SUPPORTING INFORMATION

 

for

 

Regulation of gene expression by the BLM helicase

correlates with the presence of G4 motifs

 

 

Giang Huong Nguyen1,2, Weiliang Tang3, Ana I. Robles1, Richard P. Beyer4, Lucas T. Gray5, Judith A.

Welsh1, Aaron J. Schetter1, Kensuke Kumamoto1,6, Xin Wei Wang1, Ian D. Hickson2,7, Nancy Maizels5,

Raymond J. Monnat, Jr.3,8 and Curtis C. Harris1

 

 

 

1Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health,

Bethesda, Maryland, U.S.A; 2Department of Medical Oncology, Weatherall Institute of Molecular

Medicine, John Radcliffe Hospital, University of Oxford, Oxford, U.K.; 3Department of Pathology,

University of Washington, Seattle, WA U.S.A.; 4 Center for Ecogenetics and Environmental Health,

University of Washington, Seattle, WA U.S.A.; 5Department of Immunology and Department of

Biochemistry, University of Washington, Seattle, WA U.S.A.; 6Department of Organ Regulatory Surgery,

Fukushima Medical University, Fukushima, Japan; 7Cellular and Molecular Medicine, Nordea Center for

Healthy Aging, University of Copenhagen, Denmark; 8Department of Genome Sciences, University of

WA, Seattle, WA U.S.A.

 

 

 

SI Index: Supporting Information for this manuscript includes the following 19 items. A more detailed

Materials and Methods section is followed by 18 Tables and Figures in order of their appearance in the

manuscript text:

 

 

1) SI Materials and Methods  

2) Figure S1. Study design and experimental workflow.  

3) Figure S2. Immunoblot verification of BLM depletion from human fibroblasts.  

4) Figure S3. PCA of mRNA and miRNA expression in BLM-depleted human fibroblasts.  

5) Figure S4. qPCR confirmation of mRNA array data.  

6) Table S1. BS patient and control detail.  

7) Table S2A. Significantly differentially expressed mRNAs identified in BS compared with matched

control human fibroblasts.

8) Table S2B. Significantly differentially expressed mRNAs identified in BLM-depleted compared with

isogenic, nonspecific shRNA-treated control human 82-6 fibroblasts.

9) Table S2C. Common significantly differentially expressed mRNAs in BS and BLM-depleted cells.  

10) Table S3. Gene Set Enrichment Analysis (GSEA) detail.  

11) Table S4. Significantly differentially expressed miRNAs identified in BS or BLM-depleted

fibroblasts.

12) Table S5. Experimentally validated targets of miRNAs significantly altered in BS or BLM-depleted

cells.

13) Figure S5. qPCR confirmation of miRNA array data.  

14) Figure S6. G4 motif frequencies and enrichment near transcription start sites and intron 1

boundaries of genes with altered expression in BLM-depleted cells.

15) Table S6. Hypergeometric test of miRNA targeting vs. significantly altered mRNA

expression

16) Table S6a. Selected target genes differentially expressed in BS and BLM depleted cells

17) Table S7A. Differentially Expressed Genes in BS patient vs NM cells that have at least one

G4 motif in each region

18) Table S7B. Differentially Expressed Genes in BLM-depleted vs NS-treated that have at least one  

G4 motif in each region  

19) Table S8. G4 statistics for genes significantly altered in BS and BLM-depleted cells.  

 

 

1. SI Materials and Methods:  

 

 

 

Cells and cell culture conditions. We analyzed mRNA and miRNA expression in primary

fibroblast strains from BS patients and from matched primary human skin fibroblasts from healthy

individuals (NM), as well as in primary human fibroblasts depleted for BLM protein by expression of a

BLM-specific shRNA. Primary human skin fibroblast strains from BS patients (n=16, donor median age

11.5 years) or from control donors (n=15, donor median age 19 years) were obtained from the Coriell

Cell Repositories (Camden, NJ, USA). Normal control fibroblasts (NM) were age and gender-matched

to BS cases. Additional detail on these BS patient and NM fibroblasts is given in Table S1. Cells were

cultured in Eagle's Minimum Essential Medium with Earle's salts, supplemented with 15% fetal bovine

serum, non-essential amino acids, penicillin/streptomycin and 2mM L-glutamine (all supplied by

Invitrogen, Carlsbad, CA, USA). All cells were cultured at 37°C in a humidified 5% CO2 incubator.

Passage number was calculated based on the number of passages at purchase plus the number of

passages performed prior to cell harvesting. The human primary fibroblast strain 82-6 was initiated from

a foreskin fibroblast preparation as previously described (1), and grown in Dulbecco-modified Eagle

medium (Mediatech, Manassas, VA, USA) supplemented with 10% fetal bovine serum (HyClone,

Logan, UT, USA), 100 U/mL penicillin, and 100 µg/mL streptomycin at 37oC in a humidified 5% CO2

 

incubator.  

 

 

 

BLM depletion experiments. BLM protein was depleted from 82-6 primary human fibroblasts by

lentiviral transduction with expression of a BLM-specific shRNA as previously described (2, 3). In brief,

a BLM-specific shRNA (BLM-3: 5’-GTACTAAATGGCAATTTAA-3’) was cloned into the lentiviral vector

pLKO.1 under control of the human U6 promoter (4). Depletions were performed by transducing 106

primary fibroblasts cells with a BLM-shRNA-expressing lentivirus at a multiplicity of infection (MOI) of

10 for 2 d, followed by puromycin selection (2.0 µg/mL) for 8 d. BLM protein depletion to ≥90% was

verified on day 10 by Western blot analysis, where day 0 was the start of viral transduction (2)(Figure

S2). Depletions were performed in triplicate, using either the BLM-specific shRNA or a scrambled

shRNA with no known target sequence in the human genome (plasmid 1864, Addgene, Cambridge,

MA), to provide controls for comparison with untransduced cells.

 

 

 

RNA isolation and quality control. RNA was isolated from human diploid 82-6 primary fibroblast

cultures when 75% confluent. Cells were washed in 1X PBS, scrapped off plates and collected as

pellets that were stored at -80ºC. Total RNA was isolated using TRIZOL reagent, following the

manufacturer’s protocol (Invitrogen). Total RNA samples were isolated using Qiagen’s miRNAeasy Mini

Kit (Qiagen, Valencia, CA). RNA quality was assessed using the Agilent 2100 Bioanalyzer (Agilent

Technologies, Palo Alto, CA), and only samples of high quality, defined by distinct 28S and 18S rRNA

bands together with a RIN (RNA integrity number) >7, were used for further analyses.

 

 

 

mRNA expression profiling. Whole genome transcript exon profiling of BS and NM fibroblasts

obtained from the Coriell collection of human primary fibroblasts, and of BLM-depleted 82-6 primary

human fibroblasts were performed using the Affymetrix GeneChip Human Exon 1.0 ST Array, which

contains four probes/exon and ~40 probes/gene (Affymetrix, Santa Clara, CA). RNA labeling,

hybridization, washing, and image acquisition were performed at the Laboratory of Molecular

Technology (NCI-Frederick) using a standard Affymetrix labeling, hybridization and wash protocol.

 

 

 

miRNA expression profiling. Profiling of miRNA expression in BS and NM primary fibroblasts was

performed using a custom miRNA microarray chip (OSU-CCC version 4.0) that includes 898 probes to

human and 704 probes to mouse mature or precursor miRNAs, spotted in duplicate (5). Briefly, total

RNA (5µg) was converted to biotin-labeled complementary DNA, hybridized onto the chips, and

processed by direct detection of the biotin-containing transcripts by streptavidin-Alexa 647 conjugate.

Slides were subsequently scanned with the Axon 4000B Scanner (Molecular Device) and spot

intensities were quantified with Genepix (version Pro 6.0.1.00). Profiling of miRNA expression in BLM-

depleted primary human fibroblasts was performed using the Nanostring nCounter Human miRNA

Expression Assay Kit (Nanostring, Seattle, WA). For these analyses we used 100 ng RNA and the

processing protocol recommended by the manufacturer.

In order to confirm miRNA expression differences we used qPCR. RNA samples were reverse-

transcribed using an Applied Biosystems High-Capacity cDNA Archive Kit (Applied Biosystems/AB,

Foster City, CA) prior to assay in triplicate using miRNA-specific Taqman Gene Expression Assays

(ABI). Double-stranded cDNA for each sample was amplified for 40 cycles using the TaqMan Universal

PCR Master Mix using the manufacturer’s protocol on the 7500HT Sequence Detection System (ABI).

For quality control, any samples with either an 18S rRNA or RNAU66 cycle value >20, or a gene or

miRNA cycle value >36, were considered to be of poor quality and removed. Alternatively, PCR

reactions were run following a 12-round pre-amplification on a BioMark 48.48 Dynamic Array System

(Fluidigm, South San Francisco, CA). The mRNA or miRNA readings were calculated using the

comparative method (2-ΔCt), where Ct = threshold cycle and ΔCt = (Ct gene (or miRNA) – Ct 18S rRNA

(or RNAU66)).

Identification of differentially expressed mRNAs. Raw Human Exon 1.0 ST microarray

expression data were pre-processed and normalized with Affymetrix® Expression Console™ Software

using RMA normalization (affymetrix.com). From normalized data, genes with significant evidence for

differential expression were identified using the Bioconductor limma package using a linear fixed effects

model with adjustments for age and gender for the primary fibroblast data to calculate the contrast BS-

NM (6, 7). For the BLM-depleted 82-6 normal human fibroblasts, a linear fixed effects model was used

to calculate three contrasts, BLM-control, NS-control, and BLM-NS. The limma methodology calculates

a p-value for each gene using a modified t-test in conjunction with an empirical Bayes method to

moderate the standard errors of the estimated log-fold changes. This method of detecting differentially

expressed genes draws strength across genes for more robust and accurate detection of differentially

expressed genes. Such an adjustment has repeatedly been shown to avoid an excess of false positives

when identifying differentially expressed genes (8). We then used the p-values from limma together

with the Bioconductor package qvalue (9, 10) to estimate the false discovery rate associated with our

list of differentially expressed genes (DEGs). This methodology allows us to address the multiple

testing problem without resorting to an excessively conservative approach that controls the familywise

error, such as a Bonferroni correction. In order to directly compare the genes from the two data sets

instead of probesets, we removed duplicate probesets by choosing the probesets with the maximum

median variance across all the samples (11).

Exploratory analyses and visualizations were also performed for set of results using the Partek

Genomics Suite version 6.6 (Partek Inc, St Louis, MO, USA) with default import para-meters.

Interrogating probes were imported using the Core Meta-Probeset filter (most confident probes) with

adjustment for GC content and RMA background correction, followed by Quantile Normalization and

Median Polish. Gene-level data was obtained by mean summarization of the core transcripts.

 

 

 

Identification of differentially expressed miRNAs. Preprocessing and normalization of OSU-

CCC miRNA microarrays from BS and NM primary fibroblasts were done in R (version 2.6.0). nCounter

RCC files generated from BLM-depleted samples were imported into nSolver (Nanostring), quality

control-verified and normalized to the geometric mean of the top 100 expressed miRNAs. Normalized

probes were imported into Partek Genomics Suite. Further, miRNAs were deemed absent if intensity

<10, and excluded from the analysis if they were not present in at least 40% of samples (in the case of

BS-NM comparison) or at least 2 samples (in the case of BLM-depleted set), leaving 274 and 392

miRNAs, respectively. Differential expression of these miRNAs was then analyzed using ANOVA

adjusted for age and gender for BS-NM samples. Exploratory analyses and visualizations were again

performed using Partek.

 

 

 

Ingenuity pathway analysis. In order to better characterize in vivo roles of differentially-expressed

genes, we used mRNA expression profiling results to perform an Ingenuity Pathway Analysis (IPA

Ingenuity Systems, www.ingenuity.com) Core Analysis using default parameters. The output consisted

of lists of Networks, Diseases, Biological Functions, and Canonical Pathways enriched within a given

sample type and differentially expressed gene list. IPA also identifies potential upstream regulators (i.e.,

which genes affect the expression of other genes), and predicts whether putative regulatory interactions

are activating or repressive based on the magnitude and direction of gene expression changes.

 

 

 

Gene set enrichment analyses. In order to investigate biological categories of genes and

pathways altered in BS and BLM-depleted samples, we performed a Gene Set Enrichment Analysis

(GSEA) on BS primary fibroblast and 82-6 cell strain data using the romer function in the limma

package (7). Romer is a gene set enrichment analysis program for linear models using rotation tests

(ROtation testing using MEan Ranks). Romer considers all genes in an experiment, and allows the

identification of gene sets with strong cross-correlation by boosting the signal-to-noise ratio. This makes

it possible to confidently detect even modest changes in gene expression. We used romer to perform

GSEA using the 15 gene set collections contained in the Molecular Signature Database version 4.0

(12) (http://www.broad.mit.edu/gsea/msigdb /msigdb_index.html).

 

We also determined which genes that were significantly altered in both BS primary fibroblasts and

 

BLM-depleted 82-6 cells were over-represented in statistically significant gene sets. The p-values for

the intersection of the common genes with the gene sets were calculated with the R package’s phyper

function (13), which uses a hypergeometric distribution and sampling without replacement. This is the

same statistical test used to test associations in Gene Ontology analysis (14).

 

 

 

miRNA targets analysis. In order to determine whether differentially expressed miRNAs might be

modulating gene expression in BLM-deficient cells, we used our miRNA expression profiling results to

search miRTarBase (15) (http://mirtarbase.mbc.nctu.edu.tw/), a curated database of miRNA-target

gene interactions that have been experimentally validated. Only targets validated by strong

experimental methods such as reporter assay or immunoblotting were chosen for this analysis. We

searched among the miRNA target gene lists to identify genes that were significantly differentially

expressed in BS and/or BLM-depleted cells. A hypergeometric test was then performed to determine

the significance of the association of a given miRNA with differentially expressed genes as compared

with the expectation from chance alone.

 

 

 

G4 enrichment statistics. In order to determine the frequency of G4 DNA motifs near TSS and in

the first intron of genes in the hg19 human genome, the RefSeq Gene table and FASTA genome

sequence for the hg19 human genome were downloaded from the UCSC Genome Browser Database

(16) G4 motifs were located in the hg19 genome using Quadparser (17) with settings for 4 or more runs

of 3 or more consecutive Gs separated by 1-12 nt loops on either strand of the genome (GC 3 4 1 12)

in DAS format. Quadparser results were converted to BED format using Perl scripts. This resulted in

 

722,264 G4 motif annotations. R scripts were used to select regions near RefSeq TSS (-250bp to TSS,

TSS to +250 bp, and the first 250 bp of the first intron), and to calculate the number of G4 motifs that

overlapped these regions on each strand relative to the direction of gene transcription (template and

non-template) for each gene surveyed in the expression arrays. Genes from expression arrays were

matched to RefSeq regions using mRNA accessions. Of 17,318 expression array genes, 16,745 were

matched to TSS in the RefSeq table (>96%). For the same 17,318 array genes, 15,728 genes were

matched to Intron 1 locations (>90%).

The gene sets used for G4 analysis were those with altered expression (≥1.5-fold up or down-

regulated) in BS patients (BS) compared to matched normal controls (NM), or in BLM-depleted control

primary fibroblasts (BLM) versus the same cells treated with a non-specific shRNA (NS). Genes up- or

down-regulated ≥1.5-fold in the NS samples compared to an untreated control were excluded. For

each set, we calculated the number of genes in each set with 1 or more G4 motif, the average number

of G4 motifs per gene, and the total number of G4s per gene for each gene set in each region (250bp

to TSS, TSS to +250bp, and 5’ end of intron 1) and for G4 motifs on each strand (both, non-template,

and template). We also selected a list of all genes with a G4 motif on either strand among up- or down-

regulated genes (Table S7A and Table S7B).

False discovery rates of G4 motif enrichment were empirically determined for each gene set by

selecting 1000 gene sets each made up of an equal number of regions selected at random from the

RefSeq-based region locations described above. False discovery rates were determined by calculating

the fraction of the 1000 randomly selected sets with a higher or equal value or lower or equal value

compared to the results tabulated among the genes with altered expression. A result of <0.001 means

that the value found in the experimental set was not observed within the range of 1000 random

matching sets. In Figure 3 we present only the FDR statistics for the sum of the G4 motifs over all of the

regions in each set. Statistics for the number of genes with at least one G4 motif, and the average

number of motifs per G4-containing gene and their respective FDRs are available in Supplemental

Table S8.  

In order to generate G4 motif frequency plots we took regions 250 bp up- or downstream of the TSS

and 250 bp up or downstream of the 5’ end of first introns for all genes on the expression arrays. Genes

in the up- or down-regulated gene sets were selected from these region tables using mRNA accessions,

as described above. G4 motif BED files for each strand of the genome (+ and -) and for both strands

together were converted to BEDGraph files with a value of 1 for each position that a G4 motif

overlapped. These BEDGraphs were converted to bigWig format for subsequent analysis using the

UCSC Kent source utility bedGraphToBigWig (18). Perl scripts that utilized the Bio::DB::BigWig library

from BioPerl (19) were used to calculate the frequency of overlap for each G4 motif set, at each

position relative to the TSS or 5’ end of the first intron in each gene set. Frequency plots were

generated using the R package ggplot2 (20)

 

 

 

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Statistics 1:1070129.

12. Subramanian A, et al. (2005) Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences of the United States of America 102(43):15545-15550.

