double Attention-Fused Networks for IntraoperativeStent Segmentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3

Yan-Jie Zhou, Xiao-Liang Xie , Zeng-Guang Hou , Xiao-Hu Zhou,Gui-Bin Bian, and Shi-Qi Liu

TopNet: Topology Preserving Metric Learning for Vessel TreeReconstruction and Labelling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

Deepak Keshwani, Yoshiro Kitamura, Satoshi Ihara, Satoshi Iizuka,and Edgar Simo-Serra

Learning Hybrid Representations for Automatic 3D VesselCenterline Extraction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24

Jiafa He, Chengwei Pan, Can Yang, Ming Zhang, Yang Wang,Xiaowei Zhou, and Yizhou Yu

Branch-Aware Double DQN for Centerline Extraction in CoronaryCT Angiography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35

Yuyang Zhang, Gongning Luo, Wei Wang, and Kuanquan Wang

Automatic CAD-RADS Scoring Using Deep Learning. . . . . . . . . . . . . . . . . 45Felix Denzinger, Michael Wels, Katharina Breininger,Mehmet A. Gülsün, Max Schöbinger, Florian André, Sebastian Buß,Johannes Görich, Michael Sühling, and Andreas Maier

Higher-Order Flux with Spherical Harmonics Transformfor Vascular Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55

Jierong Wang and Albert C. S. Chung

Cerebrovascular Segmentation in MRA via Reverse EdgeAttention Network. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66

Hao Zhang, Likun Xia, Ran Song, Jianlong Yang, Huaying Hao,Jiang Liu, and Yitian Zhao

Automated Intracranial Artery Labeling Using a Graph Neural Networkand Hierarchical Refinement. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76

Li Chen, Thomas Hatsukami, Jenq-Neng Hwang, and Chun Yuan

Time Matters: Handling Spatio-Temporal Perfusion Informationfor Automated TICI Scoring. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86

Maximilian Nielsen, Moritz Waldmann, Thilo Sentker, Andreas Frölich,Jens Fiehler, and René Werner

ID-Fit: Intra-Saccular Device Adjustment for Personalized CerebralAneurysm Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97

Romina Muñoz, Ana Paula Narata, and Ignacio Larrabide

JointVesselNet: Joint Volume-Projection Convolutional EmbeddingNetworks for 3D Cerebrovascular Segmentation . . . . . . . . . . . . . . . . . . . . . 106

Yifan Wang, Guoli Yan, Haikuan Zhu, Sagar Buch, Ying Wang,Ewart Mark Haacke, Jing Hua, and Zichun Zhong

Classification of Retinal Vessels into Artery-Vein in OCT AngiographyGuided by Fundus Images . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117

Jianyang Xie, Yonghuai Liu, Yalin Zheng, Pan Su, Yan Hu,Jianlong Yang, Jiang Liu, and Yitian Zhao

Vascular Surface Segmentation for Intracranial Aneurysm Isolationand Quantification. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 128

Žiga Bizjak, Boštjan Likar, Franjo Pernuš, and Žiga Špiclin

Breast Imaging

Deep Doubly Supervised Transfer Network for Diagnosis of Breast Cancerwith Imbalanced Ultrasound Imaging Modalities . . . . . . . . . . . . . . . . . . . . . 141

Xiangmin Han, Jun Wang, Weijun Zhou, Cai Chang, Shihui Ying,and Jun Shi

2D X-Ray Mammogram and 3D Breast MRI Registration . . . . . . . . . . . . . . 150Hossein Soleimani and Oleg V. Michailovich

A Second-Order Subregion Pooling Network for Breast LesionSegmentation in Ultrasound . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 160

Lei Zhu, Rongzhen Chen, Huazhu Fu, Cong Xie, Liansheng Wang,Liang Wan, and Pheng-Ann Heng

Multi-scale Gradational-Order Fusion Framework for Breast LesionsClassification Using Ultrasound Images . . . . . . . . . . . . . . . . . . . . . . . . . . . 171

Zhenyuan Ning, Chao Tu, Qing Xiao, Jiaxiu Luo, and Yu Zhang

Computer-Aided Tumor Diagnosis in Automated Breast Ultrasound Using3D Detection Network . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181

