Presentation

on

The Human Genome at TenThe Human Genome at TenThe Human Genome at TenThe Human Genome at Ten

PRIYANKA SARKAR

Roll: 40911 No: 0525241

Regn. No: 24401850 of 2009-10.

(BT-415)

� A genome is an organism’s complete set of DNA, including all of its genes. Each genome

contains all of the information needed to build and maintain that organism.

�In February 2001, the IHGSC and Celera Genomics each reported draft sequences

providing a first overall view of the human genome (Nature, 409 (6822): 860-921, 2001and

Science 291(5507): 1304-1351, 2001).

�The work of the Human Genome Project has allowed researchers to understand the

blueprint for building a person. As researchers learn more about the functions of genes andblueprint for building a person. As researchers learn more about the functions of genes and

proteins, this knowledge will have a major impact in the fields of medicine, biotechnology,

and the life sciences.

�After revealing the Human Genome Sequence in 2001, Systematic Study of genome

begins which include Identification of genes , protein architecture, genome composition,

Transposable elements, etc.

�The Human Genome Project marked a new approach in biomedical research, in which the

scientific community came together to systematically characterize a large domain of

important biological knowledge in the post genomic era.

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Opportunities for genomic medicine will come from acquiring foundational knowledge of

genome function, insights into disease biology and powerful genomic tools. The

following imperatives will capitalize on these opportunities in the coming decade.

Making genomics-based diagnostics routine.

Defining the genetic components of disease.

Comprehensive characterization of cancer genomes.

Human genome at future ten

1. 1. 1. 1. Genomic Medicine Genomic Medicine Genomic Medicine Genomic Medicine (From base pair to bedside)

Comprehensive characterization of cancer genomes.

Practical systems for clinical genomic informatics.

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The role of the human microbiome in health and disease:

Many diseases are influenced by the microbial communities that inhabit our bodies (the

microbiome). Recent initiatives are using new sequencing technologies to catalogue the

resident microflora at distinct body sites, and studying correlations between specific

diseases and the composition of the microbiome.

Human genome at future ten

2. Bioinformatics and Computational Biology:Bioinformatics and Computational Biology:Bioinformatics and Computational Biology:Bioinformatics and Computational Biology:

Advancement in the Bioinformatics can meet

the following challenges in future:

Data analysis.

Data integration.Data integration.

Visualization

Computational tools and infrastructure.

Genomics and society:Genomics and society:Genomics and society:Genomics and society:Psychosocial and ethical issues in genomics research.

Psychosocial and ethical issues in genomic medicine.

Legal and public policy issues.

Broader societal issues.

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The Future Is BrightThe Future Is BrightThe Future Is BrightThe Future Is Bright