13. Johnson NL, Kotz S, & Kemp AW (1992) Univariate Discrete Distributions (Wiley, New York) 2 Ed.

14. Ashburner M, et al. (2000) Gene Ontology: tool for the unification of biology. Nat Genet

25(1):25-29. 15. Hsu S-D, et al. (2010) miRTarBase: a database curates experimentally validated microRNA–

target interactions. Nucleic Acids Research.

16. Meyer LR, et al. (2013) The UCSC Genome Browser database: extensions and updates 2013.

Nucleic Acids Research 41(D1):D64-D69. 17. Huppert JL & Balasubramanian S (2005) Prevalence of quadruplexes in the human genome.

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18. Kent WJ, Zweig AS, Barber G, Hinrichs AS, & Karolchik D (2010) BigWig and BigBed: enabling

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Research 12(10):1611-1618.

20. Wickham H (2009) ggplot2: Elegant Graphics for Data Analysis (Springer, New York).

BS fibroblasts

BSmatched

NM

BLM-depletedfibroblasts

+ns sh +BLM sh

control +ns sh

RNAprep

expressionarray profile

mRNA: AffymetrixExon 1.0ST

miRNA: OSU array+ Nanostring

DEG calls

FDR <0.05

≥1.5-fold analyses

VennIPAGSEAG4

n = 6 n = 5

qPCRvalidate

B

n = 16 n = 15

FDR < 0.05 (mRNA)

or

FDR < 0.1 (miRNA)

Supplementary Figure S1: Study design and experimental workflow. Messenger RNA and miRNA expression profiling analyses were performed using primary fibroblasts from Bloom syndrome patients (BS) and age-, gender- and passage-matched controls (NM),

and an isogenic pair of control diploid human fibroblasts (strain 82-6) expressing either a BLM-specific (BLM sh) or nonspecific (ns sh) shRNA from a lentiviral expression vector.

Differentially expressed mRNAs and miRNAs were identified on the basis of absolute fold changes in expression of ≥1.5-fold under conditions were the false discovery rate (FDR) was <0.05 for mRNA and <0.1 for miRNA (see Methods for detail). A subset of both mRNA

and miRNA expression changes were verified by quantitative PCR, prior to analyzing expression data using several different strategies (Venn overlap, gene set enrichment

analyses (GSEA), analysis of expression as a function of G4 gene/miRNA content and by Ingenuity Pathway Analyses (IPA).

BLM

NCL

shRNA

NS BLM none

250 kD

130 kD

95 kD

Supplementary Figure S2: Immunoblot verification of BLM depletion from human fibroblasts. Whole cell lysate from BLM-depleted and control 82-6 human diploid fibroblasts were immunoblotted with a human BLM-specific antibody to

detect and quantify BLM protein expression. Controls included cells that were not depleted (none) or depleted with a non-specific, scrambled shRNA (NS). Each set

of 3 lanes are samples from biological triplicate depletion experiments. The nuclear protein nucleolin was used as a loading control across all samples (NCL). Aliquots of the same sets of triplicate samples were used for mRNA/miRNA profiling

analyses.

PC

2 (

15.3

%)

PC1 (25.6%)

PC3

(13.

4%)

PC

2 (

17.3

%)

PC1 (49.0%)

PC3

(9.7

%)

A BmRNA miRNA

BLM CO NS

PCA mapping (75.9%) PCA mapping (54.2%)

Supplementary Figure S3: Principal component analyses (PCA) of (A). mRNA expression and (B). miRNA expression in BLM-depleted (BLM, orange), non-specific shRNA depleted (NS, yellow) and normal control (CO, blue) primary

human fibroblasts (strain 82-6) using average distance and linkage measures. Percentages indicate the portion of expression differences that can be

attributed to specific principal components.

Figure S4: qPCR verification of mRNA expression levels determined by microarray. *Expression ratios are plotted for initial array-based measurements, and fold changes for qPCR confirmatory assays.

Methods: RNA was reverse-transcribed using an Applied Biosystems High-Capacity cDNA Archive Kit (Applied Biosystems/AB, Foster City, CA). Expression levels for individual genes and miRNAs were evaluated in triplicate using Taqman Gene Expression Assays (ABI). Double-stranded cDNA for each sample was amplified for 40 cycles using the TaqMan Universal PCR Master Mix using the manufacturer’s protocol on the 7500HT Sequence Detection System (ABI). For quality control, any samples with either an 18S rRNA or RNAU66 cycle value >20, or a gene or miRNA cycle value >36, were considered to be of poor quality and removed. Alternatively, PCR reactions were run following a 12-round pre-amplification on a BioMark 48.48 Dynamic Array System (Fluidigm, South San Francisco, CA), or a Rotor-Gene RG-3000 PCR machine (Qiagen, Germantown, MD, USA) according to the manufacturer’s instructions. The gene mRNA or miRNA readings were then calculated using the comparative method (2-ΔCt), where Ct = threshold cycle and ΔCt = (Ct gene (or miRNA) – Ct 18S rRNA (or RNAU66)).

Table S1 BS patient and control detail

Coriell repository Genotype Donor phenotype Age Gender No. passage miRNA array mRNA array

(N=16)

GM 01492 homozygous (2281delT of RECQL3) and T>G transversion resulting a transcated p53 protein Bloom syndrome 15 M 18 included included

GM 03498 compound heterozygous (2281delT and 3233delT of RECQL3 gene Bloom syndrome 4 M 15 included included

GM 03402 homozygous (2281delT of RECQL3 gene) Bloom syndrome 30 M 12 included included

GM 05289 homozygous (1544insA of RECQL3 gene) Bloom syndrome 5 F 18 included included

GM 16882 compound heterozygous (3261delT and 2281delT of RECQL3 gene Bloom syndrome 3 F 19 included included

GM 16886 Q700X missen mutation in BLM protein Bloom syndrome 7 M 20 included included

GM 16881 homozyguous (2293delC of RECQL3 gene) Bloom syndrome 31 M 17 included included

GM 02520 compound hererozygous (2293delC and deletion of exon 15 resulting in a frameshift ) Bloom syndrome 10 F 15 included included

GM 02548 compound hererozygous (1544insA and T2328C transition of the RECQL3 gene) Bloom syndrome 6 M 12 included included

GM 00811 homozygous (6-bp del/7-bp insertion at nucleotide 2281 of REQL3 gene) Bloom syndrome 4 M 30 included no

GM 16883 compound heterozygous ([2015A>G] and [IVS5-2A>G] of RECQL3 gene) Bloom syndrome 25 F 13 included included

GM 16859 homozygous (6-bp del/7-bp ins] at nucleotide 2,281 of RECQL3 gene) Bloom syndrome 43 F 10 included included

GM 02932 homozygous (6-bp del/7-bp insertion at nucleotide 2281 of REQL3 gene) Bloom syndrome 28 M 11 included included

GM 02085 homozygous (6-bp del/7-bp insertion at nucleotide 2281 of REQL3 gene) Bloom syndrome 2 F 30 included included

GM 16890 homozygous (Q645X missen mutation of BLM protein) Bloom syndrome 30 F Unknown included no

GM 16891 homozygous (Q645X missen mutation of BLM protein) Bloom syndrome 13 M Unknown included included

(N=15) included

GM 02185 Wildtype Not clinically affected 36 M 13 included no

GM 07532 Wildtype Not clinically affected 16 F 12 included included

GM 00408 Wildtype Not clinically affected 5 M 19 included included

GM 00497 Wildtype Not clinically affected 4 M 19 included included

GM 00499 Wildtype Not clinically affected 8 M 15 included no

GM 00969 Wildtype Not clinically affected 2 F 17 included included

GM 02674 Wildtype Not clinically affected 29 F 14 included included

GM 03377 Wildtype Not clinically affected 19 M 9 included included

GM 01651 Wildtype Not clinically affected 13 F 16 included included

GM 03651 Wildtype Not clinically affected 25 F 13 included no

GM 04260 Wildtype Not clinically affected 60 M 16 included included

GM 08398 Wildtype Not clinically affected 8 M 7 included included

GM 01948 Wildtype Not clinically affected 27 F 6 included included

GM 08402 Wildtype Not clinically affected 32 M 11 no included

GM 00730 Wildtype Not clinically affected 45 F 9 included included

Table S2A. Significantly differentially expressed mRNAs identified in BS compared with matched control human fibroblasts

Probe Set

ID

Gene

SymbolGene Description log2(ER)

unadjusted

P-ValueFDR

3919033 SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 2.59 0.000 0.004

3388807 MMP1 matrix metallopeptidase 1 (interstitial collagenase) 2.24 0.001 0.007

7385515 MALAT1metastasis associated lung adenocarcinoma transcript 1 (non-protein

coding)2.06 0.001 0.009

3770632 SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 1.88 0.001 0.0083151086 HAS2 hyaluronan synthase 2 1.86 0.002 0.0133843662 ZNF587 zinc finger protein 587 1.76 0.000 0.003

2786322 SLC7A11solute carrier family 7, (cationic amino acid transporter, y+ system)

member 111.76 0.001 0.009

3385769 CTSC cathepsin C 1.73 0.000 0.0022857416 IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 1.70 0.000 0.0012646818 ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 1.68 0.000 0.0042423829 ARHGAP29 Rho GTPase activating protein 29 1.68 0.000 0.0022741236 USP53 ubiquitin specific peptidase 53 1.66 0.000 0.0062686023 DCBLD2 discoidin, CUB and LCCL domain containing 2 1.64 0.000 0.0013812074 DSEL dermatan sulfate epimerase-like 1.64 0.000 0.0032991233 AHR aryl hydrocarbon receptor 1.63 0.000 0.0012652027 CLDN11 claudin 11 1.63 0.002 0.0123449068 TMTC1 transmembrane and tetratricopeptide repeat containing 1 1.63 0.000 0.004

3296046 KCNMA1potassium large conductance calcium-activated channel, subfamily

M, alpha member 11.62 0.000 0.001

2816459 F2R coagulation factor II (thrombin) receptor 1.59 0.000 0.0022565902 ANKRD36B ankyrin repeat domain 36B 1.56 0.004 0.0163041122 MGC87042 STEAP family protein MGC87042 1.51 0.003 0.0142720584 SLIT2 slit homolog 2 (Drosophila) 1.49 0.000 0.0022649367 PTX3 pentraxin 3, long 1.48 0.010 0.0273766960 SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1.45 0.000 0.0032733360 FGF5 fibroblast growth factor 5 1.42 0.000 0.0063376556 ATL3 atlastin GTPase 3 1.40 0.001 0.0092815043 TNPO1 transportin 1 1.37 0.000 0.0022514566 SSB Sjogren syndrome antigen B (autoantigen La) 1.34 0.003 0.0152580802 RND3 Rho family GTPase 3 1.33 0.000 0.0032992814 GPNMB glycoprotein (transmembrane) nmb 1.33 0.000 0.0053325503 RCN1 reticulocalbin 1, EF-hand calcium binding domain 1.32 0.005 0.0183020302 CAV1 caveolin 1, caveolae protein, 22kDa 1.29 0.000 0.0033319840 IPO7 importin 7 1.28 0.000 0.003

3059464 SEMA3Asema domain, immunoglobulin domain (Ig), short basic domain,

secreted, (semaphorin) 3A1.28 0.000 0.005

3253438 RPS24 ribosomal protein S24 1.28 0.020 0.0412417174 SERBP1 SERPINE1 mRNA binding protein 1 1.26 0.004 0.017

3890333 TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein

2 gamma)1.26 0.000 0.006

2750594 SC4MOL sterol-C4-methyl oxidase-like 1.26 0.000 0.0053774906 SECTM1 secreted and transmembrane 1 1.26 0.001 0.0093464983 ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.25 0.000 0.0052592268 STAT1 signal transducer and activator of transcription 1, 91kDa 1.25 0.002 0.0113292448 HERC4 hect domain and RLD 4 1.25 0.000 0.0012422722 TGFBR3 transforming growth factor, beta receptor III 1.24 0.011 0.0303759335 GJC1 gap junction protein, gamma 1, 45kDa 1.24 0.000 0.0062809245 ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.23 0.006 0.0222362394 IFI16 interferon, gamma-inducible protein 16 1.23 0.000 0.0063718555 SLFN5 schlafen family member 5 1.23 0.000 0.0053021158 C7ORF58 chromosome 7 open reading frame 58 1.22 0.000 0.0042711644 ATP13A3 ATPase type 13A3 1.22 0.000 0.0052352228 CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 1.22 0.000 0.0032593670 SF3B1 splicing factor 3b, subunit 1, 155kDa 1.21 0.000 0.0032512330 MARCH7 membrane-associated ring finger (C3HC4) 7 1.21 0.000 0.0032473571 RAB10 RAB10, member RAS oncogene family 1.20 0.000 0.0032626167 PXK PX domain containing serine/threonine kinase 1.20 0.000 0.0042434609 CTSK cathepsin K 1.20 0.024 0.0472659577 PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 1.19 0.000 0.0032406064 SFPQ splicing factor proline/glutamine-rich 1.19 0.000 0.0043058944 HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.18 0.009 0.0262879509 YIPF5 Yip1 domain family, member 5 1.18 0.000 0.0033190659 SET SET nuclear oncogene 1.18 0.000 0.0062940551 SSR1 signal sequence receptor, alpha 1.18 0.000 0.002

3472755 TBX3 T-box 3 1.17 0.000 0.0063353876 OR10G9 olfactory receptor, family 10, subfamily G, member 9 1.17 0.001 0.0103807474 C18ORF32 chromosome 18 open reading frame 32 1.17 0.002 0.0102997376 ANLN anillin, actin binding protein 1.17 0.007 0.0222584018 DPP4 dipeptidyl-peptidase 4 1.17 0.006 0.0212976360 PERP PERP, TP53 apoptosis effector 1.16 0.000 0.0022500615 TMEM87B transmembrane protein 87B 1.15 0.000 0.0013729172 CLTC clathrin, heavy chain (Hc) 1.15 0.000 0.0023415046 FLJ33996 hypothetical protein FLJ33996 1.15 0.001 0.0063505319 SACS spastic ataxia of Charlevoix-Saguenay (sacsin) 1.15 0.000 0.0052347096 DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 1.14 0.000 0.005

2601414 SERPINE2serpin peptidase inhibitor, clade E (nexin, plasminogen activator

inhibitor type 1), member 21.14 0.000 0.003

3550392 PAPOLA poly(A) polymerase alpha 1.14 0.000 0.0042571979 SLC35F5 solute carrier family 35, member F5 1.14 0.000 0.0032404819 PTP4A2 protein tyrosine phosphatase type IVA, member 2 1.13 0.001 0.0073715109 WSB1 WD repeat and SOCS box-containing 1 1.13 0.001 0.0082831124 MATR3 matrin 3 1.13 0.000 0.0023564872 GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 1.13 0.001 0.0072583602 RBMS1 RNA binding motif, single stranded interacting protein 1 1.13 0.001 0.007

3058759 SEMA3Csema domain, immunoglobulin domain (Ig), short basic domain,

secreted, (semaphorin) 3C1.12 0.002 0.010

2930753 C6ORF72 chromosome 6 open reading frame 72 1.12 0.001 0.0083462816 PHLDA1 pleckstrin homology-like domain, family A, member 1 1.12 0.000 0.0022911903 PTP4A1 protein tyrosine phosphatase type IVA, member 1 1.12 0.000 0.0032766456 UGDH UDP-glucose 6-dehydrogenase 1.12 0.000 0.0053103187 TERF1 telomeric repeat binding factor (NIMA-interacting) 1 1.11 0.000 0.0033082590 LOC286161 hypothetical protein LOC286161 1.11 0.011 0.0293429312 HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.11 0.001 0.0082714818 CRIPAK cysteine-rich PAK1 inhibitor 1.11 0.003 0.0152945677 C6ORF62 chromosome 6 open reading frame 62 1.11 0.000 0.0043434393 DYNLL1 dynein, light chain, LC8-type 1 1.11 0.004 0.0182911372 BAG2 BCL2-associated athanogene 2 1.11 0.000 0.0013942648 TUG1 taurine upregulated 1 (non-protein coding) 1.11 0.000 0.0063464747 KITLG KIT ligand 1.10 0.000 0.0043344990 PANX1 pannexin 1 1.10 0.000 0.0013061651 BET1 blocked early in transport 1 homolog (S. cerevisiae) 1.10 0.000 0.0043624697 ARPP19 cAMP-regulated phosphoprotein, 19kDa 1.10 0.001 0.0102712632 TFRC transferrin receptor (p90, CD71) 1.10 0.000 0.0042876257 SAR1B SAR1 homolog B (S. cerevisiae) 1.09 0.000 0.0042336271 BTF3L4 basic transcription factor 3-like 4 1.09 0.001 0.0093362934 ZBED5 zinc finger, BED-type containing 5 1.09 0.000 0.0042643157 CDV3 CDV3 homolog (mouse) 1.09 0.000 0.0023764738 SKA2 spindle and kinetochore associated complex subunit 2 1.09 0.002 0.010

