1

The Viruses

General CharacteristicsSize, Shape, Classification, Composition (NA, protein, lipid)

Infectivity (Host range & tissue tropism) Replication

Phages vs Animal viruses

DNA viruses vs RNA viruses

Effects on CellsCytopathology, Organismal effects

Oncogenes and tumorigenesis

2

The Viruses

General CharacteristicsSize:

Shape:

Composition:

Classification:

Infectivity:Host range Tissue tropism

ReplicationPhages vs Animal viruses

DNA viruses, RNA viruses Effects on Cells

Cytopathology, Organismal effects

Oncogenes and tumorigenesis

E. coli T- phages

Perspective:Size

Virus Shape

(d) Helical

(e) Icosahedral

Viral Diversity andMethods used in Classification

Viral Anatomy

Anatomy of aHerpes virus

Viral Diversity

Viral Diversity

Viral Diversity

16

The Viruses

General Characteristics

Size, Shape, Composition (NA, protein, lipid)

Classification, Infectivity (Host range & tissue tropism) Replication

Phages: Lytic vs lysogenic infection, Transduction

Animal viruses:

DNA viruses vs RNA viruses, Retroviruses Effects on Cells

Cytopathology, Organismal effects

Oncogenes and tumorigenesis

GeneralPhage Life Cycle

Lytic vsLysogenicCycle

Transduction

Transduction

Information Flow in Different Viruses

Replication:A DNA Virus

Replication:An RNA Virus

Penetration

Penetration:HIV virus

Biosynthesis:HIV virus

Release

29

The Viruses

General Characteristics

Size, Shape, Composition (NA, protein, lipid)Classification, Infectivity (Host range & tissue tropism)

Replication

Phages vs Animal viruses

DNA viruses, RNA viruses

Effects on CellsCytopathology

Organismal effects

Oncogenes and tumorigenesis

Cytopathology

Cytopathology

Prions:Mechanism of Action