The World of Healthcare is ChangingBringing the POWER of Genomics to Physicians

The genetic revolution has already begun. We are moving from a generalization healthcare system that is based on population averages to a world of personalized healthcare and the foundation of personalized healthcare will be your patient’s genome sequence. We want to help you evolve your clinicwith cutting-edge capabilities

Who we are!

At Egeria, we know that physicians and experts find themselves lost and overwhelmed as they simultaneously manage their clinic/business operations and attempt to stay on top of advances in research and technology. Egeria Healthcare was created to assist healthcare professionals with cutting-edge technology to realize the potential of Genetic Testing (Nex-Gen Sequencing) giving them the power to individualize treatment in healthcare planning

Our mission is to partner with Providers to bring awareness, education, and deliver a range of accredited high-complex Nex-Gen clinical services for direct use in their practice. Knowing is power, and the more information available on each patient, the more targeted healthcare plan and treatment choices will be. Nex Gen Sequencing is a new tool for clinical practice and you can rely on Egeria for fast and easy integration.

With over 25 years of strategic healthcare management experience, Egeria has developed a genetic testing integration roadmap that is designed for quick and easy implementation

Our Partners

• Crestar is a clinical reference laboratory that is certified by the Center for Medicare and Medicaid Services (CMS), as required by the Clinical Laboratory Improvement Amendment (CLIA) and accredited through the College of American Pathologists (CAP).

• Our Partner, Coriell Life Sciences offers a novel approach to genomic testing. Test once, store securely, and access expert interpretations when needed. Coriell Life Sciences core product –GeneDose – seamlessly integrates genomic medicine into clinical care while managing the breadth of information that is obtained through genomic sequencing.

• ATGC is the very best to deliver counseling services to our patients. Board certified genetic counselors are available to assist patients and providers in determining test appropriateness and interpreting test results.

Our Focus• Hereditary Cancer (CGX): Research has shown that up to 10% of

cancers are due to factors that are passed from one generation to the next. These syndromes are known as hereditary cancers and there are genetic tests that can be used to determine an individual’s risk for developing these cancers. If you suspect that a patient or someone you know may be at risk for cancer—such as a family history of cancer or membership in at risk ethnic population (such as people with Ashkenazi Jewish ancestry)—you may want to talk to your healthcare professional about genetic testing.

• Pharmacogentics (PGX): is the study of how genes affect a person’s response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person’s genetic makeup. Many drugs currently available are “one size fits all,” but they don’t work the same way for everyone. It can be difficult to predict who will benefit from a medication, who will not respond at all, and who will experience negative side effects (called adverse drug reactions).

• Adverse Drug Reactions are a significant cause of hospitalizations and deaths in the United States. With the knowledge gained from the Human Genome Project, researchers and clinicians are learning how inherited differences in genes affect the body’s response to medications. These genetic differences are being used to predict whether a medication will be effective for a particular person and to help prevent adverse drug reactions.

What is Hereditary Cancer?

Some people are born with a gene mutation that they inherited from their mother or father. This damaged gene puts them at higher risk for cancer than most people. When cancer occurs because of an inherited gene mutation, it is referred to as hereditary cancer.

In recent years, scientists have discovered a number of mutations that can contribute to a person's risk of developing certain cancers, including:

• Breast cancer • Pancreatic cancer

• Ovarian cancer • Gastric cancer

• Colon or rectal cancer • Prostate cancer

• Uterine cancer • melanoma

as well as some other, less common cancer types.

Type Prevalence Affected New Cases in 2017 Estimated Death in 2017

Breast Most common cancer in women 1 in 8 or 12.5% 231,840-women2,350-men

40,610

Ovarian 5th most common cancer in women 1 in 71 or 1.4% 21,290 14,180

Colorectal 3rd leading cause of death due to cancer 1 in 20 or 5% 135,430 50,260

Prostate 2nd most common cancer in men 1 in 7 or 14% 161,360 23,730

Melanoma 6th most common cancer in women5th most common cancer in men

1.44 in women or 2.2%1 in 28 in men or 3.5%

87,11052,170-men35,940-women

9,730

What every Healthcare

Professional should know about

Hereditary Cancer.

It’s a BIG PROBLEM !

