Silencing Inhibitor of Cell Replication Spurs Insulin-Producing Beta Cells to Reproduce AND Small Molecule Shows

Promise as Anti-Cancer Therapy

Biology Folding Teacher: Lina MartínezJorge Luis Ferreira Morales

Medicine Student III Semestrer

2014UPB

• Modifying the DNA of mutant and normal cells is the new pathway which is leading all investigations, and this offers the possibility to predict the functions of a living cell and avoid non wished facts.

• New alternatives of treatment are being discovered now, but the goal is to cure some diseases knowing their weak points and in this way, avoid deaths and extend this gorgeous life.

• Diabetes and Cancer are very important diseases and these two news bring us some findings about them.

Jan 16, 2014

SILENCING INHIBITOR OF CELL REPLICATION SPURS INSULIN-PRODUCING

BETA CELLS TO REPRODUCE

In this study, human pancreatic beta cells were transplanted in a mouse model, and they replicated showing normal functions.

Diabetes type I or II implicate destruction or less amount of

pancreatic beta cells

Diabetes type I or II implicate destruction or less amount of

pancreatic beta cells

Restoration of beta-cell mass can reverse or ameliorate both forms of diabetes.

Restoration of beta-cell mass can reverse or ameliorate both forms of diabetes.

So

SILENCING INHIBITOR OF CELL REPLICATION SPURS INSULIN-PRODUCING

BETA CELLS TO REPRODUCE

SILENCING INHIBITOR OF CELL REPLICATION SPURS INSULIN-PRODUCING

BETA CELLS TO REPRODUCE

In the future, suppressing genes like p57 could lead the whole world to better treatments.

This experiment shows that investigations are being runned out everywhere and researchers are very foccussed on important diseases with high prevalence in

the society.

Preventing or even cure a pathology is an incredible

capacity of progress.

Jan 13 2014

In this study, Johns Hopkins scientists focused on the ability of BMH-21 to sabotage the transcription pathway RNA Polymerase pathway, preventing replication and communication of cancer cells.

Transcription pathways are the means by which certain proteins that direct cell division are put

into action by cells.

Transcription pathways are the means by which certain proteins that direct cell division are put

into action by cells.

Cancer without this transcription proccess can’t

function

Cancer without this transcription proccess can’t

function

Every intend of discovering a way to fight against this tumors is a step more to get to prevent and

offer a treatment for thousands of people who become devastated

when they realized what they have is cancer.

It’s sad to see how this illness takes a lot of lives and finding a

drug like BMH-21 is really inspiring and promising to the future of

defeating Cancer

• Perelman School of Medicine at the University of Pennsylvania. (2014, January 16). Silencing inhibitor of cell replication spurs insulin-producing beta cells to reproduce. ScienceDaily. Retrieved February 14, 2014 from www.sciencedaily.com/releases/2014/01/140116162107.htm

• Johns Hopkins Medicine. (2014, January 13). Small molecule shows promise as anti-cancer therapy. ScienceDaily. Retrieved February 14, 2014 from www.sciencedaily.com/releases/2014/01/140113152629.htm