Importance of Importance of Vitamin D In Vitamin D In

Orthopedic PatientsOrthopedic Patients

OSTEOPOROSISOSTEOPOROSIS

is highly prevalent, affecting approximately

one-third of women aged 60-70 years, and

two-thirds of those aged 80 years and older

200 MILLION WOMEN 200 MILLION WOMEN

WORLDWIDEWORLDWIDE

OSTEOPOROSISOSTEOPOROSIS is the major cause of

FRACTURESFRACTURES

1992;7:1005-10

40% OF WOMEN40% OF WOMEN and 13% of men

aged 50 years and older will sustain an

OSTEOPOROTIC FRACTUREOSTEOPOROTIC FRACTURE

in their remaining lifetime

1992;7:1005-10

FRACTURESFRACTURES have a profound impact on

QUALITY OF LIFEQUALITY OF LIFE.

Approximately 20%-25%20%-25% of women over age 50

years have had one or more

VERTEBRAL FRACTUREVERTEBRAL FRACTURE, the

most common osteoporotic fracture

Both vertebral and hip fractures are associated with excess

mortality. For instance, approximately 20% OF 20% OF

HIP FRACTURE PATIENTSHIP FRACTURE PATIENTS

aged 50 years and older

DIE WITHIN 1 YEARDIE WITHIN 1 YEAR

2001;285:320-3

Patients being treated for

OSTEOPOROSISOSTEOPOROSIS should

be adequately supplemented with

calcium and VITAMIN DVITAMIN D to

maximize the benefit of treatment

2007;24(12):1017-29

Drugs & Aging Drugs & Aging

Studies have also demonstrated a correlation between

LOW SERUM VITAMIN DLOW SERUM VITAMIN D

&

INCREASED INCREASED

RISK OF FALLSRISK OF FALLS

      2004;291:1999-2006

Studies have also demonstrated a correlation between

LOW SERUM VITAMIN DLOW SERUM VITAMIN D

&

FALLS-RELATED FALLS-RELATED

FRACTURESFRACTURES

2003;18:343-51

Studies have also demonstrated a correlation between

LOW SERUM VITAMIN DLOW SERUM VITAMIN D

&

HIGHER RISK FOR HIP HIGHER RISK FOR HIP

FRACTUREFRACTURE

2008;149:242-250.

VITAMIN D RECEPTORSVITAMIN D RECEPTORS

(VDRs) are known to be present in

muscle tissue.

2001 Jan;33(1):19-24.

The Histochemical JournalThe Histochemical Journal

Studies have also demonstrated a correlation between

LOW SERUM VITAMIN DLOW SERUM VITAMIN D

&

AGE-RELATED MUSCLE AGE-RELATED MUSCLE

WEAKNESSWEAKNESS

1986;7:434-8

Studies have also demonstrated a correlation between

LOW SERUM VITAMIN DLOW SERUM VITAMIN D

&

MUSCULOSKELETAL MUSCULOSKELETAL

PAINPAIN

2003;78:1463-70

Studies have also demonstrated a correlation between

LOW SERUM VITAMIN DLOW SERUM VITAMIN D

&

CHRONIC LOW BACK PAINCHRONIC LOW BACK PAIN

2003 Jan 15;28(2):177-9

Studies have also demonstrated a correlation between

LOW SERUM VITAMIN DLOW SERUM VITAMIN D

&

INCREASED INCREASED

BODY SWAYBODY SWAY

2001;109:87-92

Lower concentrations of 25(OH)D

are associated with significant

BACK PAINBACK PAIN in older women

2008 May;56(5):785-91.

Vitamin D deficiency is now

recognized as a PANDEMIC PANDEMIC

2008 Apr;87(4):1080S-6S.

VITAMIN DVITAMIN D Reduced the

RISK OF FALLSRISK OF FALLS by More Than

20%20% Among Elderly Populations

2004;291:1999-2006

100 000 IU100 000 IU VITAMIN DVITAMIN D33 every 4

months was safe and effective in decreasing the

incidence of

OSTEOPOROTIC FRACTURESOSTEOPOROTIC FRACTURES

by by 33%33% compared with placebo

2003 Mar 1;326(7387):469.

Repletion of VITAMIN DVITAMIN D and at

the Time of Fracture May Reduce

Future Fracture Risk and

FACILITATEFACILITATE

HIP FRACTURE REPAIRHIP FRACTURE REPAIR  

1999;281:1505-1511.

A single high dose of VITAMIN VITAMIN

D3D3 stimulated

FRACTURE HEALINGFRACTURE HEALING

1997;116(1-2):37-40.

CHOLECALCIFEROL CHOLECALCIFEROL (100 000 IU) is a safe, effective, and

simple way to increase calcidiol

concentrations

Vol. 87, No. 3, 688-691, March 2008.

Oral / IM Ampoule

Containing

5mg Cholecalciferol eq to 200,000 IU Cholecalciferol

Light Resistant Ampoule Packaging

Dose

1 Ampoule (200,000 IU)

every 6 months

Elderly

1/2 Ampoule (100,000 IU)

every 3 months

Thank You