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C^O^N^T^E^N^T^S
CALENDAR OF EVENTS.................................................. 119
DABCI SCHEDULE/7WZZ.4, MISSOURI........................ 120
DABCI SCHEDULE/T(7ZA4, OKLAHOMA .....................121
FROM THE EDITOR'S DESK .........................................122
Virginia Kes singer
THE CLINICAL IMPORTANCE OF VITAMIN D(CHOLECALCIFEROL)A PARADIGM SHIFT WITH IMPLICATIONS FOR ALL^K4ZT^C47?£TP2?OF72)^^^......................................................................124
Alex Vasquez, DC, NDGilbert Manso, MDJohn Cannell, MD
RESOLUTION OF PROSTATE CANCER AFTERNUTRITIONAL PROTOCOLS AND LIFESTYLEMODIFICATIONS:^C4^£'^T£72)y.............................................................................................l38
Jason Nardi, DC, DABCI, DACBN, FIAMA
THOUGHTS AT LARGE: Issue 18CONTROVERSIES IN CLINICAL NUTRITIONAND FUNCTIONAL MEDICINEA NUTRITIONAL SUPPORT FOR CANCER PATIENTS........................ 148
Jeffrey Moss, DDS, CNS, DACBN
DABCIs AND WHERE THEY ARE........................................................... 155
CLINTPUBLICA TIONS
VOL. 26, N0.4 • ISSN 1529-4722 • DECEMBER 2020
Resolution of Prostate Cancer after Nutritional
Protocols & Lifestyle Modifications: A Case Study
by: Jason Nardi, DC, DABCI,, DACBN
, FIAMA.
Keywo rds: Prostate Cancer; Remission Induction; Clinical Nutrition; Food Habits; Lifestyle Factors
Abstract: Introduction: This case study focused on the use of lifestyle, diet and nutritional supplementation to support the treatment of prostate adenocarcinoma.
Case Presentation: The subject was a 72 year-old male recently diagnosed with prostate cancer co.nfirmed with a 12-needle biopsy by his urologist. History was positive for past prostatitis, benign prostatic hypertrophy and environmental exposure associated with prostate carcinoma.
Management & Outcome: Serological inflammatory and immunological markers were high. Focus was on the use of botanicals with high flavonoid and polyphenol content to help support the immune system to reduce inflammatory pathways. Dietary restrictions and lifestyle modifications were implemented to also lower inflammation. Vitamin therapy using oral vitamin C in combination with vitamin K as an anti-cancer method. This combination has long been thought to have benefits in preventing neoplastic activity.
After six months of following protocols, blood markers were mostly improved and imaging showed no cancer present in the prostate.
Discussion: While the use of vitamin C and vitamin K is currently being used as an adjunct to traditional prostate cancer treatment as Apatone®, oral supplementation in the same ratio may have equal benefit. This case also showed there may be evidence that botanical support and vitamin therapy may be a viable vehicle in battling prostate carcinomas. The association between infec-
THE ORIGINA l lNTERNJST DECEM
BER 2020
tious prostatitis and prostate cancer has long been suspected. Systemic and localized applications of botanical agents showed benefits, while PSA remained
_ele
vated. The use of botanicals in prostate adenocarcmomas warrants further investigation.
Introduction: Prostate cancer is the second leading cause of death in American males and the most common cancer. According to recent figures, 1 in 9 men will be diagnosed with prostate cancer during his lifetime with an estimated 164,690 new cases th.is year with an estimated 29,430 1
deaths. The most prevalent risk factors are age and race·2 Other factors include diet, tobacco use, alcoholconsumption, low physical activity and exposure to environmental contaminants.3 Data also supports pastprostatitis and infections have a strong link to future prostate cancer.4·5
The presented case focused on a 71 year-old Caucasian male with prostate cancer confirmed with a needle biopsy, who presented for nutritional support before traditional treatment. Suppo1t included oral zinc, vitamin C (VC), and vitamin K 1 and K2, as MK.7 (VK) supplementation and botanical agents.
