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PATOLOGI SISTEMIK II (PAP 442)PATOLOGI SISTEMIK II (PAP 442)PATOLOGI SISTEMIK II (PAP 442)PATOLOGI SISTEMIK II (PAP 442)

PATOLOGI ALAT REPRODUKSIPATOLOGI ALAT REPRODUKSIALAT KELAMIN JANTANALAT KELAMIN JANTANALAT KELAMIN JANTANALAT KELAMIN JANTAN

Dr. drh. Eva Harlina, MSi.Dr. drh. Eva Harlina, MSi.

Bagian Patologi Bagian Patologi Departemen Klinik, Reproduksi dan PatologiDepartemen Klinik, Reproduksi dan PatologiFakultas Kedokteran HewanFakultas Kedokteran Hewan IPBIPBFakultas Kedokteran HewanFakultas Kedokteran Hewan--IPBIPBJl. Agatis Kampus IPB Darmaga, Bogor Jl. Agatis Kampus IPB Darmaga, Bogor -- 1668016680

MALE REPRODUCTIVE SYSTEMMALE REPRODUCTIVE SYSTEMMALE REPRODUCTIVE SYSTEMMALE REPRODUCTIVE SYSTEM

•• TestisTestis

•• Excretory ductExcretory duct

•• Accessory glandsAccessory glands•• Accessory glandsAccessory glands

•• Penis and prepucePenis and prepucep pp p

Patologi Alat Kelamin Jantan 2Patologi Alat Kelamin Jantan 2

MALE REPRODUCTIVE SYSTEMMALE REPRODUCTIVE SYSTEM

•• TestisTestisSeminiferous tubules (contain germ cellsSeminiferous tubules (contain germ cellsSeminiferous tubules (contain germ cells Seminiferous tubules (contain germ cells in various stage of maturation), Sertoli in various stage of maturation), Sertoli cell Leydig cellscell Leydig cellscell, Leydig cellscell, Leydig cells

•• Excretory ductExcretory duct: epididymis, vas deferens: epididymis, vas deferens

•• Accessory glandsAccessory glands: seminal vesicles, : seminal vesicles, prostateprostate

•• Penis and prepucePenis and prepuce

DISEASES OF THE MALE DISEASES OF THE MALE REPRODUCTIVE SYSTEMREPRODUCTIVE SYSTEM

Developmental disorders Developmental disorders

Diseases of the scrotum and contentsDiseases of the scrotum and contents

Diseases of the accessory glandsDiseases of the accessory glands Diseases of the accessory glandsDiseases of the accessory glands

Diseases of the penis and prepuceDiseases of the penis and prepuce

DEVELOPMENTAL DISORDERSDEVELOPMENTAL DISORDERSDEVELOPMENTAL DISORDERSDEVELOPMENTAL DISORDERS

MAJOR ANOMALIESMAJOR ANOMALIESMAJOR ANOMALIESMAJOR ANOMALIES

Sexual dimorphism Sexual dimorphism pp

Segmental aplasia of epididymisSegmental aplasia of epididymis

CryptorchidismCryptorchidism

Testicular hypoplasiaTesticular hypoplasia Testicular hypoplasiaTesticular hypoplasia

Spermatic granuloma Spermatic granuloma

SEXUAL DIMORPHISMSEXUAL DIMORPHISM

Errors of chromose, gonadal or phenotypic sexErrors of chromose, gonadal or phenotypic sex

1. Sex chromosomes (structure and number).1. Sex chromosomes (structure and number).

a. Abnormal structure of Y a. Abnormal structure of Y (isochromosome)(isochromosome)FFemale phenotype emale phenotype H l ti dH l ti dHypoplasctic gonadsHypoplasctic gonads

b.b. Duplication of one of the sex chromosomeDuplication of one of the sex chromosomeb.b. Duplication of one of the sex chromosome Duplication of one of the sex chromosome (XXY, XYY) (XXY, XYY) Testicular hypoplasia Testicular hypoplasia Kli f lt ’ d (t i l l t)Kli f lt ’ d (t i l l t)Klinefelter’s syndrome (tricolor male cat)Klinefelter’s syndrome (tricolor male cat)