Junxiong Yu, Chaoyu Chen, Xin Yang, Yi Wang, Dan Yan,Jianxing Zhang, and Dong Ni

xxx Contents – Part VI

Auto-weighting for Breast Cancer Classificationin Multimodal Ultrasound . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 190

Jian Wang, Juzheng Miao, Xin Yang, Rui Li, Guangquan Zhou,Yuhao Huang, Zehui Lin, Wufeng Xue, Xiaohong Jia, Jianqiao Zhou,Ruobing Huang, and Dong Ni

MommiNet: Mammographic Multi-view Mass Identification Networks . . . . . 200Zhicheng Yang, Zhenjie Cao, Yanbo Zhang, Mei Han, Jing Xiao,Lingyun Huang, Shibin Wu, Jie Ma, and Peng Chang

Multi-site Evaluation of a Study-Level Classifier for Mammography UsingDeep Learning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211

Dustin Sargent, Sun Young Park, Amod Jog, Aly Mohamed,and David Richmond

The Case of Missed Cancers: Applying AI as a Radiologist’s Safety Net . . . . 220Michal Chorev, Yoel Shoshan, Ayelet Akselrod-Ballin, Adam Spiro,Shaked Naor, Alon Hazan, Vesna Barros, Iuliana Weinstein,Esma Herzel, Varda Shalev, Michal Guindy, and Michal Rosen-Zvi

Decoupling Inherent Risk and Early Cancer Signs in Image-Based BreastCancer Risk Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 230

Yue Liu, Hossein Azizpour, Fredrik Strand, and Kevin Smith

Multi-task Learning for Detection and Classification of Cancerin Screening Mammography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241

Maria V. Sainz de Cea, Karl Diedrich, Ran Bakalo, Lior Ness,and David Richmond

Colonoscopy

Adaptive Context Selection for Polyp Segmentation . . . . . . . . . . . . . . . . . . 253Ruifei Zhang, Guanbin Li, Zhen Li, Shuguang Cui, Dahong Qian,and Yizhou Yu

PraNet: Parallel Reverse Attention Network for Polyp Segmentation . . . . . . . 263Deng-Ping Fan, Ge-Peng Ji, Tao Zhou, Geng Chen, Huazhu Fu,Jianbing Shen, and Ling Shao

Few-Shot Anomaly Detection for Polyp Frames from Colonoscopy . . . . . . . . 274Yu Tian, Gabriel Maicas, Leonardo Zorron Cheng Tao Pu,Rajvinder Singh, Johan W. Verjans, and Gustavo Carneiro

PolypSeg: An Efficient Context-Aware Network for Polyp Segmentationfrom Colonoscopy Videos . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285

Jiafu Zhong, Wei Wang, Huisi Wu, Zhenkun Wen, and Jing Qin

Contents – Part VI xxxi

Endoscopic Polyp Segmentation Using a Hybrid 2D/3D CNN . . . . . . . . . . . 295Juana González-Bueno Puyal, Kanwal K. Bhatia, Patrick Brandao,Omer F. Ahmad, Daniel Toth, Rawen Kader, Laurence Lovat,Peter Mountney, and Danail Stoyanov

Dermatology

A Distance-Based Loss for Smooth and Continuous Skin LayerSegmentation in Optoacoustic Images . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309

Stefan Gerl, Johannes C. Paetzold, Hailong He, Ivan Ezhov,Suprosanna Shit, Florian Kofler, Amirhossein Bayat, Giles Tetteh,Vasilis Ntziachristos, and Bjoern Menze

Fairness of Classifiers Across Skin Tones in Dermatology . . . . . . . . . . . . . . 320Newton M. Kinyanjui, Timothy Odonga, Celia Cintas,Noel C. F. Codella, Rameswar Panda, Prasanna Sattigeri,and Kush R. Varshney

Alleviating the Incompatibility Between Cross Entropy Loss and EpisodeTraining for Few-Shot Skin Disease Classification. . . . . . . . . . . . . . . . . . . . 330

