Pathology Practical

Premalignant lesions and conditions CPC

Mild Epithelial Dysplasia

H&E showing :1. Stratified squamous

epithelium .2. Hyper chromatism.3. Cellular polymorphism.4. Loss of polority .5. Basal hyperplasia .6. Some cell in mitosis.7. Some chronic

inflammatory cells

Moderate Epithelial Dysplasia

H&E showing :

1. Hyperplatic Stratified squamous epithelium .

2. Hyper chromatism.3. Loss of polority

Basal cell .4. Loss of adhesion.5. Increase mitotic cell6. Presence of abnormal

mitotic cell7. Infiltration of chronic

inflammatory cells

Carcinoma in situH&E showing :1. Stratified squamous

epithelium .2. Bulbus retroprocess3. Dysplastic change from

top to bottom.4. Loss of adhesion.5. Increase mitotic cell6. Presence of abnormal

mitotic cell.7. Cellular polymorphism.8. Nuclear polymorphism.9. Infiltration of chronic

inflammatory cells

Lichen planus

H&E showing :1. Atrophy of Stratified

squamous epithelium .2. Hyper chratosis .3. Diffuse of chronic

inflammatory cells.4. Basal cell degeneration.5. Leuko faction.6. Sirett `s body &

breakle cell in basal layer.

Oral Submucous Fibrosis

H&E showing :1. Atrophy of Stratified

squamous epithelium .2. Hyper chratosis .3. Hyper paarachratosis.4. Absence of retroprocess.5. Fibrosis of sup epith. &

underling CT

Salivary Gland Disease & Benign Tumors

Necrotizing silometaplasia

• H&E section showing degenerated acini of minor salivary glands . • Metaplasia of ductal epithelium forming nest-like structures . • Infiltration of chronic inflammatory cells .

Cont….

• H&E section showing degenerated acini of minor salivary glands . • Metaplasia of ductal epithelium forming nest-like structures . • Infiltration of chronic inflammatory cells .

Cont….

• H&E section showing degenerated acini of minor salivary glands . • Metaplasia of ductal epithelium forming nest-like structures . • Infiltration of chronic inflammatory cells .

Chronic sialadenitis

• H&E section showing atrophy of acini and dilatation of the duct . • Infiltration of chronic inflammatory cells .

Cont….

• H&E section showing atrophy of acini and dilatation of the duct . • Infiltration of chronic inflammatory cells .

Pleomorphic adenoma

• H&E Proliferation of ductal epithelial and myoepithelial cells in the form of sheet-like structures .

• Many ductal-like structures and myxoid-like structures .

Cont….

• Proliferation of ductal epithelial and myoepithelial cells in the form of sheet-like structures .

• Many ductal-like structures and myxoid-like structures .

Cont….

• H&E Proliferation of ductal epithelial and myoepithelial cells in the form of sheet-like structures .

• Many ductal-like structures and myxoid-like structures .

Warthin’s tumor

• H&E section showing composed of papillary projections and cystic spaces . Forms of two types of oncocytic eosinophilic cells : basal cells ( cuboidal ) and columnar cells . Between these projections, there is proliferation of diffuse chronic inflammatory cells and germinal cells

Oncocytoma

H&E section showing polyhedral cells with granular eosinophilic cytoplasm arranged in sheets or duct-like structures .

MucoepidermoidCarcinoma

• H&E Many cystic spaces and two types of cells : Mucous cells surrounding cystic space , Dark-stained epidermoid cells in fibrous C.T. stroma .

Cont….

• H&E Many cystic spaces and two types of cells : Mucous cells surrounding cystic space , Dark-stained epidermoid cells in fibrous C.T. stroma .

Cribriform Pattern of Adenoid Cystic Carcinoma

H&E section showing proliferation of isomorphic basophilic basalloid ( basal-like ) cells surrounding many cystic spaces in C.T. stroma taking Swiss-cheese pattern ( cribri-form pattern ) .

Solid pattern of Adenoid Cystic Carcinoma

H&E section showing proliferation of isomorphic basophilic basalloid ( basal-like ) cells surrounding many cystic spaces in C.T.

Perineural Invasion

H&E section showing proliferation of isomorphic basophilic basalloid ( basal-like ) cells surrounding many cystic spaces in C.T. and there is perineural invasion

 Benign & malignant neoplasma

Squamouscell Papilloma

• H&E section showing finger like projection of hyperplastic Stratified keratinized squamous epithelium supported by vascular CT. core .• Superficial epithelial cell showing pernuclear vaculization

Keratoacanthoma

H&E section showing exophytic growth of hyperplastic Stratified squamous epithelium with central crater containing keratin plug & CT. showing Infiltration of chronic inflammatory cells .

Fibroma

H&E section showing proliferated of collagen in form of bundles and fibroblast surrounded by fibers CT. capsule and covered by stretched Stratified squamous epithelium.

Squamouscell Carcinoma

• Tuomur showing malignant epithelial cell forming nests invading CT stroma. The Malignant cell is hyperchromatic and mitosis can be seen.• keratin pearl & indivdul cell keratinization also present . Infiltration of

chronic inflammatory cells in CT stroma. and degenrated muscle also seen

•

Fibrosarcoma

• Malignant fibroblast arranged in vascicels & delicate CT. fibers • The fibroblast are hyperchromatic polymorphic and some mitosis.

Thank you …….