For Early Detection, Risk & Possible Prevention

• BENEFITS of KNOWING YOUR RISK

• IMPROVED PREVENTION

• DETECTION EARLIER THAN EVER BEFORE POSSIBLE

• LESS DRASTIC TREATMENT

• PRESERVE YOUR QUALITY OF LIFE

• KNOWLEDGE IS POWER

Hereditary Cancer Genetic Testing is a non-abrasive check swab that can be used to determine an individual’s risk for developing these cancers. If you suspect that a patient or someone you know may be at risk for cancer—such as a family history of cancer or membership in at risk ethnic population (such as people with Ashkenazi Jewish ancestry)—you may want to talk to your healthcare professional about genetic testing.

Hereditary Cancer Screening

4 Easy Steps

Pharmacogentics (PGX)

Pharmacogenetics (PGx) is the study of how genes affect a person’s response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person’s genetic makeup. Many drugs currently available are “one size fits all,” but they don’t work the same way for everyone.

For the first time, PGx allows healthcare providers to look inside a patient – at their DNA – to gain insight as to how they will process and respond to medications, taking the much of the guesswork out of prescribing medications and improving patient outcomes.

Adverse Drug ReactionsIt’s a BIG PROBLEM

HERE’S THE SOLUTION...GENEDOSE™ IS A MEDICATION RISK MANAGEMENT TOOL—

EMPOWERING PHYSICIANS THROUGH SIMPLIFIED GENOMICSWith this simple non-invasive test, practitioners are provided with a report indicatingwhich drugs will work, which will be dangerous, and in many cases, what dosage will

be most appropriate— all on an individual, specific patient basis.

FOR PHYSICIANS AND HEALTHCARE PROVIDERS

GeneDose™ Genetic Response Report and GeneDose™ LIVE provides easy to understand recommendations to use directly while making medical decisions—concise and understandable without a need for a genetics background.

GeneDose™ helps tune medication regimens. GeneDose™ simplifies the complex issue of personalized medication management for drugs that are affected by genetic variations.

ADVANTAGES OF GENEDOSETM

• Displays drug-specific guidance and interpretation.

• Reports medications, listed by drug class, with icons that call attention to the severity of the interpretation.

• Delivers across existing, easy-to-use computer systems.

• Reimbursable by most insurance providers.

• Decrease the risk of unanticipated Adverse Drug Reactions.

• Reduce repeat visits for dosing and drug side effects.

• Increase patient compliance.

• GeneDose™ LIVE – multivariable advisory tool that takes into account genetics, demographics, lifestyles, and medical conditions.

InsuranceCrestar Laboratories has agreements with many of the top payors throughout the United States, including CIGNA, UnitedHealthcare, Humana and Medicare/Medicaid, providing clients and their patients with a superior level of access to testing services.

All services will be billed in the name of Crestar Laboratories, LLC.

MEDICATION LIST

• Allopurinol• Amitriptyline• Azathioprine• Capecitabine• Carbamazepine• Clopidogrel• Codeine• Desipramine• Doxepin• Fluorouracil• Imipramine• Ivacaftor

The U.S. Food and Drug Administration lists more than 165 drugs which have pharmacogenomic information in at least one section of their package labeling. Of these, depending on the source (publisher) and focus (number of prescriptions versus sales) 15 to 20 of the drugs are in the top 200, with some falling in the top 10. Below are some examples of drugs (top 200 and beyond) that have PGx information that can be related to Drug response:

• Mercaptopurine• Nortriptyline• Peginterferon alfa–2a• Peginterferon alfa–2b• Phenytoin• Rasburicase• Simvastatin• Tacrolimus• Tegafur• Telaprevir• Thioguanine• Trimipramine

A Genetic Journey for Providers and their Patients Medical genetic testing is a new tool for clinic practice, and we want to help your practice evolve with cutting-edge technologies. We understand that many physicians and experts find themselves lost and overwhelmed as they simultaneously manage their clinic/business operations and attempt to stay on top of advances in research and technology.

Our implementation roadmap begins with our Hereditary Cancer Screening and Pharmacogentics training program where we provide the education, training, materials and support needed for any healthcare provider to effectively integrate CGX and PGX testing into their clinic model. As part of our partnership, Egeria Healthcare will provide on-going support to physicians, nurse practitioners, physician assistants and other healthcare professionals to help them navigate the changing landscape of delivery surrounding Genetic Testing.