SEXUAL DIMORPHISM …SEXUAL DIMORPHISM …

2 Hermaprhodites2 Hermaprhodites2. Hermaprhodites2. Hermaprhodites

•• XY genotypeXY genotype

•• Androgen receptor disorderAndrogen receptor disorder

•• Abnormal gonads (have both Abnormal gonads (have both testicular and ovarium tissue)testicular and ovarium tissue)test cu a a d o a u t ssue)test cu a a d o a u t ssue)

Male pseudo-Male pseudohermaphrodite: XY chromosome

MINOR ANOMALIESMINOR ANOMALIES

MINOR ANOMALIESMINOR ANOMALIESMINOR ANOMALIESMINOR ANOMALIES

DISEASES OF THE SCROTUMDISEASES OF THE SCROTUMDISEASES OF THE SCROTUM DISEASES OF THE SCROTUM AND CONTENTSAND CONTENTS

The scrotumThe scrotum The scrotumThe scrotum

T i d E idid iT i d E idid i Testis and EpididymisTestis and Epididymis

DISEASES OF THE SCROTUM DISEASES OF THE SCROTUM

Dermatitis Dermatitis TTTrauma Trauma Frosbite Frosbite E i t l i it tE i t l i it tEnvironmental irritants Environmental irritants Chorioptes bovisChorioptes bovis

Neoplasma Neoplasma ppMast cell tumor Mast cell tumor Melanoma Melanoma HemangiomaHemangioma

DISEASES OF TESTIS AND DISEASES OF TESTIS AND EPIDIDYMISEPIDIDYMIS

Decreased sizeDecreased size

C t hidiC t hidi CryptorchidismCryptorchidism

HypoplasiaHypoplasiayp pyp p

Testicular degenerationTesticular degeneration

Segmental aplasiaSegmental aplasia

Increased sizeIncreased size

Spermatic granuloma of epididymisSpermatic granuloma of epididymis

EpididymitisEpididymitis

OrchitisOrchitis

Testicular neoplasia: Testicular neoplasia: Seminoma Seminoma Sertoli cell tumor Sertoli cell tumor Interstitial cell tumorInterstitial cell tumor

CRYPTORCHIDISMCRYPTORCHIDISMDecreased size …Decreased size …

Incomplete descent of testisIncomplete descent of testis

Oft il t lOft il t l Often unilateral Often unilateral

Hypoplasia or atrophyHypoplasia or atrophy Hypoplasia or atrophyHypoplasia or atrophy

Testis is small, fibrotic, hyaline thickening Testis is small, fibrotic, hyaline thickening of tubular basement membraneof tubular basement membraneof tubular basement membrane, of tubular basement membrane, degeneration of germinal epithelium, only a degeneration of germinal epithelium, only a few spermatogonia remain normal Sertolifew spermatogonia remain normal Sertolifew spermatogonia remain, normal Sertoli few spermatogonia remain, normal Sertoli cellscells

P t l i (S t li CT i )P t l i (S t li CT i ) Prone to neoplasia (Sertoli CT, seminoma)Prone to neoplasia (Sertoli CT, seminoma)Patologi Alat Kelamin Jantan 20Patologi Alat Kelamin Jantan 20

HYPOPLASIAHYPOPLASIADecreased size …Decreased size …

Mild to severeMild to severe

Unilateral hypoplasiaUnilateral hypoplasia

Ab lit f ifi d iAb lit f ifi d i Abnormality of specific genes, endocrine, Abnormality of specific genes, endocrine, cytogeniccytogenic

Related to poor general nutrition, Zn deffRelated to poor general nutrition, Zn deff

HP: hypoplastic tubules, lined by sertoli HP: hypoplastic tubules, lined by sertoli cells, a few stem cells and spermatogoniacells, a few stem cells and spermatogonia

TESTICULAR ATROPHYTESTICULAR ATROPHYDecreased size …Decreased size …

Reduce in size after pubertyReduce in size after puberty

Testicular degenerationTesticular degeneration Testicular degenerationTesticular degeneration