Wei Zhu, Haofu Liao, Wenbin Li, Weijian Li, and Jiebo Luo

Clinical-Inspired Network for Skin Lesion Recognition . . . . . . . . . . . . . . . . 340Zihao Liu, Ruiqin Xiong, and Tingting Jiang

Multi-class Skin Lesion Segmentation for Cutaneous T-cell Lymphomason High-Resolution Clinical Images . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 351

Zihao Liu, Haihao Pan, Chen Gong, Zejia Fan, Yujie Wen,Tingting Jiang, Ruiqin Xiong, Hang Li, and Yang Wang

Fetal Imaging

Deep Learning Automatic Fetal Structures Segmentation in MRI Scanswith Few Annotated Datasets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 365

Gal Dudovitch, Daphna Link-Sourani, Liat Ben Sira, Elka Miller,Dafna Ben Bashat, and Leo Joskowicz

Data-Driven Multi-contrast Spectral Microstructure Imaging with InSpect . . . 375Paddy J. Slator, Jana Hutter, Razvan V. Marinescu, Marco Palombo,Laurence H. Jackson, Alison Ho, Lucy C. Chappell, Mary Rutherford,Joseph V. Hajnal, and Daniel C. Alexander

Semi-supervised Learning for Fetal Brain MRI Quality Assessmentwith ROI Consistency . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 386

Junshen Xu, Sayeri Lala, Borjan Gagoski, Esra Abaci Turk,P. Ellen Grant, Polina Golland, and Elfar Adalsteinsson

xxxii Contents – Part VI

Enhanced Detection of Fetal Pose in 3D MRI by Deep ReinforcementLearning with Physical Structure Priors on Anatomy . . . . . . . . . . . . . . . . . . 396

Molin Zhang, Junshen Xu, Esra Abaci Turk, P. Ellen Grant,Polina Golland, and Elfar Adalsteinsson

Automatic Angle of Progress Measurement of Intrapartum TransperinealUltrasound Image with Deep Learning. . . . . . . . . . . . . . . . . . . . . . . . . . . . 406

Minghong Zhou, Chao Yuan, Zhaoshi Chen, Chuan Wang,and Yaosheng Lu

Joint Image Quality Assessment and Brain Extraction of Fetal MRIUsing Deep Learning. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 415

Lufan Liao, Xin Zhang, Fenqiang Zhao, Tao Zhong, Yuchen Pei,Xiangmin Xu, Li Wang, He Zhang, Dinggang Shen, and Gang Li

Heart and Lung Imaging

Accelerated 4D Respiratory Motion-Resolved Cardiac MRI witha Model-Based Variational Network . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 427

Haikun Qi, Niccolo Fuin, Thomas Kuestner, René Botnar,and Claudia Prieto

Motion Pyramid Networks for Accurate and Efficient CardiacMotion Estimation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 436

Hanchao Yu, Xiao Chen, Humphrey Shi, Terrence Chen,Thomas S. Huang, and Shanhui Sun

ICA-UNet: ICA Inspired Statistical UNet for Real-Time 3D Cardiac CineMRI Segmentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 447

Tianchen Wang, Xiaowei Xu, Jinjun Xiong, Qianjun Jia, Haiyun Yuan,Meiping Huang, Jian Zhuang, and Yiyu Shi

A Bottom-Up Approach for Real-Time Mitral Valve Annulus Modelingon 3D Echo Images. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 458

Yue Zhang, Abdoul-aziz Amadou, Ingmar Voigt, Viorel Mihalef,Helene Houle, Matthias John, Tommaso Mansi, and Rui Liao

A Semi-supervised Joint Network for Simultaneous Left VentricularMotion Tracking and Segmentation in 4D Echocardiography . . . . . . . . . . . . 468

Kevinminh Ta, Shawn S. Ahn, John C. Stendahl, Albert J. Sinusas,and James S. Duncan

Joint Data Imputation and Mechanistic Modelling for Simulating Heart-Brain Interactions in Incomplete Datasets . . . . . . . . . . . . . . . . . . . . . . . . . . 478

