The Tuskegee Syphilis Study: How Compromised Health ... My project is on the Tuskegee Syphilis Study

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    The Tuskegee Syphilis Study: How 

    Compromised Health Created an Ethical 





    Kathleen Grube 

    Senior Division 

    Individual Exhibit 

    Exhibit contains 499 words 

    Process Paper contains 500 words 


  • My project is on the Tuskegee Syphilis Study and the ethical conflict it created after 40 

    years of compromised health. I heard about this topic last year when I saw a project on the 

    Tuskegee Airmen, and my mom asked if I had ever heard about the Tuskegee Syphilis Study. I 

    decided to investigate, and I thought it would make an excellent topic for my project.   


    I started my project by focusing on how the Public Health Service (PHS) maintained the 

    deception for 40 years. After talking with some History Day staff, I was advised to focus my 

    project on how participants’ compromised health created an ethical conflict when the study 

    was revealed in 1972. I interviewed Susan Reverby, an expert on the study. She answered 

    some questions and referred me to excellent sources. I also interviewed medical professional 

    Kari Wilhelmi, who is familiar with how Tuskegee Study affects medicine today. The book “Bad 

    Blood” by James H. Jones was my most useful source. It went through the study’s 

    developments and brought voice to multiple perspectives involved in the study. National 

    Archives had many letters between PHS officials, and political cartoons after the revelation 

    were useful in illustrating the study, making it clear the public was not going to accept their 

    government conducting studies on their citizens.   


    This project has inspired me to research twisted stories in history where you wonder 

    “How could this ​happen​?”. History Day has helped me to become a better writer, while doing a 

    board has taught me to be concise and organized. The colors on my board represent the color 

    of the men's skin and blood.   



    In 1929, the United States Public Health Service (PHS) began studying and exploring 

    treatment for syphilitic men in Tuskegee, Alabama. Altering their approach in 1932, PHS 

    compromised subjects’ health, shifting their focus from treating syphilis to observing its 

  • effects. Revealed in 1972, the study sparked a conflict around medical ethics, leading to new 

    medical standards.   

    After the Great Depression put halt to the initial 1929 syphilis treatment study, curiosity 

    about race and untreated syphilis drove PHS officer Taliaferro Clark to design a new study in 

    1932. Intending to study participants’ autopsies, PHS deceived Tuskegee men into believing 

    they were being treated in order to garner participation. Treatment was never part of this 

    study. For 40 years, participants’ health was​ compromised​ and treatment was withheld even 

    when penicillin became the accepted cure for syphilis. Only in 1972 did Peter Buxtun, a PHS 

    investigator, blow the whistle that ended the study. This caused a​ conflict ​in the medical 

    community and public about what medical ethics are. Senator Edward Kennedy held a hearing 

    to gain testimonies from multiple perspectives involved in the study, and made suggestions for 

    guidelines to protect future human subjects from compromised health. His suggestions 

    resulted in 1974 legislation that require informed consent from all participants in a study, and 

    created a panel to review and enforce medical protocol, ensuring a “Tuskegee” never happens 





  • Primary Sources   



    Clark, Taliaferro. “Outline of the Study.” Received by Dr. M.M. Davis, ​Rediscovering Black   History: Records of the African-American Experience​, The National Archives, 29 Oct.  1932. 

    This is a letter from Senior PHS officer, Taliaferro Clark to Dr. M. M. Davis of the Julius 

    Rosenwald Fund. In this letter, Clark outlines the experiment and mentions what he 

    hopes to achieve in his time frame of at least six months. Clark hopes to discover how 

    untreated syphilis affects the “human economy among people now living and engaged 

    in their daily pursuits.” Clark states that he picked this group of syphilitic men because 

    they have not previously received treatment. In five bullet points, Clark outlines the 

    experiment from getting volunteers, to health examinations, to physical exams that 

    include X-Rays and spinal taps. Clark states that he is confident that the results of this 

    experiment will “attract worldwide attention.” This letter was really useful in my build 

    up when I was trying to figure out Clark’s motives and intentions behind the 



    Duval, Merlin K, and Assistant Secretary of Health. “Memorandum Terminating the Tuskegee  

    Syphilis Study.” Received by Director Center for Disease Control, 16 Nov. 1972. 

    This letter was written shortly after the Ad Hoc Panel came out with their findings on 

    the ethicality and the amount of justification of the Tuskegee Experiment. Part of what 

    the Panel was deciding on was whether the experiment should continue or be 

    terminated. This letter was written to the director of the CDC demanding the study 

    must be terminated. Not only that, but all the participants must receive all the 

    appropriate medical care as a part of the “close-out” phase of the project. This letter 

    was used in my impact when I talk about the termination of the study and the decisions 

    of the Panel. This was really helpful to understand that the men were supposed to 

    immediately receive medical attention and care.   


    Wenger, O. C. “Wenger to Clark .” Received by Taliaferro Clark, 9 Jan. 1933. 

    This is a letter from the PHS surgeon O. C. Wenger to Senior PHS officer, Taliaferro 

    Clark. In this letter, Wenger reports on the treatment centers in Macon County, 

    Alabama from November 1, 1932 to December 31, 1932. Wenger calls attention to the 

    number of cases of Syphilis uncovered, versus the percentage of subjects that return for 

    their examination. It is stated that some didn’t return because they live too far away 

    from the clinic, or because of bad weather, but are expected to report later. This letter 

    was useful to know what the first blood tests uncovered, and how many people actually 

    came back for their examination. I used this information in my build up when I talk 

    about men testing positive for syphilis and returning for physical examinations.   


  • Newspapers 


    A.B, ​Philadelphia Inquirer,​ Letter to the editor, July 30, 1972.  This was a letter to the editor shortly after the study was revealed to the public. The 

    quote I got from this letter was simple: “If this [study] is true, how in the name of God 

    can we look others in the eye and say: ‘This is a decent country’”. I really liked this 

    quote and learned a lot from this as it is simple but powerful. In such a proud, patriotic 

    country, how can we live with pride with the knowledge that our own government 

    compromised the health of so many innocent men without their consent? I think a lot 

    of people like this author had to rethink their morals and values after this study was 

    revealed and this was an excellent source to get a feel for what people in this country 

    were thinking through after the study became public knowledge.   


    Afro-American, ​August 12, 1972.    This was an influential Black Newspaper at the time the study was revealed. In here 

    were many quotes from people responding to the revelation of the study. Many were 

    furious as there was yet another unethical study using only Black subjects who could 

    not do anything about it. I got a quote from here that talked about how condescending 

    and void the claims are that race had nothing to do with the study, when all of the 

    participants were Black. This person feels like federal officials think they can do 

    anything where Black people are concerned. This was really helpful to hear this 

    perspective. I used this in my impact when I talk about the outcry after the study was 



    "AIDE QUESTIONED SYPHILIS STUDY."​ New York Times (1923-Current file)​, Aug 09, 1972, pp.  43​. ProQuest.  

    This newspaper was written a few months after the revelation of the study. I learned a 

    bit about whistleblower Peter Buxtun’s history with the study. I learned that he tried to 

    blow the whistle earlier in 1966, but was told nothing could be done for the participants 

    in Tuskegee. I learned that the decision to not treat participants was done because of 

    their age. PHS believed they were, to an extent, doing the men a service by 

    withholding treatment. Penicillin has some awful side effects and the participants’ 

    syphilis was believed to be dormant. Treatment was believed to do more harm than 

    good, according to an Aide. This information was usef