UCLA/Orthopaedic Hospital Department of Orthopaedic Surgery

Alumni Bulletin 2012

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A Message from Chairman Dr. Jeffrey J. Eckardt:

Welcome to the 2012 AAOS UCLA/OH Alumni Reception. We have had a most successful year as we remain committed to patient care, emphasizing research while maintaining our commitment to education and community service. I am glad to report that in June 2011 the Department received word from the RRC (Residency Review Committee) that we received a 5-year accreditation without any citations. This was in large part due to the diligence of Connie Sams, our Medical Education Coordinator, and Drs. Jim Luck and Nelson SooHoo, our program directors, with help from Drs. Prosper Benhaim, Gerry Finerman and David McAllister. After many years of waiting, we have now moved into our offices, clinics and operating rooms within the new Santa Monica Hospital, officially known as the Santa Monica UCLA Medical Center and Orthopaedic Hospital. Our alliance with Orthopaedic Hospital remains steadfast as Orthopaedic Hospital celebrates their 100-year anniversary. Since June 2010 we have added eight new faculty members: Drs. Frank Petrigliano in the Division of Sports Medicine, Devon Jeffcoat and Eric Farrell in Trauma, Peter

Alexakis and Bruce Brown in General Orthopaedics and Jae Jung in PM&R. Drs. Michael Daubs in Spine and Susan Bukata in Oncology and Osteoporosis will be arriving in March 2012. We were also delighted to welcome our new R1 class that represents the best of the best applicants. Our Outpatient Ambulatory Surgical Center, with eight new operating rooms on 16th Street, is due to open by March 2012 in Santa Monica. This will bring us to a total of 16 inpatient ORs and 8 outpatient ORs for surgical procedures on the Santa Monica campus. We continue to have access to outpatient surgical rooms in Westwood for hand and sports cases, with the Ronald Reagan UCLA Medical Center being primarily used by Drs. Eric Johnson and Devon Jeffcoat for the major trauma cases. Our new outpatient Spine Center with Neurosurgery and PM&R at Wilshire and 12th Street in Santa Monica will hopefully be opened by this summer. Our newest challenge will be the implementation of the Electronic Medical Record System, a two-year process and an administrative challenge for all. All of our faculty, residents, and fellows have diligently been working with the implementation team for a smooth transition. We all hope that you will keep in touch and come to visit us if in Los Angeles. Sincerely yours, Jeffrey J. Eckardt, M.D. Professor and Chair, Department of Orthopaedic Surgery The Helga and Walter Oppenheimer Chair of Musculoskeletal Oncology

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Historical Notes Charles O. Bechtol, M.D.

1911-1998 Our Founding Division Chief

Charles O. Bechtol, M.D. (1911-1998) was the Founding Division Chief of Orthopaedic Surgery at UCLA. Dr. Bechtol received his M.D. from Stanford Medical School in 1940. From 1952-1957, he served as Chairman of the Department of Orthopaedic Surgery at Yale University where he established the Yale Biomechanics Laboratory. He joined the UCLA faculty in 1957 as Founding Division Chief of Orthopaedic Surgery and served in that capacity until 1970. Dr. Bechtol became internationally known for his research in biomechanics, designed multiple orthopaedic device systems and made major improvements in artificial limbs. Among the devices were a self tapping screw in the 1950s, the Bechtol Stepped Hip Replacement Stem in 1956, the Bechtol Straight Hip Stem with Trabecular Notches in the 1960s, the Bechtol Total Hip System in 1970, the Bechtol Total Knee System in 1972, the Bechtol Total Shoulder Replacement in 1974, and the Series II Total Hip System in 1976 among others. He served as member and chairman of research committees for the AAOS, ORS, National Science Foundation, California Medical Association and LA County Medical Association. In 1991, Dr. Bechtol received the Markowitz Award from the Academy of Surgical Research for a lifetime of outstanding contributions to medicine through experimental surgery. In 1970, he founded the Los Angeles-based Joint Implant Surgery & Research Foundation, which he chaired until his death on July 16, 1998 at the age of 86.He is survived by his wife, Louise, who graciously provided this biographical information. Dr. Bechtol set the bar for clinical care and translational bioengineering research. We are indebted to him and indeed privileged to have such an esteemed physician and researcher as our Founding Division Chief. Jeffrey J. Eckardt, M.D. January 2012

In 2010-2011, the UCLA/Orthopaedic Hospital Department of Orthopaedic Surgery continued its mission of providing outstanding clinical care, resident and fellow education, and research at the basic science, translational, and clinical levels. Our goal as a Department is to integrate clinical care, education, and research while maintaining the highest levels of patient satisfaction with cutting-edge surgical techniques. We are honored to be a part of the UCLA Health System, consistently ranked as “Best in the West” by the US News and World Report.

January 2012 marked the opening of the new Santa Monica UCLA/Orthopaedic Hospital, located on Wilshire and 16th Street in Santa Monica, CA.

This location will serve as the inpatient and outpatient hub of the UCLA/Orthopaedic Hospital Department of Orthopaedic Surgery for decades to come. Constructed as part of the alliance between UCLA Orthopaedic Surgery and Los Angeles Orthopaedic Hospital, this facility houses state of the art operating suites, inpatient facilities, faculty offices, and outpatient exam rooms. In addition, UCLA has signed a $147 million dollar 30 year lease

on a three-story ambulatory surgery center across

from the Santa Monica UCLA Medical Center slated to open in early 2012. Further, construction of a new UCLA Spine Center has commenced in conjunction with the Department of Neurosurgery, slated to open in 2012.

FACILITIES

The Los Angeles Orthopaedic Hospital has added and updated facilities to continue to provide world-class pediatric orthopaedic care both in the original downtown Los Angeles location and in Santa Monica. Led by Anthony Scaduto, M.D., interim President, Chief Executive Officer and Lowman Professor of Pediatric Orthopaedics, the Renee and Meyer Luskin Children’s Clinic moved into the new Santa Monica UCLA/Orthopaedic Hospital in January 2012 and will serve as the westside focal point of Pediatric Orthopaedics at UCLA. Also, over 95,000 children's orthopaedic visits are conducted at the 40,000-square-foot Orthopaedic Hospital Outpatient Medical Center on the downtown Los Angeles Orthopaedic Medical Center campus. In addition, we remain extremely proud of the Orthopaedic Hospital Medical Magnet High School. Opened as an alliance with Los Angeles Unified School District, this magnet high school emphasizes healthcare and medical science.

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Despite the move of the majority of orthopaedic clinical work to the new Santa Monica facility, we still maintain a strong presence at the main Westwood UCLA campus. First, we provide Level 1 orthopaedic trauma care at the new Ronald

Reagan UCLA Medical Center which serves as the nucleus for our Orthopaedic Trauma resident education. Second, the UCLA/Orthopaedic Hospital Department of

Orthopaedic Surgery maintains the state-of-the-art 35,000 square foot Orthopaedic Hospital Research Center (OHRC).

Led by Vice Chair of Research John Adams, M.D., we harbor three goals for this facility and departmental research as a whole. The first is to become the foremost research department of orthopaedic surgery in the United States. Currently, we rank 8th among Orthopaedic Surgery departments nationally for NIH funding. The second is to build a leading training program in

regenerative-restorative orthopaedic medicine and train the next generation of leaders in the field. The third is to bring research advances to the care of children with musculoskeletal disease, a 100+ year-long mission of the Orthopaedic Hospital of Los Angeles. Third, the UCLA Division of Sports Medicine continues to provide care for over 700 UCLA intercollegiate athletes at the Acosta Athletic

Training Complex and, in addition, provides musculoskeletal care at the Arthur Ashe

Student Health and Wellness Center. Lastly, UCLA Orthopaedic Surgery will maintain a clinic and Sports Medicine Center on campus at Westwood. In the UCLA/Orthopaedic Hospital Department of Orthopaedic Surgery, we aim to provide a diverse residency experience and to provide care to the underserved as well. In 2011, we maintained our strong relationship with Harbor-UCLA Department of Orthopaedic Surgery but also added a new Orthopaedic Surgery service at the county hospital, Olive View Medical Center. This new service, led by Olive View Chief Nelson Soohoo, M.D., has been tremendously well received by residents, faculty, and patients alike. The orthopaedic service joins the already extremely busy hand service at Olive View and provides Level 2 orthopaedic trauma care and sports medicine in the North San Fernando Valley.

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UCLA continues to pride itself on training some of the finest orthopaedic surgery residents in the country. Our goal is to train both future academic leaders and outstanding clinicians. Each year we are faced with the difficult task of choosing from the most outstanding applicants in the country in an increasingly competitive field. We are rewarded each year with bright young minds that provide outstanding care and strengthen our department. Led by Program Director James V. Luck, Jr., M.D. and Associate Program Director Nelson Soohoo, M.D., we currently train six residents per residency class. In addition, two residents per year choose to complete a prestigious one-year research fellowship between second and third years of residency. Our residents continue to rotate at Harbor-UCLA Medical Center, Shriner’s Hospital Los Angeles, the West Los Angeles VA Hospital, and the aforementioned Orthopaedic Surgery Service at the Olive View Medical Center.

RESIDENT/FELLOW EDUCATION

In addition, we train two Pediatric Orthopaedic Surgery Fellows, two Orthopaedic Sports Medicine Fellows, two Hand Surgery Fellows, and two Spine Surgery Fellows per year. These trainees have completed their orthopaedic surgery residencies and have chosen to spend one year at UCLA for subspecialty training. The strength of our residency program is demonstrated by the outstanding fellowships garnered by UCLA graduates. The following is a partial list of the fellowships attended by recent graduates: Scott Crow, MD, Sports Medicine, Kerlan Jobe, LA, CA Eugene Farng, MD, Hand Surgery, University of

Washington Moazzaz, Payam MD, San Diego Center for Spinal Diseases Carlos Gonzales, MD, Sports Medicine, Brigham and

Women’s Hospital, Boston, MA Chukwunenye Osuji, MD, Trauma, UC Davis Samuel Park, MD, Joint Replacement, Brigham and Women’s

Hospital, Boston, MA Brent Berger, MD Pediatric Orthopaedics, DuPont

Children’s Hospital, Wilmington, DE Adam Bier, MD, Sports Medicine, Kerlan Jobe, LA, CA

Lucie Krenek, MD, Hand Surgery, University of Washington

Michael Eagan, MD, Trauma, Shock Trauma, Baltimore, MD

April Ligato, MD, United States Air Force Hillard (Theo) Spencer, MD, Pediatric Orthopaedics,

Harvard, Boston, MA Joshua Bales, MD, Hand Surgery, Cincinnati, OH The current chief residents (graduating June 2012 and pictured left to right) are matched to the following excellent fellowships:

Mark Elzik, MD, Hand Surgery, Philadelphia Hand Center Dan Le, MD, Joint Replacement, New England Baptist

Hospital, Boston, MA Paul Celestre, MD, Spine Surgery, Norton Leatherman,

Louisville, KY Tad Kremen, MD, Sports Medicine, Duke University, NC Nicholas Bernthal, MD, Orthopaedic Oncology, University of

Utah Locky Chambers, MD, Sports Medicine, Hospital for Special

Surgery, NY, NY (not pictured) Lastly, we welcome our stellar new intern class: Michael Leathers, MD, USC Medical School Dean Wang, MD, Case Western Reserve Medical School Mark Sugi, MD, UCLA Medical School Natalie Leong, MD, Harvard Medical School Adedayo Ashana, MD, University of Pennsylvania Medical

School Benjamin Bluth, MD, UCLA Medical School Our residents have been very productive in research over the past year as well. Nick Bernthal, M.D. received the Lloyd Taylor Award, 2011 Western Orthopaedic Association and the 2011

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OREF Resident Award, California Orthopaedic Association. Alan Zhang, M.D. received an HH Lee Surgical Resident Travel Grant. Jared Niska, M.D. received the HH Lee Surgical Research Grant of$25,000 for work on an infected mouse arthroplasty model. Jonathan Pribaz, M.D. won 4th place and a $1000 honorarium at the 2011 UCLA Department of Medicine Research Day Poster Competition. Scott Montgomery, M.D. and Jared Niska, M.D. are currently doing an outstanding job as the 2011-2012 research residents.

Current and Former Research Residents (graduation year) pictured left to right: Drs. Jonathan Pribaz (2014), Jeremy Reid (2013), Jared Niska (2015), Tad Kremen (2012), Nick Bernthal (2012), Jared Johnson (2013), Scott Montgomery (2015) Resident Publications 2011 Bernthal N, Celestre P, Stavrakis A, Luddington J, Oakes D. Disappointing Short Term Results with the DePuy ASR™ Metal on Metal Total Hip Arthroplasty. J Arthroplasty October 12, 2011. Bernthal N, Hoshino C, Dichter D, Wong, M, Silva M. Assessing Long-Term Range of Motion After Lateral Condyle Fractures in Children. J Bone Joint Surg 2011;93:871-7. Bernthal N, Pribaz J, Dichter D, Wong, M, Silva M. Lateral Spurring After Lateral Condyle Fractures of the Humerus in Children. J Ped Orthop. In Press 2011. Bernthal N, Pribaz J, Stavrakis A, Finerman G, Adams J, Miller L. Protective Role of IL-1B against Post-Arthroplasty

Staphylococcus aureus Infection. J Orthop Res 2011;29:1621-6. Bernthal N, Seeger L, Motamedi K, Stavrakis A, Kremen T, McAllister D, Motamedi A. Can the Reparability of Meniscus Tears be Predicted with MRI? Am J Sports Med 2011;39:506-10. Chambers KL, Kremen TJ, Snell CJ, Gamradt SC. Arthroscopic Anterior Shoulder Stabilization in the Beach Chair Position Using Trans-Subscapularis Drilling of the 5:30 Anchor.Techniques in Shoulder & Elbow Surgery. 12(3):56-61, September 2011.

