Pharma/Cosmetics1

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Technologyof

Wet Grinding

Pharma and Cosmetics

25.- 28.October 2003

Hans Brogli

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Definition Grinding, Wet Grinding Characterisation

Modula Grinding Aggregates

Annular Gap Mill CoBall-Mill

Applications

Summary

ContentsContents

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We differentiate between:

Wet Grinding

GrindingGrinding

Dry Grinding

Grinding

Dispersing

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Grinding

Crushing of solid matters, crystals or fibres in small parts in a fluid, e.g. active substances, colour pigments

Wet GrindingWet Grinding

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destroying of agglomerates, wetting and homogeneous dispersing in a fluid, e.g. toothpaste, lipstick

Wet GrindingWet Grinding

merging of two not mixable fluids (oil, water) under the effect of shear forces, turbulences and an emulsifier e.g. ointments, body cream

Dispersing

Emulsifying

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FKFKFKFKCharacterisationCharacterisation

Effect of mechanical forces Different products are milled on our mills by

impact, pressure, shear forces, cutting or friction

Resistability - hard-elastic, fibrous fruit flesh, coconut flesh,

aloe vera plants

- hardness of crystalline parts up to mohs hardness 9.5

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Continuous Mills

Perforated Disc Mills

Toothed Colloid Mill

Corundum Stone Mill

In-Line Homogenizer

Annular Gap Mill CoBall-Mill

Wet GrindingWet Grinding

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““Modula“Modula“

The new dimension

ModulaModula

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Mills M/ML, M/MZ, M/MKOpen Execution, Outlet open Feeding with hopper Feeding with hopper and feeding screw Feeding with pump

Grinding AggregatesGrinding Aggregates

In-line ExecutionClosed Execution, Outlet pipeline Inlet connected to a tank Feeding with pump

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FKFKFKFKPerforated Disc MillPerforated Disc Mill

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FKFKFKFKPerforated Disc Mill M/MLPerforated Disc Mill M/ML

Crushing, Pre-grinding

Size up to 100 mm Fineness approx 1 mm

The desired fineness is adjusted by the size of the holes in the perforated discs

Hole dia. 1.5 to 20 mm or slotted discs

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FKFKFKFKToothed Colloid Mill M/MZToothed Colloid Mill M/MZ

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FKFKFKFKToothed Colloid Mill M/MZToothed Colloid Mill M/MZ

Fine Grinding Starting size depending on

product up to 5mm Fineness approx 100 µ

The desired fineness is adjustable with Toothing, coarse, normal, crosswise Grinding gap infinitely adjustable

(gap between rotor and stator)

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FKFKFKFKCorundum Stone Mill M/MKCorundum Stone Mill M/MK

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Finest Grinding Fineness 30 - 50 µ

Corundum Stone MillCorundum Stone Mill

The desired fineness is adjustable with Different graining of grinding discs

grain 20 to 120 Grinding gap infinitely adjustable

(gap between rotor- and stator disc)

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FKFKFKFKModulaModula

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FKFKFKFKModulaModula

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FKFKFKFKModula - RangeModula - Range

TypeToothed Colloid

Mill

Tool Diameter

[mm]

Drive Capacity

[kW]

Throughput [kg/h]

M/MZ-80 80 5.5 100 - 1000

M/MZ-130 130 15 500 - 5000

M/MZ-150 150 22 1000 - 10000

M/MZ-190 190 45 2000 - 20000

M/MZ-250 250 75 3000 - 40000

TypeCorundum Stone

Mill

Tool Diameter

[mm]

Drive Capacity

[kW]

Throughput [kg/h]

M/MK-95 95 5.5 20 - 200

M/MK-160 160 11 60 - 800

M/MK-180 180 11 150 - 1500

M/MK-250 250 22 300 - 3000

M/MK-300 300 45 400 - 4000

TypePerforated Disc

Mill

Tool Diameter

[mm]

Drive Capacity

[kW]

Throughput [kg/h]

M/ML-150 150 5.5 200 - 2000

M/ML-180 180 15 1000 - 10000

M/ML-250 250 22 2000 - 25000

M/ML-330 300 45 4000 - 50000

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Dispersing, crushing of agglomerates

Emulsifying

Exchangeable rotor-, stator elements, different toothing

Modula M/DILModula M/DIL

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FKFKFKFKModula M/DILModula M/DIL

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FKFKFKFKM/DIL - RangeM/DIL - Range

TypeDisHo-Inline

Tool Diameter[mm]

Drive Capacity[kW]

Throughputbased on: Water [l/h]

M/DIL-100 100 7,5 7000

M/DIL-160 160 22 40000

M/DIL-180 180 45 60000

M/DIL-230 200 110 85000

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FKFKFKFKAnnular Gap CoBall MillAnnular Gap CoBall Mill

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product inlet

coolingmedium

product outlet

coolingmediumoutlet

beads outlet

Processing CoBall MillProcessing CoBall Mill

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Finest grinding down to the Nano range < 0.5 µAdjusting Possibilities Rotor speed Diameter of grinding beads and grinding gap (rotor).

Material of grinding beads (spec. weight)

CoBall MillCoBall Mill

Degree of beads filling Capacity Product temperature

Product viscosity (contents of dry substances)

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FKFKFKFKCoBall MillCoBall Mill

MS-12MS-12

MS-50MS-50

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FKFKFKFKCoBall MillCoBall Mill

Advantages

Narrow grinding gap (four times beads diameter) high energy density narrow grain spectrum

Optimum cooling, all surfaces rotor, stator, lid coolable

Smooth grinding elements resistant to wear, no pins, naps etc.

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FKFKFKFKCoBall MillCoBall Mill

Products from fluid to very viscous can be processed

Cleaning, sterilizing and drying without emptying of grinding beads

Small grinding chamber volume

- Little remnants at product change

- Quick cleaning, little consumption of cleaning material

- Easy and efficient change of products

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FKFKFKFKCoBall Mill - RangeCoBall Mill - Range

Typ MS-12 MS-18 MS-32 MS-50

Rotor diameter

(mm)120 180 320 500

RotorDriving

capacity (kw)

2,2- 3 5,5- 11 18,5- 30 37- 55

Throughput(l/h)

10- 40 30- 80 60- 300 200- 1000

Net weight(kg) (approx.)

160 400 800 1750

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FKFKFKFKApplicationsApplications

Pharmasuspensions, ointments, veterinary products, eye drops, tablet coating, active-substances, clotrimazole, betametasone, etc.

Cosmeticscreams, emulsions, lipstick, nail polish, mascara, eye shadow, titandioxyde, animal skins, shrimp shells, plants, roots, aloe vera etc.

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All mill types are constructed according to GMP guidelines

All mills can be equipped with CIP, SIP and DIP Delivery with all qualification documents, possibility

of validation All lubricants with USDA-H1 admission For clean rooms all mills can be delivered with water

cooled motors (no turbulences) Products with a viscosity from fluid to highly viscous

can be processed Due to the new modular construction all mills are easy

to handle and quickly convertable

SummarySummary