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The CDD Vault is a 1) Lightweight Solution for Chemical Registration & SAR for budget sensitive labs that is also2) Collaborative to Scale
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Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc. Copyright © 2011 All Rights Reserved Collaborative Drug Discovery
Barry Bunin, Ph.D.
CEO and President
Collaborative Drug Discovery, Burlingame, CA.
www.collaborativedrug.com
A Web-Based Collaborative Drug Discovery Platform
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
• Users: 21,197 unique logins last year (scalable in the cloud)
• Interoperability/Standards: csv/SMILES, sdfiles, PubMed, ChemSpider-Pubchem, REST Based Architecture for APIs
• Employing technology to facilitate partnerships: both pre- and post-IP agreements supported
• Expanding the precompetitive space: the key is supporting traditional (IP sensitive), collaborative (pre-IP), and open (post-IP) – all these are real use cases
Copyright © 2011 All Rights Reserved Collaborative Drug Discovery
CDD for Private, Collaborative, & Public Research
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
CDD Platform For Collaborating with IP Sensitive SAR Data
Copyright © 2009 All Rights Reserved Collaborative Drug Discovery
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
Data Partitioning for Multiple Collaborations
Collaborator 1 Collaborator 2 Collaborator 4Collaborator 3
Consolidated
CDD DB
Project A Project D
Pro
ject B
Company A
Project C
Copyright © 2009 All Rights Reserved Collaborative Drug Discovery
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
Copyright © 2011 All Rights Reserved Collaborative Drug Discovery
Collaborative Capabilities for Efficient International Drug Discovery
Individual Pain Points Organizational Need Technical Solution
Keep scientist’s data
private until ready to
share (i.e. with the rest of
their groups)
Collaboration is as much
about more efficient work
within a single
organization as between
organizations.
Temporal data access
controls
Allow scientists to
partition or sequester data
to enable selective data
sharing
Control of chemical or
biological data access
based on Project-specific
permissions
Spatial data partitioning
Allow collaboration in
scientist’s natural
workflow (i.e. without
uploading data multiple
times in multiple places)
Control based on type of
data – especially given a
marketplace with
specialization in
synthesis, screening,
discovery, development
Sequester by data
classification
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
User Roles and Privileges in CDD
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
CDD Convenient Mining & Export Options
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
CDD Configurable IC50 Dose Response Capabilities
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
CDD database system
• Web based (log in securely into to your database from any computer).
• We host the server for you
• Highly secure, all traffic encrypted, server in a secure professionally hosted environment.
Secure and Low TCO (Total Cost of Ownership)
Copyright © 2009 All Rights Reserved Collaborative Drug Discovery
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
CDD Drug Repurposing 2009 Case Study #1
Result
New leads reveal known
drugs that reverse
chloroquine resistance
Archive, Mine, Collaborate © 2009 Collaborative Drug Discovery, Inc.
CDD 2011 EU PPP Case Study #2
