The Organizing Committee is building a program that follows the journey of cancer metastasis from detection at the molecular level to genomic identification to precision treatment and survival. This 7th itineration of the Symposium brings together international experts in oncology, immunobiology, pharmacology, molecular biology and molecular imaging to discuss pre-clinical, translational and clinical advances in diagnosing, treating and preventing cancer metastasis as we enter the era of precision medicine.

PRELIMINARY PROGRAM AT A GLANCE

Thursday April 20, 2017

7:00 AM 8:35 AM Emerald Ballroom CME EDUCATIONAL SESSION 1 7:00 AM

8:35 AM

Staging and Management of Malignant Melanoma Mini Symposium Session Chairs: Mohammed Kashani-Sabet & Jonathan S. Zager

7:00 AM 7:20 AM Molecular Staging of Melanoma, Mohammed Kashani-Sabet, MD 7:20 AM 7:40 AM Sentinel Lymph Node Staging for Melanoma, Mark B. Faries, MD, FACS 7:40 AM 8:00 AM Treatment of Intransit Metastatic Melanoma, Jonathan S. Zager, MD 8:00 AM 8:20 AM Treatment of Metastatic Melanoma, Kevin Kim, MD 8:20 AM 8:35 AM Q&A Panel Discussion

8:35 AM 8:45 AM Emerald Ballroom Opening Remarks, Welcome Mayor of San Francisco 8:45 AM - 9:15 AM Emerald Ballroom CME EDUCATIONAL SESSION 2

8:45 AM

9:15 AM

Donald Morton Surgical Oncology Memorial Lecture: Clinical Utility of Sentinel Lymph Nodes (KEYNOTE), Charles M. Balch, MD

9:15 AM 10:25 AM Emerald Ballroom CME EDUCATIONAL SESSION 3

9:15AM

10:25 AM

Tumor Microenvironment in Cancer Initiation and Progression Session Chairs: Athena Aktipis & Stanley Leong

9:15 AM

9:35 AM

Interactions between Cancer and Stromal Cells: Selection of the Fittest Clone to Metastasize, Stanley Leong, MD, FACS

9:35 AM

9:55 AM

Social Evolution and Natural Selection as Applied to Cancer Progression, Athena Aktipis, PhD

9:55 AM

10:15 AM

Understanding Cancer Evolution and Progression by Mathematical Computation, Carlo C. Maley, PhD

10:15 AM 10:25 AM Q&A Panel Discussion 10:25 AM 10:55 AM Coffee Break - Opening of the Exhibits & e-Posters Gold Rush Ballroom & Foyer

Page 2 of 5CancerMetastasisSymposium2017ProgramataGlance 11:00 AM 12:35 PM Emerald Ballroom CME EDUCATIONAL SESSION 4 11:00 AM

12:35 PM

Tumor Growth and Metastatic Spread Session Chairs: Marlys Witte & Donald McDonald

11:00 AM 11:20 AM Cancer Metastasis and the Lymphatic System, Marlys H. Witte, MD 11:20 AM

11:40 AM

Plasticity of Lymphatics in Cancer and Inflammation, Donald M. McDonald, MD, PhD

11:40 AM

12:00 PM

Angiogenesis & Lymphangiogenesis in Cancer Metastasis: Concordant or Independent, Michael Dellinger, PhD

12:00 PM

12:20 PM

Biomarkers to Explain Patterns of Metastasis Using Melanoma and Sarcoma as a Model, Nicola Mozzillo, MD

12:20 PM 12:35 PM Q&A Panel Discussion 12:35 PM

1:45 PM

Lunch Mini-Symposium (Biomarker Topic TBD), NON-CME EDUCATIONAL SESSION 1, Gold Rush Ballroom

1:45 PM 3:45 PM Emerald Ballroom CME EDUCATIONAL SESSION 5

1:45 PM

3:45 PM

Biomarkers for Cancer Metastasis Session Chairs: David Hoon & Isaac Witz

1:45 PM 2:05 PM Molecular biomarkers for cancer, Mohammed Kaschani-Sabet, MD 2:05 PM 2:25 PM Genomics for Cancer Metastasis, Marcus W. Bosenberg, PhD 2:25 PM

2:45 PM

Utility of Circulating Tumor Cells/DNA to Detect Clinical Metastasis, David S. B. Hoon, PhD

2:45 PM 3:05 PM The Metastatic Microenvironment, Isaac P. Witz, PhD 3:05 PM

3:25 PM

Biomarkers Predictive of Response to Systemic Therapy including Brain Metastasis, Harriett Kluger, MD

3:25 PM 3:45 PM Q&A Panel Discussion

3:45 PM 4:15 PM Coffee Break -Visit the Exhibits & e-Posters - Gold Rush Ballroom & Foyer 4:20 PM 4:50 PM Emerald Ballroom CME EDUCATIONAL SESSION 6

4:20 PM

4:50 PM

Super Resolution Microscopy to study Cancer and non-Cancer Diseases (KEYNOTE), Nobel Laureate W.E. Moerner, PhD