2847967 SEMA5A

sema domain, seven thrombospondin repeats (type 1 and type 1-

like), transmembrane domain (TM) and short cytoplasmic domain,

(semaphorin) 5A

1.08 0.002 0.010

2921374 RPF2 ribosome production factor 2 homolog (S. cerevisiae) 1.08 0.008 0.0243301857 TM9SF3 transmembrane 9 superfamily member 3 1.08 0.001 0.0092815791 HEXB hexosaminidase B (beta polypeptide) 1.08 0.000 0.0013174816 ANXA1 annexin A1 1.07 0.000 0.0063103523 LY96 lymphocyte antigen 96 1.07 0.000 0.0022395177 ERRFI1 ERBB receptor feedback inhibitor 1 1.07 0.000 0.0052693081 ZNF148 zinc finger protein 148 1.07 0.000 0.0043002640 EGFR epidermal growth factor receptor 1.07 0.000 0.0012635641 PVRL3 poliovirus receptor-related 3 1.06 0.000 0.0043764103 SRSF1 serine/arginine-rich splicing factor 1 1.06 0.000 0.0042961317 TMEM30A transmembrane protein 30A 1.06 0.000 0.0062838598 CCNG1 cyclin G1 1.06 0.000 0.0023107342 PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 1.06 0.000 0.0053623865 SPPL2A signal peptide peptidase-like 2A 1.06 0.002 0.0102551924 CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.05 0.002 0.0122813060 PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.05 0.000 0.0063087167 TUSC3 tumor suppressor candidate 3 1.05 0.000 0.0022492496 NCRNA00152 non-protein coding RNA 152 1.05 0.012 0.0322559807 MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 1.05 0.000 0.0043610110 NR2F2 nuclear receptor subfamily 2, group F, member 2 1.05 0.001 0.0093012019 CLDN12 claudin 12 1.04 0.000 0.0033971877 EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 1.04 0.000 0.0032369796 TOR1AIP1 torsin A interacting protein 1 1.04 0.000 0.0012522439 BZW1 basic leucine zipper and W2 domains 1 1.04 0.002 0.013

3150455 TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.04 0.002 0.0133771800 SRSF2 serine/arginine-rich splicing factor 2 1.04 0.000 0.0023210808 GNAQ guanine nucleotide binding protein (G protein), q polypeptide 1.04 0.001 0.0073322048 C11ORF58 chromosome 11 open reading frame 58 1.04 0.006 0.0222852333 ZFR zinc finger RNA binding protein 1.04 0.000 0.0022978026 FBXO30 F-box protein 30 1.03 0.000 0.0033938817 BMS1 BMS1 homolog, ribosome assembly protein (yeast) 1.03 0.004 0.0163904226 RBM39 RNA binding motif protein 39 1.03 0.001 0.0072975680 BCLAF1 BCL2-associated transcription factor 1 1.03 0.000 0.0063766893 DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 1.03 0.000 0.0053209623 ZFAND5 zinc finger, AN1-type domain 5 1.03 0.002 0.0133471374 PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 1.03 0.001 0.0072910364 TMEM14A transmembrane protein 14A 1.03 0.000 0.0043256560 MINPP1 multiple inositol-polyphosphate phosphatase 1 1.03 0.000 0.0052367154 BAT2L2 HLA-B associated transcript 2-like 2 1.03 0.000 0.0043012978 GNG11 guanine nucleotide binding protein (G protein), gamma 11 1.03 0.000 0.0043393946 DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 1.03 0.000 0.0052522094 SPATS2L spermatogenesis associated, serine-rich 2-like 1.02 0.000 0.0042677653 C3ORF63 chromosome 3 open reading frame 63 1.02 0.000 0.0052820925 RHOBTB3 Rho-related BTB domain containing 3 1.02 0.001 0.0072649723 MFSD1 major facilitator superfamily domain containing 1 1.02 0.000 0.0043751463 NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 1.02 0.000 0.0063425134 TMTC3 transmembrane and tetratricopeptide repeat containing 3 1.02 0.002 0.011

2707764 DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S.

cerevisiae)1.02 0.000 0.006

3535515 FRMD6 FERM domain containing 6 1.02 0.003 0.0143580179 HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.02 0.004 0.0162590736 NCKAP1 NCK-associated protein 1 1.02 0.000 0.0032806468 IL7R interleukin 7 receptor 1.02 0.002 0.0112518428 SSFA2 sperm specific antigen 2 1.02 0.000 0.0012463864 CEP170 centrosomal protein 170kDa 1.01 0.000 0.0042548699 CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.01 0.015 0.0362732273 SEPT11 septin 11 1.01 0.002 0.0112331822 ZMPSTE24 zinc metallopeptidase (STE24 homolog, S. cerevisiae) 1.01 0.000 0.0032958325 DST dystonin 1.01 0.000 0.0062738664 SGMS2 sphingomyelin synthase 2 1.01 0.000 0.0043764066 VEZF1 vascular endothelial zinc finger 1 1.01 0.000 0.0032378256 SYT14 synaptotagmin XIV 1.01 0.000 0.0062500919 SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.00 0.003 0.0143538470 C14ORF135 chromosome 14 open reading frame 135 1.00 0.001 0.0093074640 LUZP6 leucine zipper protein 6 1.00 0.000 0.0053445908 EPS8 epidermal growth factor receptor pathway substrate 8 1.00 0.000 0.0063185063 UGCG UDP-glucose ceramide glucosyltransferase 1.00 0.002 0.0122812435 ERBB2IP erbb2 interacting protein 1.00 0.000 0.0062325593 CLIC4 chloride intracellular channel 4 1.00 0.004 0.0172971801 MAN1A1 mannosidase, alpha, class 1A, member 1 1.00 0.000 0.0023519309 SPRY2 sprouty homolog 2 (Drosophila) 1.00 0.001 0.007

2879312 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid

receptor)1.00 0.000 0.004

3969855 CA5B carbonic anhydrase VB, mitochondrial 1.00 0.001 0.0073320944 TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 1.00 0.000 0.0052417390 WLS wntless homolog (Drosophila) 0.99 0.019 0.0413298977 GLUD1 glutamate dehydrogenase 1 0.99 0.000 0.0062924898 RNF146 ring finger protein 146 0.99 0.002 0.0112569908 SEPT10 septin 10 0.99 0.000 0.0043988740 PGRMC1 progesterone receptor membrane component 1 0.99 0.000 0.0062550522 ZFP36L2 zinc finger protein 36, C3H type-like 2 0.99 0.000 0.0013105904 CPNE3 copine III 0.99 0.000 0.0032417272 GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.98 0.000 0.0042869880 EFNA5 ephrin-A5 0.98 0.003 0.0153283991 KIF5B kinesin family member 5B 0.98 0.002 0.0113628469 RPS27L ribosomal protein S27-like 0.98 0.017 0.0383364759 PIK3C2A phosphoinositide-3-kinase, class 2, alpha polypeptide 0.98 0.005 0.0193692895 NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 0.98 0.000 0.0032915828 NT5E 5'-nucleotidase, ecto (CD73) 0.98 0.000 0.0032821761 RGMB RGM domain family, member B 0.98 0.000 0.0033143660 MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.97 0.003 0.0153507798 UBL3 ubiquitin-like 3 0.97 0.003 0.0133299585 LIPA lipase A, lysosomal acid, cholesterol esterase 0.97 0.001 0.0073589141 SPRED1 sprouty-related, EVH1 domain containing 1 0.97 0.000 0.0022588066 ATF2 activating transcription factor 2 0.97 0.000 0.005

2844203 CANX calnexin 0.97 0.000 0.0052997097 SEPT7 septin 7 0.97 0.001 0.0083066818 NAMPT nicotinamide phosphoribosyltransferase 0.97 0.004 0.0163024275 MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.96 0.000 0.0032659560 PIGX phosphatidylinositol glycan anchor biosynthesis, class X 0.96 0.001 0.0092815965 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.96 0.000 0.0053218067 MRPL50 mitochondrial ribosomal protein L50 0.96 0.000 0.0062642887 CCRL1 chemokine (C-C motif) receptor-like 1 0.96 0.010 0.0283020273 CAV2 caveolin 2 0.96 0.000 0.0042684187 GBE1 glucan (1,4-alpha-), branching enzyme 1 0.96 0.000 0.0053325680 EIF3M eukaryotic translation initiation factor 3, subunit M 0.95 0.001 0.0063178416 SPIN1 spindlin 1 0.95 0.000 0.0042459173 PRO2012 hypothetical protein PRO2012 0.95 0.004 0.0163626555 ADAM10 ADAM metallopeptidase domain 10 0.95 0.002 0.0112548617 CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.95 0.001 0.010

3623424 COPS2COP9 constitutive photomorphogenic homolog subunit 2

(Arabidopsis)0.95 0.000 0.004

3452323 SLC38A2 solute carrier family 38, member 2 0.95 0.000 0.0063565361 GMFB glia maturation factor, beta 0.95 0.002 0.0102593159 STK17B serine/threonine kinase 17b 0.95 0.000 0.0052649113 TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.95 0.001 0.0082819044 RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.95 0.001 0.0073716579 LRRC37BP1 leucine rich repeat containing 37B pseudogene 1 0.95 0.000 0.0053427098 ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 0.95 0.000 0.0032979056 NUP43 nucleoporin 43kDa 0.94 0.000 0.0062706297 TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.94 0.002 0.010

3886639 YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation

protein, beta polypeptide0.94 0.000 0.005

2423907 F3 coagulation factor III (thromboplastin, tissue factor) 0.94 0.008 0.0252809831 GPX8 glutathione peroxidase 8 (putative) 0.94 0.000 0.0063402315 CD9 CD9 molecule 0.94 0.009 0.0273566304 EXOC5 exocyst complex component 5 0.94 0.000 0.0053252036 PLAU plasminogen activator, urokinase 0.94 0.000 0.0033304624 NT5C2 5'-nucleotidase, cytosolic II 0.94 0.001 0.0093628923 FAM96A family with sequence similarity 96, member A 0.94 0.002 0.0103223872 RAB14 RAB14, member RAS oncogene family 0.94 0.001 0.0072835960 G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.94 0.000 0.0053247818 BICC1 bicaudal C homolog 1 (Drosophila) 0.94 0.001 0.0082866704 ARRDC3 arrestin domain containing 3 0.94 0.001 0.0082774971 ANTXR2 anthrax toxin receptor 2 0.93 0.000 0.0052687739 CD47 CD47 molecule 0.93 0.000 0.0022677356 WNT5A wingless-type MMTV integration site family, member 5A 0.93 0.005 0.0193075531 ZC3HAV1L zinc finger CCCH-type, antiviral 1-like 0.93 0.001 0.0082778856 TSPAN5 tetraspanin 5 0.93 0.000 0.0023130161 GSR glutathione reductase 0.93 0.000 0.0062697792 COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.93 0.000 0.0042791197 PDGFC platelet derived growth factor C 0.93 0.003 0.0143996755 BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.93 0.001 0.0103139882 TRAM1 translocation associated membrane protein 1 0.93 0.000 0.0053463571 PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.93 0.002 0.0132875555 AFF4 AF4/FMR2 family, member 4 0.93 0.000 0.0022520533 OBFC2A oligonucleotide/oligosaccharide-binding fold containing 2A 0.93 0.001 0.0073927480 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.93 0.014 0.0342601648 DOCK10 dedicator of cytokinesis 10 0.93 0.000 0.0032870889 C5ORF13 chromosome 5 open reading frame 13 0.92 0.012 0.0312810458 GPBP1 GC-rich promoter binding protein 1 0.92 0.000 0.0053885464 TOP1 topoisomerase (DNA) I 0.92 0.000 0.0042731831 USO1 USO1 vesicle docking protein homolog (yeast) 0.92 0.000 0.0053363923 COPB1 coatomer protein complex, subunit beta 1 0.92 0.001 0.0082638962 DTX3L deltex 3-like (Drosophila) 0.92 0.009 0.0262349043 SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.92 0.000 0.0023505781 PARP4 poly (ADP-ribose) polymerase family, member 4 0.92 0.000 0.0032332566 PPCS phosphopantothenoylcysteine synthetase 0.92 0.000 0.0022375810 ZC3H11A zinc finger CCCH-type containing 11A 0.92 0.004 0.0172602901 TRIP12 thyroid hormone receptor interactor 12 0.92 0.000 0.0033020444 CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.92 0.000 0.0052696764 MSL2 male-specific lethal 2 homolog (Drosophila) 0.92 0.000 0.0043109191 POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 0.92 0.004 0.0183284302 NRP1 neuropilin 1 0.92 0.000 0.0053429754 KIAA1033 KIAA1033 0.92 0.001 0.0092830861 EGR1 early growth response 1 0.92 0.005 0.018

3146433 COX6C cytochrome c oxidase subunit VIc 0.92 0.008 0.0253388631 TMEM123 transmembrane protein 123 0.91 0.007 0.0222364155 UHMK1 U2AF homology motif (UHM) kinase 1 0.91 0.000 0.0032727226 PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.91 0.000 0.0043618333 MEIS2 Meis homeobox 2 0.91 0.000 0.0053638607 ANPEP alanyl (membrane) aminopeptidase 0.91 0.000 0.0023982811 SH3BGRL SH3 domain binding glutamic acid-rich protein like 0.91 0.003 0.0143430389 C12ORF23 chromosome 12 open reading frame 23 0.91 0.001 0.0073631397 UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.91 0.000 0.0062345929 LRRC8C leucine rich repeat containing 8 family, member C 0.91 0.001 0.0093153428 ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.90 0.000 0.0053300350 IDE insulin-degrading enzyme 0.90 0.001 0.0073763270 MMD monocyte to macrophage differentiation-associated 0.90 0.020 0.0423126191 PSD3 pleckstrin and Sec7 domain containing 3 0.90 0.002 0.0112973376 PTPRK protein tyrosine phosphatase, receptor type, K 0.90 0.000 0.0043212919 ISCA1 iron-sulfur cluster assembly 1 homolog (S. cerevisiae) 0.90 0.005 0.0193352503 ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.90 0.000 0.0043311832 ADAM12 ADAM metallopeptidase domain 12 0.90 0.003 0.0144019849 LAMP2 lysosomal-associated membrane protein 2 0.90 0.000 0.0042588827 NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.90 0.000 0.0053513883 KPNA3 karyopherin alpha 3 (importin alpha 4) 0.90 0.001 0.0092905118 SRSF3 serine/arginine-rich splicing factor 3 0.90 0.001 0.0102958670 RAB23 RAB23, member RAS oncogene family 0.89 0.001 0.0073066751 SYPL1 synaptophysin-like 1 0.89 0.000 0.0032742109 FGF2 fibroblast growth factor 2 (basic) 0.89 0.016 0.0372458082 WDR26 WD repeat domain 26 0.89 0.000 0.0033809826 ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.89 0.001 0.0102361154 SYT11 synaptotagmin XI 0.89 0.001 0.010

2526980 XRCC5X-ray repair complementing defective repair in Chinese hamster cells

5 (double-strand-break rejoining)0.89 0.000 0.003

2821194 CAST calpastatin 0.89 0.000 0.0062518583 DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.89 0.000 0.0062342391 TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) 0.89 0.000 0.0022520429 MYO1B myosin IB 0.89 0.002 0.0113214668 IARS isoleucyl-tRNA synthetase 0.89 0.001 0.0072548402 EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.89 0.007 0.0232648141 MBNL1 muscleblind-like (Drosophila) 0.88 0.000 0.0052915133 TPBG trophoblast glycoprotein 0.88 0.000 0.0012664452 ANKRD28 ankyrin repeat domain 28 0.88 0.001 0.008

3408733 RASSF8Ras association (RalGDS/AF-6) domain family (N-terminal) member

80.88 0.000 0.003

3620590 ZFP106 zinc finger protein 106 homolog (mouse) 0.88 0.000 0.0062536298 SEPT2 septin 2 0.88 0.000 0.0053407824 GOLT1B golgi transport 1B 0.88 0.005 0.0192994342 TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.88 0.001 0.0082401275 HNRNPR heterogeneous nuclear ribonucleoprotein R 0.88 0.000 0.0063760625 CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.88 0.001 0.0073689922 VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.88 0.000 0.0062871821 TMED7 transmembrane emp24 protein transport domain containing 7 0.88 0.000 0.0042390307 OR2L3 olfactory receptor, family 2, subfamily L, member 3 0.88 0.003 0.0152823551 MAN2A1 mannosidase, alpha, class 2A, member 1 0.88 0.000 0.0063446868 LDHB lactate dehydrogenase B 0.88 0.000 0.0053603408 PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.88 0.002 0.0113327906 API5 apoptosis inhibitor 5 0.87 0.001 0.0082997952 STARD3NL STARD3 N-terminal like 0.87 0.000 0.0043608113 IQGAP1 IQ motif containing GTPase activating protein 1 0.87 0.001 0.0082435383 S100A10 S100 calcium binding protein A10 0.87 0.000 0.0043100166 RAB2A RAB2A, member RAS oncogene family 0.87 0.003 0.0132839671 RARS arginyl-tRNA synthetase 0.87 0.000 0.0033220384 LPAR1 lysophosphatidic acid receptor 1 0.87 0.001 0.0072769539 CHIC2 cysteine-rich hydrophobic domain 2 0.87 0.001 0.0092870397 PJA2 praja ring finger 2 0.87 0.001 0.0072588319 KIAA1715 KIAA1715 0.87 0.003 0.0132883609 CLINT1 clathrin interactor 1 0.87 0.000 0.0042429277 CSDE1 cold shock domain containing E1, RNA-binding 0.87 0.001 0.0073510450 LHFP lipoma HMGIC fusion partner 0.86 0.002 0.0132700404 WWTR1 WW domain containing transcription regulator 1 0.86 0.000 0.0022340078 CACHD1 cache domain containing 1 0.86 0.001 0.0083666779 NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.86 0.000 0.0052555490 XPO1 exportin 1 (CRM1 homolog, yeast) 0.86 0.000 0.0053984779 HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 0.86 0.001 0.008