Clinical History: The patient a 71 year-old Caucasian retiree. His social and work history included tobacco use at the age of ten until 22 and exposme to petrochemicals as an auto mechanic. The subject worked at a family-owned nursery and greenhouse but does not remember using chemical fertilizers or pesticides. He also reported a history of hematospermia eight years before the diagnosis of prostate cancer; Hematospennia is associated with chronic prostatitis. 6
The patient had increasing PSA lab values from 3.8ng/ mL to 4.2ng/mL and was sent by his PCP to a urologist in January 2018, who confirmed with a surgical biopsy of 12 specimens in March 2018. Biopsy results showed prostatic adenocarcinoma in the left apex with a Gleason Score of 6 (3+3)7consisting of IO¾ of needle core tissue. Using the ISUPS grading, this amounts to a prognostic grade group 1.8 After being told tr
_eatm�nt
would be determined with follow-up labs and unagmg that would be scheduled in July and August, respectively, the subject sought immediate alternative treatment methods for the interim.
Discussion: Alternative treatment began with simple dietary changes to cut down on and eliminate inflammatory foods. Processed meats were removed due to the high
(Continued on page 140)
138
association in raising overall cancer risks, and red
meats were replaced with grass-fed versions to help
increase Omega 3 intake, especially conjugated linoleic
acid (CLA), due to its anticarcinogenic effect.Other modifications were to increase activities to in-
elude 20 minutes or more of walking, increase water
intake to 2-3 quarts daily, and replace coffee with greentea.12
Initial Phase:The initial 30-day phase of care included nutritionalsupplementation aimed at promoting clearance in the
body using botanicals that also contained anticarcino-
genie properties. A product containing 50 mg each ofMilk Thistle,13 turmeric,14 artichoke,15'16schisandra,17
rosemary,18'19 dandelion,20'2' yellow dock,22 gentian,23
and barberry was used. Dosing was 50 mg of each,
combined in a capsule taken twice daily. Polyphenol
intake from these botanicals showed promise in fight-
ing cancerous cells; polyphenols' anti-carcinogenic
properties include inhibitory effects on cancer cell pro-
liferation, tumor growth, angiogenesis, metastasis, and
inflammation, and help induce apoptosis.25'2 Polyphe-
nols have shown promise in targeting signal transduc-
tion pathways involved in carcinogenesis and reduces
NF-kB mediated pathways, reducing inflammation as-
sociated with tumor cells; Up-regulation of NF-kB in
tumors cells inhibits apoptosis, increases angiogenesis
and metastatic capacity of tumor cells.27'28 Enzymatic
and antioxidative properties of flavonoids add to theireffectiveness; Antioxidative effects of flavonoids in-
duce enzyme deactivation of free radicals and reactive
oxygen species (ROS) and prevent them from becom-
mg mutagens/
Second Phase:
Compliance with suggestions was good after the initial30 days. While dietary restrictions and lifestyle modifi-cations did not change after the initial 30 days, newnutritional support was implemented. This phase of
care was focused on concepts that would arrest and
lower inflammation in the prostate and help support
anticancer pathways.
With ample indicators of prostatitis, a large focus was
on reducing inflammation. It is well known that copper
has a proclivity for prostate tissue. Copper is readily
leached from pipes used for plumbing in the US andcan at times exceed safe levels, depending on the tem-
perature of the water, mineral content, the age of the
plumbing and how long water has been standing in the
plumbing. To remove suspected copper from the pa-
tient, 60 mg of zinc picolinate was given daily. Some
data shows that zinc is essential to good prostate health.
THE ORIGINAL INTERNIST DECEMBER 2020
In one study, zinc levels were examined in several
groups of men with prostate issues: In prostate carci-
noma, zinc levels were decreased by 83%, and in BPH
there was a 61% decrease in tissue link levels com-
pared to normal tissues.
