Glycyrrhiza glabra (Liquorice)

  • View
    823

  • Download
    0

Embed Size (px)

Text of Glycyrrhiza glabra (Liquorice)

1

Glycyrrhiza glabra

CONTENTIntroductionUsesConstituentsSide EffectsMechanism of ActionToxicityDosageDrug InteractionsContraindications

3

INTRODUCTIONFAMILYLEGUMINACEAEBOTANICAL NAMEGLYCERYIZA GLABRA L. ENGLISH NAMELIQUORICEURDU NAMEMULHATIPART USEDROOTS,RHIZOME

CONSTITUENTSOther ComponentsGlycyrrhizinic Acid 20%GlycrrhizinGlabranin A & BGlycyrrhetolGlabrolideIsoflavonesCoumarinsTriterpene SterolsActive ingriedientsGlycyrrhizinic Acid 10%

5

TOXICITY

Hypokalemic Paralysis

Cardiac Myopathy

Metabolic Alkalosis

Hypoxemia

Pseduoaldosteronism

USESAntiviralAnti-cancerAnti-inflammatoryCardiac DentalDiabetesGI ComplaintsHormonal EffectsHepatoprotection

7

MECHANISM OF ACTION

Hypocholester-olemic action

Anti mutagenic Activity

Decrease Lipid Peroxidation

Stimulate Hormones

Free Radical Scavenging Activity

SIDE EFFECTSSalt RetentionWater RetentionLow Potassium levelHypertensionCardiac dysfunctionsDisturbance in cortisol level

9

DOSAGE

LICORICE ROOTSLicorice Roots Doses Varies Between 2-15 g for Ulcer And Gastritis

Glycyrrhizin Is Suggested To Be 0.2 Mg/Kg/Day

DRUG INTERACTIONInteraction With WarfarinLicorice Decreases Effectiveness Of Warfarin Increasing Risk Of ClottingInteraction With DigoxinLicorice Decreases Potassium Levels Which Increase Side Effects Of DigoxinsIt May Altar Prednisolone Plasma Concentration

CONTRAINDICATIONSLicorice might interfere with blood pressure control during and after surgery. Stop taking licorice at least 2 weeks before a scheduled surgery.

It may effect the kidneys also .so dont use it during kidney problems.

It may lower the potassium levels in the blood. Thus causing hypokalemia.

Licorice has the ability to store water in the body, thus it can make congestive heart failure worse.

Surgery: Licorice might interfere with blood pressure control during and after surgery. Stop taking licorice at least 2 weeks before a scheduled surgery.It may also cause problems in the kidneys.so do not take licorice during kidney problems.It may lower the potassium levels in the blood causing hypokalemia.

Licorice can store water in the body, thus cause a severe congestive heart failure.so be careful while using.

12

REFERENCESwww.herblist.com

www.ncbi.nlm.nih.gov

www.drhmeo.com

www.henrietess-herb.com

book of medical pharmacology

American medicinal plants

THEEND