3909354 ADNP activity-dependent neuroprotector homeobox 0.86 0.000 0.004

2328465 KHDRBS1KH domain containing, RNA binding, signal transduction associated

10.86 0.000 0.002

2462511 HEATR1 HEAT repeat containing 1 0.86 0.000 0.0033409006 MED21 mediator complex subunit 21 0.86 0.003 0.0132319340 SLC25A33 solute carrier family 25, member 33 0.86 0.002 0.0102867693 TTC37 tetratricopeptide repeat domain 37 0.86 0.000 0.0063264004 SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.86 0.001 0.0093072435 TMEM209 transmembrane protein 209 0.85 0.000 0.0062366028 DCAF6 DDB1 and CUL4 associated factor 6 0.85 0.001 0.0082913694 CD109 CD109 molecule 0.85 0.003 0.0133099750 SDCBP syndecan binding protein (syntenin) 0.85 0.001 0.006

3768412 SLC16A6solute carrier family 16, member 6 (monocarboxylic acid transporter

7)0.85 0.012 0.032

3602723 RCN2 reticulocalbin 2, EF-hand calcium binding domain 0.85 0.010 0.0272973694 ARHGAP18 Rho GTPase activating protein 18 0.85 0.000 0.0012772968 COX18 COX18 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.85 0.000 0.0053282213 YME1L1 YME1-like 1 (S. cerevisiae) 0.85 0.000 0.0053374746 PATL1 protein associated with topoisomerase II homolog 1 (yeast) 0.85 0.000 0.0052558511 TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.85 0.000 0.0052556529 SERTAD2 SERTA domain containing 2 0.85 0.001 0.0083014904 ZNF655 zinc finger protein 655 0.85 0.000 0.0032779638 PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.85 0.000 0.0043197318 AK3 adenylate kinase 3 0.84 0.001 0.0084004819 DYNLT3 dynein, light chain, Tctex-type 3 0.84 0.003 0.0143189311 PBX3 pre-B-cell leukemia homeobox 3 0.84 0.001 0.0072377427 CD46 CD46 molecule, complement regulatory protein 0.84 0.001 0.0072501697 ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.84 0.004 0.0163529082 PABPN1 poly(A) binding protein, nuclear 1 0.84 0.000 0.0042972310 SERINC1 serine incorporator 1 0.84 0.001 0.0092960955 SLC17A5 solute carrier family 17 (anion/sugar transporter), member 5 0.84 0.001 0.0082374345 CAMSAP1L1 calmodulin regulated spectrin-associated protein 1-like 1 0.84 0.000 0.0053553607 EIF5 eukaryotic translation initiation factor 5 0.84 0.000 0.0063886050 SRSF6 serine/arginine-rich splicing factor 6 0.83 0.001 0.0072766492 C4ORF34 chromosome 4 open reading frame 34 0.83 0.003 0.0153888133 CSE1L CSE1 chromosome segregation 1-like (yeast) 0.83 0.002 0.0102353881 MAN1A2 mannosidase, alpha, class 1A, member 2 0.83 0.000 0.0043134511 SNAI2 snail homolog 2 (Drosophila) 0.83 0.005 0.0192730673 MOBKL1A MOB1, Mps One Binder kinase activator-like 1A (yeast) 0.83 0.001 0.0093508330 HSPH1 heat shock 105kDa/110kDa protein 1 0.83 0.000 0.0043061438 SAMD9 sterile alpha motif domain containing 9 0.83 0.008 0.0252829416 SEC24A SEC24 family, member A (S. cerevisiae) 0.83 0.000 0.0033152220 KIAA0196 KIAA0196 0.83 0.000 0.0032553282 PSME4 proteasome (prosome, macropain) activator subunit 4 0.83 0.000 0.0042879105 SPRY4 sprouty homolog 4 (Drosophila) 0.83 0.000 0.0052657250 LPP LIM domain containing preferred translocation partner in lipoma 0.83 0.000 0.0063306516 SMNDC1 survival motor neuron domain containing 1 0.83 0.000 0.0042809399 FST follistatin 0.83 0.011 0.0302831209 PAIP2 poly(A) binding protein interacting protein 2 0.83 0.000 0.005

2615600 STT3BSTT3, subunit of the oligosaccharyltransferase complex, homolog B

(S. cerevisiae)0.83 0.001 0.009

2766893 APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.82 0.000 0.0063039177 ETV1 ets variant 1 0.82 0.002 0.0122922215 MARCKS myristoylated alanine-rich protein kinase C substrate 0.82 0.003 0.0162636185 SLC35A5 solute carrier family 35, member A5 0.82 0.001 0.0072875929 C5ORF15 chromosome 5 open reading frame 15 0.82 0.000 0.0042683763 ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.82 0.002 0.011

4054117 TAF13TAF13 RNA polymerase II, TATA box binding protein (TBP)-

associated factor, 18kDa0.82 0.023 0.046

3625674 RFX7 regulatory factor X, 7 0.82 0.000 0.0037385547 CCL2 chemokine (C-C motif) ligand 2 0.82 0.022 0.0443136782 NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 0.82 0.000 0.0052515240 CYBRD1 cytochrome b reductase 1 0.82 0.003 0.0152407439 SF3A3 splicing factor 3a, subunit 3, 60kDa 0.82 0.002 0.0113281621 ARHGAP21 Rho GTPase activating protein 21 0.82 0.002 0.0102408855 FOXJ3 forkhead box J3 0.82 0.000 0.0043448975 ERGIC2 ERGIC and golgi 2 0.82 0.001 0.0083346584 BIRC2 baculoviral IAP repeat-containing 2 0.82 0.001 0.0102943808 NUP153 nucleoporin 153kDa 0.82 0.001 0.0083560617 SNX6 sorting nexin 6 0.82 0.014 0.0342726323 SLAIN2 SLAIN motif family, member 2 0.82 0.000 0.005

3659858 TMEM188 transmembrane protein 188 0.82 0.002 0.0133542689 PCNX pecanex homolog (Drosophila) 0.82 0.001 0.0093560673 CFL2 cofilin 2 (muscle) 0.81 0.004 0.0163110317 CTHRC1 collagen triple helix repeat containing 1 0.81 0.010 0.0273351315 UBE4A ubiquitination factor E4A (UFD2 homolog, yeast) 0.81 0.000 0.0052942504 RANBP9 RAN binding protein 9 0.81 0.001 0.008

3961664 ST13suppression of tumorigenicity 13 (colon carcinoma) (Hsp70

interacting protein)0.81 0.000 0.003

3237088 STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.81 0.000 0.0053595096 TCF12 transcription factor 12 0.81 0.001 0.0093043936 FKBP14 FK506 binding protein 14, 22 kDa 0.81 0.000 0.0052412529 NRD1 nardilysin (N-arginine dibasic convertase) 0.81 0.000 0.0042642791 DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.81 0.001 0.0082628682 ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5 0.81 0.001 0.007

3468103 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta

subunits0.81 0.001 0.008

3923426 AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.81 0.001 0.0074018729 IL13RA2 interleukin 13 receptor, alpha 2 0.81 0.024 0.0473809324 TXNL1 thioredoxin-like 1 0.81 0.000 0.0033511031 ELF1 E74-like factor 1 (ets domain transcription factor) 0.81 0.000 0.0042601995 IRS1 insulin receptor substrate 1 0.81 0.000 0.0012968054 SEC63 SEC63 homolog (S. cerevisiae) 0.81 0.001 0.0103061805 SGCE sarcoglycan, epsilon 0.81 0.001 0.0093999395 MID1 midline 1 (Opitz/BBB syndrome) 0.80 0.001 0.0073020343 MET met proto-oncogene (hepatocyte growth factor receptor) 0.80 0.006 0.0203114358 FAM91A1 family with sequence similarity 91, member A1 0.80 0.000 0.0062370991 DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 0.80 0.000 0.0053795733 COLEC12 collectin sub-family member 12 0.80 0.018 0.0402512701 PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.80 0.000 0.0043422269 RAB21 RAB21, member RAS oncogene family 0.80 0.005 0.0192773907 SDAD1 SDA1 domain containing 1 0.80 0.000 0.0062666904 SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.80 0.000 0.0062701927 SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 0.80 0.000 0.0043498502 TM9SF2 transmembrane 9 superfamily member 2 0.80 0.005 0.0183041294 FAM126A family with sequence similarity 126, member A 0.80 0.002 0.0122966636 ASCC3 activating signal cointegrator 1 complex subunit 3 0.80 0.001 0.0072746024 ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 0.80 0.000 0.0063810472 LMAN1 lectin, mannose-binding, 1 0.80 0.002 0.0113013255 PEG10 paternally expressed 10 0.80 0.001 0.0102705748 NCEH1 neutral cholesterol ester hydrolase 1 0.80 0.000 0.0063263555 ADD3 adducin 3 (gamma) 0.80 0.001 0.0083248999 REEP3 receptor accessory protein 3 0.80 0.004 0.017

2591421 TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation

inhibitor)0.80 0.001 0.010

3060051 C7ORF23 chromosome 7 open reading frame 23 0.80 0.001 0.0083728964 PRR11 proline rich 11 0.80 0.008 0.0253541137 EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.80 0.003 0.0153421300 MDM2 Mdm2 p53 binding protein homolog (mouse) 0.80 0.000 0.0062990342 TMEM106B transmembrane protein 106B 0.79 0.000 0.0042636589 ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.79 0.000 0.0022341565 SRSF11 serine/arginine-rich splicing factor 11 0.79 0.001 0.0082651782 SEC62 SEC62 homolog (S. cerevisiae) 0.79 0.000 0.0063765689 MED13 mediator complex subunit 13 0.79 0.001 0.0083405587 GPRC5A G protein-coupled receptor, family C, group 5, member A 0.79 0.013 0.0333913712 YTHDF1 YTH domain family, member 1 0.79 0.000 0.0033801943 ZNF521 zinc finger protein 521 0.79 0.001 0.0083429857 C12ORF75 chromosome 12 open reading frame 75 0.79 0.005 0.0193590388 NUSAP1 nucleolar and spindle associated protein 1 0.79 0.016 0.0363563922 MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.79 0.001 0.010

3017547 MLL5myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog,

Drosophila)0.79 0.000 0.005

3114832 SQLE squalene epoxidase 0.79 0.001 0.010

4021149 SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of

chromatin, subfamily a, member 10.79 0.001 0.007

3033209 INSIG1 insulin induced gene 1 0.79 0.001 0.0072614142 NR1D2 nuclear receptor subfamily 1, group D, member 2 0.79 0.002 0.0132366156 SFT2D2 SFT2 domain containing 2 0.79 0.001 0.0103597476 RAB8B RAB8B, member RAS oncogene family 0.78 0.000 0.0032682436 RYBP RING1 and YY1 binding protein 0.78 0.000 0.0062496727 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.78 0.000 0.0032414998 MYSM1 Myb-like, SWIRM and MPN domains 1 0.78 0.004 0.016

2601021 FARSB phenylalanyl-tRNA synthetase, beta subunit 0.78 0.000 0.0062551786 MCFD2 multiple coagulation factor deficiency 2 0.78 0.000 0.0053061456 SAMD9L sterile alpha motif domain containing 9-like 0.78 0.005 0.0192366132 TIPRL TIP41, TOR signaling pathway regulator-like (S. cerevisiae) 0.78 0.001 0.0073421630 CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.78 0.001 0.0073058156 TMEM60 transmembrane protein 60 0.78 0.002 0.0122970532 HDAC2 histone deacetylase 2 0.78 0.000 0.0053041550 TRA2A transformer 2 alpha homolog (Drosophila) 0.78 0.004 0.0163503119 ZNF828 zinc finger protein 828 0.78 0.000 0.0053731826 PRKCA protein kinase C, alpha 0.78 0.001 0.0093362719 EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.78 0.001 0.0083632492 NPTN neuroplastin 0.78 0.003 0.0153273484 LARP4B La ribonucleoprotein domain family, member 4B 0.78 0.003 0.0143419641 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.78 0.000 0.0052364231 DDR2 discoidin domain receptor tyrosine kinase 2 0.78 0.001 0.0082827388 PRRC1 proline-rich coiled-coil 1 0.77 0.000 0.0062614120 RPL15 ribosomal protein L15 0.77 0.008 0.0243809671 NARS asparaginyl-tRNA synthetase 0.77 0.003 0.0142581430 STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.77 0.000 0.0062336497 ZYG11B zyg-11 homolog B (C. elegans) 0.77 0.001 0.0082555277 USP34 ubiquitin specific peptidase 34 0.77 0.001 0.0072703217 KPNA4 karyopherin alpha 4 (importin alpha 3) 0.77 0.001 0.0073894228 CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.77 0.001 0.0083075566 ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.77 0.000 0.0063717052 NF1 neurofibromin 1 0.77 0.000 0.0063045739 HERPUD2 HERPUD family member 2 0.77 0.000 0.0062728448 POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.77 0.000 0.0053247757 UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.77 0.001 0.0072515369 HAT1 histone acetyltransferase 1 0.77 0.001 0.0083451375 PRICKLE1 prickle homolog 1 (Drosophila) 0.77 0.017 0.0382458289 LBR lamin B receptor 0.77 0.001 0.0082881554 DCTN4 dynactin 4 (p62) 0.77 0.000 0.0042691014 GSK3B glycogen synthase kinase 3 beta 0.77 0.001 0.0073422231 TMEM19 transmembrane protein 19 0.77 0.002 0.0122382360 DEGS1 degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) 0.77 0.002 0.0113804195 SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.77 0.001 0.0102711034 C3ORF59 chromosome 3 open reading frame 59 0.77 0.002 0.0132689208 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.76 0.001 0.0082726483 OCIAD1 OCIA domain containing 1 0.76 0.000 0.0052877171 FAM13B family with sequence similarity 13, member B 0.76 0.000 0.0063097152 MCM4 minichromosome maintenance complex component 4 0.76 0.002 0.0112732942 BMP2K BMP2 inducible kinase 0.76 0.001 0.0073724782 KPNB1 karyopherin (importin) beta 1 0.76 0.001 0.0063136413 IMPAD1 inositol monophosphatase domain containing 1 0.76 0.001 0.0103146012 NIPAL2 NIPA-like domain containing 2 0.76 0.002 0.0122335986 RNF11 ring finger protein 11 0.76 0.004 0.0172482230 ERLEC1 endoplasmic reticulum lectin 1 0.76 0.001 0.0092800906 MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.76 0.000 0.0033042610 SKAP2 src kinase associated phosphoprotein 2 0.76 0.000 0.003

2325251 TCEB3transcription elongation factor B (SIII), polypeptide 3 (110kDa,

elongin A)0.76 0.000 0.003

3137530 ASPH aspartate beta-hydroxylase 0.76 0.001 0.0092648873 GMPS guanine monphosphate synthetase 0.76 0.002 0.0112807359 OSMR oncostatin M receptor 0.76 0.003 0.0153406589 MGST1 microsomal glutathione S-transferase 1 0.75 0.006 0.021

3150663 TAF2TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated

factor, 150kDa0.75 0.000 0.006

2523213 BMPR2bone morphogenetic protein receptor, type II (serine/threonine

kinase)0.75 0.003 0.014

2507495 UBXN4 UBX domain protein 4 0.75 0.000 0.0062782545 CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.75 0.002 0.0112523045 FZD7 frizzled homolog 7 (Drosophila) 0.75 0.000 0.0053303255 ERLIN1 ER lipid raft associated 1 0.75 0.015 0.0352668021 CMTM6 CKLF-like MARVEL transmembrane domain containing 6 0.75 0.000 0.0053536663 MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.75 0.001 0.0092400322 HP1BP3 heterochromatin protein 1, binding protein 3 0.75 0.000 0.0063959203 RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.75 0.000 0.0063693673 CNOT1 CCR4-NOT transcription complex, subunit 1 0.75 0.000 0.0063005956 C7ORF42 chromosome 7 open reading frame 42 0.75 0.000 0.0043918959 MRPS6 mitochondrial ribosomal protein S6 0.75 0.000 0.0053212294 HNRNPK heterogeneous nuclear ribonucleoprotein K 0.75 0.000 0.005

3732885 PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue

specific extinguisher 1)0.75 0.001 0.009

3666732 CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.75 0.002 0.0112902574 LY6G5B lymphocyte antigen 6 complex, locus G5B 0.75 0.000 0.0054011096 EDA2R ectodysplasin A2 receptor 0.75 0.001 0.0072806091 RAI14 retinoic acid induced 14 0.75 0.001 0.0083719702 MRPL45 mitochondrial ribosomal protein L45 0.75 0.000 0.0052669157 EPM2AIP1 EPM2A (laforin) interacting protein 1 0.74 0.001 0.0092822407 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.74 0.000 0.0043662612 RSPRY1 ring finger and SPRY domain containing 1 0.74 0.000 0.0052510884 ARL6IP6 ADP-ribosylation-like factor 6 interacting protein 6 0.74 0.008 0.0252558045 GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.74 0.003 0.0153136178 PLAG1 pleiomorphic adenoma gene 1 0.74 0.005 0.0192329341 ZSCAN20 zinc finger and SCAN domain containing 20 0.74 0.002 0.0103887635 NCOA3 nuclear receptor coactivator 3 0.74 0.003 0.0142616317 PDCD6IP programmed cell death 6 interacting protein 0.74 0.000 0.0063768015 HELZ helicase with zinc finger 0.74 0.001 0.009