Chambers L, Hame S, Levine B. Acute Exertional Medial Compartment Syndrome of the Foot after Playing Basketball. Journal of Skeletal Radiology. 2011 40(7): 931-5. Gamradt, SC, Gelber J, Zhang, AL. Shoulder Function and Pain Level after Revision of Failed Reverse Shoulder Replacement to Hemiarthroplasty.International Journal of Shoulder Surgery, In Press 2011. Hartzell T, Shahbazian J, Pandey A, Stofman L, Rubinstein R, Bernthal N, Azari K, Benhaim P. Does the gatekeeper

model work in hand surgery? In Press 2011. Johnson JS, Meliton V, Kim WK, Lee KB, Wang JC, Nguyen K, Yoo D, Jung ME, Atti E, Tetradis S, Pereira RC, Magyar C, Nargizyan T, Hahn TJ, Farouz F, Thies S, Parhami F. Novel Oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo. J Cell Biochem. 2011 Jun; 112(6): 1673-84. Kremen T, Bernthal N, Seeger L, Nelson S, Eckardt J. Giant Cell Tumor of Bone: Risk Stratification and Long Term Outcomes. Clin Orthop Relat Res Nov 29, 2011. Kremen TJ,Bernthal NM, Eckardt MA, Eckardt JJ. Giant Cell Tumor of Bone: Are We Stratifying Results Appropriately? Clin Orthop Relat Res. 2011 Nov 29. Kremen TJ, McAllister DM. Graft Selection in Multiple Ligament Injured Knee Surgery. In: The Multiple Ligament Injured Knee: A Practical Guide to Management 2nd ed.,edited by Gregory C. Fanelli. New York, NY: Springer; 2011 (In Press). Kremen TJ, Petrigliano FA, McAllister DR. Revision Anterior Cruciate Ligament Reconstruction.Orthopaedia®

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Collaborative Orthopaedic Knowledgebase. Lee KB, Johnson JS, Song KJ, Taghavi CE, Keorochana G, Wang JC. The use of autogenous bone graft compared to rhBMP in high risk patients: A comparison of fusion rates and time to fusion. In Press, Journal of Spinal Disorders and Techniques. Lee KB, Murray SS, Taghavi CE, Song KJ, Brochmann EJ, Johnson JS, Keorochana G, Liao JC, Wang JC. Bone morphogenetic protein-binding peptide reduces the inflammatory response to recombinant human bone morphogenetic protein-2 and recombinant human bone morphogenetic protein-7 in a rodent model of soft tissue inflammation. Spine J. 2011 Jun;11(6):568-76. Lee KB, MurraySS, Duarte ME, Spitz JF, Johnson JS, Song KJ, Brochmann EJ, Taghavi CE, Keorochana G, Liao JC, Wang JC. Effects of the bone morphogenic protein binding protein spp24 (secreted phosphoprotein 24 kD) on the growth of human lung cancer cells. J Orthop Res. 2011 Nov29(11):1712-8. Leelapattana P, Keorochana G, Johnson J, Wajanavisit W, Laohacharoensombat W. Reliability and validity of an adapted Thai version of the Scoliosis Research Society-22 questionnaire. J Child Orthop. 2011 Feb;5(1):35-40. Liao JC, Tzeng ST, Keorochana G, Lee KB, Johnson JS, Moroshita Y, Murray SS, Wang JC.Enhancement of recombinant human BMP-7 bone formation with bmp binding peptide in a rodent femoral defect model.J Orthop Res. 2011 May;29(5):753-9. Niska JA, Shahbazian J, Ramos RI, Pribaz J, Billi F, Francis K, Miller L. Daptomycin and tigecycline have a broader effective dose range than vancomycin as prophylaxis against a surgical implant Staphylococcus aureus infection in mice. Antimicrobial Agents and Chemotherapy In Press, 2011. Pribaz J, Bernthal N, Stavrakis A, Finerman G, Adams J, Miller L. Mouse Model of Chronic Post-Arthroplasty Infection: Noninvasive in vivo bioluminescence imaging to monitor bacterial burden for long term study. J Orthop Res 2011; doi:10.1002/jor.21519. Reid JJ, Johnson JS, Wang JC.Challenges to bone formation in spinal fusion. J Biomech. 2011 Jan 11;44(2):213-20. Silva M, Wong T, Bernthal N.Outcomes of Reduction More than Seven Days After Injury in Supracondylar Humerus Fractures in Children. Accepted J Ped Orthop 2011;31:751-6. Tian H, Yuan W, Johnson JS, Chen H, Chen D. Pharyngoesophageal Diverticulum: A Delayed Complication of

Anterior Cervical Spine Surgery. Eur Spine J. 2011 Feb;20 Suppl 2:S211-6. Zhang AL, Kreulen C, Ngo, S, Hame S, Wang J, Gamradt SC. Demographic Trends in Arthroscopic SLAP Repair. Am J Sports Med. In press, 2011. Zhang, AL, Gelber J, Gamradt, SC. Removal of the Reverse Shoulder Prosthesis. Tech Should Elbow Surg. 2011 June; 12(2):40-45.

Bernthal N, Pribaz J, Stavrakis A, Billi F, Francis K, Iwakura Y, Miller L. Protective role of IL-1b against post-arthroplasty

Resident Abstracts/Presentations 2011 Bernthal N, Eilber F, Eilber F, Eckardt J. Total Femoral Endoprostheses: The UCLA Experience 1980-2011. Podium Presentation – Combined Connective Tissue Oncology Society (CTOS)/ Musculoskeletal Tumor Society (MSTS) Annual Meeting, Chicago, October 2011. Bernthal N, Hoshino C, Dichter D, Wong M, Silva M. Prospective Longitudinal Evaluation of Elbow Range of Motion Following Pediatric Lateral Condyle Elbow Fractures. Podium Presentation – American Academy of Orthopaedic Surgeons (AAOS) Annual Meeting, San Diego, February 16, 2011. Bernthal N, Ludington J, Gamradt S, Oakes D. To Screen or Not to Screen: Results of Routine DVT Screening in Knee Arthroplasty Patients in the Era of Regional Anesthesia. Poster Presentation – Western Orthopaedic Association Annual Meeting, Honolulu HI, July 28, 2011. Bernthal N, Pribaz J, Stavrakis A, Billi F, Cho J, Francis K, Iwakura Y, Eckardt J, Miller L. Using Bioluminescence to Combat Biofilm: Mouse Modeling of Implant Infections to Protect Endoprosthetic Reconstructions. Podium Presentation – Combined Connective Tissue Oncology Society (CTOS)/ Musculoskeletal Tumor Society (MSTS) Annual Meeting, Chicago, October 2011. Bernthal N, Pribaz J, Stavrakis A, Billi F, Cho J, Francis K, Iwakura Y, Miller L. Protective role of IL-1b against post-arthroplasty Staphylococcus aureus infection. Podium Presentation – Western Orthopaedic Association Annual Meeting, Honolulu HI, July 30, 2011. Winner of the Lloyd Taylor Award. Bernthal N, Pribaz J, Stavrakis A, Billi F, Cho J, Francis K, Iwakura Y, Miller L. Using Bioluminescence to Monitor Biofilm: A Murine Model of Post-Arthroplasty Infection. Podium Presentation – Western Orthopaedic Association Annual Meeting, Honolulu HI, July 28, 2011.

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Staphylococcus aureus infection. Podium Presentation – Orthopaedic Research Society (ORS) Annual Meeting, Long Beach, January 16, 2011. Bernthal N, Pribaz J, Stavrakis A, Billi F, Francis K, Miller L. Mouse Model of Chronic Post-Arthroplasty Staphylococcus aureus Infection: Determination of the Optimal Bioluminescent Bacterial Strain for Long-Term Study. Poster Presentation – Orthopaedic Research Society (ORS) Annual Meeting, Long Beach, January 2011. Bernthal N, Pribaz J, Stavrakis A, Miller L. Mouse Modeling of Implant Infection – Using Bioluminscence Against Biolfilms. Podium Presentation – California Orthopaedic Association Annual Meeting, Laguna Nigel CA, May, 2011. Winner of the OREF Award. Bernthal N, Pribaz J, Watts H, Scaduto A.A Novel Surgical Technique for Reconstruction in Tibial Deficiency. Poster Presentation – Western Orthopaedic Association Annual Meeting, Honolulu HI, July 28, 2011. Kremen T, Bernthal N, Eckardt M, Nelson S, Seeger L, Eckardt J. Long Term Results for Giant Cell Tumor of Bone. Podium Presentation – Western Orthopaedic Association Annual Meeting, Honolulu HI, July 28, 2011. Kremen T, Reid J, Estrada K, Bernthal N, Lyons K.A Novel Murine Model of Delayed Long Bone Healing. Poster Presentation – Orthopaedic Research Society (ORS) Annual Meeting, Long Beach, January 2011. Kremen T, Reid J, Estrada K, Bernthal N, Lyons K.A Novel Murine Model of Delayed Long Bone Healing. Podium Presentation – Western Orthopaedic Association Annual Meeting, Honolulu HI, July 28, 2011. Reid JJ, Kremen TJ, Estrada KD, Miranda-Carboni GA, Tetradis S, Lyons KM. Augmentation of the BMP Pathway in the Osteoblast Lineage and in a Critical Defect Osteosynthesis Model. Podium Presentation at American Academy of Orthopaedic Surgeons Annual Meeting, San Francisco, CA February 2012. Silva M, Bernthal N, Ebramzedeh E. Supracondylar Humeral Fractures: Evaluation of Multiple Pin Configurations with Emphasis on Medial Column Comminution. Poster Presentation – Western

Orthopaedic Association Annual Meeting, Honolulu HI, July 28, 2011. Silva M, Wong T, Bernthal N.Outcomes of Reduction More than Seven Days After Injury in Supracondylar Humerus Fractures in Children. Podium Presentation – Western Orthopaedic Association Annual Meeting, Honolulu HI, July 28, 2011. SooHoo N, Chambers L, Farng E, Lieberman JR. Mortality, Revision, and Complication Rates of Total Hip Arthroplasty Versus Hemiarthroplasty for Femoral Neck Fractures. Podium presentation AAOS 2011, San Diego. SooHoo NF, Fitzgerald JD, Chambers L, Weng HH, Ettner SL. Variations in Acute Care Length of Stay After Orthopedic Surgery. Poster presentation AAOS 2011, San Diego. Zhang AL, Kreulen C, Ngo, S, Hame S, Wang J, Gamradt SC. Demographic Trends in Arthroscopic SLAP Repair. Accepted for Podium Presentation at AAOS 2012 Annual Meeting, San Francisco, CA- February 2012. Zhang AL, Ngo, S, Hame S, Gamradt SC. Recent Trends in Arthroscopic Versus Open Rotator Cuff Repair and Acromioplasty. Accepted for Podium Presentation at AAOS 2012 Annual Meeting, San Francisco, CA- February 2012.

The outstanding facilities described above mean nothing without outstanding faculty to provide

excellent clinical care. The following is a brief

FACULTY

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description of each center of excellence at UCLA and the faculty that comprise each subspecialty. A sampling of publications follows the description of each Division.

William Oppenheim, M.D., Margaret Holden Jones-Kaanar Professor, Cerebral Palsy continues as Emeritus Chief, Pediatric Orthopaedics, and Director of the Orthopaedic Hospital/

UCLA Center for Cerebral Palsy. He has assumed the role as attending orthopaedist at the newly established muscle disease clinic at UCLA. In 2011 Dr. Oppenheim was named a Super Doctor by Los Angeles Magazine, a Top Doctor by the Castle Connolly survey, and a Best Doctor in America (

PEDIATRIC ORTHOPAEDIC SURGERY The alliance between UCLA and Orthopaedic Hospital began in 1998 and creates a platform for unparalleled contributions to patient care and scientific discovery in orthopaedic surgery and musculoskeletal medicine. We strive to be the destination for satisfied patients, world-class faculty, and inquisitive students, to create a new standard of pediatric musculoskeletal care for the 21st century. James V. Luck, Jr., M.D., long-time Orthopaedic Hospital CEO, has recently stepped down and passed the torch to new interim President and Chief Executive Officer, Anthony Scaduto, M.D. who remains Chief of Staff and Lowman Professor of Pediatric Orthopaedics. Rick Bowen, M.D. is a specialist in pediatric orthopaedic surgery and spine surgery. He also recently completed a traveling fellowship in sports medicine at Kaiser Orange County. Stanford Noel, M.D., is a specialist in pediatric hip disease. Mauricio Silva, M.D. serves as the Medical Director, Los Angeles Orthopaedic Hospital Urgent Care Center. He also serves as Junior Vice-Chair, Musculoskeletal Committee of the World Federation of Hemophilia, Member, Steering Committee of the International Registry on Knee Arthroplasty in Hemophiliacs, and Member, Medical and Scientific Advisory Committee, National Hemophilia Foundation. Dr. Silva was also a Guest Speaker on Articular Cartilage Damage in Hemophilic Patients at the 12th International Musculoskeletal Congress, World Federation of Hemophilia, Dubai, United Arab Emirates, March 2011.

www.bestdoctors.com) and was a recipient of the Patients Choice Award 2012 (www.Vitals.com). The Center for Cerebral Palsy received its second endowed Chair this past year, the Peter Shapiro Chair, occupied by Eileen Fowler, Ph.D., P.T. Dr. Oppenheim is a Past President of the American Academy for Cerebral Palsy and Developmental Medicine and current Chair of the Financial Developmental Committee, and Dr. Fowler currently serves on the Board of Directors. Lewis E. Zionts, M.D., a specialist in pediatric foot deformity and pediatric trauma, currently directs the Orthopaedic Hospital Clubfoot Clinic. He served as Visiting Professor at the Ponseti Clubfoot Symposium, University of Iowa Hospitals and Clinics, September 29-30, 2011 and spoke to the Nevada Orthopaedic Society on “The Treatment of Clubfoot in the 21st Century,” Las Vegas, Nevada, April 30, 2011.At the Pediatric Orthopaedic Society of North America in 2011, Dr. Zionts co-authored a podium presentation with Jose Morcuende, M.D. of the University of Iowa, entitled “Management Changes for Idiopathic Clubfoot: A POSNA Membership Survey.” He also spoke at that meeting's Fracture Symposium on “Fractures Gone Bad: Supracondylar Fractures of the Humerus.” Pediatric Orthopaedic Publications 2011

Bernthal NM, Hoshino CM, Dichter D, Wong MA, Silva M. Recovery of Range of Motion Following Pediatric Lateral Condyle Fractures of the Humerus. J Bone J Surg, Am. 93-A(9):871-877, 2011. Goldberg EJ, Fowler EG, Oppenheim WL. Case Reports: The Influence of Selective Voluntary Motor Control on Gait After Hamstring Lengthening Surgery. Clin Orthop Relat Res. 2011 Aug 24. Silva M, Eagan M, Wong MA, Dichter D, Ebramzadeh E, Zionts L.A Comparison of Two Approaches to the Closed Treatment

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of Low-Energy Tibia Fractures in Children. In press, J Bone Joint Surg (Am), 2011. Silva M, Wong T, Bernthal NM. Outcomes of Reduction More Than 7 Days After Injury in Supracondylar Humeral Fractures in Children. J Pediatr Orthop, 31(7): 751-756, 2011. Silva, M and Moazzaz, P.Coronal Shear Fracture of the Distal Humerus in an Eleven-Year-Old Patient.A Case Report. J Pediatr Orthop B, 20(1):50-55, 2011. Pediatric Orthopaedic Abstracts 2011 Silva M, Eagan M, Wong MA, Dichter D, Ebramzadeh E, ZiontsL.Early Weight-bearing in the Closed Treatment of Tibial Shaft Fractures in Children.Proceedings of the 2011 Annual Meeting, American Academy of Orthopaedic Surgeons, San Diego, CA, February of 2011. Bernthal N, Hoshino C, Dichter D, Wong M, Silva M. Prospective Evaluation of Fractures of the Lateral Condyle of the Humerus in Pediatric Patients.Proceedings of the 2011 Annual Meeting, American Academy of Orthopaedic Surgeons, San Diego, CA, February of 2011. Spencer HT, Dory FJ, Zionts LE, Dichter DH, Wong MA, Moazzaz P, Silva M. Selective Non-operative treatment of Type II Supracondylar Humerus Fractures.Pediatric Orthopaedic Society of North America 2011 Annual Meeting, Montreal, Canada, May of 2011. Silva M, Eagan M, Wong MA, Dichter D, Ebramzadeh E, Zionts L.The Treatment of Pediatric Tibial Shaft Fractures with an Extended Cast and Early Weight-bearing.Pediatric Orthopaedic Society of North America 2011 Annual Meeting, Montreal, Canada, May of 2011. Silva M, Wong T, Bernthal NM. Is it Safe to Reduce a Pediatric Supracondylar Humeral Fracture (SCHF) More Than 7 Days After the Injury? Western Orthopaedic Association, 75th Annual Meeting, Honolulu, HI, July of 2011. Silva M, Bernthal NM, Spencer HT, Borkowski SL, Knutsen AR, Kalma JJ, Sangiorgio SN, Ebramzadeh E. Supracondylar Humeral Fractures: Evaluation of Multiple Pin Configurations with Emphasis on Medial Column Comminution. Western Orthopaedic Association, 75th Annual Meeting, Honolulu, HI, July of 2011.

