Preventive health and wellness approach based on scientific evidence

What can DNA Health Test tell you?

Overview

1. Our journey with you 2. Basic concepts 3. Risk assessment frameworks

I’m frustrated with my ongoing

symptoms and not performing in my

daily life.

I NEED answers!

Our journey with you

The future of health care will be a world away from the current system that typically treats people only after they become sick.

Our journey with you

Meeting of minds Research

2012

Launched 1st DNA Test Lifestyle Questionnaire Portal

2014

Practitioner Portal Best New Product award

2015

Our journey with you

Report Generator Tool

Health and wellness DNA Test

2016

New look Reports Practitioner Support Notes

Our journey with you

Risk for Coeliac Disease/Gluten sensitivity

Increased need for antioxidants

Risk for essential fatty acids imbalance

2017

Lifestyle Assessment

Report

PUFA levels influenced by diet and genetic availability

• FADS1: reduced D5D activity; impacts downstream

production of omega 3 precursors

• FADS2: increased D6D activity; impacts downstream

production of omega 6 precursors

Our journey with you

CYP7A1 Response to cholesterol lowering functional foods

2018 Research and development

CYP7A1 genetic variant affects how well foods such as plant sterols and beta-glucan (found in many cholesterol-lowering functional food products) will reduce total cholesterol (TC) and Low-Density Lipoprotein cholesterol (LDL-C)

Why might this be useful to know? • How likely a nutritional protocol designed to optimise LDL-C levels using plant sterols may be

effective genetically. • Alongside this, G allele genetic variants of CYP7A1 may also be sensitive to increased TC and

LDL-C when including dairy in their diet.

Our journey with you

32 and you evidence for genetic dental disorders

2018 Research and development

Sports Performance evidence for genetic variants and epigenetics

Scientific process

Our scientific process to assess potential candidate SNPs

Relevance: Susceptibility genes need to be characterised by biological studies

Reliability: Scientific papers, research data and population

Actionable: Nutritional and lifestyle interventions

Lab testing

Who are we working with

Nutritional Practitioners

Naturopaths Functional Medicine

Osteopaths GPs/Holistic Dentists

myDNAhealth approach

The environment around us, our genetic inheritance, how we live our lives and the opportunities we have together largely determine our health.

myDNAhealth approach

THE GREATEST HEALTH THREATS NOW ARISE FROM HOW WE LIVE, WORK, EAT, PLAY, AND MOVE

• NCDs can progress slowly in people and include type 2 diabetes, Alzheimer’s and Cardiovascular Disease …

• Non-communicable symptoms can be weight gain, tiredness, joint pain, low mood, gut health issues etc.

• Risk factors include environment, excessive weight gain, age, genetics, physical inactivity, smoking, unhealthy diet, stress and insufficient sleep

You today

(your health state)

Who are you today?

Is it a result of your DNA? Your genes

(nature)

Your environment

(nurture)

Or is it a consequence of your environment?

It’s Both

Genetic predisposition + Environmental Inputs

= Function / Dysfunction

Understanding the genetic association with human biochemical function and connection with nutrition and lifestyle offers clinical tools with which to practice.

Nutritional Genomics In Practice

e.g. turmeric, food

45 gene variants

What’s the implication for healthy living and ageing?

If your environment is problematic …

you eat badly, and live in a heavily polluted area, you do little exercise and suffer from stress, poor sleep

… then you are likely to exceed your genetic ability to adapt and you may eventually develop health issues.

Connecting your DNA and lifestyle

Our DNA Reports makes connections between your DNA and lifestyle for healthy living and ageing.

Putting it all together

Our focus is on those genetic variations that can be influenced by EPIGENTIC MODIFCIATIONS (lifestyle)

Market acknowledgement

US Direct-to-Consumer DNA Testing Landscape (April 2018) Source: Mintel

myDNAhealth appears to be the only company that adds the epigenetic component to testing

and has a unique engagement model

That’s why we are different!

Brain Health

Stress/ Sleep

Diet – Sugar &

Fat

Exercise

Obesity

Smoking

Gut Atopic

Disorders /IgE

Toxicity

Vitamin D

Inflamm-ation

APoE

MTHFR

Self-assessment online questionnaires (environment, lifestyle, habits, symptoms)

17

Practitioner Tools: A health risk analysis and preventive framework

Obesity

Stress & Trauma /

Sleep

Diet

Vitamin D

Gut health

Atopic Disorders

Toxicity

Exercise/

Lifestyle

Inflammation

Nutri-genetics

Example: A metabolic risk analysis and preventative framework

Interactive secure client portal

Practitioner Tools: A health risk analysis and preventive framework

Practitioner Tools: A health risk analysis and preventive framework

Inflammation

Stress Trauma Sleep

Diet

Infection&

Dysbiosis

Gut Permeab-

ility

Atopic Disorder

/IgE

Xenobiotic Toxicity

Endocrine Imbalance

EFA Balance

Genetic Mediators

Some Triggers to think about

Summary

1. Multi faceted approach

2. Gain experience by practice

3. Try our risk analysis frameworks

4. Make sure your genetic testing company provides this type of support

5. If your client is healthy, then support through diet and lifestyle

6. If they are symptomatic, further functional testing may be needed

More information: https://mydnahealth.co.uk/

Practitioner Support:

T: +44 (0)1603 861614

practitioner@mydnahealth.co.uk

Come and talk to us today