Jaume Banus, Maxime Sermesant, Oscar Camara, and Marco Lorenzi

Contents – Part VI xxxiii

Learning Geometry-Dependent and Physics-Based InverseImage Reconstruction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 487

Xiajun Jiang, Sandesh Ghimire, Jwala Dhamala, Zhiyuan Li,Prashnna Kumar Gyawali, and Linwei Wang

Hierarchical Classification of Pulmonary Lesions: A Large-ScaleRadio-Pathomics Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 497

Jiancheng Yang, Mingze Gao, Kaiming Kuang, Bingbing Ni,Yunlang She, Dong Xie, and Chang Chen

Learning Tumor Growth via Follow-Up Volume Predictionfor Lung Nodules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 508

Yamin Li, Jiancheng Yang, Yi Xu, Jingwei Xu, Xiaodan Ye,Guangyu Tao, Xueqian Xie, and Guixue Liu

Multi-stream Progressive Up-Sampling Network for Dense CTImage Reconstruction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 518

Qiuyue Liu, Zhen Zhou, Feng Liu, Xiangming Fang, Yizhou Yu,and Yizhou Wang

Abnormality Detection in Chest X-Ray Images Using UncertaintyPrediction Autoencoders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 529

Yifan Mao, Fei-Fei Xue, Ruixuan Wang, Jianguo Zhang, Wei-Shi Zheng,and Hongmei Liu

Region Proposals for Saliency Map Refinement for Weakly-SupervisedDisease Localisation and Classification . . . . . . . . . . . . . . . . . . . . . . . . . . . 539

Renato Hermoza, Gabriel Maicas, Jacinto C. Nascimento,and Gustavo Carneiro

CPM-Net: A 3D Center-Points Matching Network for Pulmonary NoduleDetection in CT Scans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 550

Tao Song, Jieneng Chen, Xiangde Luo, Yechong Huang, Xinglong Liu,Ning Huang, Yinan Chen, Zhaoxiang Ye, Huaqiang Sheng,Shaoting Zhang, and Guotai Wang

Interpretable Identification of Interstitial Lung Disease (ILD) AssociatedFindings from CT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 560

Yifan Wu, Jiancong Wang, William D. Lindsay, Tarmily Wen,Jianbo Shi, and James C. Gee

Learning with Sure Data for Nodule-Level Lung Cancer Prediction. . . . . . . . 570Hanxiao Zhang, Yun Gu, Yulei Qin, Feng Yao, and Guang-Zhong Yang

Cascaded Robust Learning at Imperfect Labels for ChestX-ray Segmentation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 579

Cheng Xue, Qiao Deng, Xiaomeng Li, Qi Dou, and Pheng-Ann Heng

xxxiv Contents – Part VI

Class-Aware Multi-window Adversarial Lung Nodule SynthesisConditioned on Semantic Features. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 589

Qiuli Wang, Xingpeng Zhang, Wei Chen, Kun Wang,and Xiaohong Zhang

Nodule2vec: A 3D Deep Learning System for Pulmonary Nodule RetrievalUsing Semantic Representation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 599

Ilia Kravets, Tal Heletz, and Hayit Greenspan

Deep Active Learning for Effective Pulmonary Nodule Detection . . . . . . . . . 609Jingya Liu, Liangliang Cao, and Yingli Tian

Musculoskeletal Imaging

Towards Robust Bone Age Assessment: Rethinking Label Noiseand Ambiguity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 621

Ping Gong, Zihao Yin, Yizhou Wang, and Yizhou Yu

Improve Bone Age Assessment by Learning from AnatomicalLocal Regions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 631

Dong Wang, Kexin Zhang, Jia Ding, and Liwei Wang

An Analysis by Synthesis Method that Allows Accurate Spatial Modelingof Thickness of Cortical Bone from Clinical QCT. . . . . . . . . . . . . . . . . . . . 641

Stefan Reinhold, Timo Damm, Sebastian Büsse, Stanislav Gorb,Claus-C. Glüer, and Reinhard Koch

Segmentation of Paraspinal Muscles at Varied Lumbar Spinal Levelsby Explicit Saliency-Aware Learning. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 652