Nelson SooHoo, M.D. is Division Chief of Foot and Ankle Surgery at UCLA. Dr. SooHoo is an outstanding clinician and researcher, having received grant support, awards, and national recognition for his outcomes research. Dr. SooHoo also holds several leadership positions within our group, serving as Chief of Orthopaedic

Surgery at the West LA VA and Chief of Orthopaedic Surgery at Olive View Medical Center, as well as Associate Program Director of our residency program. Dr. SooHoo had several prestigious speaking engagements in 2011: Symposium Speaker, Instructional Course Lecture: Emerging Methods for Treatment of Ankle Arthritis, American Academy of Orthopaedic Surgery 78th Annual Meeting, San Diego 2011; Symposium Speaker, Thromboprophylaxis Symposium, American Foot and Ankle Society, Winter Annual Meeting, San Diego 2011; and International Guest Speaker, Korean Foot and Ankle Society 20th Annual Meeting, Seoul, Korea 2011. Andrea Cracchiolo III, M.D. has recently become an Emeritus Professor. Although no longer operating, he still maintains an office in Santa Monica and is involved with UCLA medical student education and medical school admission committee and he reviews for several peer reviewed journals. Dr. Cracchiolo also oversees the HH LEE Grants which give $25,000 research grants and $1500 travel grants to surgical residents. He also administers the Viola Hyde Scholarships which are given to senior women medical students who choose a residency in any of the surgical fields. Foot/Ankle Publications 2011 Farng E, Zingmond D, Krenek L, SooHoo NF. Factors predicting complication rates after primary shoulder arthroplasty. J Shoulder Elbow Surg. 2011 Jun;20(4):557-63.

FOOT AND ANKLE

Krenek L, Farng E, Zingmond D, SooHoo NF. Complication and

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revision rates following total elbow arthroplasty. J Hand Surg Am. 2011 Jan;36(1):68-73. Lieberman JR, Engstrom SM, Meneghini RM, SooHoo NF. Which Factors Influence Preservation of the Osteonecrotic Femoral Head? Clin Orthop Relat Res. 2011 Aug 31. SooHoo NF, Eagan M, Krenek L, Zingmond DS.Incidence and factors predicting pulmonary embolism and deep venous thrombosis following surgical treatment of ankle fractures. Foot Ankle Surg. 2011 Dec;17(4):259-62. Epub 2010 Sep 22. SooHoo NF, Farng E, Krenek L, Zingmond DS. Complication rates following operative treatment of calcaneus fractures. Foot Ankle Surg. 2011 Dec;17(4):233-8. Epub 2010 Aug 31. SooHoo NF, Farng E, Zingmond DS.Disparities in the utilization of high-volume hospitals for total hip replacement. J Natl Med Assoc. 2011 Jan;103(1):31-5. SooHoo NF, Lieberman JR, Farng E, Park S, Jain S, Ko CY. Development of quality of care indicators for patients undergoing total hip or total knee replacement. BMJ Qual Saf. 2011 Feb;20(2):153-7. SooHoo NF, Tang EY, Krenek L, Eagan M, McGlynn E. Variations in the quality of care delivered to patients undergoing total knee replacement at 3 affiliated hospitals. Orthopedics. 2011 May 18;34(5):356. Foot/Ankle Abstracts 2011 Fitzgerald JD, Katz JN, Losina N, SooHoo NF. Impact of restricting patient access to low-volume hospitals for total knee replacement.American Academy of Orthopaedic Surgery, Annual Meeting, San Diego 2011. Sandman DN, Motamedi K, Levine BD, SooHoo NF, Gottsegen CG, Seeger LL. MR evaluation of asymptomatic lateral ankle ligaments and comparative findings in patients with chronic lateral ankle instability.AOFAS Specialty Day, San Diego 2011. SooHoo NF, Farng E, Chambers KL, Zingmond DS, Lieberman JR. Comparison of complication rates between hemiarthroplasty and THA for hip fracture. American Academy of Orthopaedic Surgery, Annual Meeting, San Diego 2011. SooHoo NF, Fitzgerald JD, Chambers KL, Peng J, Ettner S. Variations in acute care length of stay after orthopaedic surgery.American Academy of Orthopaedic Surgery, (Poster) Annual Meeting, San Diego 2011. SooHoo NF, Farng E, Zingmond DS. Disparities in the utilization of high-volume hospitals for total hip

replacement.American Academy of Orthopaedic Surgery, Annual Meeting, San Diego 2011.

Sports Medicine continues to be a strength at UCLA. The Division of Sports Medicine is comprised of six faculty members. Along with Head Team Physician and Emeritus Chair Gerald Finerman, M.D., the group is responsible for the care of over 700 UCLA intercollegiate athletes. This group of athletes has collectively won well over 100 NCAA national championships.

SPORTS MEDICINE

David McAllister, M.D., a leader in the field of Sports Medicine and Knee Surgery, is Division Chief of the Sports Medicine service. He serves on the Board of Directors for AOSSM and the AOSSM Membership Committee, Traveling Fellowship Committee, and Abstract Review Committee. Dr. McAllister is the co-chair

of the AAOS/AOSSM annual Sports Medicine Board Review Course in Chicago, IL. Dr. McAllister was a Visiting Professor at the 14th Brazilian Congress of Knee Surgery in Praia do Forte, Bahia State, Brazil, March 29-31, 2011. He was also a Visiting Professor at the DMC Detroit Sports Medicine Institute in June 2011and the Sociedad Colombiana de Cirugía Ortopédica y Traumatología (SCCOT) in Cartagena, Colombia, in May 2011. He was also Visiting Professor and Keynote Speaker, Fowler Fellows

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Orthopaedic Society Meeting, March 2011, Santa Barbara, California. Dr. McAllister was an invited Guest speaker on PCL reconstruction in elite athletes at the Major League Soccer Team Physicians Meeting in January 2012, Fort Lauderdale, Florida. Dr. McAllister received a VA Shared Equipment Evaluation Program grant for $48,000 and was co-investigator on two funded NIH grants: John Adams, M.D. (P.I.), “Regenerative Musculoskeletal Medicine” and Rick Wright, M.D. (P.I.), “Revision ACL Reconstructions: A Comparative Effectiveness Treatment Study.” Sharon Hame, M.D.is an associate clinical professor of orthopaedic surgery with a subspecialty in Sports Medicine. Dr. Hame has expertise in all areas of sports medicine including the anterior cruciate ligament, posterior cruciate ligament, meniscus injury, shoulder rotator cuff tears and labral tears. Most recently, Dr. Hame has become a leader in the diagnosis and treatment of hip disorders including hip labral tears and femoro-acetabular impingement (FAI).Dr. Hame has become a national leader both in sports medicine and as a woman orthopaedic surgeon. She was recently named one of the top 70 female orthopaedic surgeons in the country by Becker’s Orthopedic, Spine and Pain Management Review. She has served as the President of the Ruth Jackson Orthopaedic Society and has held committee positions in the American Academy of Orthopaedic Surgeons (AAOS) and the American Orthopaedic Society for Sports Medicine (AOSSM). Currently she serves on the research committee and research awards and grants subcommittee for the AOSSM. At UCLA she serves on the Risk Management Committee and is the APCA representative for the Department of Orthopaedic Surgery.Dr. Hame is involved in clinical research and has over 30 publications and 50 national presentations. Dr. Hame works closely with the UCLA Athletic Department caring for the athletes at UCLA. She is an assistant team physician for the UCLA Football Team and is the team physician for UCLA Women’s Volleyball and Basketball teams. However, given her unique expertise in hip arthroscopy she

continues to evaluate and treat members from all 23 of UCLA’s Division 1 sports teams. This year she travelled to the NCAA Women’s Volleyball National Championships in San Antonio TX and helped UCLA bring home its 108th National Championship! Robert Pedowitz, M.D., Ph.D. is a Professor of Orthopaedic Surgery at UCLA. He is on the editorial boards of the Arthroscopy Journal and

Sports Medicine & Arthroscopy Review. He serves on the Board of Directors for the Arthroscopy Association of North America (AANA), and currently chairs the Surgical Simulation Project Teams for AANA and AAOS.

Seth Gamradt, M.D. joined the UCLA faculty in 2007 after completing a sports medicine and shoulder fellowship at the Hospital for Special Surgery in New York. Dr. Gamradt has a special interest in complex arthroscopic and open shoulder surgery. In April/May 2011, Dr. Gamradt traveled to Mexico and six cities in South America as an American Orthopaedic Society for Sports Medicine Traveling Fellow and made 9 international

presentations regarding revision shoulder and knee surgery. He serves as one of the team physicians for United States Women’s Soccer and will be serving as a Team Physician for the U-17 Women’s National Team in 2012. Dr. Gamradt is on the editorial board of the journal Techniques in

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Shoulder and Elbow Surgery and serves also on the editorial board for the Journal of Bone and Joint Surgery Sports Highlights, a new JBJS publication that comments on latest research/techniques in orthopaedic sports medicine. Dr. Gamradt was an invited guest speaker on Ulnar Collateral Ligament Reconstruction at the Kaiser Permanente Upper Extremity Symposium, in Mammoth Lakes, CA, April 2011 and at the Kaiser Permanente Winter Symposium, Beaver Creek, CO, February 2011. Frank Petrigliano, M.D. joined the sports medicine faculty in 2010 after completing his fellowship at the Hospital for Special Surgery in New York. Dr. Petrigliano has already garnered a $100,000 Young Investigator Award research grant from the Musculoskeletal Transplant Foundation for “A Bioengineered Biphasic Scaffold for Ligament Replacement.” He also received the Academic Senate Faculty Research Grant for “A novel non-invasive device for quantification of the pivot shift test.” Dr. Petrigliano has been instrumental in developing the Olive View Medical Center orthopaedic surgery service and also performs complex shoulder surgery and reconstruction at the West LA VA Medical Center. Dr. Petrigliano also recently received a Career Development Award from OREF to study the rotator cuff in an animal model. Sports Medicine Publications 2011 Adler R, Johnson K, Fealy S, Maderazo A, Gallo R, Gamradt S, Warren RF. Contrast-Enhanced Ultrasound Characterization of the Vascularity of the Repaired Rotator Cuff: utility of Maximum-Intensity-Projection Imaging. Journal of Ultrasound in Medicine.2011 Aug;30(8):1103-9. Bhalla A, Higashigawa K, McAllister DR: Subscapularis Tendon Rupture in an 8-Year-Old Boy: A Case Report", The American Journal of Orthopedics. 2011 Sept 9: 471-474. Borchers JR, Kaeding CC, Pedroza AD, Huston LJ, Spindler KP, Wright RW, Hame SL, McAllister DR, York JJ: Intraarticular Findings in Primary and Revision ACL Reconstruction: A Comparison of the MOON and MARS Study Groups. Am J Sports Med. 2011 Sep;39(9):1889-93. Epub 2011 Jun 6.

Cadet ER, Adler RS, Gallo RA, Gamradt SC, Warren RF, Cordasco F, Fealy S. Contrast-Enhanced Ultrasound Characterization of the Vascularity of the Repaired Rotator Cuff Tendon: Short and Intermediate-Term Follow-up.Journal of Shoulder and Elbow Surgery.2011 Jul 21. Chambers KL, Kremen T, Gamradt SC. Arthroscopic anterior shoulder stabilization in the beach chair position using trans-subscapularis placement of the 5:30 suture anchor.Techniques in Shoulder and Elbow Surgery.201, 12 (3), 56–61. Chambers L, Hame SL, Levine B: Acute exertional medial compartment syndrome of the foot after playing basketball. Skeletal Radiology July; 40(7):931-5, 2011 Epub 2011 Apr 15. Chung AS, Hwang HS, Das D, Zuk P, McAllister DR, Wu B: Lamellar Stack Formation and Degradative Behaviors of Hydrolytically Degraded Poly(- aprolactone) and Poly(glycolide--caprolactone) Blended Fibers. J Biomed Mater Res B Appl Biomater. 2011 Nov 9. Eagan MJ, Bluth BE, Zhao KW, BrinkmannEJ, Zuk PA, Wu BM, McAllister DR: The Suitability of Human Adipose-Derived Stem Cells for the Engineering of Ligament Tissue. J Tissue Eng Regen Med. 2011 Sep 22. Gallo RA, Gamradt, SC, Mattern CJ, Cordasco FA, Craig EV, Dines DM, Warren RF. Instability after reverse total shoulder replacement: Analysis of cause, rationale for treatment. Journal of Shoulder and Elbow Surgery, 2011 Jun;20(4):584-90. Gamradt SC, Bier A, Van Gelderen J, Petrigliano F. Revision of failed transtibial anterior cruciate ligament reconstruction using anteromedial femoral reaming. Journal of Bone and Joint Surgery Sports Medicine Newsletter 2011 Oct 5;93(19):1-6. Gamradt SC, Previous shoulder stabilization surgery may decrease career length in professional american football. J Bone Joint Surg Am.Sports Medicine Newsletter 2011 Jun 1;93(11):1N. Gamradt SC. AOSSM/SLARD Latin American Traveling Fellows Learn and Develop New Colleagues: Report of the AOSSM/SLARD Latin American Traveling Fellows 2011. Sports Medicine Update (AOSSM Newsletter) Sept/Oct 2011. 12-14. Gamradt SC. Long Term Reoperation Rate After Open Rotator Cuff Repair.Journal of Bone and Joint Surgery Sports Medicine NewsletterJul 2011; 93 (13); 1-3. Gamradt SC. Patients with an ALPSA Lesion Have an Increased Risk of Redislocation After Arthroscopic Anterior

