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PRACTICAL PATHOLOGY 2: AMYLOIDOSIS AND BONE TUMOURS

1.Jars

Organ: Piece of skull bone

Description:

The bone shows in one area small, sessile, hard bony projection with asmooth ivory-like surface.

Diagnosis: Osteoma

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Organ: Part of vertebrae column.

Description:

The dorsal part of one vertebrae shows a mass which is:

Solitary Well circumscribed Non-encapsulated Colour-brown Cut surface- honey comb appearance

Diagnosis: Cavernous hemangioma of a vertebrae.

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Organ: Upper hand of humerus

Description:

The upper hand of the humerus shows a bulky tumour mass arising at

metaphyseal region.

The mass destroyed the bone cortex and extended to soft tissue producinga fusiform mass giving a mutton leg appearance.

On section, the mass is:o Fleshyo Grayish white in colouro Focal brownish area of haemorrhageo Yellowish area of necrosis

The epiphyseal cartilage is intact. New bone formation is noted in subperiosteal area.

Diagnosis: Osteosarcoma

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Organ: Lower end of femur.

Description:

The epiphyseal end of the femur is expended by a tumour mass and with marked

thinning of the cortical bone.

Cut surface of the mass shows:o Brownish area of necrosiso Focal cystic area of degeneration.

The remnants soft bone is seen. No new bone formation.

Diagnosis: Osteoclastoma (Giant cell tumour of bone)

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Organ: liver

Description:

A slice from an enlarged liver shows.

Surface- smooth Border- sharp Consistency- firm Cut surface

o Colour dark browno Semitranslucento Appearance waxy

Description: Amyloidosis of the liver

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Organ: Slice of the brain

Description:

The brain is swollen with flatten gyri The meninges are

o Opaque, lusterlesso Covered by purulent exudative material particularly abundant in the

sulci.

Diagnosis: Acute suppurative meningitis.

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1.HISTOPATHOLOGY

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Osteochondroma:

Tumour tissue shows:-

A cap of benign looking hyaline cartilage. Underlying core of bone trabeculae enclosing mostly fatty marrow

elements.

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Amyloidosis, Liver

Section in the liver showing.

The liver architecture is preserved Eosinophilic structureless homogenous amyloid material is deposited

extracellularly in space of Disse ( the space between the hepatocyte and

sinusoidal epithelial cells.

The compressed hepatocytes are atrophied.

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Osteoclastoma (Giant Cell tumour of bone)

Tissue tumour formed of:

Numerous evenly distributed osteoclast like tumour cell showing numerouscentrally clustered nuclei within abundant cytoplasm.

interverning round to spindle shaped mononuclear cells.

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Chondroma

Sections revealed lobulated tumour tissue formed of irregularly scattered benign

looking chondrocytes of different sizes and shapes in groups embedded within

abundant faint blue condroid matrix.