2722151 RBPJrecombination signal binding protein for immunoglobulin kappa J

region0.74 0.001 0.009

3874751 PRNP prion protein 0.74 0.002 0.0112456849 RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.74 0.000 0.0043960629 DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.74 0.002 0.0103680610 GSPT1 G1 to S phase transition 1 0.74 0.000 0.0033328069 HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.74 0.002 0.0102969677 REV3L REV3-like, catalytic subunit of DNA polymerase zeta (yeast) 0.74 0.002 0.0113228007 SETX senataxin 0.74 0.002 0.0102601544 CUL3 cullin 3 0.74 0.000 0.0053948898 LOC150381 hypothetical LOC150381 0.74 0.000 0.0023788302 SMAD4 SMAD family member 4 0.74 0.001 0.0092830638 KIF20A kinesin family member 20A 0.74 0.020 0.0422457988 ZNF706 zinc finger protein 706 0.74 0.001 0.0093454331 LIMA1 LIM domain and actin binding 1 0.74 0.010 0.0283490655 CKAP2 cytoskeleton associated protein 2 0.73 0.016 0.0372477203 VIT vitrin 0.73 0.023 0.0462550790 LRPPRC leucine-rich PPR-motif containing 0.73 0.000 0.0053275132 GDI2 GDP dissociation inhibitor 2 0.73 0.001 0.0072457261 DUSP10 dual specificity phosphatase 10 0.73 0.012 0.0323060245 SLC25A40 solute carrier family 25, member 40 0.73 0.007 0.0233581221 AHNAK2 AHNAK nucleoprotein 2 0.73 0.011 0.0293376155 NXF1 nuclear RNA export factor 1 0.73 0.000 0.0023183111 SLC44A1 solute carrier family 44, member 1 0.73 0.003 0.0152544179 SF3B14 splicing factor 3B, 14 kDa subunit 0.73 0.001 0.0072725332 TMEM33 transmembrane protein 33 0.73 0.000 0.0033435853 TMED2 transmembrane emp24 domain trafficking protein 2 0.73 0.004 0.0163682135 C16ORF63 chromosome 16 open reading frame 63 0.73 0.002 0.0123100909 YTHDF3 YTH domain family, member 3 0.73 0.000 0.0063724698 NPEPPS aminopeptidase puromycin sensitive 0.73 0.001 0.0083742756 DERL2 Der1-like domain family, member 2 0.73 0.001 0.0093390180 KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2 0.73 0.003 0.0142840002 CCDC99 coiled-coil domain containing 99 0.72 0.016 0.0363256279 FAM35A family with sequence similarity 35, member A 0.72 0.000 0.0032829542 C5ORF24 chromosome 5 open reading frame 24 0.72 0.003 0.0152825907 PRR16 proline rich 16 0.72 0.001 0.0073653317 RBBP6 retinoblastoma binding protein 6 0.72 0.000 0.0052369557 SOAT1 sterol O-acyltransferase 1 0.72 0.001 0.0083205506 FBXO10 F-box protein 10 0.72 0.001 0.0072646327 C3ORF58 chromosome 3 open reading frame 58 0.72 0.000 0.0032531522 CAB39 calcium binding protein 39 0.72 0.000 0.005

3539070 HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix

transcription factor)0.72 0.019 0.040

3339167 FAM86C family with sequence similarity 86, member C 0.72 0.002 0.0123466826 CDK17 cyclin-dependent kinase 17 0.72 0.000 0.0032685304 PROS1 protein S (alpha) 0.72 0.002 0.0112814756 MAP1B microtubule-associated protein 1B 0.72 0.002 0.0133672830 MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.72 0.002 0.0112584134 FAP fibroblast activation protein, alpha 0.72 0.004 0.0163290785 CCDC6 coiled-coil domain containing 6 0.72 0.001 0.0093145149 TP53INP1 tumor protein p53 inducible nuclear protein 1 0.72 0.009 0.0263017123 PMPCB peptidase (mitochondrial processing) beta 0.72 0.000 0.0054023274 MMGT1 membrane magnesium transporter 1 0.72 0.001 0.0082442134 TMCO1 transmembrane and coiled-coil domains 1 0.72 0.001 0.010

2890148 HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.72 0.002 0.0123395464 ASAM adipocyte-specific adhesion molecule 0.72 0.002 0.0112719361 CPEB2 cytoplasmic polyadenylation element binding protein 2 0.71 0.000 0.0022979679 ZBTB2 zinc finger and BTB domain containing 2 0.71 0.000 0.0033497790 IPO5 importin 5 0.71 0.007 0.0233537747 PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.71 0.005 0.0202935475 QKI quaking homolog, KH domain RNA binding (mouse) 0.71 0.005 0.0182984573 SFT2D1 SFT2 domain containing 1 0.71 0.003 0.0153971329 MBTPS2 membrane-bound transcription factor peptidase, site 2 0.71 0.000 0.0062890413 RNF130 ring finger protein 130 0.71 0.003 0.0143249788 CCAR1 cell division cycle and apoptosis regulator 1 0.71 0.000 0.0042632051 C3ORF38 chromosome 3 open reading frame 38 0.71 0.001 0.0072766588 PDS5A PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) 0.71 0.001 0.0073991698 HPRT1 hypoxanthine phosphoribosyltransferase 1 0.71 0.005 0.0183561952 SEC23A Sec23 homolog A (S. cerevisiae) 0.71 0.006 0.0213402978 DSTNP2 destrin (actin depolymerizing factor) pseudogene 2 0.71 0.007 0.0223653398 TNRC6A trinucleotide repeat containing 6A 0.71 0.000 0.0053387537 MAML2 mastermind-like 2 (Drosophila) 0.71 0.002 0.0122504883 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.71 0.001 0.0102556667 RAB1A RAB1A, member RAS oncogene family 0.71 0.005 0.0193405531 DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 0.71 0.002 0.0123362124 TMEM9B TMEM9 domain family, member B 0.71 0.001 0.0082475209 PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.71 0.000 0.0052531712 PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.71 0.001 0.0082817386 PAPD4 PAP associated domain containing 4 0.71 0.000 0.0052394784 NOL9 nucleolar protein 9 0.71 0.000 0.0042652410 FNDC3B fibronectin type III domain containing 3B 0.71 0.002 0.0123716664 SUZ12P suppressor of zeste 12 homolog pseudogene 0.71 0.013 0.0333489020 RB1 retinoblastoma 1 0.70 0.002 0.0123564210 PYGL phosphorylase, glycogen, liver 0.70 0.026 0.0493661718 LPCAT2 lysophosphatidylcholine acyltransferase 2 0.70 0.012 0.031

2702154 SSR3signal sequence receptor, gamma (translocon-associated protein

gamma)0.70 0.015 0.035

3352904 SC5DLsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S.

cerevisiae)-like0.70 0.003 0.015

2968232 SNX3 sorting nexin 3 0.70 0.003 0.013

2734629 PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95

(Fas)-associated phosphatase)0.70 0.004 0.017

3802129 SS18 synovial sarcoma translocation, chromosome 18 0.70 0.002 0.0113443891 CLEC2B C-type lectin domain family 2, member B 0.70 0.013 0.0332854737 PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.70 0.000 0.0052999485 STK17A serine/threonine kinase 17a 0.70 0.005 0.0183724197 NSF N-ethylmaleimide-sensitive factor 0.70 0.001 0.0082480619 SOCS5 suppressor of cytokine signaling 5 0.70 0.002 0.0112403158 AHDC1 AT hook, DNA binding motif, containing 1 0.70 0.000 0.0032603460 NCL nucleolin 0.70 0.001 0.0083538324 JKAMP JNK1/MAPK8-associated membrane protein 0.70 0.002 0.0113683037 ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.70 0.012 0.0313054165 SBDS Shwachman-Bodian-Diamond syndrome 0.70 0.010 0.0283690193 ITFG1 integrin alpha FG-GAP repeat containing 1 0.70 0.005 0.0193497270 DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.70 0.002 0.0133351531 ARCN1 archain 1 0.70 0.002 0.0112932360 RBM16 RNA binding motif protein 16 0.69 0.000 0.0042329752 ZMYM4 zinc finger, MYM-type 4 0.69 0.001 0.0073535395 TMX1 thioredoxin-related transmembrane protein 1 0.69 0.001 0.0093351359 ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G 0.69 0.020 0.0423901333 CST4 cystatin S 0.69 0.009 0.0263042919 HOXA9 homeobox A9 0.69 0.000 0.0043717635 ZNF207 zinc finger protein 207 0.69 0.001 0.0093180263 HIATL1 hippocampus abundant transcript-like 1 0.69 0.003 0.0142787459 INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.69 0.001 0.0072531779 ARMC9 armadillo repeat containing 9 0.69 0.005 0.020

2989050 RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP

binding protein Rac1)0.69 0.001 0.007

3574207 SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.69 0.003 0.0153806913 SMAD2 SMAD family member 2 0.69 0.001 0.0072434438 MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.69 0.003 0.0152613386 RAB5A RAB5A, member RAS oncogene family 0.69 0.002 0.0113502710 TFDP1 transcription factor Dp-1 0.69 0.002 0.0132964771 MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.69 0.000 0.0053346453 YAP1 Yes-associated protein 1 0.69 0.000 0.005

2542816 PUM2 pumilio homolog 2 (Drosophila) 0.69 0.001 0.0092727793 TMEM165 transmembrane protein 165 0.69 0.001 0.0102774049 SCARB2 scavenger receptor class B, member 2 0.69 0.002 0.0123042421 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.69 0.003 0.0152648378 RAP2B RAP2B, member of RAS oncogene family 0.69 0.000 0.0023129121 CCDC25 coiled-coil domain containing 25 0.69 0.000 0.0053716048 TAOK1 TAO kinase 1 0.69 0.001 0.0082714644 C4ORF42 chromosome 4 open reading frame 42 0.69 0.000 0.0063148582 EIF3E eukaryotic translation initiation factor 3, subunit E 0.69 0.000 0.0052363919 ATF6 activating transcription factor 6 0.68 0.000 0.0053040363 TWIST1 twist homolog 1 (Drosophila) 0.68 0.004 0.0172708922 IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.68 0.001 0.0072416522 JAK1 Janus kinase 1 0.68 0.003 0.0142550959 PREPL prolyl endopeptidase-like 0.68 0.001 0.0083592484 PLDN pallidin homolog (mouse) 0.68 0.000 0.0062822215 PAM peptidylglycine alpha-amidating monooxygenase 0.68 0.008 0.0253952718 UFD1L ubiquitin fusion degradation 1 like (yeast) 0.68 0.003 0.0143003193 CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.68 0.000 0.0053326183 CAPRIN1 cell cycle associated protein 1 0.68 0.002 0.0112876046 PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.68 0.000 0.0062688759 ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.68 0.002 0.0122769947 CLOCK clock homolog (mouse) 0.68 0.000 0.0053775686 USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.68 0.001 0.0072817053 SCAMP1 secretory carrier membrane protein 1 0.68 0.001 0.0102382336 FBXO28 F-box protein 28 0.68 0.000 0.005

2860666 TAF9TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated

factor, 32kDa0.68 0.000 0.004

2863885 LHFPL2 lipoma HMGIC fusion partner-like 2 0.68 0.001 0.0093426215 MRPL42 mitochondrial ribosomal protein L42 0.68 0.005 0.0193680524 ZC3H7A zinc finger CCCH-type containing 7A 0.68 0.001 0.008

3284188 ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29

includes MDF2, MSK12)0.68 0.005 0.019

3740171 CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.68 0.001 0.0092642325 ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.68 0.001 0.0082922972 DCBLD1 discoidin, CUB and LCCL domain containing 1 0.68 0.002 0.0132582562 ACVR1 activin A receptor, type I 0.68 0.001 0.0082842101 SFXN1 sideroflexin 1 0.68 0.001 0.0092647216 HPS3 Hermansky-Pudlak syndrome 3 0.67 0.001 0.0083096545 SGK196 protein kinase-like protein SgK196 0.67 0.002 0.010

3909395 DPM1dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic

subunit0.67 0.004 0.018

3147726 SLC25A32 solute carrier family 25, member 32 0.67 0.001 0.0092452637 NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.67 0.005 0.0183556323 SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.67 0.004 0.0163570454 COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.67 0.009 0.0262823745 SLC25A46 solute carrier family 25, member 46 0.67 0.000 0.0042927506 TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.67 0.001 0.0083755714 MED1 mediator complex subunit 1 0.67 0.001 0.0083149754 EIF3H eukaryotic translation initiation factor 3, subunit H 0.67 0.001 0.0082418929 PIGK phosphatidylinositol glycan anchor biosynthesis, class K 0.67 0.002 0.0123847959 TUBB4Q tubulin, beta 4 // tubulin, beta 4 0.67 0.007 0.0232470654 DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.67 0.001 0.0092423264 TMED5 transmembrane emp24 protein transport domain containing 5 0.67 0.000 0.0043294438 ANXA7 annexin A7 0.67 0.001 0.0073850501 LOC147727 hypothetical LOC147727 0.67 0.009 0.0262496962 IL1R1 interleukin 1 receptor, type I 0.67 0.010 0.0272962767 PGM3 phosphoglucomutase 3 0.67 0.000 0.0062615060 RBMS3 RNA binding motif, single stranded interacting protein 3 0.67 0.004 0.0173533184 SSTR1 somatostatin receptor 1 0.67 0.007 0.0242696252 RYK RYK receptor-like tyrosine kinase 0.67 0.002 0.0112487696 PCYOX1 prenylcysteine oxidase 1 0.67 0.011 0.029

3469319 APPL2adaptor protein, phosphotyrosine interaction, PH domain and leucine

zipper containing 20.67 0.001 0.010

3518169 COMMD6 COMM domain containing 6 0.67 0.024 0.0473998444 HDHD1 haloacid dehalogenase-like hydrolase domain containing 1 0.67 0.004 0.0173400034 WNK1 WNK lysine deficient protein kinase 1 0.67 0.001 0.0083509910 FAM48A family with sequence similarity 48, member A 0.67 0.001 0.0093775842 TYMS thymidylate synthetase 0.66 0.017 0.0383108433 MTDH metadherin 0.66 0.002 0.0102620641 LIMD1 LIM domains containing 1 0.66 0.000 0.0033018535 BCAP29 B-cell receptor-associated protein 29 0.66 0.001 0.008

2768981 SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 0.66 0.014 0.0343225348 PPP6C protein phosphatase 6, catalytic subunit 0.66 0.006 0.0223629103 KIAA0101 KIAA0101 0.66 0.019 0.0402645764 ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.66 0.000 0.0052644155 NCK1 NCK adaptor protein 1 0.66 0.001 0.0073111530 ENY2 enhancer of yellow 2 homolog (Drosophila) 0.66 0.005 0.0194006841 SLC9A7 solute carrier family 9 (sodium/hydrogen exchanger), member 7 0.66 0.003 0.0143074362 CNOT4 CCR4-NOT transcription complex, subunit 4 0.66 0.000 0.0033223928 STOM stomatin 0.66 0.008 0.0243918574 IFNAR1 interferon (alpha, beta and omega) receptor 1 0.66 0.001 0.0073695268 NAE1 NEDD8 activating enzyme E1 subunit 1 0.66 0.000 0.0062960010 LMBRD1 LMBR1 domain containing 1 0.66 0.008 0.0253987996 PLS3 plastin 3 0.66 0.010 0.0282830010 SMAD5 SMAD family member 5 0.66 0.000 0.0043930360 RUNX1 runt-related transcription factor 1 0.66 0.000 0.0063426917 METAP2 methionyl aminopeptidase 2 0.66 0.002 0.0112476219 BIRC6 baculoviral IAP repeat-containing 6 0.66 0.001 0.0072951916 STK38 serine/threonine kinase 38 0.66 0.005 0.0183010082 PHTF2 putative homeodomain transcription factor 2 0.66 0.000 0.0063309215 EIF3A eukaryotic translation initiation factor 3, subunit A 0.66 0.002 0.0113445670 WBP11 WW domain binding protein 11 0.66 0.000 0.0053765299 APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.66 0.000 0.0032380991 IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 0.66 0.000 0.0043252534 SAMD8 sterile alpha motif domain containing 8 0.66 0.001 0.0093147591 AZIN1 antizyme inhibitor 1 0.66 0.001 0.0092813364 SLC30A5 solute carrier family 30 (zinc transporter), member 5 0.66 0.000 0.0062746269 LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.65 0.003 0.0152688882 C3ORF17 chromosome 3 open reading frame 17 0.65 0.000 0.0042455418 PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.65 0.001 0.0082929168 UTRN utrophin 0.65 0.002 0.0123090922 PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.65 0.000 0.0033427767 TMPO thymopoietin 0.65 0.010 0.0273559570 HECTD1 HECT domain containing 1 0.65 0.003 0.0143047660 GLI3 GLI family zinc finger 3 0.65 0.008 0.0253134034 PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.65 0.003 0.0153624607 MYO5A myosin VA (heavy chain 12, myoxin) 0.65 0.000 0.0052974188 MED23 mediator complex subunit 23 0.65 0.000 0.0053591963 EIF3J eukaryotic translation initiation factor 3, subunit J 0.65 0.004 0.0183717395 SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.65 0.001 0.0093460593 TMBIM4 transmembrane BAX inhibitor motif containing 4 0.65 0.001 0.010

