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HORMONE: RECEPTORS AND MECHANISM OF ACTION
MCQMCQ
• Which of the following is not Which of the following is not considered a second messenger? considered a second messenger?
A. Ca2+ A. Ca2+ B. Cyclic AMP B. Cyclic AMP C. diacylglycerol (DAG) C. diacylglycerol (DAG) D. guanylyl cyclase D. guanylyl cyclase E. Inosital triphosphate (IP3E. Inosital triphosphate (IP3
• guanylyl cyclaseguanylyl cyclase
Hormone receptorsHormone receptors
All hormones act through All hormones act through specific receptors. Almost specific receptors. Almost all hormone receptors are all hormone receptors are large proteins present in large proteins present in hormone sensitive target hormone sensitive target cells.cells.
Specificity of hormone action is Specificity of hormone action is because of specific receptors.because of specific receptors.
Characteristics of hormone Characteristics of hormone receptorsreceptors
Mechanism of action of Mechanism of action of hormoneshormones
Action through change in membrane permeability
Action through effect on gene expression by Action through effect on gene expression by binding of hormones with intracellular binding of hormones with intracellular
receptorsreceptors
Action of hormones through their Action of hormones through their effect of gene expression.effect of gene expression.
Action through second Action through second messengersmessengers
Schematic mechanism of coupling by G-Schematic mechanism of coupling by G-protein leading to increase in second protein leading to increase in second messenger which mediates hormone’s messenger which mediates hormone’s physiological responsephysiological response
Mechanism of action of hormone via tyrosine kinase activation
Mechanism of action of hormone via tyrosine kinase activity: A, by receptors that possess intrinsic
tyrosine activity: and B, by receptors that do not possess intrinsic tyrosine activity
Measurement of Measurement of hormoneshormones
Enzyme-linked immunosorbent assay method