4:50 PM 6:00 PM Emerald Ballroom CME EDUCATIONAL SESSION 7

4:50 PM

6:00 PM

Sentinel Lymph Node: Incubator or Marker for Cancer Metastasis? Session Chairs: Dale Han & Douglas Reintgen

4:50 PM

5:10 PM

Sentinel Lymph Nodes Represent an Incubator for Metastasis, Mark B. Faries, MD

5:10 PM 5:30 PM Sentinel Lymph Nodes Represent a Marker for Metastasis, Dale Han, MD 5:30 PM

5:50 PM

Nodal Staging, Survival and the Need for CLND with the SLN Procedure, Douglas S. Reintgen, MD

5:50 PM 6:00 PM Q&A Panel Discussion

6:00 PM

7:30 PM

e-Poster Session, Poster Reception, Visit the Exhibits, Session Chair: Richard White, NON-CME E-POSTER SESSION 1, Gold Rush Ballroom & Gold Rush Foyer

Page 3 of 5CancerMetastasisSymposium2017ProgramataGlance Friday April 21, 2017

7:00 AM

8:00 AM

Breakfast Mini-Symposium (Regional Therapies Topic TBD), NON-CME EDUCATIONAL SESSION 2, Gold Rush Ballroom

8:00 AM 10:20 AM Emerald Ballroom CME EDUCATIONAL SESSION 8

8:00 AM

10:20 AM

Breast Cancer metastasis to the Regional Lymph Nodes and Beyond - Mini-Symposium, Session Chairs: David Nathanson & Barbara Pockaj

8:00 AM

8:20 AM

What Have We Learned from the Breast Cancer Sentinel Node Clinical Trials? David Krag, MD

8:20 AM

8:40 AM

Molecular Heterogeneity of Breast Cancer in Different Racial Groups, Lisa Newman

8:40 AM

9:00 AM

Complete Axillary Dissection in Breast Cancer: Less is More, Henry M. Kuerer, MD

9:00 AM

9:20 AM

Molecular Aspects of Breast Cancer Metastasis, Funda Meric-Bernstam, MD

9:20 AM 9:40 AM TBD 9:40 AM 10:00 AM TBD

10:00 AM 10:20 AM Q&A Panel Discussion

10:20AM 10:50 AM Coffee Break -Visit the Exhibits & e-Posters - Gold Rush Ballroom & Foyer 10:55 AM 12:05 PM Emerald Ballroom CME EDUCATIONAL SESSION 9

10:55 AM

12:05 PM

Novel Treatment for Metastatic Gynecological Cancer Based on New Biology, Session Chair: John K. Chan

10:55 AM 11:15 AM TBD 11:15 AM 11:35 AM TBD 11:35 AM 11:55 AM TBD 11:55 AM 12:05 PM Q&A Panel Discussion

12:05 PM

1:15 PM

Lunch Mini-Symposium - Novel Imaging Modalities for Sentinel Lymph Node Identification and Resection, Session Chairs: John V. Frangioni & Allessandro Testori, NON-CME EDUCATIONAL SESSION 3, Gold Rush Ballroom

1:20 PM 2:30 PM Emerald Ballroom CME EDUCATIONAL SESSION 10

1:20 PM

2:30 PM

Frontiers in Immunotherapy using Checkpoint Inhibitors and Molecular Targeted Therapy, Session Chair: Kevin Kim

1:20 PM 1:50 PM Checkpoint Inhibitor Therapy in Solid Tumors, TBD 1:50 PM 2:10 PM Latest Development in Targeted Therapy in Solid Tumors, Kevin Kim, MD 2:10 PM 2:30 PM Q&A Panel Discussion

2:30 PM 3:30 PM Emerald Ballroom CME EDUCATIONAL SESSION 11

2:30 PM

3:00 PM

Molecular Imaging of Cancer Metastasis (KEYNOTE), Sanjiv Sam Gambhir, MD, PhD

3:00 PM 3:30 PM Coffee Break -Visit the Exhibits & e-Posters - Gold Rush Ballroom & Foyer

Page 4 of 5CancerMetastasisSymposium2017ProgramataGlance

3:35 PM

4:45 PM

Translating the Promise of Academic Research into Reality: Industry - Regulatory - Academic - Town Hall Meeting, Session Chair: John Frangioni, NON-CME EDUCATIONAL SESSION 4, Emerald Ballroom

4:45 PM

5:15 PM

Immuno-Oncology: A CRO’s Perspective (KEYNOTE), Jai Balkissoon, MD, FACS. Moderator: Stanley Leong, MD, FACS NON-CME EDUCATIONAL SESSION 5, Emerald Ballroom

5:15 PM

6:30 PM

Rapid Fire Oral Abstract Presentations - Tumor Microenvironment & Cancer Progression – NON-CME EDUCATIONAL SESSION 6, Emerald Ballroom

5:15 PM

6:30 PM

Rapid Fire Oral Abstract Presentations – Cancer Metastasis – NON-CME EDUCATIONAL SESSION 7, Gold Rush Ballroom

