10 years of the ABPLaunch, limitations and lessons
Prevalence of blood doping in the 2000’s
2
Track & Field AthleticsP.-E. Sottas et al., Clinical Chemistry. 57, 762–769 (2011).
The Science in the 2000’s
3
Autumn 2007
4
“Annus horribilis: Cheating has dogged cycling for years, but this year more than most.”
05-Sep-2007: decision by the UCI to launch the ABP
First ABP tests on 26-Oct-2007 Out-of-competition testing in
place
5
6
7
8
9
CAS AWARDS: Jurisprudence for the ABP
“The Panel recalls the CAS award in the case CAS 2010/A/2235 which confirmed the validity and reliability of the ABP”
“Therefore, following a consideration of the written and oral testimonies of the Parties’ experts, the Panel is convinced that the ABP model is a reliable and valid mean of establishing an ADRV.”
Number of Blood Doping Cases (ADRVs all sports)
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~ 20 cases per year pre-2008
›70 cases per year post-2008
>300% increase
>800 athletes sanctioned since introduction of the ABP
0
20
40
60
80
100
120
140
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017
ABP
ESA
Source: ADAMS reports and decisions received by WADA
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EPO microdosing: how much?
Dose administered inclinical trials
Normal endogenous production
Evolution of doses administered in clinical trials follows advances in detection methods
Term “EPO microdosing” introduced in early 2000’s (40 UI/kg IV EOD)
Rider caught for EPO admitted doping with 8 UI/kg IV EOD
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Worldwide variations in testosterone metabolism
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Increase in IRMS positives below T/E of 4
IRMS Positive
0
5
10
15
20
25
2014 2015 2016 2017
Cases with T/E<4
Source: ADAMS reports
/ 14
Sample swapping
Different persons
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Outcomes of current ABP modules
Drug testingArticle 2.1
Passport caseArticle 2.2
InvestigationsArticles 2.5-2.10
Haematological Module ++ ++ ++
SteroidalModule ++ - ++
Deterrence?
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