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Shoulder Stabilization. J. Bone Joint Surg. Am.Sports Medicine Newsletter, Dec 2011; 93 (23); 1-3. Gamradt SC. Short Term Positive Effects of Platelet Rich Plasma in Arthroscopic Rotator Cuff Repair.Journal of Bone and Joint Surgery Sports Medicine Newsletter Jul 2011; 93 (13); 1-3. Gamradt SC. Summary of the AOSSM 2011 Annual Meeting.Journal of Bone and Joint Surgery Sports Medicine Newsletter.2011 Sep 21;93(18):1-7. Gamradt SC.Suprascapular Neuropathy is a Common Diagnosis in a Shoulder Referral Practice. J. Bone Joint Surg. Am. Sports Medicine Newsletter.Nov 2011; 93 (22); 1-3. Markolf KL, Jackson SR, McAllister DR: Force Measurements in the Medial Meniscus Posterior Horn Attachment; Effects of ACL Removal. Am J Sports Med. 2011 Nov 15. Montgomery S, Petrigliano F, Gamradt SC. Biologic augmentation of rotator cuff repair. Current reviews in musculoskeletal medicine. 2011 Dec;4(4):221-30. Pedowitz RA, Higashigawa K, Nguyen V: Level V Evidence - The “50% Rule” in Arthroscopic and Orthopaedic Surgery. Arthroscopy: The Journal of Arthroscopic and Related Surgery 27(11):1584-7, 2011. Pedowitz RA, Yamaguchi K, Ahmad CS, Burks RT, Flatow EL, Green A, Ianotti JP, Miller BS, Tashjian RZ, Watters WC 3rd, Weber k, Turkelson CM, Wies JL, Anderson S, St Andre J, Boyer K, Raymond L, Sluka P, McGowan R: Optimizing the Management of Rotator Cuff Problems. Journal of the American Academy of Orthopaedic Surgeons. 19(6):368-79, 2011. Petrigliano FA, Musahl V, Citak M, Suero E, Pearle AP. The Effect of Meniscal Loss on Knee Stability After Single-Bundle ACL Reconstructions: A Cadaveric Experiment. Knee Surg Sports Traumatol Arthrosc. 2011 May 12. Petrigliano FA, Suero EM, Lane CG, Allen AA, Pearle AD. Combined PCL and Posterolateral Corner Insufficiency Results in a Reverse Pivot Shift. Clin Orthop Relat Res. 2011 Aug 27. Toth AP, Warren RF, Petrigliano FA, Doward DA, Cordasco FA, Altchek DW, O’Brien SJ. Thermal Shrinkage for Shoulder Instability. HSS J 2011 7(2):108-114. Virk MS, Alaee F, Petrigliano FA, Sugiyama O, Chatziioannou AF, Stout D, Dougall WC, Lieberman JR. Combined Inhibition of the BMP pathway and the RANK-RANKL axis in a Mixed

Lytic/blastic Prostate Cancer Lesion. Bone. 2011 Mar 1;48(3):578-87. Zhang A, Gelber J, Gamradt S. Removal of reverse shoulder replacement.Techniques in Shoulder and Elbow Surgery.2011 June; 12: 40-45.

Prosper Benhaim, M.D. is Division Chief of Hand Surgery at UCLA. Dr. Benhaim is a hand surgeon, microsurgeon and reconstructive plastic surgeon at the UCLA School of Medicine and joined the

Department of Orthopaedic Surgery and the Division of Plastic & Reconstructive Surgery in 1998. He is currently an associate professor and Chief of Hand Surgery at UCLA and Olive View-UCLA Medical Centers. He has numerous local and national committee positions, including

an editorial position for the Journal of the American Society for Surgery of the Hand. Dr. Benhaim remains very active in research on Dupuytren's disease, stem cells, and in the clinical practice of hand surgery and reconstructive plastic surgery.

HAND SURGERY

Kodi Azari, M.D. came to UCLA from the University of Pittsburgh Medical Center. Dr. Azari has been involved in both clinical and laboratory research for over 18 years and is the author of numerous

research articles, book chapters, and presentations. He lectures extensively both nationally and internationally on hand surgery as well as plastic surgery. Dr. Azari is the surgical director of the newly established UCLA Hand Transplant Program. In

2011, he led a team of Surgeons at Ronald Reagan UCLA Medical Center that performed the first hand transplant in the western United States in an operation that lasted 14-1/2 hours and concluded on Saturday, March 5.

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The transplant was performed on a 26-year-old woman from northern California who lost her right hand in a traffic accident nearly five years ago. UCLA is only the fourth center in the nation to offer this procedure, and the first west of the Rockies. It was the 13th hand transplant surgery performed in the United States. Dr. Azari has been one of the lead surgeons on seven hand transplantation operations including the first double hand

transplantation and first arm transplantation performed in the United States.(Photos: Drs. Azari, Benhaim, and Busuttil, and the surgical team; Hand transplant patient using the in occupational therapy)www.handtransplant.ucla.edu Scott Mitchell, M.D. is a former outstanding UCLA resident who completed his hand fellowship at UCLA in 2009 and performs complex hand, wrist, and elbow surgery at UCLA, Santa Monica-UCLA, Olive View Medical Center, and the West Los Angeles Veterans Affairs Hospital. Hand Publications 2011 Azari KK, Imbriglia JE, Goitz RJ, Shores JT, Balk ML, Brandacher G, Schneeberger S, Gorantla V, Lee WP. Technical Aspects of the Recipient Operation in Hand Transplantation. J Reconstr Microsurg. 2011 Aug 2. Bales JG, Mitchell S, Bernthal N, Silva M, Benhaim P. “Treatment patterns for pediatric distal radius fractures”

Carpe Diem Hand Surgery Club annual meeting; Grand Wailea, HI, 2011. Benhaim P, Jones NF, Eaton C, Hentz VR, Kamal S. Treatment of Dupuytren’s Disease.“Around the Hand Table” column, American Association for Hand Surgery Hand Surgery Quarterly – January 2011. Chou YF, Zuk PA, Chang TL, Benhaim P, Wu BM. Adipose-derived stem cells and BMP2: Part 1. BMP2-treated adipose-derived stem cells do not improve repair of segmental femoral defects. Connective Tissue Research2011 April;52(2):109-18. Hartzell TL, Benhaim P, Imbriglia JE, Shores JT, Goitz RJ, Balk M, Mitchell S, Rubinstein R, Gorantla VS, Schneeberger S, Brandacher G, Lee WP, Azari KK. Surgical and technical aspects of hand transplantation: is it just another replant? Hand Clin. 2011 Nov;27(4):521-30. Herrera FA, Suliman A, Benhaim P, Meals R, Mitchell S. “Cost comparison of open fasciectomy vs percutaneous needle aponeurotomy for treatment of Dupuytren’s contracture” Plastic Surgery Research Council annual meeting; Louisville, KY, May, 2011. McDiarmid SV, Azari KK. Donor-related issues in hand transplantation. Hand Clin. 2011 Nov;27(4):545-52. Zuk P, Chou YF, Mussano F, Benhaim P, Wu BM. Adipose-derived stem cells and BMP2: Part 2. BMP2 may not influence the osteogenic fate of human adipose-derived stem cells. Connective Tissue Research2011 April;52(2):119-32.

Our outstanding primary care sports medicine team is headed by Division Chief John DiFiori, M.D. Dr. DiFiori is the Chief of the Division of Sports Medicine in the Department of Family Medicine and serves as Co-Director for the Primary Care Sports Medicine Fellowship Program at UCLA (three fellows per year). He is a Team Physician for UCLA Department of Intercollegiate Athletics. Dr. DiFiori continues to be active in many national leadership roles. He was recently elected to serve on the Executive Board of Directors for the American Medical Society for Sports Medicine. He was also appointed to the Scientific Advisory Board for the National Youth Sports Health and Safety Institute. He was invited to serve on the panel for the International Summit on EKG Interpretation in

PRIMARY CARE SPORTS MEDICINE

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the Athlete. He is also a Co-Director for the UCLA Musculoskeletal Ultrasound Course. Dr. DiFiori is an Associate Editor for the Clinical Journal of Sports Medicine and is a section editor for joint conditions for Current Sports Medicine Reports. Aurelia Nattiv, M.D. serves as Director of the UCLA Osteoporosis Center. Her areas of research include assessment of bone health in young athletes with amenorrhea, disordered eating and stress fractures, as well as risk taking behaviors in athletes. Dr. Nattiv is a team physician at UCLA and USA Track and Field, and is the medical representative for the USA Gymnastics National Health Care Advisory Board. Heather Gillespie, M.D., M.P.H. joined the faculty

in 2007after completing her fellowship training at Maine Medical Center in Portland, Maine. She is a team physician for the UCLA Department of Intercollegiate Athletics and has a sports medicine practice at Santa Monica-UCLA. Additionally, she

runs a pediatric sports medicine specialty clinic at Orthopaedic Hospital. Dr. Gillespie's current research interests include the epidemiology of pediatric sports medicine in underserved populations and swimming injury patterns in Division I athletes. Primary Care Sports Medicine Publications 2011 Arends J, Cheung M, Barrack M, Nattiv A. Restoration of menses with nonpharmacologic therapy in collegiate athletes with menstrual disturbances: A 5 year retrospective study. Accepted December 2011(In Press). International Journal of Sport Nutrition and Exercise Metabolism. Ascenzi, M-G, Hetzer N, Lomovtsev A, Rude R, Nattiv A, Favia A. Variation of trabecular architecture in proximal femur of postmenopausal women. Journal of Biomechanics, 44 (2):248-256, 2011.

Babikian T, DiFiori J, Giza C. “Pathophysiologic Outcomes of Mild Traumatic Brain Injury”in Pediatric Mild Traumatic Brain

Injury: From Basic Science to Clinical Management. Kirkwood M , Yeates K editors, in press.

DiFiori J, Caine D. “Gymnastics Injuries” inSports Medicine: A Comprehensive Review. Casa D. editor. Published by the American College of Sports Medicine. In press.

DiFiori J, Gray A, Kimlin E. Sports Participation History and Early Sport Specialization inNational Collegiate Athletic Association Division I Athletes Clin J Sport Med 21:168, 2011. Giza C and DiFiori JP. Pathophysiology of Sports-Related Concussion: Basic Science and Translational Research. Sports Health, 3(1):46-51, 2011. Goolsby M, Barrack M, Nattiv A. Case of a female adolescent runner with a displaced femoral neck stress fracture. Accepted Dec 2011 (In Press). Sports Health. Sisson R, Gillespie H, DiFiori J. Epidemiology of Youth Sports Injuries in an Inner City Primary Care Sports Medicine Clinic. Clin J Sport Med 21:172, 2011. Sugi MT, Sheridan K, Lewis L, Nattiv A, Kado DM, Bengs B. Active referral intervention following fragility fractures leads to enhanced osteoporosis follow-up care. Accepted Oct 2011 (In Press). Journal of Osteoporosis.

Francis Cyran, M.D. completed his orthopaedic oncology fellowship here at UCLA in 2005 and has

JOINT REPLACEMENT Bert Thomas, M.D., Division Chief of Joint Replacement Surgery at UCLA, continues to apply his wealth of experience here at UCLA having performed thousands or primary and revision knee and hip replacements. Benjamin Bengs, M.D. joined the faculty in 2007 after completing orthopaedic surgery training from the Harvard Combined Orthopaedic Surgery Residency Program and a joint replacement fellowship here at UCLA. He specializes in complex joint replacement and fragility fractures. In 2010, Dr. Bengs received a Career Development Award from the Orthopedic Research & Education Foundation in Total Joint And Trauma Surgery for “Proximal Femoral Bone Loss and Femoral Stem Stability in Total Hip Arthroplasty.”

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been on faculty since then specializing in joint replacement and tumor surgery. Dr. Cyran’s teaching evaluations from the residents are consistently among the highest in the group and he recently was awarded a prestigious teaching award from the UCLA residents. James V. Luck, Jr., M.D. is a senior faculty member in Joint Replacement and one of the world leaders in research and treatment of hemophilic arthropathy. Dr. Luck is Former President and Chief Executive Officer, Los Angeles Orthopaedic Hospital. He is also President and Director of the American Board of Orthopaedic Surgery, Inc. (ABOS). He does an outstanding job as program director for our highly sought after residency program.

Eric Johnson, M.D., a world expert in orthopaedic traumatology and fracture surgery, is Division Chief of the UCLA Orthopaedic Trauma service. He serves as a Member of the Board of Directors of the AO Foundation and was awarded an Honorary Fellowship in the Royal College of Surgeons in Ireland, July 13, 2009, Dublin, Ireland. In

2011, Dr. Johnson gave an impressive array of national and international presentations.

ORTHOPAEDIC TRAUMATOLOGY

First, Dr. Johnson was the Guest of Honor in Paris, France at the 23rd at the Letournel Pelvic and Acetabular Fracture Course, Paris, France, in September 2011, giving the Keynote Lecture: 30 Years of Acetabular Fracture Surgery. Second, Dr. Johnson traveled to Ireland in November 2011 to give four lectures at the 10th Current Controversies in Trauma Management, Royal College of Surgeons in Ireland, Dublin, Ireland. Third, Dr. Johnson continues to travel, lecture, and teach as part of his

commitment to the AO Foundation, traveling to Sun Valley, Idaho and Puerto Rico in 2011. Devon Jeffcoat, M.D. joined the faculty at UCLA in 2010 after completing his fellowship at the Hospital for Special Surgery in New York under the tutelage of Dr. David Helfet. Dr. Jeffcoat volunteered his time during the earthquake crisis in Haiti. He has already developed a busy trauma surgery practice in his first year of practice. Eric D. Farrell, M.D. has recently joined the UCLA orthopaedic trauma staff in August of 2011. He previously spent almost 6.5 years as Assistant Director of Orthopaedic Trauma at Cooper University Hospital in Camden N.J. His training consists of a trauma fellowship at Haborview Medical Center in Seattle, Washington; AO Fellowship in Salzburg Austria and an Ilizarov Fellowship in Lecco, Italy. He has a particular interest in nonunions and deformity correction.