Additionally, Biocidin® capsules were used as anightly rectal suppository to help with possible infec-tious causes of prostatitis. Initial laboratory analysis
showed increases in both lymphocytes and monocytes,
with normal white blood cell counts (Figure 1). Bio-
cidin® was chosen for its ingredient content (Figure 2),
especially bilberry; because it was in capsules that
could be delivered more locally as a suppository. The
most common infectious agents in the prostatitis are
Escherichia coli, Klebsiella, Proteus, Pseudomonas,
Enterobacter, Enterococcus, Serratia, and Staphylo-
coccus aiireus, all of which rely on efflux pumps to get
rid of toxic substances, including antibiotics. Inhibitingefflux pump activity is shown to reduce biofilm forma-
tion.3 Bilberry, or Vaccinium myrtilhis L., contains the
polyphenol proanthocyanidin that has been shown to
prevent bacterial adhesion.
Vitamin K (VK) has been well known to have antioxi-dant effects on cancer, however recent studies are
showing that VK and its analogs have additional effectson cancer, including apoptosis, cell cycle arrest, auto-
phagy and modulation of various transcription fac-
tors.34 It has long been suspected that VK combined
with vitamin C (VC) would be effective in treating can-cer. Tareen, et. al. showed that VC and VK as Apa-
tone® were effective in delaying the progression of
advanced prostate cancer in 17 patients who did not
respond to standard therapy. While VC has been shown
to be an effective anti-oxidant and is shown to reduce
chromosomal damage, thus reducing neoplasm activity.
Taper et al. demonstrated that VC inhibited the growthof both androgen-dependent and androgen-independent
human prostate carcinoma cells in mouse models. Dos-
ing for this phase was Apatone® of 100:1 VC to VK;6,000 mg ofVC was used with 620 mcg ofVK.
Results:
The subject remained compliant with care after four
months of the above dietary and lifestyle modifications,
and nutritional supplementation. A new PSA lab was
taken in July; though still elevated at 5.2 ng/mL, thiswould be within normal for a patient of this age.38 One
month after the PSA lab multiplanar magnetic reso-
nance images of the pelvis were obtained using Gadav-
ist IV contrast. Clinical findings were: post obstmctive
hypertrophy of the bladder wall, most likely due toBPH. The prostate measured 4.3 x 4.8 x 4.8 cm, with
(Continued on next page)
140
an overall volume of 48 ec. This is considered
enlarged39 and was elevated at the bladder base; there
was mild heterogeneity of peripheral zone without sig-
nificant foci of diffusion restriction, or unusual vascu-
larity on computer-aided postcontrast evaluation; The
prostate capsule was intact; The neurovascular bundle
appeared normal bilaterally. The overall impression
was an enlarged prostate with BPH centrally. There
was no evidence of any suspicious lesion in the gland
and no evidence of extracapsular spread of a tumor.
The treating medical doctor agreed and stated their im-
pression overall was an enlarged prostate gland with
benign prostatic hypertrophy. No suspicious lesions in
the gland were noted and no evidence of any tumor.
Post-treatment suggestions were to continue with die-
tary and lifestyle modifications and follow throughwith the urologist's recommendations of annual PSA
and DRE.
Conclusion:
There has been ample study in the use of nutrition, sup-
plementation, lifestyle and dietary changes being used
to help hinder neoplastic activity. There appears to be
much overlap in the lifestyle changes having a benefitin different forms of cancer; from the removal of sugars
and high inflammatory foods to the addition of foodsthat support the body as a whole. Nutritional protocols,
on the other hand, should be aimed at supporting
Figures & Charts
Figure 1: Initial and follow-up lab values
Element
Glucose
AlkPhos
AST
ALT
Femtin
Hs CRP, Male
WBC
RBC
Neutrophils
Lymphocytes
M;onocytes
Eosinophils
Basophils
141
specific functions in treatment; the use of polyphe-
nols and flavonoids to reduce inflammatory signal-
ing pathways and cell proliferation, while inducingapoptosis appears to be a good reason for their in-
clusion.
While there is evidence that associates infection
with prostatitis and evidence that links prostatitis toprostate carcinoma, the connection between infec-
tious prostatitis and the prevalence of prostate can-
cer has never been shidied in-depth. Localized appli-
cation of botanicals may prevent bacterial adhesion
and the reduction of biofilms which may be an ef-
fective, low-cost solution to treat several prostate-
related disorders, most especially benign prostatic
hypertrophy and prostatitis.
