NUCLEOTIDE BIOSYNTHESISBio-synthesis of Purines & Pyrimidines

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“The formation of DNA's structure by Watson and Crick may turn out to be the

greatest developments in the field of molecular genetics in recent years”

Linus Pauling, 1953

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Learning objectives:How nucleotides are synthesized in the cells?

Understand the Two Pathways of nucleotide biosynthesis

(1). De-novo synthesis and (2). Salvage Pathways

De-novo synthesis of purines

Synthesis of IMP (precursor of adenine and guanine)

Synthesis of Adenine and Guanine from IMP

De-novo synthesis of pyrimidines

Synthesis of Uracil

Synthesis of Cytosine

Synthesis of deoxy nucleotides

Synthesis of Thymine

Salvage pathways of Purines and Pyrimidines

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NUCLEOTIDE BIOSYNTHESIS

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o-salvage-purine-pyrimidine-nucleotides-cells

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