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MUSCULOSKELETAL ONCOLOGY Chair Jeffrey Eckardt, M.D., world expert in limb salvage surgery, endoprosthetic reconstruction, and musculoskeletal tumor surgery, heads our Division of Musculoskeletal Oncology. Dr. Eckardt was Invited Visiting Professor and Guest Lecturer at the Cleveland Clinic, Cleveland, Ohio, for The Dickson Lecture in December 2009. He was also Invited Visiting Professor and Guest Speaker at Massachusetts General Hospital’s Department of Orthopaedic Surgery Grand Rounds at Harvard Medical School in April 2010. Dr. Eckardt continues to add to his terrific array of outcomes studies regarding orthopaedic oncology; a few of those recent studies are listed below. Musculoskeletal Oncology Publications 2011 Bernthal N, Eilber F, Eilber F, Eckardt J. Total Femoral Endoprostheses: The UCLA Experience 1980-2011. Podium Presentation – Combined Connective Tissue Oncology Society (CTOS)/ Musculoskeletal Tumor Society (MSTS) Annual Meeting, Chicago, October 2011. Bernthal N, Pribaz J, Stavrakis A, Billi F, Cho J, Francis K, Iwakura Y, Eckardt J, Miller L. Using Bioluminescence to Combat Biofilm: Mouse Modeling of Implant Infections to Protect Endoprosthetic Reconstructions. Podium Presentation – Combined Connective Tissue Oncology Society (CTOS)/ Musculoskeletal Tumor Society (MSTS) Annual Meeting, Chicago, October 2011. Eckardt, J. J., Schwartz, A., Kabo, J.M., Cyran, F., Eilber, F.C. Eilber, F.R. Cemented endoprostheses in limb salvage surgery: The UCLA Experience 1980-2008. Accepted: Clinical Orthopaedics and Related Research, 2011. Hermann, K., Benz, M.R., Czernin, J., Allen-Auerbach, M.S., Tap, W.D., Dry, S.M., Schuster, T., Eckardt, J.J., Phelps, M., Weber, W.A. and Eilber, F.C. F-FDG-PET/CT imaging as an early survival predictor in patients with primary high grade soft tissue sarcomas undergoing neoadjuvant therapy. Clinical Cancer Research: In Print: September 2011. Jones NF, Lin MP, Dickinson BP, Eckardt J. Successful salvage of venous thrombosis of a free flap by creation of a veno-cutaneous fistula. Journal of Reconstructive Microsurgery 27: 243, 2011.

Kim, F. Hayes, C., Williams, Paige L., Whitford, G., Joshipura, K., Hoover; Douglass, D., Simon, M., Gebhardt, M., Scarborough, M., Gitelis, Steven, Eckardt, J., Joyce, M., Malawer, M., McGuire, M., Anderson, H.An assessment of Bone Fluoride and Osteosarcoma. J. Dental Research. Epub August 2011. Kremen T, Bernthal N, Eckardt M, Nelson S, Seeger L, Eckardt J. Long Term Results for Giant Cell Tumor of Bone. Podium Presentation – Western Orthopaedic Association Annual Meeting, Honolulu HI, July 28, 2011. Kremen TJ, Bernthal NM, Eckardt MA, Eckardt JJ. Giant Cell Tumor of Bone: Are We Stratifying Results Appropriately? Clin Orthop Relat Res. 2011 Nov 29. Kremen, T. J., Bernthal, N., Kabo, J.M. Eckardt, M.A., Nelson, S., Eckardt, J.J. Long term treatment results of giant cell tumor of bone.Accepted for Clinical Orthopaedics and Related Research. December 2010. Kremen, TJ Jr., Bernthal, N.M., Eckardt, M.A., Eckardt, J.J. Giant Cell Tumor of Bone: Are We Stratifying Results Appropriately? Clin Orthop Rel Res. 2011 Nov 29 Mirabello, L., Yu. K., Berndt S.I., Burdett L., Wang Z., Chowdhury S., Teshome K., Uzoka A., Hutchinson A., Grotmol T., Douglass C., Hayes R.B., Hoover R.N., Savage S.A., and for the National Osteosarcoma Etiology Study Group (including Eckardt J.E.). A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. BMC Cancer 2011. 11:209.

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SPINE SURGERY

Jeffrey C. Wang, M.D. is the Division Chief of Orthopaedic Spine Surgery and an exceptional academic orthopaedic surgeon. He maintains a high-volume clinical practice while conducting a tremendous amount of both basic science and

clinical spine research. He is recognized as one of the important leaders in spine surgery in our country. Dr. Wang was the program chair of the Cervical Spine Research Society Meeting for 2011. He was selected as Program Chair of the North American Spine Society meeting for 2012, the only person in history to be selected twice (2005). Dr. Wang was on the Board of Directors for the Cervical Spine Research Society for 2011 and is on the Board of Directors for the California Orthopaedic Association. He is also on the Board of Directors for the North American Spine Society, and was elected as Education Council Director starting in 2011. Dr. Wang was also just elected as the Chair

of AOSpine International. His three-year term as the Chair of all AOSpine globally starts in 2012. He also was the sole editor of the North American Spine Society’s Advanced Reconstruction Spine Textbook published by the AAOS in 2011.

Spine Center Faculty (left to right): Nick Shamie, M.D., Jeff Wang, M.D., Langston Holly, M.D., David Fish, M.D., Duncan McBride, M.D., Ulrich Batzdorf, M.D., Jae Jung, M.D., and Daniel Lu, M.D., Ph.D. Dr. Wang received the 4th annual The Spine Journal Editors’ Choice Award, chosen as the top paper among those published in volume year 2010, chosen by the Executive Editorial Board of The Spine Journal. The title of the paper was: “Cost and Utilization of Conservative Management of Lumbar Disc Herniation Prior to Surgical Discectomy,” published in the June 2010 issue of The Spine Journal. Dr. Wang won the 2011 Reviewer of the Year for The Spine Journal. He was Visiting Professor at The University of Washington Dept. of Orthopaedics and Sports Medicine and the University of Washington Orthopaedic Alumni, Resident Graduation Research Day, May 20, 2011. He was Visiting Professor at the UCSF Department of Orthopaedic Surgery in January 2011. He was also the Keynote Speaker at the 6th Annual Meeting of the Korean American Spine Society, Los Angeles, CA, July 8, 2011. He was also course faculty or director at 9 spine courses in 2011. Dr. Wang serves or has served as Editor or Reviewer for 26 spine-related publications. He serves on the Cervical Spine Research Society Board of Directors and the North American Spine Society Board of Directors. He is also Chairman, American Orthopaedic Association – North American Traveling Fellowship Committee. Dr. Wang continues to be a leading national

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contributor to both basic science and clinical spine research as noted below. Arya (Nick) Shamie, M.D. is an attending spine surgeon at UCLA. He was elected for a second

term as President, American College of Spine Surgery. He serves as Medical Director for Vertiflex Spine and is overseeing an IDE Trial for percutaneous

interspinous device for lumbar stenosis. He was named on the Becker’s list of "10 Spine Surgeon Leaders of Academic Medical Centers to Know.”

Daniel Lu, M.D., Ph.D. is a surgeon-scientist who has recently joined the Departments of

Neurosurgery and Orthopaedic Surgery. He employs minimally invasive surgical techniques in the treatment of spinal disorders in the operating room. As a principal investigator in the Orthopaedic Hospital Research

Center, he is elucidating the molecular mechanisms and potential therapeutic treatments for spinal degeneration. Additionally, in the field of spinal cord injury, he is investigating the interneuronal spinal cord circuitry in hopes of improving the spinal cord function after injury. He currently is conducting 4 clinical trials in this effort. Dr. Lu is on the Executive Committee, Section on Spine and Peripheral Nerves, Executive Committee, Section on Trauma, and the Awards Committee, Section on Spine and Peripheral Nerves American Association of Neurological Surgeons. He also serves as a reviewer for the Journal of Neuro-Oncology and the Journal of Spinal Disorders and Techniques.

Orthopaedic Spine Publications 2011 Abdullah KG, Nowacki AS, Steinmetz MP, Wang JC, Mroz TE. Factors affecting lateral mass screw placement at C-7. J Neurosurg Spine. 2011 Mar;14(3):405-11.

Celestre PC, Pazmiño PR, Mikhael MM, Wolf CF, Feldman LA, Lauryssen C, Wang JC. Minimally invasive approaches to the cervical spine. Orthop Clin North Am. 2012 Jan;43(1):137-47. Epub 2011 Oct 13. Devine J, Norvell D, Ecker E, Grouney D, Vaccaro A, Wang J, Andersson G. Evaluating the correlation and responsiveness of patient-reported prain with function and quality-of-life outcomes after spine surgery. Spine. 2011 Vol.36(21S):S69-S74. Do DH, Taghavi CE, Fong W, Kong MH, Morishita Y, Wang JC. The relationship between degree of facet tropism and amount of dynamic disc bulge in lumbar spine of patients symptomatic for low back pain. Eur Spine J. 2011, 20:71-78. Hong SW, Choi KY, Ahn Y, Baek OK, Wang JC, Lee SH, Lee HY. A comparison of unilateral and bilateral laminotomies for decompression of L4-L5 spinal stenosis.Spine (Phila Pa 1976). 2011 Feb 1;36(3):E172-8. Johnson JS, Meliton V, Kim WK, Lee KB, Wang JC, Nguyen K, Yoo D, Jung ME, Atti E, Tetradis S, Pereira RC, Magyar C, Nargizyan T, Hahn TJ, Farouz F, Thies S, Parhami F. Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo. J Cell Biochem. 2011 Jun;112(6):1673-84. Keorochana G, Taghavi CE, Lee KB, Yoo JH, Liao JC, Fei Z, Wang JC. Effect of sagittal alignment on kinematic changes and degree of disc degeneration in the lumbar spine: an analysis using positional MRI. Spine (Phila Pa 1976). 2011 May 15;36(11):893-8. Lee KB, Murray SS, Duarte ME, Spitz JF, Johnson JS, Song KJ, Brochmann EJ, Taghavi CE, Keorochana G, Liao JC, Wang JC. Effects of the bone morphogenetic protein binding protein spp24 (secreted phosphoprotein 24 kD) on the growth of human lung cancer cells. J Orthop Res. 2011 Apr 20. doi: 10.1002/jor.21383. Lee KB, Murray SS, Taghavi CE, Song KJ, Brochmann EJ, Johnson JS, Keorochana G, Liao JC, Wang JC. Bone morphogenetic protein–binding peptide reduces the inflammatory response to recombinant human bone morphogenetic protein-2 and recombinant human bone morphogenetic protein-7 in a rodent model of soft-tissue inflammation. The Spine Journal 11 (2011) 568–576. Lee KB, Taghavi CE, Song KJ, Sintuu C, Yoo JH, Keorochana G, Tzeng ST, Fei Z, Liao JC, Wang JC. Inflammatory characteristics of rhBMP-2 in vitro and in an in vivo rodent model.Spine (Phila Pa 1976). 2011 Feb 1;36(3):E149-54.

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Liao JC, Tzeng ST, Keorochana G, Lee KB, Johnson JS, Morishita Y, Murray SS, Wang JC.Enhancement of recombinant human BMP-7 bone formation with bmp binding peptide in a rodent femoral defect model. J Orthop Res. 2011 May;29(5):753-9. Lieberman IH, Hardenbrook MA, Wang JC, Guyer RD. Assessment of Pedicle Screw Placement Accuracy, Procedure Time, and Radiation Exposure Using a Miniature Robotic Guidance System. J Spinal Disord Tech. 2011 May 19. Mark M. Mikhael, MD, Christopher F. Wolf, MD, A. Nick Shamie, MD, and Jeffrey C. Wang, MD. Minimally Invasive Techniques for the Posterior Cervical Spine: Foraminal Decompression and Instrumented Fusion. Oper Tech Orthop 21:240-244. Mikhael MM, Celestre PC, Wolf CF, Mroz TE, Wang JC. Minimally Invasive Cervical Spine Foraminotomy and Lateral Mass Screw Placement. Spine (Phila Pa 1976).2011 Oct 21. Reid JJ, Johnson JS, Wang JC. Challenges to bone formation in spinal fusion. Journal of Biomechanics.Volume 44, Issue 2, 11 January 2011, pp.213-220. Sintuu C, Simon RJ, Miyazaki M, Morishita Y, Hymanson HJ, Taghavi C, Brochmann EJ, Murray SS, Wang JC.Full-Length spp24, but Not Its 18.5-kDa Proteolytic Fragment, Inhibits Bone-Healing in a Rodent Model of Spine Fusion. J Bone Joint Surg Am. 2011 Jun 1;93(11):1022-32. Siu RK, Lu SS, Li W, Whang J, McNeill G, Zhang X, Wu BM, Turner AS, Seim HB 3rd, Hoang P, Wang JC, Gertzman AA, Ting K, Soo C. Nell-1 protein promotes bone formation in a sheep spinal fusion model. Tissue Eng Part A. 2011 Apr;17(7-8):1123-35. Epub 2011 Feb 8. Wolf CF, Wang JC. Does Stem Cell Therapy Have a Role in Spinal Fusion? Spineline. 2011. Vol.12(1):19-24.

Jeffrey C. Wang MD, Scott McGovern MD, Winston Fong MD. Bone Substitutes: Basic Science and Clinical Applications. In: Rothman-Simeone The Spine, 6th Edition. Elsevier Saunders 2011; 1159-1170. Takashi Kaito, Stephanie S. Ngo and Jeffrey C. Wang (2011). Ex Vivo Gene Therapy for Spinal Fusion, Gene Therapy Applications, Chunsheng Kang (Ed.), ISBN: 978-953-307-541-9, InTech. Jeffrey C. Wang, MD. Spinal Reconstructive Surgery Textbook.Editor, Jeffrey C. Wang, MD.American Academy of Orthopaedic Surgeons. 2011

Orthopaedic Spine Presentations 2011 Jeffrey C. Wang, MD. Biologics for Spine: The Lack of Evidence. Presented at the 7th Annual Evidence and Technology Spine Summit, Park City, UT, Feb. 2-5, 2011. Jeffrey C. Wang, MD. Anterior and Posterior Surgery for Cervical Myelopathy. Presented at the Annual Meeting of the American Academy of Orthopaedic Surgeons Instructional Course Lectures, San Diego, CA, Feb. 16, 2011. Jen-Chung Liao, Kweishian Taoyuan, Shiau-Tzu Tzend, Kwong-Bok Lee, Jeonju Chonbuk, Gun Keorochana, Jared Johnson, Jeffrey C. Wang. Bone Healing of rhBMP-7 is Enhanced by Combination with BMP Binding Peptide in a Femoral Defect Model. Presented at the Annual Meeting of the American Academy of Orthopaedic Surgeons, San Diego, CA, Feb. 16, 2011. Kwong-Bok Lee, Jeonju Chonbuk, Cyrus Taghavi, Kyung Jin Song, Jeffrey C. Wang. Inflammatory Characteristics and Comparison of rhBMP-7 to rhBMP-2. Presented at the Annual Meeting of the American Academy of Orthopaedic Surgeons, San Diego, CA, Feb. 17, 2011. Jared Johnson, Jeong-Hyun Yoo, Koyand Kyunggi, Vicente Meliton, Woo Kim, Jeffrey C. Wang, Renata Pereira, Theodore Hahn, Farhad Parhami. Hedgehog Signaling and BMP-2-Induced Osteogenic Differentiation In Vitro and Spine Fusion In Vivo. Presented at the Annual Meeting of the American Academy of Orthopaedic Surgeons, San Diego, CA, Feb. 17, 2011. Jeffrey C. Wang, MD. Cervical Myelopathy: Need for Subsequent Surgery. Presented at the 27th Annual Meeting of the AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, Phoenix, AZ, March 9, 2011. Jeffrey C. Wang, MD. Cervical Arthroplasty: Outcomes and Complications. Presented at the AOSpine North America Advanced Concepts in the Management of Spinal Disorders, San Diego, CA, April 29, 2011. Jeffrey C. Wang, MD. Synthetic Products for Spinal Fusion. Presented at the AOSpine North America Advanced Concepts in the Management of Spinal Disorders, San Diego, CA, April 29, 2011. Jeffrey C. Wang, MD. Lumbar Arthroplasty and Anterior Fusion: Surgical Techniques. Presented at the AOSpine Advanced Spine Course, Xian, China, August 19, 2011. Jeffrey C. Wang, MD. Lumbar Instability and How to Assess for Fusion. Presented at the AOSpine Advanced Spine Course, Xian, China, August 19, 2011.