HP: deg. of the seminiferous tubulesHP: deg. of the seminiferous tubules

Causes by: inflammation, obstruction of Causes by: inflammation, obstruction of flow of spermatozoa (segmental flow of spermatozoa (segmental aplasia, injury of epididymis, torsion of aplasia, injury of epididymis, torsion of spermatic cord)spermatic cord)

Systemic injurious factor: Systemic injurious factor: hypovitaminosis A, Zn, antibiotic, hypovitaminosis A, Zn, antibiotic, toxins, estrogen produced by sertoli cell toxins, estrogen produced by sertoli cell tumortumor Patologi Alat Kelamin Jantan 25Patologi Alat Kelamin Jantan 25

Some Causes of Testicular Degeneration Some Causes of Testicular Degeneration Advancing ageAdvancing age EpididymitisEpididymitis ChemicalsChemicals HeatHeat HormonesHormones HormonesHormones Metal compound toxicosisMetal compound toxicosis NeoplasiaNeoplasia Nutritional disordersNutritional disorders Nutritional disordersNutritional disorders PlantsPlants RadiationRadiation StressStress TraumaTrauma UltrasoundUltrasound UltrasoundUltrasound Viral infectionViral infection

EPIDIDYMITIS AND EPIDIDYMITIS AND SPERMATIC GRANULOMASPERMATIC GRANULOMA

Inflammation, testicular neoplasiaInflammation, testicular neoplasia

SPERMATIC GRANULOMASPERMATIC GRANULOMA

Inflammation, testicular neoplasiaInflammation, testicular neoplasia

Spermatic granuloma: congenital Spermatic granuloma: congenital obstruction inflammation as respon toobstruction inflammation as respon toobstruction, inflammation as respon to obstruction, inflammation as respon to spermiostatisspermiostatis

Epididymitis is almost accompanied by Epididymitis is almost accompanied by spermatic granuloma and periorchitisspermatic granuloma and periorchitis

Cause testicular degenerationCause testicular degeneration

B. abortus, E. coliB. abortus, E. coliPatologi Alat Kelamin Jantan 29Patologi Alat Kelamin Jantan 29

Increased sizeIncreased sizec eased s ec eased s e

Spermatic granuloma of epididymisSpermatic granuloma of epididymis

EpididymitisEpididymitis

OrchitisOrchitis

PeriorchitisPeriorchitis PeriorchitisPeriorchitis

Testicular neoplasia Testicular neoplasia S iS iSeminoma Seminoma Teratoma Teratoma Sertoli cell tumorSertoli cell tumorSertoli cell tumor Sertoli cell tumor Interstitial cell tumorInterstitial cell tumor

ORCHITISORCHITIS

Extension of epididymitisExtension of epididymitis

HematogenousHematogenous

B b t B iB b t B i B. abortus, B. suis, B. abortus, B. suis, C. pseudotuberculosisC. pseudotuberculosis

Intratubular orchitis, Intratubular orchitis, necrotizing orchitis, necrotizing orchitis,

l t hitil t hiti (M b i(M b igranulomatous orchitisgranulomatous orchitis (M. bovis, (M. bovis, mycotic orchitismycotic orchitis))

TESTICULAR NEOPLASIATESTICULAR NEOPLASIA

Common in older dogCommon in older dog

TESTICULAR NEOPLASIATESTICULAR NEOPLASIA

Arise from germ cellsArise from germ cells

Seminoma Seminoma

I t titi l ll tI t titi l ll t Interstitial cell tumorsInterstitial cell tumors

Sertoli cell tumors: feminizing effectSertoli cell tumors: feminizing effect Sertoli cell tumors: feminizing effect Sertoli cell tumors: feminizing effect ((GynecomasticaGynecomastica: enlargement of : enlargement of mammary gland)mammary gland)

Veneric Sarcoma

Kulit hingga ke mukosa

Sel tumor menyebar seperti anggur

stroma

stromastroma

Sertoli Cell Tumor

Stroma menebal

Tubuli seminiferi berisi sel Sertoli yangSertoli yang berproliferasi

Ukuran tubuli seminiferi bervariasi: membesarmembesar, mengecill

Stroma menebal

Sel Sertoli

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