“ Adaptive Immune System”

Muhammed Al Bashir

MBBS student

at Sulaiman AlRajhi University

@M7mdAlBashir

Deference Between Adaptive & Innate Immunity

• Innate; presence, order of protection, mechanism of protection, & names

• Adaptive; developmental speed, specialization & effectiveness, requirements, memory, & names

• Components of the innate; 1- first line of defense in innate immunity 2-What happens if microbe breached epithelia?

• Components of the adaptive

• Define antigen & what bend with them?

• Adaptive usage of innate & example

Type of Adaptive Immunity

• Types & definition

• What mediates the humoral?

• What is antibody ( name, structure, & functions & prevention of infection starting )

• What mediates the CMI ? And how it works ?

• Deference between T & B cells in antigen recognition.

Active & Passive Immunities

• Active Immunity; names, & how ?

• Passive Immunity; How? power & duration, and example.

Properties of Adaptive Immune Responses

• Specificity; definition, what does it implies (lymphocyte repertoire ) ? clonal selection hypothesis

• Diversity; definition, # of naive cells

• Memory; type of response & their mediators , & reasons for the 2nd

• Clonal expansion

• Immunological tolerance

Cells of the Adaptive Immune System

• Cells & definitions

• Lymphocytes

o Unique characteristic

o Morphology, lineage, function, and phenotype

o Distinguishing & CD

o What is the only cell produce antibodies?

o Antibodies way of function

o T cells recognition of antigens ( type of antigen & its bound ) Helper T cells; type, name, function in humoral & CMI, & how they

work (cytokines & CD40 ligand )

cytotoxic T lymphocytes (CTLs); name, function

o Regulatory T lymphocytes; type of cells in it, & function

o Natural killer (NK) cells; function & deference from T&B cells

• Origin & maturation

• What happens when naive lymphocytes recognize microbial antigens? (effector cells and memory cells ) & what happens if they are not activated ?

• What are the effector cells B lymphocyte lineage? & what is their precursors ?

• Antigen-Presenting Cells

o Location

o What happens if microbe evaded the epithelia?

o Example ( professional, and macrophages, & B cells)

o Function of DC (transport to lymphoid nodes, (usually with T cells ) & function of follicular dendritic cell ( settle? , usually with B )

o Direct recognition

• Effector Cells

• In innate immunity, macrophages and some granulocytes directly recognize microbes and eliminate them

• In adaptive immunity, the products of B and T lymphocytes enhance the activities of macrophages

@M7mdAlBashir

ThanQAny ?