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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

PRACTICAL PATHOLOGY 1 LYMPH NODES AND CNS DISORDER

1.Jars

Organ: Slice of brain

Description:

The brain shows

Cystic areas surrounded and traversed by glial tissue that give it honey-comb appearance.

Diagnosis: Healed brain infarct.

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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

Organ :Two hemispheres of the brain

Description:

The right hemispheres is distorted by massive area of haemorrhage which is:

In the lateral ventricle Dark brown in colour

Diagnosis: Intracerebral haemorrhage.

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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

Organ: Two hemispheres of the brain

Description:

The cerebrum is infiltrated in one area by a tumour mass, which is:

Ill defined Infiltrating the surrounding brain tissue Greyish white in colour with areas of hemorrhage and necrosis

Diagnosis: Glioblastoma multiforme.

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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

Organ: Spleen

Description:

Part of a moderately enlarged spleen Firm rubbery in consistency The external surface is smooth Cut surface:

o Mottled by translucent light brown areas of amyloid material seenagainst a red background of splenic tissue

Diagnosis: Amyloid (sago) spleen.

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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

Organ: Spleen

Description:

Spleen is slightly enlarged The cut section is studded whith numerous tubercles distributed all over

the spleen, but more condensed near the periphery.

Tubercles are rounded, soft in consistency, showing central yellow cheesynecrotic tissue.

Diagnosis: Miliary tuberculosis-spleen.

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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

Organ: Spleen

Description:

An enlarged spleen The cut section shows a large well-circumscribed grayish white well defined

non-encapsulated tumour formed of multiple coalescent nodules.

The tumour shows foci of necrosis.Diagnosis: lymphoma of the spleen.

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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

Organ: Lymph nodes.

Description:

A group of lymph nodes that are enlarged and matted together. Cut surface:

o Shows numerous areas of yellowish cheese like necrotic tissue.Diagnosis: Tuberculous lymphadenitis.

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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

Organ: Lymph nodes

Description:

A group of lymph nodes that are enlarged , firm, and discrete. Lymph nodes are variable in size and have a smooth surface. Cut surface

o Tan-coloured with foci of necrosis.Diagnosis: Hodgkins lymphoma.

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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

2.HISTOPATHOLOGY

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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

Diffuse Non-Hodgkins Lymphoma, LN

Section revealed lymph node showing

Loss of normal architecture. Infiltration by diffuse sheets of monotonous large lymphomatous cells

showing large vesicular nuclei within scant indistinct cytoplasm.

Mitotic figures are detected.

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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

Chronic venous congestion, Spleen.

Splenic tissue showing:

The Malpighian bodies (white pulp) are atrophic The venous sinuses (red pulp) are dilated and show marked congestion. Focal areas of fibrosis, haemorrhage and hemosiderin pigmentation are

seen (fibrosiderotic nodules of Gamna Gandy bodies)

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MODULE 19 PATHOBIOLOGY MODULE (PATHOLOGY)

ACE 2013/14

Adenocarcinoma metastases, Lymph node

The lymph node is infiltrated by carninomatous cells

The tumor cells are arranged in acini of variable sizes and shapes. These cells showing larged hyperchromatic nuclei within scant cytoplasm. Mitotic figures are detected.