5:15 PM

6:30PM

e-Poster Session, NON-CME E-POSTER SESSION 2, Gold Rush Ballroom & Gold Rush Foyer

7:00 PM 10:00 PM GALA DINNER IN CHINA TOWN Far East Café

Saturday April 22, 2017

7:00 AM

8:00 AM

Breakfast Mini-Symposium (Topic TBD), NON-CME EDUCATIONAL SESSION 8, Gold Rush Ballroom

8:00 AM 9:20 AM Emerald Ballroom CME EDUCATIONAL SESSION 12

8:00 AM 9:20 AM Top 3 Trainee (students/postdoc/resident/fellows) and Top 3 Young Investigator (within 5 years completion of training) Abstract Presentations

8:00 AM 8:12 AM 1st Place Trainee 8:12 AM 8:24 AM 2nd Place Trainee 8:24 AM 8:36 AM 3rd Place Trainee 8:36 AM 8:48 AM 1st Place Young Investigator 8:48 AM 9:00 AM 2nd Place Young Investigator 9:00 AM 9:12 AM 3rd Place Young Investigator 9:12 AM 9:20 AM Awards Presented to all award winners

9:20 AM 9:50 AM Emerald Ballroom CME EDUCATIONAL SESSION 13

9:20 AM 9:50 AM Keynote Speaker TBD

9:50 AM 10:20 AM Coffee Break -Visit the Exhibits & e-Posters - Gold Rush Ballroom & Foyer

10:20 AM 11:30 AM Emerald Ballroom CME EDUCATIONAL SESSION 14 10:20 AM

11:30 AM

Radiotherapy of Cancer, Chairs: Baldassarre Stea & Roy E. Abendroth

10:20 AM 10:40 AM Cancer Biology and Radiation, Baldassarre Stea, MD, PhD 10:40 AM 11:00 AM Radiotherapy of Cancer: Adjuvant Approach, Roy E. Abendroth, MD 11:00 AM 11:20 AM Radiotherapy for Oligometastatic Cancer, Charles C. Hsu, MD, PhD 11:20 AM 11:30 AM Q&A Panel Discussion

Page 5 of 5CancerMetastasisSymposium2017ProgramataGlance 11:30 AM 1:15 PM Emerald Ballroom CME EDUCATIONAL SESSION 15

11:30 AM 1:15 PM Lymphedema Following Cancer Therapy: Treatment Controversies & Patient Summit, Session Chairs: Saskia Thiadens & Michael Bernas

11:30 AM 11:40 AM Introduction to Lymphedema, Saskia R.J. Thiadens, RN 11:40 AM 11:55 AM Cancer-related lymphedema and incidence, TBD 11:55 AM 12:10 PM Imaging techniques for the lymphatic system, Michael J. Bernas, MS 12:10 PM 12:25 PM Genetics of cancer-related lymphedema, TBD 12:25 PM 12:40 PM Treatment and advocacy of cancer-related LE, TBD 12:40 PM 12:55 PM Surgical treatments for lymphedema, TBD 12:55 PM 1:15 PM Q&A Panel Discussion

1:15 PM

1:30 PM

Closing Remarks, Stanley P.L. Leong, MD, FACS, A summary of the status of and future perspectives on the study and management of cancer metastasis as presented during the Congress, address any unanswered questions, and pose others for future consideration.

SPONSORED BY THE SENTINEL NODE ONCOLOGY FOUNDATION The Symposium is sponsored by the Sentinel Node Oncology Foundation (SNOF) whose mission is to advance the care and treatment of patients with solid cancer and to help develop new preventative strategies, diagnostics and treatments. SNOF is incorporated as a 501 (c) 3 non-profit organization. ORGANIZING COMMITTEE: STANLEY P.L. LEONG, MD, SYMPOSIUM CHAIR, California Pacific Medical Center, San Francisco, USA MICHAEL J. BERNAS, MS, University of Arizona, Tuscon, USA DALE HAN, MD, Yale School of Medicine, New Haven, USA DAVE S. B. HOON, PHD, John Wayne Cancer Institute, Santa Monica, USA MOHAMMED KASHANI-SABET,MD,, California Pacific Medical Center, San Francisco, USA KEVIN KIM, MD, California Pacific Medical Center, San Francisco, USA DONALD M. MCDONALD, MD, PHD, University of California, San Francisco, USA DAVID NATHANSON, MD, Henry Ford Health System, Detroit, USA BARBARA POCKAJ, MD, Mayo Clinic, Phoenix, USA DOUGLAS S. REINTGEN, MD, University of South Florida, Tampa, USA SASKIA R.J. THIADENS, RN, San Francisco, USA RICHARD L. WHITE, JR, MD, Carolinas HealthCare System, Charlotte, USA MARLYS H. WITTE, MD, University of Arizona, Tuscon, USA JONATHAN S. ZAGER, MD, Moffitt Cancer Center, Tampa, USA SYMPOSIUM MANAGER: JOAN OEFNER, Rhema Association Management joefner@cancermetastasis.org Visit our website for program updates, invited speaker profiles, online abstract submission, award applications, more details and info: www.cancermetastasis.org