10 years of the ABPLaunch, limitations and lessons

Prevalence of blood doping in the 2000’s

2

Track & Field AthleticsP.-E. Sottas et al., Clinical Chemistry. 57, 762–769 (2011).

The Science in the 2000’s

3

Autumn 2007

4

“Annus horribilis: Cheating has dogged cycling for years, but this year more than most.”

05-Sep-2007: decision by the UCI to launch the ABP

First ABP tests on 26-Oct-2007 Out-of-competition testing in

place

5

6

7

8

9

CAS AWARDS: Jurisprudence for the ABP

“The Panel recalls the CAS award in the case CAS 2010/A/2235 which confirmed the validity and reliability of the ABP”

“Therefore, following a consideration of the written and oral testimonies of the Parties’ experts, the Panel is convinced that the ABP model is a reliable and valid mean of establishing an ADRV.”

Number of Blood Doping Cases (ADRVs all sports)

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~ 20 cases per year pre-2008

›70 cases per year post-2008

>300% increase

>800 athletes sanctioned since introduction of the ABP

0

20

40

60

80

100

120

140

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017

ABP

ESA

Source: ADAMS reports and decisions received by WADA

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EPO microdosing: how much?

Dose administered inclinical trials

Normal endogenous production

Evolution of doses administered in clinical trials follows advances in detection methods

Term “EPO microdosing” introduced in early 2000’s (40 UI/kg IV EOD)

Rider caught for EPO admitted doping with 8 UI/kg IV EOD

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Worldwide variations in testosterone metabolism

/ 13

Increase in IRMS positives below T/E of 4

IRMS Positive

0

5

10

15

20

25

2014 2015 2016 2017

Cases with T/E<4

Source: ADAMS reports

/ 14

Sample swapping

Different persons

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Outcomes of current ABP modules

Drug testingArticle 2.1

Passport caseArticle 2.2

InvestigationsArticles 2.5-2.10

Haematological Module ++ ++ ++

SteroidalModule ++ - ++

Deterrence?

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