Beyond Asthma and COPD Challenges and Opportunities

Dry Powder Inhalers

Management Forum - 19 & 20 June 2012

David Harris, John Burke

Presentation_ManagementForum-DPIs_v1-0.ppt

Ben has severely injured his hand

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Catch twenty-two? The vast majority of dry powder inhalers are used to treat asthmatic and COPD patients...

They’re powered by the impaired organ!

What’s this?

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Pain relief How many tonnes of OTC analgesics are produced globally per year? 185,000 tonnes! If all analgesic tablets were placed end-to-end, how many times would they pass around the Earth?

140 times!

How many analgesic tablets are taken globally every second? >14,800!

2. http://www.in-pharmatechnologist.com/Ingredients/Univar-steps-into-paracetamol-breach

4. http://www.rsc.org/chemistryworld/Issues/2009/February/BusinessRoundup.asp

3. Warner TD, Mitchell JA (2002); Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?

Proc Natl Acad Sci USA 99 (21): 13371–3

1. Richard L Myers; The 100 Most Important Chemical Compounds, ISBN-13: 978-0-313-33758-1, p151

1, 2, 3, 4

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What’s the cost? 468,000,000,000 analgesic tablets are taken every year.

If it takes around 30 minutes for the tablets to kick-in.

Working at 75% productivity during this time amounts to: 29,302,884,615 hours! Which equates to 16,987,179 years!

The average cost of time per hour is around $10.

The total cost per year is a staggering: $293,028,846,154

5. http://www.bbc.co.uk/news/magazine-17512040

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What are the challenges?

Current analgesics are large doses need more potent drugs

Tablet blister packs are simple, effective and inexpensive need simple devices!

Delivering drugs with much narrower therapeutic indices accurate and repeatable delivered dose

Imagine...

Vaccination without needles

no pain

no cold chain

stable formulation

less fear

no needlestick

faster delivery

shorter queues

Can DPIs deliver

vaccinations successfully?

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What are the challenges?

• Delivery of dose needs to be as accurate as a needle and syringe

• Usability

many users will never have seen an

inhaler before!

• Majority of vaccinations given to infants or children

• Very low cost

on par with a needle and syringe

Excellent DCU

Perfectly intuitive

Works for children & adults

Very low cost

50 years on from the first DPI...

what next?

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Some exciting developments

• Inhaled insulin – Mannkind Corporation

• Nasal migraine relief – Sumatriptan

• Breakthrough cancer pain – inhaled Fentanyl, Akela Pharma

• Inhaled tuberculosis vaccine

6. http://www.mannkindcorp.com/product-pipeline-diabetes-afrezza.htm

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7. http://www.akelapharma.com/products.html

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8. http://www.pnas.org/content/105/12/4656.full.pdf

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The future for DPIs? simple low cost

accurate low

wastage

high payload

intuitive desirable

safe

efficient

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DPIs offer significant advantages...

Their future is up to us!