2580635 MMADHCmethylmalonic aciduria (cobalamin deficiency) cblD type, with

homocystinuria0.65 0.002 0.013

2412624 RAB3B RAB3B, member RAS oncogene family 0.65 0.017 0.0383087501 ZDHHC2 zinc finger, DHHC-type containing 2 0.65 0.000 0.0013431376 ANKRD13A ankyrin repeat domain 13A 0.65 0.005 0.0183974838 DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.65 0.004 0.0162610336 VHL von Hippel-Lindau tumor suppressor 0.65 0.001 0.0072921296 AMD1 adenosylmethionine decarboxylase 1 0.65 0.005 0.018

2957596 ELOVL5ELOVL family member 5, elongation of long chain fatty acids

(FEN1/Elo2, SUR4/Elo3-like, yeast)0.65 0.003 0.016

2457496 HHIPL2 HHIP-like 2 0.65 0.010 0.0283453218 CCNT1 cyclin T1 0.65 0.002 0.0112371346 RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.65 0.000 0.0043379777 MRGPRF MAS-related GPR, member F 0.65 0.001 0.0082476116 SLC30A6 solute carrier family 30 (zinc transporter), member 6 0.65 0.000 0.006

2709631 MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating

component of Ra-reactive factor)0.65 0.024 0.047

2728189 PAICSphosphoribosylaminoimidazole carboxylase,

phosphoribosylaminoimidazole succinocarboxamide synthetase0.64 0.000 0.004

2355615 SEC22BSEC22 vesicle trafficking protein homolog B (S. cerevisiae)

(gene/pseudogene)0.64 0.002 0.013

2733287 PRDM8 PR domain containing 8 0.64 0.000 0.0022404254 PUM1 pumilio homolog 1 (Drosophila) 0.64 0.000 0.0053598959 SMAD3 SMAD family member 3 0.64 0.002 0.0113518455 FBXL3 F-box and leucine-rich repeat protein 3 0.64 0.004 0.0173497659 RAP2A RAP2A, member of RAS oncogene family 0.64 0.009 0.0263532313 SRP54 signal recognition particle 54kDa 0.64 0.002 0.0113460127 GNS glucosamine (N-acetyl)-6-sulfatase 0.64 0.003 0.0143212143 UBQLN1 ubiquilin 1 0.64 0.001 0.0093958005 C22ORF30 chromosome 22 open reading frame 30 0.64 0.000 0.0033229943 SDCCAG3 serologically defined colon cancer antigen 3 0.64 0.000 0.004

3326635 CD44 CD44 molecule (Indian blood group) 0.64 0.000 0.0033512527 TPT1 tumor protein, translationally-controlled 1 0.64 0.002 0.0123592023 B2M beta-2-microglobulin 0.64 0.005 0.0192389789 SCCPDH saccharopine dehydrogenase (putative) 0.64 0.002 0.0112633773 TFG TRK-fused gene 0.64 0.000 0.0053535922 STYX serine/threonine/tyrosine interacting protein 0.64 0.006 0.0213956290 PITPNB phosphatidylinositol transfer protein, beta 0.64 0.001 0.0093929395 GCFC1 GC-rich sequence DNA-binding factor 1 0.64 0.021 0.0432857131 DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 0.64 0.001 0.0072515276 DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.64 0.004 0.0162752006 SAP30 Sin3A-associated protein, 30kDa 0.64 0.000 0.0023293244 SAR1A SAR1 homolog A (S. cerevisiae) 0.64 0.003 0.0162928392 VTA1 Vps20-associated 1 homolog (S. cerevisiae) 0.64 0.002 0.0112424524 DPYD dihydropyrimidine dehydrogenase 0.63 0.002 0.0133162529 C9ORF150 chromosome 9 open reading frame 150 0.63 0.001 0.0072553576 RTN4 reticulon 4 0.63 0.000 0.0053815165 PTBP1 polypyrimidine tract binding protein 1 0.63 0.000 0.0042421883 GBP1 guanylate binding protein 1, interferon-inducible, 67kDa 0.63 0.024 0.0462772017 YTHDC1 YTH domain containing 1 0.63 0.000 0.0062344542 RPF1 ribosome production factor 1 homolog (S. cerevisiae) 0.63 0.001 0.0092373336 CFH complement factor H 0.63 0.015 0.035

3778601 VAPAVAMP (vesicle-associated membrane protein)-associated protein A,

33kDa0.63 0.000 0.004

3058991 CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.63 0.001 0.0093651955 METTL9 methyltransferase like 9 0.63 0.003 0.0133456630 CBX5 chromobox homolog 5 0.63 0.008 0.0243681956 KIAA0430 KIAA0430 0.63 0.003 0.0143144235 TMEM55A transmembrane protein 55A 0.63 0.000 0.0042573232 TMEM185B transmembrane protein 185B (pseudogene) 0.63 0.000 0.0023974708 USP9X ubiquitin specific peptidase 9, X-linked 0.63 0.008 0.0243429460 TXNRD1 thioredoxin reductase 1 0.63 0.009 0.0263762473 TOB1 transducer of ERBB2, 1 0.63 0.000 0.0063567984 PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.63 0.000 0.0063773426 NPTX1 neuronal pentraxin I 0.63 0.026 0.0492356344 RNF115 ring finger protein 115 0.63 0.006 0.0202866590 LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.63 0.005 0.0183033924 UBE3C ubiquitin protein ligase E3C 0.63 0.000 0.0053954238 MAPK1 mitogen-activated protein kinase 1 0.63 0.001 0.0093597521 APH1B anterior pharynx defective 1 homolog B (C. elegans) 0.63 0.000 0.0042506570 GPR39 G protein-coupled receptor 39 0.63 0.003 0.0152491336 KCMF1 potassium channel modulatory factor 1 0.63 0.002 0.0112496628 C2ORF29 chromosome 2 open reading frame 29 0.63 0.000 0.0052676319 GLT8D1 glycosyltransferase 8 domain containing 1 0.63 0.002 0.0113478457 STX2 syntaxin 2 0.63 0.005 0.0192926969 PDE7B phosphodiesterase 7B 0.63 0.002 0.0112330899 UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast) 0.63 0.001 0.0073697799 AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.63 0.002 0.0112464484 FAM36A family with sequence similarity 36, member A 0.63 0.002 0.0112639129 DIRC2 disrupted in renal carcinoma 2 0.63 0.003 0.0142415084 JUN jun proto-oncogene 0.63 0.000 0.0053917155 USP16 ubiquitin specific peptidase 16 0.63 0.002 0.0122419046 ZZZ3 zinc finger, ZZ-type containing 3 0.62 0.001 0.0082796790 KIAA1430 KIAA1430 0.62 0.002 0.0133110272 FZD6 frizzled homolog 6 (Drosophila) 0.62 0.010 0.0283094778 TACC1 transforming, acidic coiled-coil containing protein 1 0.62 0.002 0.0113359910 NUP98 nucleoporin 98kDa 0.62 0.000 0.0063603199 IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.62 0.008 0.0242653932 MFN1 mitofusin 1 0.62 0.000 0.0052777412 PIGY phosphatidylinositol glycan anchor biosynthesis, class Y 0.62 0.003 0.0143225398 HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.62 0.008 0.0252319252 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.62 0.000 0.0043545525 C14ORF156 chromosome 14 open reading frame 156 0.62 0.015 0.036

3592755 SEMA6Dsema domain, transmembrane domain (TM), and cytoplasmic

domain, (semaphorin) 6D0.62 0.004 0.016

2530599 AGFG1 ArfGAP with FG repeats 1 0.62 0.002 0.0113240340 WAC WW domain containing adaptor with coiled-coil 0.62 0.001 0.0103725779 MYST2 MYST histone acetyltransferase 2 0.62 0.000 0.0063067302 LAMB1 laminin, beta 1 0.62 0.010 0.0282783316 SEC24D SEC24 family, member D (S. cerevisiae) 0.62 0.004 0.0173220977 ROD1 ROD1 regulator of differentiation 1 (S. pombe) 0.62 0.011 0.0292808438 NNT nicotinamide nucleotide transhydrogenase 0.62 0.003 0.014

4019900 CUL4B cullin 4B 0.62 0.004 0.0162784687 ANKRD50 ankyrin repeat domain 50 0.62 0.004 0.0163886512 TTPAL tocopherol (alpha) transfer protein-like 0.62 0.001 0.0082863730 AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.62 0.004 0.0163677795 CREBBP CREB binding protein 0.62 0.000 0.0043636470 BTBD1 BTB (POZ) domain containing 1 0.62 0.000 0.0032680819 SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.62 0.011 0.0303362468 SBF2 SET binding factor 2 0.61 0.006 0.0202925590 TMEM200A transmembrane protein 200A 0.61 0.006 0.0222853768 NUP155 nucleoporin 155kDa 0.61 0.005 0.0193414739 METTL7A methyltransferase like 7A 0.61 0.001 0.0092446198 TOR1AIP2 torsin A interacting protein 2 0.61 0.000 0.0063725392 CALCOCO2 calcium binding and coiled-coil domain 2 0.61 0.000 0.0062609608 SETD5 SET domain containing 5 0.61 0.000 0.0053882854 ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.61 0.001 0.0093332015 OR4D10 olfactory receptor, family 4, subfamily D, member 10 0.61 0.015 0.0353092325 DCTN6 dynactin 6 0.61 0.002 0.0113167220 UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.61 0.000 0.0033542207 SRSF5 serine/arginine-rich splicing factor 5 0.61 0.003 0.0152430370 GDAP2 ganglioside induced differentiation associated protein 2 0.61 0.001 0.0092975287 HBS1L HBS1-like (S. cerevisiae) 0.61 0.001 0.0073792952 SOCS6 suppressor of cytokine signaling 6 0.61 0.002 0.0102951674 SRPK1 SRSF protein kinase 1 0.61 0.000 0.0052484970 EHBP1 EH domain binding protein 1 0.61 0.003 0.0163348852 DLAT dihydrolipoamide S-acetyltransferase 0.61 0.000 0.0043980887 NONO non-POU domain containing, octamer-binding 0.61 0.001 0.0083149528 TRPS1 trichorhinophalangeal syndrome I 0.61 0.007 0.0233474372 PXN paxillin 0.61 0.000 0.0032345196 HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.61 0.000 0.0032577958 DARS aspartyl-tRNA synthetase 0.61 0.000 0.0053043165 HIBADH 3-hydroxyisobutyrate dehydrogenase 0.61 0.018 0.0402608801 EDEM1 ER degradation enhancer, mannosidase alpha-like 1 0.61 0.001 0.0092469910 LPIN1 lipin 1 0.61 0.000 0.0042437417 ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.61 0.003 0.014

2659918 LRCH3leucine-rich repeats and calponin homology (CH) domain containing

30.61 0.001 0.009

3388914 DCUN1D5DCN1, defective in cullin neddylation 1, domain containing 5 (S.

cerevisiae)0.61 0.000 0.003

2485257 UGP2 UDP-glucose pyrophosphorylase 2 0.61 0.005 0.0182805581 SUB1 SUB1 homolog (S. cerevisiae) 0.61 0.004 0.0173304012 MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.61 0.001 0.0092763805 DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 0.61 0.001 0.0083019981 MDFIC MyoD family inhibitor domain containing 0.61 0.001 0.0073623771 TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.61 0.003 0.0132335132 CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.61 0.005 0.0193428131 SCYL2 SCY1-like 2 (S. cerevisiae) 0.61 0.004 0.0163488985 ITM2B integral membrane protein 2B 0.61 0.010 0.0272880932 CSNK1A1 casein kinase 1, alpha 1 0.61 0.000 0.0053720228 CDK12 cyclin-dependent kinase 12 0.61 0.000 0.0053774635 FASN fatty acid synthase 0.60 0.001 0.0083303165 DNMBP dynamin binding protein 0.60 0.000 0.0042382117 CAPN2 calpain 2, (m/II) large subunit 0.60 0.001 0.0072458701 ACBD3 acyl-CoA binding domain containing 3 0.60 0.001 0.0062676041 WDR82 WD repeat domain 82 0.60 0.015 0.0353318009 RRM1 ribonucleotide reductase M1 0.60 0.024 0.0473319937 WEE1 WEE1 homolog (S. pombe) 0.60 0.002 0.0123191589 FUBP3 far upstream element (FUSE) binding protein 3 0.60 0.001 0.0073670668 ATMIN ATM interactor 0.60 0.001 0.0073564919 FERMT2 fermitin family member 2 0.60 0.024 0.0462828856 HSPA4 heat shock 70kDa protein 4 0.60 0.001 0.0093342983 TMEM126B transmembrane protein 126B 0.60 0.001 0.0102962820 ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 0.60 0.005 0.0182364677 PBX1 pre-B-cell leukemia homeobox 1 0.60 0.010 0.0282641263 RAB7A RAB7A, member RAS oncogene family 0.60 0.002 0.0123707352 RNF167 ring finger protein 167 0.60 0.000 0.0033728889 TMEM49 transmembrane protein 49 0.60 0.000 0.0063178545 C9ORF47 chromosome 9 open reading frame 47 0.60 0.002 0.0132916390 ORC3 origin recognition complex, subunit 3 0.60 0.002 0.0113974556 ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.60 0.007 0.0223599495 CORO2B coronin, actin binding protein, 2B 0.60 0.023 0.0452807862 C5ORF51 chromosome 5 open reading frame 51 0.60 0.010 0.027

2894711 TMEM14B transmembrane protein 14B 0.60 0.023 0.0463181302 NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.60 0.001 0.0102859195 DIMT1L DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) 0.60 0.000 0.0033772661 TIMP2 TIMP metallopeptidase inhibitor 2 0.60 0.000 0.0043253683 ZMIZ1 zinc finger, MIZ-type containing 1 0.60 0.000 0.0063732230 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.60 0.006 0.0212574798 MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.60 0.000 0.0052886130 PANK3 pantothenate kinase 3 0.60 0.001 0.008

2427469 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter

5)0.60 0.009 0.026

3499453 TPP2 tripeptidyl peptidase II 0.60 0.000 0.0063125775 CNOT7 CCR4-NOT transcription complex, subunit 7 0.60 0.002 0.0133220513 KIAA0368 KIAA0368 0.60 0.003 0.0143473083 MED13L mediator complex subunit 13-like 0.60 0.005 0.0192407729 RRAGC Ras-related GTP binding C 0.60 0.002 0.012

3134922 PCMTD1protein-L-isoaspartate (D-aspartate) O-methyltransferase domain

containing 10.60 0.025 0.048

2772614 GRSF1 G-rich RNA sequence binding factor 1 0.60 0.000 0.0053494102 UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.60 0.002 0.0133279108 NMT2 N-myristoyltransferase 2 0.60 0.007 0.0232542737 LAPTM4A lysosomal protein transmembrane 4 alpha 0.60 0.000 0.0063552847 DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.60 0.005 0.0192369339 RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.60 0.003 0.0154022781 FAM122B family with sequence similarity 122B 0.60 0.000 0.0032982381 TCP1 t-complex 1 0.60 0.004 0.0162594812 TRAK2 trafficking protein, kinesin binding 2 0.60 0.005 0.0192790570 PLRG1 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) 0.60 0.002 0.0122977265 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.60 0.001 0.0092676219 PBRM1 polybromo 1 0.59 0.002 0.0133026988 LUC7L2 LUC7-like 2 (S. cerevisiae) 0.59 0.001 0.0083929664 TMEM50B transmembrane protein 50B 0.59 0.003 0.0153489212 FNDC3A fibronectin type III domain containing 3A 0.59 0.000 0.0042558150 AAK1 AP2 associated kinase 1 0.59 0.001 0.0072349863 NTNG1 netrin G1 0.59 0.001 0.009

2506903 MGAT5mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-

glucosaminyltransferase0.59 0.005 0.018

2418000 ZRANB2 zinc finger, RAN-binding domain containing 2 0.59 0.000 0.0064012868 RLIM ring finger protein, LIM domain interacting 0.59 0.009 0.0262887633 BOD1 biorientation of chromosomes in cell division 1 0.59 0.001 0.0082468811 ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.59 0.000 0.0032402459 STMN1 stathmin 1 0.59 0.017 0.0383337618 PPP6R3 protein phosphatase 6, regulatory subunit 3 0.59 0.001 0.0083237548 ARL5B ADP-ribosylation factor-like 5B 0.59 0.008 0.0243371719 CKAP5 cytoskeleton associated protein 5 0.59 0.007 0.0223812206 TMX3 thioredoxin-related transmembrane protein 3 0.59 0.002 0.0123591838 CASC4 cancer susceptibility candidate 4 0.59 0.001 0.0073240095 RAB18 RAB18, member RAS oncogene family 0.59 0.020 0.0413431483 ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.59 0.006 0.0203537813 ACTR10 actin-related protein 10 homolog (S. cerevisiae) 0.59 0.005 0.0192712858 UBXN7 UBX domain protein 7 0.59 0.003 0.0153163136 SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 0.59 0.005 0.0182973995 EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.59 0.002 0.0133246372 NCOA4 nuclear receptor coactivator 4 0.59 0.006 0.0203984655 CENPI centromere protein I 0.59 0.009 0.0263467315 IKBIP IKBKB interacting protein 0.59 0.001 0.0073537264 C14ORF101 chromosome 14 open reading frame 101 0.59 0.000 0.0052345617 PKN2 protein kinase N2 0.59 0.002 0.0123565303 CNIH cornichon homolog (Drosophila) 0.59 0.002 0.0112529546 ACSL3 acyl-CoA synthetase long-chain family member 3 0.59 0.001 0.0083414561 DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.59 0.000 0.0042402942 SLC9A1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.59 0.000 0.0022454378 SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.59 0.001 0.0073907234 SDC4 syndecan 4 0.59 0.001 0.0093217736 ERP44 endoplasmic reticulum protein 44 0.59 0.002 0.0113921391 WRB tryptophan rich basic protein 0.59 0.014 0.0333030285 CUL1 cullin 1 0.59 0.000 0.0062930592 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.59 0.003 0.0142403557 SNORA44 small nucleolar RNA, H/ACA box 44 0.59 0.008 0.0243462949 OSBPL8 oxysterol binding protein-like 8 0.59 0.015 0.0353992354 SLC9A6 solute carrier family 9 (sodium/hydrogen exchanger), member 6 0.59 0.000 0.0053506153 MTMR6 myotubularin related protein 6 0.59 0.002 0.013