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Jeffrey C. Wang, MD. Persistent Low Back Pain After Surgery. Presented at the AOSpine Advanced Spine Course, Xian, China, August 20, 2011. Jeffrey C. Wang, MD. Indications for Revision Surgery. Presented at the AOSpine Masters Symposium, Helsinki, Finland, Sept. 2, 2011. Jeffrey C. Wang, MD. Revision Strategies for Adjacent Segment Disease. Presented at the AOSpine Masters Symposium, Helsinki, Finland, Sept. 2, 2011. Jeffrey C. Wang, MD. Outcomes of Revision Surgery. Presented at the AOSpine Masters Symposium, Helsinki, Finland, Sept. 2, 2011. Jeffrey C. Wang, MD. Dynamic Stabilization for Adjacent Segment Disease. Presented at the AOSpine Masters Symposium, Helsinki, Finland, Sept. 3, 2011. Jeffrey C. Wang, MD. Minimally Invasive Surgery and Adjacent Segment Disease. Presented at the AOSpine Masters Symposium, Helsinki, Finland, Sept. 3, 2011. Jeffrey C. Wang, MD. Osteobiologics in Spine Surgery: The Need for Scientific Evidence. Presented at the Osteobiologics Use in Spine Surgery Meeting, Santa Monica, CA. Oct. 29, 2011. Stephanie Ngo, Jessica Ellerman, William Pannell, David Savin, Jeffrey Wang. Regional Variations in Lumbar Fusion Performed for the Top Ten Primary Lumbar Diagnoses. Presented at the 26th Annual Meeting of the North American Spine Society. Chicago, IL, Nov. 2, 2011. Jeffrey C. Wang, MD. Biological Regenerative Strategies for Disc Regeneration. Presented at the 26th Annual Meeting of the North American Spine Society. Chicago, IL, Nov. 2, 2011. Jeffrey C. Wang, MD. Effect of BMP on Spinal Fusion and Disc Regeneration. Presented at the International Society for the Advancement of Spine Surgery Turkey. KOC University, Istanbul, Turkey. Nov. 11, 2011. Jeffrey C. Wang, MD. Anterior and Posterior Approaches for Cervical Myelopathy and Dynamic MRI. Presented at the International Society for the Advancement of Spine Surgery Turkey. KOC University, Istanbul, Turkey. Nov. 11, 2011. John Shin MD, Micheal Steinmetz MD, Isador Lieberman MD, Jeffrey Wang MD. Biomechanical Analysis of Open Door Cervical Laminaplasty with and without Spinal Processes and Interspinous Ligaments. Presented at the 39th Annual

Meeting of the Cervical Spine Research Society. Scottsdale, AZ, Dec. 9, 2011 Kyung-Jin Song MD, Hun Park MD, Byung-Wan Choi MD, Jeffrey Wang MD, Kwong-Bok Lee MD. Efficacy of Combined Anterior/Posterior Fusion vs. Anterior Fusion Alone for Multi-level Degeneration of the Cervical Spine. Presented at the 39th Annual Meeting of the Cervical Spine Research Society. Scottsdale, AZ, Dec. 9, 2011.

Neurosurgery Spine Publications 2011

Chou D.C., Lu D.C. Mini-open transpedicular corpectomies with expandable cage reconstruction. J Neurosurg Spine (2010).

Clark A.J., Lu D.C., Richardson R.M., Tihan T., Parsa A.T., Chou D., Barbaro N.M., Kunwar S., Weinstein P.R., Lawton M.T., Berger M.S., McDermott M.W. Surgical technique of temporary arterial occlusion in the operative management of spinal hemangioblastomas. World Neurosurg 74: 200-205 (2010).

Han S.J., Lau D., Lu D.C., Chou D. Anterior thoracolumbar corpectomies: apporach morbidity with and without an access surgeon Feb 4 (2011).

Lau D., Han S.J., Lee J.G., Lu D.C., Chou D. Minimally invasive compared to open microdiscectomy for lumbar disc herniation. J Clin Neurosci (2010).

Lau D., Lee J.G., Han S.J., Lu D.C., Chou D. Complications and perioperative factors associated with learning the technique of minimally invasive transforaminal interbody fusion (TLIF). J Clin Neurosci. 18: Feb 23 (2011).

Lu D.C., Chou D., Mummaneni P.V. A comparison of mini-open and open approaches for resection of thoracolumbar intradural spinal tumors. J Neurosurg Spine 14: 758-64 (2011).

Lu D.C., Dhall S.S., Mummaneni P.V. The transpinous mini-open approach for resection of intradural spinal neoplasms: cadaveric feasibility study and report of 3 clinical cases. World Neurosurg 74: 195-199 (2010).

Lu D.C., Lau D., Lee J.G., Chou D. The transpedicular approach versus the anterior approach: an analysis of 80 thoracolumbar corpectomies. JNS Spine 12: 583-91 (2010).

Lu D.C., Lawton M.T. Clinical presentation and surgical management of intramedullary spinal cord cavernous malformations. Neurosurg Focus 29: E12 (2010).

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Lu D.C., Roeser A.C., Mummaneni V.P., Mummaneni P. Nuances of occipitocervical fixation. Neurosurgery 66, 141-6 (2010).

Lu D.C., Zador Z., Mummaneni P.V., Lawton M.T. Rotational vertebral artery occlusion-series of 9 cases. Neurosurgery 67: 1066-72 (2010).

Mummaneni P., Lu D.C., Dhall, S., Mummaneni V., Chou D. C1 Lateral Mass Fixation: A comparison of ccnstructs. Neurosurgery 66, 153-60 (2010).

Rodriguez-Hernandez A., Lu D.C., Meric S., Lawton M.T. Aneurysms associated with non-moyamoya collateral arterial networks: report of three cases and review of literature. Neurosurg Rev. 34: 517-22 (2011).

Wang V., Chin C., Lu D.C., Smith J.S., Chou D. Free-hand thoracic pedicle screw placed by neurosurgery residents: a CT analysis. Eur Spine J (2010).

Zador Z., Lu D.C., Arnold C.M., Lawton M.T. Deep bypasses to the distal posterior circulation: anatomical and clinical comparison of pretemporal and subtemporal approaches. Neurosurgery 66, 92-100 (2010).

Division Chief Bruce Brown, M.D., specialist in joint replacement and general orthopaedics, leads a group of three generalists on staff: S. Andrew Schwartz, M.D. and Peter Alexakis, M.D. With the addition of these excellent faculty members, we have greatly improved the access and community service aspects of our group while streamlining surgical referrals. Dr. Schwartz also serves as director of medical student education. Steven Zeitzew, M.D. (West LA VA) was selected as one of the Fellows for the Institute for Science in Medicine. S. Andrew Schwartz, M.D., F.A.C.S. has been working on the Medical School Orthopaedic Education and has been helping to rewrite the Musculoskeletal block, both for the anatomy section as well as the lectures. He has received the Outstanding Tutor Award for each of the past 2 years and well as Teaching Humanism Award which included a $2500honorarium. He is also happy to announce that the final payment has been received which completes the $5,000,000grant he obtained from the Lincy Foundation for the Orthopaedic

Department. The grant was secured to help in all aspects of the department, especially in student education and special research projects.

GENERAL ORTHOPAEDIC SURGERY

The UCLA Metabolic Bone Disease and Osteoporosis Center, headed by Division Chief Aurelia Nattiv, M.D. and also including John Adams, M.D., Deborah Kado, M.D., and Benjamin Bengs, M.D. provides comprehensive service for

patients with osteoporosis including diagnosis and treatment. These physicians work closely with a

variety of health professionals, beginning with the patient’s own referring physician. When referring patients to the center, physicians can request only a DXA for accurate assessment of bone health or refer patients for complete evaluation and consultation with UCLA’s team of experts for interpretation of test results and recommendations for fracture prevention. Center physicians work closely with other health professionals at UCLA to offer patients a full spectrum of health expertise. This includes physical therapists who specialize in balance and fall prevention, occupational therapists who help patients with the activities of daily life, and dieticians who provide guidance in nutrition.

OSTEOPOROSIS/METABOLIC BONE DISEASE

Deborah Kado, M.D., M.S., clinician scientist, internist and geriatrician, joined the Orthopaedic Surgery faculty in 2008 from the UCLA Department of Medicine. Clinically, she sees patients in the UCLA Osteoporosis Center. Her research expertise is in osteoporosis and spinal changes with aging. In 2011, she was awarded a new $1 million NIH/NIAMS RO1 four year grant to study the biological and structural predictors of kyphosis progression in over 3,000 older men from six clinical centers across the United States. A few

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selected publications in 2011 include: Denard PJ, Holton K, Miller J, Fink H, Kado DM, Marshall LM, Yoo JU. Back pain, neurogenic symptoms, and physical function in relation to spondylolisthesis among elderly men, The Spine Journal, 2010; 10:865-873. Hillier T, Lui LY, Kado DM, LeBlanc KV, Bauer DC, Cauley JA, Ensrud KE, Black DM, Hochberg MC, Cummings SR. Shrinking To Death: Height Loss is Associated with Increased Risk of Hip Fracture and Mortality Independent of Vertebral Fractures in Older Women. J Bone Miner Res, 2011 Nov 9. Holton KF, Denard P, Yoo J, Kado DM, Barrett-Connor E, Marshall L. Lower reported back pain in elderly community dwelling men with Diffuse Idiopathic Skeletal Hyperostosis (DISH): the MrOS Study, Semin Arthritis Rheum, 2011 Mar 3. Katzman W, Vittinghoff E, Ensrud K, Black D, Kado DM. Increasing kyphosis predicts worsening mobility in older community-dwelling women: a prospective cohort study, J Am Geriatr Soc, 2011; 59:96-100. Katzman W, Cawthon P, Hicks G, Vittinghoff E, Cauley JA, Harris T, Simonsick EM, Womak C, Kado DM. Association of spinal muscle composition and prevalence of hyperkyphosis in healthy community-dwelling older men and women, J Gerontol Med Sci, 2011 Aug 30 . Katzman W, Vittinghoff E, Kado DM. Age-related hyperkyphosis, independent of spinal osteoporosis, is associated with impaired mobility in community dwelling older women, Osteoporos Int, 2011; 22:85-90. Sugi MT, Sheridan K, Lewis L, Huang MH, Nattiv A, Kado DM, Bengs B. Active referral intervention following fragility fractures leads to enhanced osteoporosis follow-up care. J of Osteoporosis, in press.

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Drs. Karen Lyons & John Adams secured the first ever NIH postdoctoral training grant for the Department of Orthopaedic Surgery. It is one of the eleven funded training grants in Orthopaedic Surgery in the country and the only one on the West Coast. The first two trainees were recently

appointed (see picture). The total award is for $1.9M, supports four trainees per year, and runs through July 31, 2016. Jia Jiang and Michael

Weinstein are our first awardees.

ORTHOPAEDIC RESEARCH Highlights from the Orthopaedic Hospital Research Center: Our Orthopaedic Surgery Department boasts a tremendous array of non-clinical faculty that contribute a great deal to our academic output as a group. Led by Division Chief and Vice Chair of Research John Adams, M.D., our research center boasts over 30,000 square feet of research space. Recently, Dr. Adams was part of a successful team obtaining a $5 million grant in tissue engineering.

The initial NIH-supported Clinical and Translational Science Award was made to UCLA and its partners, Cedars-Sinai, Harbor-UCLA and King-Drew Medical Centers in June of 2011 (see logo); it generates $16.4M per year in support of clinical and translational research at UCLA. Dr. John Adams is the Associate Director. The Third Edition of the two-volume text Vitamin D was published in 2011. It is considered the definitive text in

the field. Dr. John Adams is one of the three editors. The Orthopaedic Hospital Research Center (OHRC; pictured) hosted its 4th annual research retreat on November 19, 2011. The theme of the retreat was “Advances in Translational Orthopaedic Research.” Faculty, fellows, and residents of the Department were joined by Dr. Randy Rosier (University of Rochester) and Dr. Tom Clemens (Johns Hopkins University), members of our External Advisory Board, as well as representatives from Amgen and the Executive Committee for Research of the Board of the Orthopaedic Hospital. Dr. Gerald Finerman was recognized in appreciation for his vision and role in creation of the OHRC. The J. Vernon Luck Sr. M.D. Orthopaedic Research Center at Orthopaedic Hospital has a goal to

develop a deeper understanding of the biology and biomechanics of the musculoskeletal system, and to apply this knowledge to the improvement of orthopaedic implants and the treatment of musculoskeletal injuries, including the associated surgical instrumentation and techniques, thereby improving the quality of care to orthopaedic patients world-wide. To accomplish this goal, the Luck Center investigators welcome and, indeed, depend on close collaboration with the clinical faculty, fellows, and residents in identifying appropriate targets for research and development that will have immediate and substantial impact on their ability

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to treat patients effectively. The value of this collaborative approach is evident from the many journal publications and award papers from the Luck Center that include clinicians and basic science faculty as co-authors. Implant Tribology Laboratory The faculty of the Tribology lab includes Harry McKellop, Ph.D. as director, Zhen Lu, Ph.D. as lab manager, and Fu-Wen Shen, Ph.D. as materials scientist. For the past twenty years, a key program of the Tribology lab has been the development and ongoing improvement of highly wear-resistant crosslinked polyethylenes for hip and knee arthroplasty. Since clinical use began in 1998, several hundred thousand hips and knees using crosslinked polys from the Luck Center have been implanted. To date, none have required replacement due to clinically significant osteolysis. During the past year, Drs. McKellop and Shen were awarded several additional US and international patents for improvements in the crosslinked polyethylene. Biomaterials, Ions and Particle Analysis Laboratory In 2011, this research team, led by Fabrizio Billi, Ph.D., and Paul Benya, Ph.D., received the John Charnley Award from the Hip Society for their development of a new method to isolate and characterize wear particles from joint replacements, which has enabled several important new lines of research. The group is developing an animal model to evaluate the biological effects of nano-sized wear particles on osteolysis. Another project will identify the specific TCR-cognate antigens that are responsible for T-cell mediated response in patients with hip replacements. Both studies will eventually lead to the development of pharmacological approaches to minimize the adverse local and systemic reactions to all types of wear particles and ions.

