10
Total Synthesis of (+)-6-epi-Ophiobolin A DOI: 10.1002/anie.201913150.

Total Synthesis of (+)-6-epi-Ophiobolin Afshan.ciac.jl.cn/wp-content/uploads/sites/14/2020/01/... · 2020. 1. 7. · methylene blue DCM -78 oc €3:1 dr) AcO TBSO" H Me Me 26 Me Me

  • Upload
    others

  • View
    1

  • Download
    0

Embed Size (px)

Citation preview

Page 1: Total Synthesis of (+)-6-epi-Ophiobolin Afshan.ciac.jl.cn/wp-content/uploads/sites/14/2020/01/... · 2020. 1. 7. · methylene blue DCM -78 oc €3:1 dr) AcO TBSO" H Me Me 26 Me Me

Total Synthesis of (+)-6-epi-Ophiobolin A

DOI: 10.1002/anie.201913150.

Page 2: Total Synthesis of (+)-6-epi-Ophiobolin Afshan.ciac.jl.cn/wp-content/uploads/sites/14/2020/01/... · 2020. 1. 7. · methylene blue DCM -78 oc €3:1 dr) AcO TBSO" H Me Me 26 Me Me
Page 3: Total Synthesis of (+)-6-epi-Ophiobolin Afshan.ciac.jl.cn/wp-content/uploads/sites/14/2020/01/... · 2020. 1. 7. · methylene blue DCM -78 oc €3:1 dr) AcO TBSO" H Me Me 26 Me Me

Stereochemical considerations in past and present routes to

ophiobolin members.

Page 4: Total Synthesis of (+)-6-epi-Ophiobolin Afshan.ciac.jl.cn/wp-content/uploads/sites/14/2020/01/... · 2020. 1. 7. · methylene blue DCM -78 oc €3:1 dr) AcO TBSO" H Me Me 26 Me Me

Retrosynthetic analysis of the (+)-6-epi-Ophiobolin A

Page 5: Total Synthesis of (+)-6-epi-Ophiobolin Afshan.ciac.jl.cn/wp-content/uploads/sites/14/2020/01/... · 2020. 1. 7. · methylene blue DCM -78 oc €3:1 dr) AcO TBSO" H Me Me 26 Me Me
Page 6: Total Synthesis of (+)-6-epi-Ophiobolin Afshan.ciac.jl.cn/wp-content/uploads/sites/14/2020/01/... · 2020. 1. 7. · methylene blue DCM -78 oc €3:1 dr) AcO TBSO" H Me Me 26 Me Me
Page 7: Total Synthesis of (+)-6-epi-Ophiobolin Afshan.ciac.jl.cn/wp-content/uploads/sites/14/2020/01/... · 2020. 1. 7. · methylene blue DCM -78 oc €3:1 dr) AcO TBSO" H Me Me 26 Me Me
Page 8: Total Synthesis of (+)-6-epi-Ophiobolin Afshan.ciac.jl.cn/wp-content/uploads/sites/14/2020/01/... · 2020. 1. 7. · methylene blue DCM -78 oc €3:1 dr) AcO TBSO" H Me Me 26 Me Me
Page 9: Total Synthesis of (+)-6-epi-Ophiobolin Afshan.ciac.jl.cn/wp-content/uploads/sites/14/2020/01/... · 2020. 1. 7. · methylene blue DCM -78 oc €3:1 dr) AcO TBSO" H Me Me 26 Me Me
Page 10: Total Synthesis of (+)-6-epi-Ophiobolin Afshan.ciac.jl.cn/wp-content/uploads/sites/14/2020/01/... · 2020. 1. 7. · methylene blue DCM -78 oc €3:1 dr) AcO TBSO" H Me Me 26 Me Me

谢谢