3716411 CPD carboxypeptidase D 0.59 0.023 0.0452998333 C7ORF36 chromosome 7 open reading frame 36 0.59 0.013 0.032

3781531 CABLES1 Cdk5 and Abl enzyme substrate 1 -0.59 0.011 0.0293337835 IGHMBP2 immunoglobulin mu binding protein 2 -0.59 0.002 0.0103676262 SEPX1 selenoprotein X, 1 -0.59 0.002 0.0112558736 ADD2 adducin 2 (beta) -0.59 0.000 0.0033378210 BRMS1 breast cancer metastasis suppressor 1 -0.59 0.020 0.0423205033 YBX1 Y box binding protein 1 -0.59 0.018 0.0393191074 METTL11A methyltransferase like 11A -0.59 0.001 0.0083947036 MEI1 meiosis inhibitor 1 -0.59 0.001 0.0083376832 BAD BCL2-associated agonist of cell death -0.59 0.001 0.0093540398 FNTB farnesyltransferase, CAAX box, beta -0.59 0.000 0.0033238761 MSRB2 methionine sulfoxide reductase B2 -0.59 0.000 0.0052562271 CAPG capping protein (actin filament), gelsolin-like -0.60 0.021 0.0432492783 THNSL2 threonine synthase-like 2 (S. cerevisiae) -0.60 0.005 0.0193884158 MANBAL mannosidase, beta A, lysosomal-like -0.60 0.000 0.0042451043 LMOD1 leiomodin 1 (smooth muscle) -0.61 0.023 0.0453073981 AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.61 0.014 0.0332450668 TMEM9 transmembrane protein 9 -0.61 0.000 0.0043957679 SELM selenoprotein M -0.61 0.002 0.0113903836 EIF6 eukaryotic translation initiation factor 6 -0.61 0.002 0.0122453881 IRF6 interferon regulatory factor 6 -0.61 0.005 0.0193601511 ISLR immunoglobulin superfamily containing leucine-rich repeat -0.61 0.010 0.0283936951 SEPT5 septin 5 -0.62 0.001 0.0073607183 MRPS11 mitochondrial ribosomal protein S11 -0.62 0.001 0.0072427208 GSTM3 glutathione S-transferase mu 3 (brain) -0.62 0.005 0.0203942838 LIMK2 LIM domain kinase 2 -0.62 0.000 0.0053824874 IFI30 interferon, gamma-inducible protein 30 -0.62 0.013 0.0333714659 DHRS7B dehydrogenase/reductase (SDR family) member 7B -0.62 0.000 0.0042333658 ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -0.63 0.001 0.0093837081 NPAS1 neuronal PAS domain protein 1 -0.63 0.000 0.0063830189 FXYD1 FXYD domain containing ion transport regulator 1 -0.64 0.001 0.0092528774 SLC4A3 solute carrier family 4, anion exchanger, member 3 -0.64 0.000 0.0032545953 FNDC4 fibronectin type III domain containing 4 -0.64 0.009 0.0263923764 LRRC3 leucine rich repeat containing 3 -0.65 0.003 0.0153921933 BACE2 beta-site APP-cleaving enzyme 2 -0.65 0.011 0.0293825823 NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -0.65 0.001 0.0073832292 KCNK6 potassium channel, subfamily K, member 6 -0.65 0.005 0.0202875193 P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.66 0.000 0.0062397025 DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.66 0.016 0.0363953524 SCARF2 scavenger receptor class F, member 2 -0.66 0.000 0.0053750939 SDF2 stromal cell-derived factor 2 -0.66 0.001 0.0102899171 HIST1H1E histone cluster 1, H1e -0.67 0.025 0.0483194613 TMEM141 transmembrane protein 141 -0.67 0.002 0.0123351775 TRAPPC4 trafficking protein particle complex 4 -0.68 0.001 0.0104012154 RPS4X ribosomal protein S4, X-linked -0.68 0.000 0.0043645626 IL32 interleukin 32 -0.68 0.015 0.0352899216 HIST1H4E histone cluster 1, H4e -0.68 0.002 0.0133881045 FAM182A family with sequence similarity 182, member A -0.68 0.002 0.0123064591 FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -0.68 0.003 0.0153771642 CYGB cytoglobin -0.69 0.012 0.0323168255 HRCT1 histidine rich carboxyl terminus 1 -0.69 0.005 0.0203638760 IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.69 0.000 0.0053708160 ALOX12 arachidonate 12-lipoxygenase -0.69 0.001 0.0093416977 ORMDL2 ORM1-like 2 (S. cerevisiae) -0.70 0.000 0.0023982462 PGK1 phosphoglycerate kinase 1 -0.70 0.003 0.0133403077 C12ORF57 chromosome 12 open reading frame 57 -0.70 0.002 0.0123337137 AIP aryl hydrocarbon receptor interacting protein -0.70 0.001 0.0083436329 FAM101A family with sequence similarity 101, member A -0.71 0.001 0.0093336680 RHOD ras homolog gene family, member D -0.71 0.002 0.0123403015 ENO2 enolase 2 (gamma, neuronal) -0.71 0.000 0.0042491676 VAMP5 vesicle-associated membrane protein 5 (myobrevin) -0.71 0.007 0.0222950798 C6ORF125 chromosome 6 open reading frame 125 -0.72 0.000 0.0063907011 ADA adenosine deaminase -0.74 0.004 0.0163455973 SPRYD3 SPRY domain containing 3 -0.74 0.000 0.0023924041 ADARB1 adenosine deaminase, RNA-specific, B1 -0.74 0.001 0.0103883236 MMP24 matrix metallopeptidase 24 (membrane-inserted) -0.75 0.000 0.0033557209 SLC7A8 solute carrier family 7 (amino acid transporter, L-type), member 8 -0.75 0.003 0.0153315217 C10ORF125 chromosome 10 open reading frame 125 -0.75 0.001 0.0072335048 CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 -0.75 0.001 0.009

3415915 PFDN5 prefoldin subunit 5 -0.76 0.000 0.0033355145 ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 -0.76 0.000 0.0022977690 SF3B5 splicing factor 3b, subunit 5, 10kDa -0.76 0.008 0.0242447148 RGS16 regulator of G-protein signaling 16 -0.76 0.003 0.0153853108 NOTCH3 notch 3 -0.76 0.015 0.0352902935 STK19 serine/threonine kinase 19 -0.77 0.000 0.0013863869 PSG8 pregnancy specific beta-1-glycoprotein 8 -0.79 0.011 0.0303164086 ADAMTSL1 ADAMTS-like 1 -0.80 0.005 0.0193694215 CDH8 cadherin 8, type 2 -0.80 0.021 0.0433555736 NDRG2 NDRG family member 2 -0.81 0.000 0.0013855104 CRLF1 cytokine receptor-like factor 1 -0.81 0.011 0.0293527684 RNASE3 ribonuclease, RNase A family, 3 -0.82 0.000 0.0063725714 NXPH3 neurexophilin 3 -0.82 0.000 0.0064007437 SLC38A5 solute carrier family 38, member 5 -0.82 0.006 0.0214007216 UXT ubiquitously-expressed transcript -0.83 0.000 0.0043865635 DMPK dystrophia myotonica-protein kinase -0.83 0.000 0.0032450865 CSRP1 cysteine and glycine-rich protein 1 -0.84 0.001 0.0093707199 PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -0.84 0.001 0.0083986514 PRPS1 phosphoribosyl pyrophosphate synthetase 1 -0.85 0.010 0.0283708074 XAF1 XIAP associated factor 1 -0.86 0.023 0.046

2805635 NPR3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic

peptide receptor C)-0.87 0.024 0.047

3903052 SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic

component)-0.88 0.000 0.003

4022370 GPC4 glypican 4 -0.88 0.002 0.0113513147 HTR2A 5-hydroxytryptamine (serotonin) receptor 2A -0.89 0.004 0.0173719962 PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.91 0.001 0.0093394315 C1QTNF5 C1q and tumor necrosis factor related protein 5 -0.92 0.000 0.0013333622 POLR2G polymerase (RNA) II (DNA directed) polypeptide G -0.94 0.000 0.0022489606 POLE4 polymerase (DNA-directed), epsilon 4 (p12 subunit) -0.94 0.000 0.0053756689 KRTAP1-1 keratin associated protein 1-1 -0.95 0.021 0.0432828787 UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.95 0.000 0.0043671695 WFDC1 WAP four-disulfide core domain 1 -0.95 0.010 0.0283557048 PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -0.96 0.000 0.0042946232 HIST1H1C histone cluster 1, H1c -0.96 0.001 0.0083286776 C10ORF10 chromosome 10 open reading frame 10 -0.97 0.000 0.0032600089 PTPRN protein tyrosine phosphatase, receptor type, N -0.98 0.002 0.0103816509 GADD45B growth arrest and DNA-damage-inducible, beta -0.98 0.000 0.0012383859 GUK1 guanylate kinase 1 -0.99 0.000 0.0042351004 GSTM5 glutathione S-transferase mu 5 -1.00 0.025 0.0482716328 ADRA2C adrenergic, alpha-2C-, receptor -1.01 0.000 0.0063328600 TSPAN18 tetraspanin 18 -1.03 0.019 0.0403169331 ALDH1B1 aldehyde dehydrogenase 1 family, member B1 -1.04 0.000 0.0052328320 TINAGL1 tubulointerstitial nephritis antigen-like 1 -1.04 0.005 0.0193726252 SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -1.06 0.000 0.0043750767 ALDOC aldolase C, fructose-bisphosphate -1.08 0.000 0.0033638819 CIB1 calcium and integrin binding 1 (calmyrin) -1.08 0.000 0.0033417457 MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -1.09 0.000 0.0013638188 HAPLN3 hyaluronan and proteoglycan link protein 3 -1.10 0.010 0.0282451693 FMOD fibromodulin -1.10 0.015 0.0353350830 TAGLN transgelin -1.10 0.001 0.0083756911 KRT34 keratin 34 -1.14 0.013 0.0322475678 LBH limb bud and heart development homolog (mouse) -1.15 0.002 0.0112397898 HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) -1.17 0.007 0.0232401493 ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -1.19 0.005 0.0192764192 SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -1.20 0.000 0.0043667508 CALB2 calbindin 2 -1.20 0.001 0.0083414440 C12ORF62 chromosome 12 open reading frame 62 -1.21 0.000 0.0053630736 ITGA11 integrin, alpha 11 -1.21 0.002 0.0103852381 PODNL1 podocan-like 1 -1.23 0.000 0.0013299970 ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -1.28 0.013 0.0323391149 FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -1.28 0.000 0.0023821263 CNN1 calponin 1, basic, smooth muscle -1.33 0.000 0.0043349858 NNMT nicotinamide N-methyltransferase -1.35 0.000 0.0013617712 GJD2 gap junction protein, delta 2, 36kDa -1.36 0.000 0.0033815097 FSTL3 follistatin-like 3 (secreted glycoprotein) -1.39 0.000 0.0034035833 CD24 CD24 molecule -1.42 0.001 0.0103299504 ACTA2 actin, alpha 2, smooth muscle, aorta -1.46 0.003 0.013

2363618 SDHCsuccinate dehydrogenase complex, subunit C, integral membrane

protein, 15kDa-1.46 0.001 0.007

3944210 RASD2 RASD family, member 2 -1.61 0.004 0.016

3394264 MCAM melanoma cell adhesion molecule -1.69 0.000 0.0023443226 MFAP5 microfibrillar associated protein 5 -2.09 0.001 0.0093855218 COMP cartilage oligomeric matrix protein -2.09 0.000 0.0023607332 ACAN aggrecan -2.90 0.000 0.0043617719 ACTC1 actin, alpha, cardiac muscle 1 -2.95 0.001 0.007

1153 protein coding genes (1012 up and 141 down) were identified as significantly differentially expressed in BS cells using the following cutoff:

absolute expression ratio (ER) ≥ 1.5 and false discovery rate (FDR) < 0.05. Thus significantly differentially expressed genes have log 2 expression

values of ≥|0.59|.

Table S2B. Significantly differentially expressed mRNAs identified in BLM-depleted compared with isogenic, nonspecific

shRNA-treated control human 82-6 fibroblasts

Probe Set

ID

Gene

SymbolGene Description log2(ER)

unadjusted

P-ValueFDR

2931036 ULBP1 UL16 binding protein 1 5.05 3.3E-10 9.8E-08

2731542 AREG amphiregulin 3.95 1.3E-10 7.6E-08

3998766 KAL1 Kallmann syndrome 1 sequence 3.81 1.4E-11 2.2E-08

3768412 SLC16A6 solute carrier family 16, member 6 (monocarboxylic acid transporter 7) 3.66 1.0E-10 7.6E-08

2710599 CLDN1 claudin 1 3.17 1.6E-09 2.1E-07

2642720 ACPP acid phosphatase, prostate 2.88 1.5E-09 2.1E-07

3464276 SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 2.85 5.0E-10 1.3E-07

3849894 OLFM2 olfactomedin 2 2.73 9.1E-11 7.6E-08

3727928 NOG noggin 2.46 7.3E-07 1.3E-05

3927480 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 2.31 6.9E-08 2.5E-06