A project being developed with Dr.Luck will monitor the level of ions and particles in blood serum and joint fluids from patients with metal-on-metal hip replacements, with the goal of identifying why severe tissue reactions occur in some patients. Another project with Dr.Pedowitz is studying the effect of metal particles on chondrolysis. Collaboration with Drs. Lloyd Miller and Nick Bernthal is directed at minimizing the occurrence of implant-related infections, and Drs. Niska, Miller, and Billi are developing an animal model to study the effect of wear nanoparticles on the propagation of bacterial infections. Finally, a study with Maria-Grazia Ascenzi, Ph.D. on bone architecture was recently published in the Journal of Biomedical Materials Research. Implant Retrieval Laboratory The faculty of the Implant Retrieval lab includes Patricia Hosseinian-Campbell, Ph.D., director, and Sang-Hyun Park, Ph.D., manager of the ASR metal-metal retrieval project. In 2011, the Implant Retrieval lab was awarded a competitive, multi-year contract to provide detailed analysis of all of the ASR metal-metal hip prostheses that are retrieved in the US – in close collaboration with the London Implant Retrieval Center at the Imperial College, which will analyze ASRs recovered outside the US. In 2006, Dr. Campbell led an international team that received the John Charnley Award from the Hip Society for their study of the causes of failure of metal-metal hip surface replacements, and she is a member of another international team that will receive the Hip Society’s 2012 Otto Aufranc Award for their study of "The Interpretation of Metal Ion Levels in Unilateral and Bilateral Hip Resurfacing." In collaboration with Koen De Smet, M.D., and Catherine Van Der Straeten, M.D., Dr. Campbell has just completed a textbook on the techniques of hip resurfacing that will be published by Woodhead in 2012.

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Implant Biomechanics Laboratory The faculty of the Implant Biomechanics Laboratory includes Edward Ebramzadeh, Ph.D., director, and Sophia Sangiorgio, Ph.D., lab manager. Dr. Sangiorgio has been a member of the J. Vernon Luck Research Center at Orthopaedic Hospital since 2000, and faculty in the UCLA Department of Orthopaedics since 2007, after receiving her Ph.D. in Biomedical Engineering from UCLA in 2006. Dr. Ebramzadeh has been a member of the J. Vernon Luck Research Center at Orthopaedic Hospital in the Implant Biomechanics Laboratory since 1982. He joined the UCLA faculty in 1998. He has been awarded the John Charnley Award by the Hip Society twice over the last decade for his work in total hip replacement research, most recently in 2011. The focus of the lab’s research is to evaluate existing and prototype implants and the associated surgical techniques, in order to improve their function and avoid clinical failures. Historically, much of the research focused on the optimization of the design of hip and knee prostheses. During the past few years, the scope of the research has been substantially expanded to include spinal and pediatric devices and procedures. Current clinical collaborators include Drs. Scaduto, Bengs, Bowen, Silva and Zionts. Luck Research Center Recent Publications Sangiorgio, S.N., Longjohn, D.B., Dorr, L.D. Ebramzadeh, E.: “The influence of proximal stem geometry and surface finish on the stability of a double-tapered cemented femoral stem.” J Biomech 2011 Jan 4;44(1):22-7. Sangiorgio, S.N., Longjohn, D.B., Dorr, L.D. Ebramzadeh, E.: “Challenges in relating experimental hip implant fixation predictions to clinical observations.” J Biomech 2011 Jan 11;44(2):235-43. Sangiorgio, S.N., Sheikh, H., Borkowski, S.L., Khoo, L., Warren, C.R., Ebramzadeh, E.: “Comparison of Three Posterior Dynamic Stabilization Devices.” Spine (Phila Pa 1976). 2011 Sep 1;36(19):E1251-8. Ebramzadeh, E.,Campbell, P.A., Takamura, K.M., Lu, Z., Sangiorgio, S.N., Kalma, J.J., De Smet, K., Amstutz, H.C.: “Failure Modes of 433 Metal-on-Metal Hip Implants: How,

Why and Wear.” Orthop Clin North Am. 2011 Apr;42(2):241-50. Yang, J, Silvestro, C, Sangiorgio, SN, Borkowski, SL, Ebramzadeh, E, DeNardo, L, Daraio, C: “Nondestructive evaluation of orthopaedic implant stability in THA using highly nonlinear solitary waves.” Smart Materials and Structures (Epub ahead of print). Lu, Z., McKellop, H. “Use of a constant load to generate equivalent viscoelastic strain in finite element analysis of cemented prosthetic joints subjected to cyclic loading.” Proc. Inst. Mechanical Engineers, Part H, Journal of Engineering in Medicine. N. Bernthal, J. Pribaz, A.Stavrakis, F. Billi, J. Cho, R.Ramos, K.Francis, Y. Iwakura, and L. Miller “Protective role of IL-β against post-arthroplasty Staphylococcus aureus infection.” J. Orthop Res, available on-line 28-Mar-2011 J.R. Pribaz, N.M. Bernthal, F. Billi, J.S. Cho, R.I. Ramos, A.L. Cheung, K.P. Francis , and L.S. Miller. “Mouse model of chronic post-arthroplasty infection: noninvasive in vivo bioluminescence imaging to monitor bacterial burden for long-term study.” J. Orthop Res, Aug 2011, doi: 10.1002/jor.21519. F. Billi, P. Benya, A. Kavanaugh, J.S. Adams, E. Ebramzadeh, H.A. McKellop. The Hip Society John Charnley Award – “An Accurate and Extremely Sensitive Method to Separate, Display And Characterize Wear Debris Part 1: Polyethylene Particles.” Clin Orthop Relat Res. 2011 Oct 14. [Epub ahead of print] F. Billi, P. Benya, A. Kavanugh, J.S. Adams, H.A. McKellop, E. Ebramzadeh. The Hip Society John Charnley Award – “An Accurate and Extremely Sensitive Method to Separate, Display And Characterize Wear Debris Part 2: Metallic and Ceramic Particles.”Clin Orthop Relat Res. 2011 Sep 20. [Epub ahead of print]. C. Van Der Straeten, G. Grammatopoulos, H.S. Gill, A. Calistri, P. Campbell, K.A. "The Interpretation of Metal Ion Levels in Unilateral and Bilateral Hip Resurfacing." Otto Aufranc award paper, to be published in CORR, 2012. Amstutz HC, Le Duff MJ, Campbell PA, Wisk LE, Takamura KM. “Complications after metal-on-metal hip resurfacing arthroplasty.” Orthop Clin North Am 2011; 42:207-30, viii. Takamura KM, Yoon J, Ebramzadeh E, Campbell PA, Amstutz HC. “Incidence and significance of femoral neck narrowing in the first 500 Conserve(R) Plus series of hip resurfacing cases: a clinical and histologic study.” Orthop Clin North Am 2011; 42:181-93, viii.

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Ebramzadeh E, Campbell PA, Takamura KM, Lu Z, Sangiorgio SN, Kalma JJ, De Smet KA, Amstutz HC. “Failure modes of 433 metal-on-metal hip implants: how, why, and wear.” Orthop Clin North Am 2011; 42:241-50, ix. Chia Soo, M.D., Ph.D. joined the Orthopaedic Research Faculty in 2008. Her research focuses on translational studies in skin wound healing, bone and cartilage regeneration, and stem cells. For 2011, she wishes to thank her hard-working researchers for 16 publications, 22 abstracts/presentations, and 4 awards from the International Association for Dental Research, World Stem Cell Summit, American Society for Bone and Mineral Research, and American College of Surgeons. Dr. Soo’s 2011 Publications Li W, Zara J, Siu R, Lee M, Aghaloo T, Zhang X, Wu B, Gertzman A, Ting K, Soo C.Nell-1 enhances bone regeneration in a rat critical sized femoral segmental defect model. PRS 127:580-7, 2011. Khorasani H, Zheng Z, Nguyen C, Zara, J, Zhang X, Wang J, Ting K, Soo C.A quantitative approach to scar analysis.Am J Pathol 178:621-8, 2011. Zhang X, Ting K, Bessette CM, Culiat CT, Sung SJ, Lee H, Feng C, Shen J, Wang JJ, Kuroda S, Soo C. Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2+/- mice. JBMR 26:777-91, 2011. Chen W, Zhang X, Siu RK, Chen F, Shen J, Zara JN, Culiat CT, Tetradis S, Ting K, Soo C. Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells. JBMR 2010 Dec 15. [Epub ahead of print] Zheng Z, Nguyen C, Zhang X, Khorasani H, Wang JZ, Zara JN, Chu F, Le A, Ting K, Soo C. Delayed Wound Closure in Fibromodulin Deficient Mice is Associated with Increased TGF-3 Signaling. JID 131:769-78, 2011. Siu RK, Lu SS, Li W, Whang J, McNeill G, Zhang X, Wu BM, Turner AS, Seim HB, Wang JC,Gertzman A, Ting K, Soo C. Nell-1 protein promotes bone formation in a sheep spinal fusion model. Tissue Eng Part A. 2011 Feb 8. [Epub ahead of print] Zara J, Siu R, Zhang X, Shen J, Ngo R, Lee M, Li W, Chiang M, Chung J, Wu B, Ting K, Soo C.High doses of BMP2 induce

structurally abnormal bone and inflammation in vivo. Tissue Eng Part A 2011 Mar 3. [Epub ahead of print] James AW, Zara JN, Corselli M, Chiang M, Lee M, Adams JS, Ting K, Péault B, Soo C. Use of Human Perivascular Stem Cells for Bone Regeneration. J Vis Exp.in press, 2011. Corselli M, Scholes J, Stoker D, Ting K, Rubin JP, Adams JS,Soo C, Péault B. Purification of Perivascular Stem Cells from Human White Adipose Tissue. J Vis Exp., In press 2011. Zhang X, Ting K, Pathmanathan D, Ko T, Chen W, Chen F, Lee H, James AW, Siu RK, Shen J, Culiat CT, Soo C. Calvarial cleidocraniodysplasia-like defects with ENU-induced Nell-1 deficiency. J of Craniofacial Surgery (Accepted). Zhang X, Peault B, Chen W, Li W, Corselli M, Lee M, Siu R, Pang S, Zhong Z, Shen J, Kwak JH, Chen F, Zhang H, Yin W, Wu B, Ting K, Soo C. The Nell-1 growth factor stimulates bone formation bypurified human perivascular cells. Tissue Eng Part A(Accepted). James AW, Pan A, Chiang M, Zara J, Zhang X, Ting K, Soo C. A new function of Nell-1 protein in repressing adipogenic differentiation. Biochemical and Biophysical Research Communications, 2011 Jul 22;411(1):126-31. Epub 2011 Jun 23. Zou X, Shen J, Chen F, Ting K, Zheng Z, Pang S, Zara JN, Adams JS, Soo C and Zhang X . NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation. FEBS Letter 2011 585(15):2410-8. Epub 2011 Jun 26. Feng C, Zhang X, Zara JN, Zou X, Chiu R, Culiat CT, Ting K, Soo C. NELL-1, an osteoinductive factor, is a direct transcriptional target of Osterix. PLoS ONE (Accepted). Siu RK, ZaraJN, Hou Y, Li W, James AW, Kwak J, Zhang X, Ting K, Wu B, Soo C, M Lee. Nell-1 promotes cartilage regeneration in a rabbit model. Tissue Eng Part A (Accepted). Scott M, Levi B, Askarinam A, Nguyen A, Rackohn T, Ting K, Soo C, James A. Brief review of models of ectopic bone formation. Stem Cells and Development (Accepted). Dr. Soo’s 2011 Abstracts/Presentations Kwak, J., Ting, K., Gou, Z., Shen, J., Zara, J., Siu, R.K., Ngo, R., Moon, C.E., Zhang, X., Lee, M., Wu, B.M., Wang, J.J., Soo, C. Harnessing the Osteogenic Potential of Bone Marrow Stem Cells in vivo. Abstract for oral presentation, Orthopaedic Research Society 2011 Annual Meeting, Long Beach, CA (Jan 2011).

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Zara, J., Zheng, Z., Yin, W., Li, W., Siu, R.K., Kwak, J., Ngo, R., Chiang, M., Zhang, X., Ting, K., Soo, C. Infected Femoral Segmental Defect Model: Effects of Nanosilver in Re-Establishing BMP-2 Osteoinductivity in Infected Wounds. Abstract for oral presentation, Orthopaedic Research Society 2011 Annual Meeting, Long Beach, CA (Jan 2011). Siu, R.K., Lu, S.S., Li, W., Whang, J., McNeill, G., Zhang, X., Wu, B.M., Turner, A.S., Seim, H.B., Wang, J.C., Gertzman, A.A., Ting, K., Soo, C. Sheep Spinal Fusion Mediated by Nell-1 Protein in a Demineralized Bone Matrix Carrier.Abstract for poster presentation, Orthopaedic Research Society 2011 Annual Meeting, Long Beach, CA (Jan 2011). Yin W, Zheng Z, Zara J, Li W, Zhang X, Wang J, Ting K, Soo C. Fibromodulin Improves Adult Porcine Wound Healing. IADR Annual Meeting 2011. San Diego, CA (Mar 2011). Kwak J, Gou Z, Shen J, Zara J, Siu R, Ngo R, Moon C, Lee M, Wu B, Wong J, Zhang X, Soo C, Ting K. Nell-1 Effectively Harnesses Osteogenic Potential of Bone Marrow Stem Cells. Abstract for oral and poster presentations, 89th General Session and Exhibition of the International Association for Dental Research/40th Annual Meeting of the American Association for Dental Research, San Diego, CA (Mar 2011). Selected as finalist for the AADR/Johnson & Johnson Healthcare Products Hatton Awards Competition. Shen J, Zara J, Siu K, Zhang X, Ngo R, Lee M, Li WM, Chiang M, Chung J, Wu B, Ting K, Soo C. High Dose BMP2 Induce Structurally Abnormal Bone. IADR Annual Meeting 2011. San Diego, CA (Mar 2011). Siu, R.K., Zhang, X., Chen, W., Chen, F., Shen, J., Zara, J., Culiat, C., Tetradis, S., Ting, K., Soo, C. Nfatc2 is a Primary Response Gene of Nell-1 Regulating Chondrogenesis. Abstract for oral and poster presentations, 89th General Session and Exhibition of the International Association for Dental Research/40th Annual Meeting of the American Association for Dental Research, San Diego, CA (Mar 2011). Winner of the AADR/Johnson & Johnson Healthcare Products Hatton Awards Competition. Zara J, Siu K, Zhang X, Shen J, Ngo R, Lee M, Li WM, Chiang M, Chung J, Wu B, Ting K, Soo C. Induction of Structurally Abnormal Bone and Inflammation In Vivo with High Doses of BMP2. Presented at the Plastic Surgery Research Council Annual Meeting April 27-30, 2011. Louisville, KY. Zara JN, James AW, Pang S, Corselli M, Chiang M, Zhang X, Adams J, Ting K, Peault B, Soo C. Adipose Derived Human Perivascular Stem Cells are Superior to Stromal Vascular Fraction in Bone Formation. California Institute of Regenerative Medicine Grantee Meeting (September 14-16, 2011, San Francisco, CA).