Jiawei Huang, Haotian Shen, Bo Chen, Yue Wang, and Shuo Li

Manifold Ordinal-Mixup for Ordered Classes in TW3-Based BoneAge Assessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 662

Byeonguk Bae, Jaewon Lee, Seo Taek Kong, Jinkyeong Sung,and Kyu-Hwan Jung

Contour-Based Bone Axis Detection for X-Ray Guided Surgeryon the Knee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 671

Florian Kordon, Andreas Maier, Benedict Swartman, Maxim Privalov,Jan Siad El Barbari, and Holger Kunze

Automatic Segmentation, Localization, and Identification of Vertebraein 3D CT Images Using Cascaded Convolutional Neural Networks . . . . . . . . 681

Naoto Masuzawa, Yoshiro Kitamura, Keigo Nakamura, Satoshi Iizuka,and Edgar Simo-Serra

Contents – Part VI xxxv

Discriminative Dictionary-Embedded Network for ComprehensiveVertebrae Tumor Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 691

Shen Zhao, Bin Chen, Heyou Chang, Xi Wu, and Shuo Li

Multi-vertebrae Segmentation from Arbitrary Spine MR Images UnderGlobal View. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 702

Heyou Chang, Shen Zhao, Hao Zheng, Yang Chen, and Shuo Li

A Convolutional Approach to Vertebrae Detection and Labelling in WholeSpine MRI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 712

Rhydian Windsor, Amir Jamaludin, Timor Kadir, and Andrew Zisserman

Keypoints Localization for Joint Vertebra Detection and FractureSeverity Quantification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 723

Maxim Pisov, Vladimir Kondratenko, Alexey Zakharov,Alexey Petraikin, Victor Gombolevskiy, Sergey Morozov,and Mikhail Belyaev

Grading Loss: A Fracture Grade-Based Metric Loss for VertebralFracture Detection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 733

Malek Husseini, Anjany Sekuboyina, Maximilian Loeffler,Fernando Navarro, Bjoern H. Menze, and Jan S. Kirschke

3D Convolutional Sequence to Sequence Model for Vertebral CompressionFractures Identification in CT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 743

David Chettrit, Tomer Meir, Hila Lebel, Mila Orlovsky,Ronen Gordon, Ayelet Akselrod-Ballin, and Amir Bar

SIMBA: Specific Identity Markers for Bone Age Assessment . . . . . . . . . . . . 753Cristina González, María Escobar, Laura Daza, Felipe Torres,Gustavo Triana, and Pablo Arbeláez

Doctor Imitator: A Graph-Based Bone Age Assessment Framework UsingHand Radiographs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 764

Jintai Chen, Bohan Yu, Biwen Lei, Ruiwei Feng, Danny Z. Chen,and Jian Wu

Inferring the 3D Standing Spine Posture from 2D Radiographs . . . . . . . . . . . 775Amirhossein Bayat, Anjany Sekuboyina, Johannes C. Paetzold,Christian Payer, Darko Stern, Martin Urschler, Jan S. Kirschke,and Bjoern H. Menze

Generative Modelling of 3D In-Silico Spongiosa with ControllableMicro-structural Parameters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 785

Emmanuel Iarussi, Felix Thomsen, and Claudio Delrieux

xxxvi Contents – Part VI

GAN-Based Realistic Bone Ultrasound Image and Label Synthesisfor Improved Segmentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 795

Ahmed Z. Alsinan, Charles Rule, Michael Vives, Vishal M. Patel,and Ilker Hacihaliloglu

Robust Bone Shadow Segmentation from 2D Ultrasound ThroughTask Decomposition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 805

Puyang Wang, Michael Vives, Vishal M. Patel, and Ilker Hacihaliloglu

Correction to: The Case of Missed Cancers: Applying AI as a Radiologist’sSafety Net . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C1

Michal Chorev, Yoel Shoshan, Ayelet Akselrod-Ballin, Adam Spiro,Shaked Naor, Alon Hazan, Vesna Barros, Iuliana Weinstein,Esma Herzel, Varda Shalev, Michal Guindy, and Michal Rosen-Zvi

Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 815

Contents – Part VI xxxvii