XL100 Overview

XL100 Vial Handling Instrument


• Beyond the XL20 Tube Handling Instrument

– Vials ~18mm diameter x 100mm tall

– Increased amount of tubes, vials, and modular functionality

• Similar operation, robotics, and software interface as the XL20 Tube Handling Instrument

• Easy transition between vial sizes

– User-definable labware files

– Interchangeable pick-fingers

• Modules Options Available

– Liquid Handling – single channel pipettor

– Linear Barcode Reader – MS-2 Microscan

– 2D Barcode Reader – BioMicroLab

– Analytical Balance – Mettler Toledo

• 0.1mg – 4-place balance

• 0.01mg – 5-place balance

– Decapper/Recapper – BioMicroLab

– Automated Capper Carousel

– Rack Transfer Station

– Third-party robotic integration via XL100 Software Developer’s Toolkit

Benchtop vial handling system

20 SBS Rack Positions

Customizable Deck Modules Options Area


XL100 Benchtop Vial Handling System

XL100 Applications

– Automate routine and repetitive vial

sample handling tasks

– Vial Rearraying for consolidated liquid

handling operations

– Combine multiple manual tasks in one

instrument

Decode

Decap

Weigh

– Automate sample receipt processing

– Walk-away vial decapping and

recapping

– Basic Liquid Handling via single

channel pipette


Customizable Sorting Platform

Examples:

BD Vacutainer – 24 well 16mL

vials

2D Barcoded tubes - Matrix,

Micronic, and ABgene

Beckman - 2mL screw cap vials

Tecan – 1 x 16 2mL screw cap

vials

One Dram Vials – 4mL glass

vials – not shown

Corning/Nunc Cryovials –

frozen sorting options – not

shown

Decoding Vacutainer linear barcodes Decoding 2D barcoded tubes

Beckman Racks with 2mL screw cap vials Tecan Racks with 2mL screw cap vials

XL100 1D and/or 2D Reader Options

XL100 Microscan 1D Reader

1D reader captures barcode from labels

wrapped around the vial

XL100 on-platform rotator spins the vial

Symbologoies - Linear bar codes

XL100 2D Reader

BioMicroLab integrated camera

Captures and decodes 2D mark from

bottom of vials

Symbologoies – data matrix bar codes

Located under the XL100 platform at the 1D

reader location 1D Reader 2D Reader

XL100 Analytical Balance Option

XL100 Analytical Balance

4-Place balance specs

Weighing range 60g

Readability at the interface 0.1mg

Repeatability 0.04mg

Linearity 0.25mg

Response time average <= 2 sec

XL100 Decap/Recap

XL100 Decap/Recap Station

– Version for one dram vials,

cryovials, and others

– Decaps a vial and discards the

cap

– Or, decaps a vial and holds the

cap while the vial is weighed,

then recap with the same cap

– Example application:

Decap a vial

Hold the cap

Weigh the vial

Recap the vial

Typically designed and

implemented for one vial and

cap combination. Multiple

combinations can be evaluated.

XL100 Automated Carousel Capper

XL100 Automated Capping Station

– Currently compatible with screw cap

closures

One dram vials – or similar

Cryovials – Nunc/Corning/Greiner/Wheaton

Sarstedt vials

– Holds up to 480 caps (cap dependent)

– Caps a screw cap vial with a new closure

– Operated in conjunction with the XL100

decap/recap module

– Mounted to module side of XL100

– Typically designed for one vial/cap

combination

– Controlled via BioMicroLab API software or

ActiveX

XL100 Rack Transfer Station

XL100 Rack Transfer Station

Positions #5 and #20 on XL100 sorting platform can be rack transfer stations

#20

#5

XL100 Liquid Handling Option

XL100 with Liquid Handling

Single channel: 5uL to 200uL range pipette module

Based on Biohit rLine 200uL pipette module

Aspirate / dispense to all 20 SBS deck positions

Automatic tip load and unload

Separate z-axis controlled directly by the XL100

XL100 Throughput Examples

XL100 Seconds/Vial

Sort Only 7

Sort and 2D Decode 10

Sort and 1D Decode 12

Sort and Decap 22

Sort, 2D or 1D Decode,

and Weigh 23

Capping Only 25

Aspirate 200uL 7

Dispense 200uL 7

XL Work List Manager Software

XL Tube Handler Processing Modes

Tube handling modes of operation

• Work List Based – rearray applications

1. Sequential

• Racks are processed in work list

order only

2. Random

• Racks are processed in random

order

• No Work List Required – pick and place vial from

same location

1. Tare/Gross Weigh

• Tare and gross weight of vials

• Streamlined weighing mode

2. Data Collection Mode

• Typically used to collect linear

barcodes or vial weight with

XL100

XL Tube Handler Input Work List

• Work list example

Source Rack ID

Source Tube Location

Expected Tube 2D bar

code (optional)

Target Rack ID

Target Tube Location

Input File Settings

Input Files Settings

Provides flexibility for importing

work lists with header files or extra

characters

XL Tube Handler Software Features

• Main Processing Screen

– Work list or non-work list

controlled movement of tubes

– Confirms tube ID from work

list with captured 1D/2D data

– Captures image of 2D

barcode for error handling

– Sample weight capture

displayed

– Status of processing

displayed

– Software generates Job ID for

tracking in your LIMS system

– Start, Stop, and Pause

Click to import

work list

XL Tube Handler Rack Setup

• XL Tube Handling Instrument Work

List Software

– Assignment of racks to XL platform

locations

– Color coded interface guides user

through tube rack loading process

– Supports input from hand held bar

code scanner

XL Tube Handler Software Features

To Start - press job

initiator button

Can view live video vs.

captured bitmap

Barcode Read

Returns decoded

barcode

Status column

OK

Barcode mismatch

Weight column

Returns weight

Captures data

while processing

tubes

XL Work List Mode Output File

Generates LIMS output file for use

by sample tracking systems

Operator can pre-determine

content of output file

Output file can be placed in folder

on a network

Example of Work List Processing

Mode Output

Example of Work List Mode Output File

XL Tube Handler Tare/Gross Weigh

XL Tube Handling Instrument Tare

Gross Weighing

Interactive selection of tube

positions during the weighing mode

set up

Provides full flexibility for a wide

variety of weighing applications

Tare/Gross Weigh Output File Options

Output File Options for

Tare/Gross Weigh Mode

Operator can pre-determine

content of output file

Output file can be placed in

folder on a network

Example of Tare/Gross Weigh Output File

XL Tube Handler Error Handling

Error handling:

Tube Movement:

Picking Tube

Placing Tube

Barcode Decoding:

Barcode Mismatch

Decode failure

• Error handling features

selectable by the operator

• Audible Alarms

Contact Information

BioMicroLab, Inc.

Web: www.biomicrolab.com

Email: [email protected]

Tel: (925) 689-1200 or Fax: (925) 689-1263

Mail: 2500-A Dean Lesher Drive

Concord, CA 94520 USA

Documents

XL100 Overview