Zara JN, James AW, Pang S, Corselli M, Chiang M, Zhang X, Adams J, Ting K, Peault B, Soo C. Human Perivascular Stem Cells are Superior to Stromal Vascular Fraction in Ectopic and Orthotopic Bone Formation. World Stem Cell Summit.(October 3-5, 2011, Pasadena, CA).Winner of a 2011 Best Poster Award. Shen J, Siu R, Pang S, Zara J, Kwak J, Zhang X, James A, Chiang M, Ngo R, Li W, Lee M, Chung J, Lee K, Ting K, Soo C. The novel osteoinductive Wnt regulator NELL-1 potently antagonizes BMP2-induced adipogenesis and augments BMP2-induced osteogenesis. Accepted for presentation at the 33rd Annual Meeting of the American Society for Bone and Mineral Research (September 16-20, 2011, San Diego, CA). Winner of a 2011 Young Investigator Award. Siu RK, Zara JN, Hou Y, Kwak J, Zhang X, James AW, Covarrubias K, Wu BM, Ting K, Soo C, Lee M. NELL-1 promotes cartilage regeneration in an in vivo rabbit model. Accepted for presentation at the 33rd Annual Meeting of the American Society for Bone and Mineral Research (September 16-20, 2011, San Diego, CA). James A, Nguyen V, Zara J, Chiang M, Soofer D, Askarinam A, Zhang X, Ting K, Soo C. Nell-1 deficiency results in an osteopenic / osteoporotic phenotype. Accepted for presentation at the 97th Annual Clinical Congress, American College of Surgeons (October 23-27, 2011, San Franciso, CA). Winner of a 2011 Surgical Forum/Excellence in Research Award. Zheng Z, Zara J, Nguyen V, James A, Liu K, Le K, Yoon S, Singh H, Soo C. Fibromodulin, a TGF-beta modulator, inhibits scar formation and increases tensile strength. Accepted for presentation at the 97th Annual Clinical Congress, American College of Surgeons (October 23-27, 2011, San Francisco, CA). Zara J, James A, Nguyen V, Corselli M, Chiang M, Zhang X, Stoker D, Ting K, Peault B, Soo C. Human perivascular stem cells are superior to stromal vascular fraction in ectopic bone formation. Accepted for presentation at the 97th Annual Clinical Congress, American College of Surgeons (October 23-27, 2011, San Francisco, CA). Liu Y, Nguyen V, Zara J, James A, Chiang M, Yuan W, Zheng Z, Soo C, Ting K. Use of nanosilver, BMP2 and Nell-1 for the healing of infected long bone injuries. Accepted for presentation at the 97th Annual Clinical Congress, American College of Surgeons (October 23-27, 2011, San Francisco, CA). Zara JN, Kwak J, Ngo R, Chiang M, Shen J, James A, Zhang X, Ting K, Soo C. Potentiating the Osteogenic Capacity of Bone Marrow Stem Cells Using Nell-1 in an Osteoporotic Rat Model. Accepted for presentation at the World Congress on

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Debates and Consensus in Bone, Muscle & Joint Diseases. (January 19-22, 2012, Barcelona, Spain). Zara JN, James AW, Chiang M, Askarinam A, Nguyen A, Zhang X, Ting K, Soo C. Induction of an Osteoporotic Phenotype with Nell-1 Deficiency. Accepted for presentation at the World Congress on Debates and Consensus in Bone, Muscle & Joint Diseases. (January 19-22, 2012, Barcelona, Spain). Askarinam A, Zara JN, James AW, Yuan W, Chiang M, Nguyen A, Stoker D, Pang S, Corselli M, Zhang X, Peault B, Ting K, Soo C. Adipose-Derived Purified PSCs Heal Critical-Size Mouse Calvarial Defects. Accepted for presentation at the Orthopaedic Research Society Annual Meeting. (February 4-7, 2012, San Francisco, CA). Goyal R, James AW, Zara JN, Chiang M, Yuan W, Askarinam A, Pang S, Corselli M, Stoker D, Zhang X, Peault B, Ting K, Soo C. FACS Purified Human Perivascular Stem Cells Induce More Bone Formation in Comparison with Unsorted SVF in Response to rhBMP2. Accepted for presentation at the Orthopaedic Research Society Annual Meeting. (February 4-7, 2012, San Francisco, CA). Chiang M, Zhou A, James AW, Zara JN, Goyal R, Covarrubias K, Seim H, Adams J, Zhang X, Ting K, Soo C. Nell-1 Enhances Bone Formation in an Osteoporotic Sheep Model. Accepted for presentation at the Orthopaedic Research Society Annual Meeting. (February 4-7, 2012, San Francisco, CA). Le K, James AW, Zara JN, Pang S, Askarinam A, Chiang M, Yuan W, Stoker D, Zhang X, Ting K, Soo C. Combinatorial Effects of Sonic Hedgehog and Nell-1 Signaling in Osteogenic versus Adipogenic Differentiation of Human Adipose-Derived Stromal Cells. Accepted for presentation at the Orthopaedic Research Society Annual Meeting. (February 4-7, 2012, San Francisco, CA). Philip T. Liu, Ph.D. joined the Orthopaedic Surgery Department research team in July 2010. His training in the development and function of innate immune cells helps bolster the department’s goal of establishing a multidisciplinary research program. Recently, his study investigating the role of microRNA in the pathogenesis of mycobacterial diseases was accepted for publication in Nature Medicine. (Liu PT, Wheelwright M, Teles R, Komisopoulou E, Edfeldt K, Ferguson B, Vazirnia A, Rea T, Sarno EN, Graeber TG, Modlin RL. MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy. In Press, Nat. Med., 2011.)

A January 2011 special issue of the JOURNAL OF

BIOMECHANICS, of which Maria-Grazia Ascenzi, Ph.D. was guest editor, featured papers presented at the April 2010 interdisciplinary workshop Bone Tissue: Hierarchical Simulations for Clinical Applications, held at UCLA in our Department with co-sponsorship of UCLA’s Institute of Pure and Applied Mathematics and the Dean’s Office of Continuous Medical Education. Contributions authored by Department members addressed spine disorders (Drs. Jeff Wang, Jeremy Reid, and Jared Johnson), bone-implant interface (Drs. Sophia Sangiorgio and Edward Ebramzadeh), and cancellous structure in osteoporosis (Drs. Maria-Grazia Ascenzi and Aurelia Nattiv). In furtherance of the interdisciplinary exploration of bone structure that probes the factors that reduce bone quality and heighten the risk of fracture, Dr. Ascenzi’s research uses novel techniques of micro-dissection, innovative applications of imaging technologies, and multi-scale finite element modeling to create realistic virtual bone. Dr. Ascenzi has organized also a special Research Interest Group (RIG) session on Bone Tissue: Hierarchical Simulations for Clinical Applications at the 2011 annual meeting of the Orthopaedic Research Society and is invited to present a further session at the 2012 annual meeting of the Orthopaedic Research Society and the American Academy of Orthopaedic Surgeons in San Francisco to address progress in current clinical research at the Department relative to bone tissue simulation and her recent publications: Ascenzi, M.-G., Blanco, C., Drayer, I., Kim, H., Wilson, R., Retting, K., Lyons, K. and Mohler, G. (2011) Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization. JOURNAL OF

THEORETICAL BIOLOGY, 285, 147-155. Ascenzi, M.-G., Kawas, N., Lutz,A., Kardas,D., Nackenhorst,,

U., and Keyak, J. (2011) Individual-specific, multi-scale finite element simulation of the proximal femur cortex. JOURNAL OF

COMPUTATIONAL PHYSICS.Special Issue on Multi-scale Modeling. Guest Editor Ching-Long Lin (in press). Ascenzi, M.-G., Liao, V.P., Lee, B.M., Billi, F., Zhou, H., Lindsay, R., Cosman, F., Nieves, J., Bilezikian, J.P. and Dempster, D.W. (2011) Parathyroid hormone treatment improves cortical bone micro-structure by improving collagen type I in

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postmenopausal women with osteoporosis. JOURNAL OF BONE

AND MINERAL RESEARCH (in press). In the last year the Vitamin D Group, headed by Martin Hewison, Ph.D., had published 13 papers (including 7 reviews and a Commentary), with a further manuscript in press. Prominent in this work was a FASEB Journal paper demonstrating a link between vitamin D and the mTOR signaling pathway in bone forming osteoblastic cells. Dr. Hewison has also published 2 book chapters. Work by the Hewison group has been presented at many meetings. Dr. Hewison was an invited speaker at 11 national and international meetings, presenting plenary and seminar talks on various aspects of vitamin D function. This included two presentations at the ASBMR meeting in San Diego and a further talk at the Crohn’s and Colitis Foundation of America’s Pediatric Bone Meeting in New York. Hewison group members were also active with Dr. Thomas Lisse, giving an oral presentation at the ORS meeting in Long Beach, and Dr. Nancy Liu, presenting at the SGI meeting in Miami Beach. Clinical Fellow Dr. Justine Bacchetta was also successful and awarded an oral presentation and prize poster at the ASN meeting in Philadelphia. Hewison Lab Selected Publications 2011 Lisse TS, Liu T, Irmler M, Beckers J, Chen H, Adams JS, Hewison M (2011). Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling. FASEB Journal 25:937-947. Liu NQ, Kaplan AT, Lagishetty V, Ouyang YB, Ouyang Y, Simmons CF, Equils O, Hewison M (2011) Vitamin D and the regulation of placental inflammation. Journal of Immunology 186:5968-74. LepeniesJ, EardleyKS, KienitzT, HewisonM, IhlT, Stewart PM, Cockwell P, Quinkler M (2011) Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGFβ-1 in patients with chronic kidney disease. Nephron Clinical Practice 119:c97-c104. Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR,

Modlin RL (2011) Vitamin D Is Required for IFN-{gamma}-Mediated Antimicrobial Activity of Human Macrophages. Science Translational Medicine 3:104ra102. Chun RF, PeercyB, ShermanA, AdamsJS, Hewison M. Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling. PLoS1 (in press). Hewison M (2011) Antibacterial effects of vitamin D. Nature Reviews in Endocrinology 7:337-745. Lisse TS, Hewison M, Adams JS (2011) Hormone response element binding proteins: novel regulators of vitamin D and estrogen signaling. Steroids 76:331-339. Hewison M (2010) Vitamin D and innate and adaptive immunity.Vitamins and Hormones 86:23-62. Grayson R and Hewison M (2011) Vitamin D and human pregnancy.Fetal and Maternal Medicine Review 22:67-90. Lagishetty V, Liu NQ, Hewison M (2011) Vitamin D metabolism and innate immunity.Molecular and Cellular Endocrinology 247: 97-105. Hewison M (2011) Vitamin D and immune function.Proceedings of the Nutrition Society 18:1-12. Chun RF, Adams JS, Hewison M (2011) Immunomodulation by vitamin D: implications for Tuberculosis. Expert Reviews of Clinical Pharmacology 4:583-591. Hewison M, Adams JS (2011) Extra-renal 1α-hydroxylase.Vitamin D 3nd Edition.Eds D Feldman, JS Adams and JW Pike.Academic Press, San Diego.pp777-804.

Lisse TS, Chen H, Nanes MS, Hewison M, Adams JS (2011) Vitamin D-response element binding protein. Vitamin D 3nd Edition.Eds D Feldman, JS Adams and JW Pike.Academic Press, San Diego.pp2517-270.

Lloyd S. Miller, M.D., Ph.D., is a member of the orthopaedic surgery research faculty who studies the pathogenesis and novel therapeutic strategies to combat infections associated with orthopaedic implants and prostheses. Dr. Miller’s research utilizes state-of-the-art imaging technology to monitor these infections in real-time. His work has been highly regarded among the orthopaedic surgery scientific community as his research was awarded the Lloyd Taylor Western Orthopaedic Association Award and the Longmire Surgical

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Society Scientific Award in 2011, as well as podium presentations at the Orthopaedic Research Society Annual Meetings in 2010 and 2011 and at the American Academy of Orthopaedic Surgeons Annual Meeting in 2012.

Bernthal, NM, Stavrakis, AI, Billi, F, Cho, JS, Kremen, TJ, Simon, SI, Cheung, AL, Finerman, G, Lieberman, JR, Adams, JS, Miller, LS. 2010. A novel mouse model of post-arthroplasty joint infection to evaluate in vivo the efficacy of antimicrobial implant coatings. PLoS ONE 5(9): e12580.

Bernthal, NM, Pribaz, JR, Stavrakis, AI, Billi, F, Cho, JS, Ramos, RI, Francis, KP, Iwakura, Y, Miller, LS. 2010. Protective role of IL-1 against post-arthroplasty Staphylococcus aureus infection. Journal of Orthopaedic Research 29:1621-1626.

Pribaz, JR, Bernthal, NM, Billi, F, Cho, JS, Ramos, RI, Francis, KP, Miller, LS. 2011. Mouse model of chronic post-arthroplasty infection: noninvasive in vivo bioluminescence imaging to monitor bacterial burden for long-term study. Journal of Orthopaedic Research.29: 1621-1626.

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A Message from Alumni Director, Seth C. Gamradt, M.D.: Welcome to the 2012 AAOS UCLA/Orthopaedic Hospital Alumni Reception. I have put together this alumni bulletin with great pride in 2012. We have an outstanding group of faculty, researchers, and residents and their achievements deserve to be recognized and collected each year. It is my intention for this bulletin to serve as a template for a Departmental Annual Report in the future and to formalize and strengthen the UCLA Alumni Association.

Having graduated from UCLA Orthopaedic Surgery residency in 2006, I am honored to be among such a distinguished and accomplished group of alumni. Moving forward my goal is to engage alumni and connect peers. The UCLA Alumni Association should serve as a network for career opportunities, referrals, collaboration, and collegiality. Lastly, as some of my best friends were made in residency training at UCLA, a strong Alumni Association should foster these friendships and lifetime connections made during training. Please enjoy yourself at the reception tonight and help me strengthen the UCLA Alumni network by updating your contact information and donating to the residency or fellowship program and/or Alumni Association: Update your contact information at: www.ortho.ucla.edu/alumni. Donate at: http://ortho.ucla.edu/body.cfm?id=70. Thank you, Seth C. Gamradt, MD Assistant Professor Orthopaedic Surgery and Sports Medicine UCLA Orthopaedic Surgery Class of 2006 sgamradt@mednet.ucla.edu