The use of VC and VK has long been thought tohave antineoplastic effects. While the drug Apa-
tone® has been shown safe and is moving into ad-
vanced clinical studies, the use of oral VC and VK
supplementation is limited to case and small cohort
studies, which warrant further investigation.
Acknowledgments:
This case would not have been a success without the
guidance of Dr. Delilah Renegar.
Conflicts of Interest:
The author declares that they do not have conflicts
of interest.
3/31/2018
117.00
51.00
36.00
61.00
753.00
4.10
5.40
4.86
45.00
41.60
11.00
2.00
0.40
12/28/2018 Units
113.00
59.00
26.00
34.00
604.00
1.19
5.20
4.56
49.80
11.00
2.10
0.40
mg/dL
IU/L
IU/L
IU/L
ng/mL
mg/L
k/cumm
m/cumm
%
%%
%
Optimal Range
72.00-90.00
70-100
10.00-26.00
10.00-26.00
50.0-150.0
0.00-0.99
5.30-7.50
4.20-4.90
40.00-60.00
0.00-7.00
0.00-3.00
0.00-1.00
Standard Range
65.00-99.00
35-115
10.00-25.00
6.00-29.00
10.0-232.0
0.00-2.90
3.80-10.80
4.20-5.80
40.00-60.00
0.00-7.00
0.00-3.00
0.00-1.00
(Continued on next page)
THE ORIGINAL INTERNIST DECEMBER 2020
Fignre2: Biocidin ingredients &
Ingredient
BilberryNoni
Milk Thistle
Echinacea
Golden Seal
Shitakemushroom
White willowbarkGarlic
Grape Seed
Black Walnut
Raspberry
FumitoryGentian
Tea Tree oil
Galbanum oil
Lavender oil
Oregano oil
Vaccinhim myrtillns
Morinda citrifolia
Silybiim marianum
Echinacea pnrpnrea
Echinacea
angiistifolia
Hydrastiscanadensis
Lentimilaedodes
Salix albaAllium sativum
Vitis vinifera
Juglans nigra
Rubus idaens
Fnmaria
officinalisGenriana lntea
Melalenca
allernifoliaFerula
galbanifluaLavandiila
officinalis
Origanumvulgare
actions
Medicinal Action
Anti-inflammatory, antimicrobial, antioxidant, urinary antisepticAnti-inflammatory, antimicrobial, antioxidant
Antimicrobial, antioxidant, choleretic, hepatic trophorestorative, hepa-
toprotective.
Anti-inflammatory, antifungal, antiviral, depurative,
immune-enhancing, immune-modulating, lymphatic
Antibacterial, antihistamine, anti-inflammatory, antimicrobial, mucous
membrane, trophorestorative.
Antibacterial, antifungal, antioxidant, iiTimune-modulating.
Analgesic, anti-inflammatory.
Anthehnintic, anti-inflammatory, antimicrobial, antioxidant.
Antheknintic, anti-inflammatory, antioxidant.
Anthelmintic, antimicrobial, depurative.
Anti-inflammatory, antimicrobial, antioxidant.
Antimicrobial, antioxidantAnti-inflammatory, antimicrobial, antioxidant.
Antifangal, antimicrobial.
Anti-inflammatory, antimicrobial, antiseptic.
Antifungal, anti-mflammatory, antimicrobial.
Antibacterial, antifungal, anti-inflanimatory
Reference40.41.42
41
40,42
41.42
40.42
42
40
40
42
40
40.42
40,42
44. 45,46
47
48
49
About the AuthorDr. Jason Nardi is a Board-Certifled Chiropractic Intermst
and clinical nntritiomst and he holds a fellow in medical acu-
puncture. Dr. Nardi maintains a private practice in Jimean,
Alaska that focuses on neuro-strnctnral issues, pain condi-
tions, and digestive and hormonal health using a whole-
person, holistic approach. Dr. Nardi has a passion for ediica-
tion and research and has worked with several magazines in
the including HealthLine, LifeZette, Organic Authority, and
CafeMom as an expert source for authors. He is the past Di-
rector of Research and current Director of Education for the
American Chiropractic Association's Council on Nutrition.
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