3801492 ANKRD29 ankyrin repeat domain 29 2.30 4.4E-09 3.8E-07

3401704 CCND2 cyclin D2 2.28 3.0E-09 3.1E-07

3354443 SLC37A2 solute carrier family 37 (glycerol-3-phosphate transporter), member 2 2.26 3.4E-09 3.3E-07

3282974 SVIL supervillin 2.19 8.3E-09 5.8E-07

2648677 MME membrane metallo-endopeptidase 2.15 2.8E-08 1.3E-06

3132782 SFRP1 secreted frizzled-related protein 1 2.13 6.3E-10 1.3E-07

3463112 E2F7 E2F transcription factor 7 2.08 4.2E-09 3.7E-07

3546924 FLRT2 fibronectin leucine rich transmembrane protein 2 2.04 6.8E-08 2.4E-06

3262129 INA internexin neuronal intermediate filament protein, alpha 2.03 4.5E-10 1.2E-07

2786322 SLC7A11solute carrier family 7, (cationic amino acid transporter, y+ system)

member 112.01 3.3E-07 7.4E-06

3285119 FZD8 frizzled homolog 8 (Drosophila) 2.00 8.2E-10 1.5E-07

3058944 HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.99 1.3E-05 1.1E-04

3186491 PAPPA pregnancy-associated plasma protein A, pappalysin 1 1.98 2.4E-08 1.2E-06

2817941 RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 1.98 1.2E-08 7.1E-07

2946383 HIST1H4H histone cluster 1, H4h 1.88 9.2E-06 8.6E-05

2791419 FAM198B family with sequence similarity 198, member B 1.88 8.3E-07 1.5E-05

2571483 IL1A interleukin 1, alpha 1.81 3.5E-06 4.1E-05

3519309 SPRY2 sprouty homolog 2 (Drosophila) 1.81 2.7E-09 2.8E-07

3104489 STMN2 stathmin-like 2 1.81 1.9E-08 1.0E-06

3908358 SULF2 sulfatase 2 1.80 1.4E-10 7.6E-08

3279313 ITGA8 integrin, alpha 8 1.80 1.7E-09 2.2E-07

2818517 VCAN versican 1.79 2.4E-07 5.8E-06

2809245 ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.76 7.5E-09 5.5E-07

3590275 CHAC1 ChaC, cation transport regulator homolog 1 (E. coli) 1.73 2.3E-10 9.7E-08

2930418 UST uronyl-2-sulfotransferase 1.73 1.3E-08 7.8E-07

4004853 SRPX sushi-repeat-containing protein, X-linked 1.73 1.0E-09 1.6E-07

2904485 SCUBE3 signal peptide, CUB domain, EGF-like 3 1.73 1.2E-10 7.6E-08

3790704 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.72 3.5E-08 1.5E-06

2476510 LTBP1 latent transforming growth factor beta binding protein 1 1.70 4.8E-08 1.9E-06

3862873 CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 1.69 6.6E-03 1.5E-02

3356539 NTM neurotrimin 1.68 1.0E-08 6.7E-07

3781531 CABLES1 Cdk5 and Abl enzyme substrate 1 1.67 4.2E-07 8.8E-06

3386217 CHORDC1 cysteine and histidine-rich domain (CHORD)-containing 1 1.66 3.9E-05 2.6E-04

3143660 MMP16 matrix metallopeptidase 16 (membrane-inserted) 1.65 1.2E-08 7.5E-07

2771342 EPHA5 EPH receptor A5 1.64 7.1E-06 7.1E-05

3020192 TES testis derived transcript (3 LIM domains) 1.63 4.4E-08 1.8E-06

2913694 CD109 CD109 molecule 1.61 5.0E-07 9.9E-06

3801943 ZNF521 zinc finger protein 521 1.61 3.9E-08 1.6E-06

2474071 MAPRE3 microtubule-associated protein, RP/EB family, member 3 1.61 4.4E-06 4.9E-05

3819474 ANGPTL4 angiopoietin-like 4 1.59 9.6E-09 6.4E-07

3808745 CCDC68 coiled-coil domain containing 68 1.59 4.9E-07 9.8E-06

3128046 STC1 stanniocalcin 1 1.57 1.1E-07 3.4E-06

3073013 PODXL podocalyxin-like 1.56 1.2E-07 3.7E-06

2956052 TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.54 9.2E-09 6.2E-07

2872047 SEMA6Asema domain, transmembrane domain (TM), and cytoplasmic domain,

(semaphorin) 6A1.53 1.0E-07 3.2E-06

2671787 TMEM158 transmembrane protein 158 (gene/pseudogene) 1.50 4.7E-09 4.0E-07

3162529 C9ORF150 chromosome 9 open reading frame 150 1.49 4.9E-08 1.9E-06

2343823 LPHN2 latrophilin 2 1.48 1.3E-05 1.1E-04

3771642 CYGB cytoglobin 1.47 5.7E-09 4.5E-07

3068097 DOCK4 dedicator of cytokinesis 4 1.46 7.1E-08 2.5E-06

2611056 PPARG peroxisome proliferator-activated receptor gamma 1.45 2.2E-08 1.1E-06

2711610 LRRC15 leucine rich repeat containing 15 1.45 1.2E-08 7.5E-07

2794704 ASB5 ankyrin repeat and SOCS box-containing 5 1.42 1.5E-06 2.3E-05

3039177 ETV1 ets variant 1 1.41 2.4E-08 1.2E-06

3971806 SAT1 spermidine/spermine N1-acetyltransferase 1 1.41 2.4E-08 1.2E-06

4004819 DYNLT3 dynein, light chain, Tctex-type 3 1.40 6.6E-06 6.7E-05

2835792 GM2A GM2 ganglioside activator 1.36 1.5E-09 2.1E-07

2566848 AFF3 AF4/FMR2 family, member 3 1.35 1.5E-07 4.2E-06

2970086 LAMA4 laminin, alpha 4 1.35 3.1E-07 7.1E-06

3732793 ARSG arylsulfatase G 1.35 3.8E-08 1.6E-06

3844470 PPAP2C phosphatidic acid phosphatase type 2C 1.34 1.3E-09 1.9E-07

2925590 TMEM200A transmembrane protein 200A 1.33 3.0E-08 1.3E-06

3075778 HIPK2 homeodomain interacting protein kinase 2 1.32 3.8E-08 1.6E-06

2626167 PXK PX domain containing serine/threonine kinase 1.32 8.7E-08 2.9E-06

2501204 IL1RN interleukin 1 receptor antagonist 1.32 4.6E-07 9.4E-06

3801621 OSBPL1A oxysterol binding protein-like 1A 1.32 1.6E-07 4.4E-06

2327817 PTPRU protein tyrosine phosphatase, receptor type, U 1.31 8.2E-09 5.8E-07

3420316 HMGA2 high mobility group AT-hook 2 1.30 2.3E-08 1.1E-06

3960930 CBX6 chromobox homolog 6 1.29 9.6E-10 1.6E-07

3504226 CRYL1 crystallin, lambda 1 1.29 4.2E-08 1.7E-06

2359377 LCE2A late cornified envelope 2A 1.29 7.1E-06 7.1E-05

2832459 PCDHB14 protocadherin beta 14 1.29 9.1E-06 8.5E-05

3594031 TMOD2 tropomodulin 2 (neuronal) 1.29 3.8E-06 4.4E-05

2731513 EREG epiregulin 1.28 1.0E-06 1.7E-05

2946714 HIST1H2BK histone cluster 1, H2bk 1.27 4.0E-07 8.4E-06

3043936 FKBP14 FK506 binding protein 14, 22 kDa 1.27 6.2E-06 6.4E-05

3151086 HAS2 hyaluronan synthase 2 1.27 5.2E-05 3.3E-04

2915420 PRSS35 protease, serine, 35 1.26 2.5E-06 3.2E-05

3595441 GCOM1 GRINL1A complex locus 1.26 1.6E-06 2.4E-05

3300115 PPP1R3C protein phosphatase 1, regulatory (inhibitor) subunit 3C 1.26 5.0E-08 1.9E-06

3812074 DSEL dermatan sulfate epimerase-like 1.25 6.0E-08 2.2E-06

2890660 GFPT2 glutamine-fructose-6-phosphate transaminase 2 1.25 2.6E-07 6.2E-06

3260985 SFXN3 sideroflexin 3 1.24 5.5E-09 4.5E-07

3160175 VLDLR very low density lipoprotein receptor 1.24 1.6E-07 4.3E-06

3129731 DUSP4 dual specificity phosphatase 4 1.22 4.0E-08 1.7E-06

2671728 CDCP1 CUB domain containing protein 1 1.22 1.5E-06 2.2E-05

3050462 GRB10 growth factor receptor-bound protein 10 1.22 9.0E-08 2.9E-06

3928590 KRTAP21-1 keratin associated protein 21-1 1.22 6.5E-04 2.4E-03

4018729 IL13RA2 interleukin 13 receptor, alpha 2 1.20 1.3E-06 2.0E-05

3399004 OPCML opioid binding protein/cell adhesion molecule-like 1.19 1.6E-07 4.3E-06

3061621 TFPI2 tissue factor pathway inhibitor 2 1.19 3.7E-05 2.6E-04

2385967 SLC35F3 solute carrier family 35, member F3 1.19 1.7E-08 9.3E-07

3936951 SEPT5 septin 5 1.19 2.2E-08 1.1E-06

3374402 LPXN leupaxin 1.19 5.0E-08 1.9E-06

2554018 EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 1.18 9.9E-08 3.1E-06

3638607 ANPEP alanyl (membrane) aminopeptidase 1.18 7.8E-10 1.5E-07

3430086 TCP11L2 t-complex 11 (mouse)-like 2 1.18 1.2E-06 1.9E-05

3095313 C8ORF4 chromosome 8 open reading frame 4 1.18 1.2E-04 6.4E-04

4002173 RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 1.18 3.9E-06 4.4E-05

2356115 TXNIP thioredoxin interacting protein 1.17 4.0E-08 1.7E-06

3882949 DYNLRB1 dynein, light chain, roadblock-type 1 1.16 6.1E-07 1.2E-05

3026216 CHRM2 cholinergic receptor, muscarinic 2 1.15 2.8E-03 7.6E-03

2837029 SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 1.14 4.8E-06 5.2E-05

3786868 SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 1.13 1.1E-05 9.8E-05

3797561 LAMA1 laminin, alpha 1 1.13 2.7E-08 1.3E-06

3288518 C10ORF72 chromosome 10 open reading frame 72 1.13 4.5E-07 9.2E-06

3429566 CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 1.13 1.4E-08 8.2E-07

2991150 TSPAN13 tetraspanin 13 1.12 2.1E-07 5.3E-06

2594089 SATB2 SATB homeobox 2 1.12 6.0E-08 2.2E-06

3321150 ARNTL aryl hydrocarbon receptor nuclear translocator-like 1.12 7.9E-06 7.7E-05

2386747 GPR137B G protein-coupled receptor 137B 1.11 3.9E-07 8.3E-06

2502762 STEAP3 STEAP family member 3 1.11 7.0E-07 1.3E-05

3756750 KRTAP4-12 keratin associated protein 4-12 1.11 1.1E-04 6.0E-04

3843156 ZNF460 zinc finger protein 460 1.11 7.7E-06 7.6E-05

2835300 SLC26A2 solute carrier family 26 (sulfate transporter), member 2 1.11 9.1E-06 8.5E-05

4009288 HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 1.10 5.5E-08 2.0E-06

3178147 CTSL1 cathepsin L1 1.10 3.0E-07 6.9E-06

3942062 NF2 neurofibromin 2 (merlin) 1.10 4.5E-08 1.8E-06

3773241 TBC1D16 TBC1 domain family, member 16 1.10 1.1E-07 3.4E-06

3977299 CLCN5 chloride channel 5 1.10 5.2E-06 5.5E-05

3592755 SEMA6Dsema domain, transmembrane domain (TM), and cytoplasmic domain,

(semaphorin) 6D1.10 1.0E-05 9.2E-05

2351294 KCNC4 potassium voltage-gated channel, Shaw-related subfamily, member 4 1.09 1.5E-07 4.2E-06

3140213 MSC musculin 1.09 8.2E-07 1.4E-05

2775214 PRKG2 protein kinase, cGMP-dependent, type II 1.09 3.0E-07 6.9E-06

2816494 F2RL1 coagulation factor II (thrombin) receptor-like 1 1.08 1.4E-08 8.2E-07

3608398 FURIN furin (paired basic amino acid cleaving enzyme) 1.08 5.1E-09 4.2E-07

3240452 BAMBI BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) 1.07 8.7E-05 4.9E-04

2378068 G0S2 G0/G1switch 2 1.07 2.8E-06 3.5E-05

3075531 ZC3HAV1L zinc finger CCCH-type, antiviral 1-like 1.06 3.9E-06 4.4E-05

3145149 TP53INP1 tumor protein p53 inducible nuclear protein 1 1.06 2.6E-06 3.4E-05

3135567 LYPLA1 lysophospholipase I 1.06 1.2E-03 3.9E-03

3396593 FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 1.06 3.9E-08 1.7E-06

2995254 C7ORF41 chromosome 7 open reading frame 41 1.06 2.0E-06 2.8E-05

3460584 LLPH LLP homolog, long-term synaptic facilitation (Aplysia) 1.06 2.8E-04 1.2E-03

3921933 BACE2 beta-site APP-cleaving enzyme 2 1.06 2.6E-09 2.7E-07

2614120 RPL15 ribosomal protein L15 1.06 5.9E-06 6.2E-05

2740067 ANK2 ankyrin 2, neuronal 1.05 1.6E-07 4.3E-06

3457549 ANKRD52 ankyrin repeat domain 52 1.05 2.4E-06 3.2E-05

3664952 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 1.04 2.9E-07 6.7E-06

2816459 F2R coagulation factor II (thrombin) receptor 1.04 2.3E-08 1.1E-06

3741547 P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5 1.04 2.9E-08 1.3E-06

3630736 ITGA11 integrin, alpha 11 1.04 3.7E-06 4.3E-05

3175971 PSAT1 phosphoserine aminotransferase 1 1.03 3.3E-05 2.3E-04

4002148 EIF1AX eukaryotic translation initiation factor 1A, X-linked 1.03 3.5E-05 2.4E-04

2477438 QPCT glutaminyl-peptide cyclotransferase 1.02 1.4E-06 2.1E-05

2967276 POPDC3 popeye domain containing 3 1.02 5.4E-06 5.7E-05

3392332 CADM1 cell adhesion molecule 1 1.02 1.9E-06 2.7E-05

3063463 CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 1.01 1.1E-06 1.8E-05

3820571 ATG4D ATG4 autophagy related 4 homolog D (S. cerevisiae) 1.01 5.6E-07 1.1E-05

3920850 KCNJ15 potassium inwardly-rectifying channel, subfamily J, member 15 1.01 8.0E-06 7.8E-05

2343418 PTGFR prostaglandin F receptor (FP) 1.01 2.6E-06 3.3E-05

2649723 MFSD1 major facilitator superfamily domain containing 1 1.00 4.6E-07 9.4E-06

3917305 BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 1.00 2.2E-06 3.0E-05

3125001 LONRF1 LON peptidase N-terminal domain and ring finger 1 1.00 1.9E-05 1.5E-04

3721579 NKIRAS2 NFKB inhibitor interacting Ras-like 2 0.99 5.9E-09 4.6E-07

3759105 FAM171A2 family with sequence similarity 171, member A2 0.99 1.0E-06 1.7E-05

2448382 PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and

cyclooxygenase)0.99 2.9E-05 2.1E-04

2791063 CTSO cathepsin O 0.99 6.7E-06 6.7E-05

3134922 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.99 2.4E-04 1.1E-03

2515627 ITGA6 integrin, alpha 6 0.98 7.6E-07 1.4E-05

2907568 KLHDC3 kelch domain containing 3 0.98 1.6E-06 2.4E-05

3984468 SRPX2 sushi-repeat-containing protein, X-linked 2 0.98 2.0E-06 2.8E-05

3252036 PLAU plasminogen activator, urokinase 0.98 8.0E-07 1.4E-05

2950629 TAPBP TAP binding protein (tapasin) 0.98 9.8E-09 6.5E-07

2372858 RGS2 regulator of G-protein signaling 2, 24kDa 0.98 5.7E-04 2.2E-03

2731332 IL8 interleukin 8 0.98 6.8E-04 2.5E-03

2421753 GTF2B general transcription factor IIB 0.98 4.1E-05 2.7E-04

3127745 TNFRSF10Dtumor necrosis factor receptor superfamily, member 10d, decoy with

truncated death domain0.97 2.2E-07 5.5E-06

2832297 PCDHB2 protocadherin beta 2 0.97 5.5E-06 5.8E-05

2832403 PCDHB9 protocadherin beta 9 0.97 3.8E-06 4.3E-05

3599495 CORO2B coronin, actin binding protein, 2B 0.97 1.7E-07 4.5E-06

3740770 RTN4RL1 reticulon 4 receptor-like 1 0.97 2.4E-03 6.8E-03

2352338 FAM19A3family with sequence similarity 19 (chemokine (C-C motif)-like), member

A30.97 2.9E-06 3.6E-05

3367231 BDNF brain-derived neurotrophic factor 0.96 1.0E-06 1.7E-05

3766960 SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.96 1.8E-08 9.9E-07

3362159 NRIP3 nuclear receptor interacting protein 3 0.96 9.1E-07 1.6E-05

2686023 DCBLD2 discoidin, CUB and LCCL domain containing 2 0.95 1.3E-07 3.9E-06

3916527 JAM2 junctional adhesion molecule 2 0.95 1.7E-06 2.5E-05

3886294 TOX2 TOX high mobility group box family member 2 0.95 2.0E-08 1.1E-06

3126191 PSD3 pleckstrin and Sec7 domain containing 3 0.95 7.5E-06 7.3E-05

2665199 SATB1 SATB homeobox 1 0.94 1.8E-05 1.5E-04

3590239 DLL4 delta-like 4 (Drosophila) 0.94 2.9E-06 3.6E-05

3062738 OCM2 oncomodulin 2 0.94 3.0E-03 8.0E-03

3978760 MAGEH1 melanoma antigen family H, 1 0.94 1.9E-06 2.7E-05

3756668 KRTAP3-1 keratin associated protein 3-1 0.94 3.1E-06 3.8E-05

3650762 TMC7 transmembrane channel-like 7 0.93 2.3E-02 4.1E-02

3260001 MARVELD1 MARVEL domain containing 1 0.93 3.1E-09 3.1E-07

3443296 M6PR mannose-6-phosphate receptor (cation dependent) 0.93 8.2E-09 5.8E-07

2465778 OR6F1 olfactory receptor, family 6, subfamily F, member 1 0.93 3.2E-04 1.4E-03

2832387 PCDHB8 protocadherin beta 8 0.93 4.7E-04 1.9E-03

2967249 BVES blood vessel epicardial substance 0.93 1.8E-05 1.4E-04

2832467 PCDHB18 protocadherin beta 18 pseudogene 0.93 6.9E-04 2.5E-03

2353717 PTGFRN prostaglandin F2 receptor negative regulator 0.92 3.3E-07 7.3E-06

3850501 LOC147727 hypothetical LOC147727 0.92 1.4E-06 2.1E-05

3898355 FLRT3 fibronectin leucine rich transmembrane protein 3 0.92 1.7E-04 8.4E-04

2896177 JARID2 jumonji, AT rich interactive domain 2 0.92 2.3E-06 3.1E-05

2461891 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.92 2.5E-06 3.3E-05

3464860 DUSP6 dual specificity phosphatase 6 0.92 1.7E-07 4.6E-06

3914050 STMN3 stathmin-like 3 0.92 1.1E-07 3.4E-06

3359121 IGF2 insulin-like growth factor 2 (somatomedin A) 0.91 2.0E-05 1.6E-04

3947227 SEPT3 septin 3 0.91 2.8E-06 3.6E-05

2499053 LIMS1 LIM and senescent cell antigen-like domains 1 0.91 2.5E-04 1.1E-03

3059464 SEMA3Asema domain, immunoglobulin domain (Ig), short basic domain,

secreted, (semaphorin) 3A0.91 6.3E-05 3.8E-04

3830277 USF2 upstream transcription factor 2, c-fos interacting 0.91 9.0E-08 2.9E-06

3048778 TMED4 transmembrane emp24 protein transport domain containing 4 0.91 7.1E-08 2.5E-06

2349043 SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.90 3.2E-06 3.9E-05

2434575 CTSS cathepsin S 0.90 3.0E-04 1.3E-03

3801411 NPC1 Niemann-Pick disease, type C1 0.90 4.0E-07 8.4E-06

3147286 RRM2B ribonucleotide reductase M2 B (TP53 inducible) 0.90 6.9E-05 4.1E-04

3846316 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.90 2.4E-08 1.2E-06

2568968 UXS1 UDP-glucuronate decarboxylase 1 0.90 2.0E-05 1.6E-04

3449068 TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.89 6.9E-05 4.1E-04

3205633 MCART1 mitochondrial carrier triple repeat 1 0.89 5.5E-03 1.3E-02

2344984 CLCA2 chloride channel accessory 2 0.89 3.1E-06 3.8E-05

3246888 PRKG1 protein kinase, cGMP-dependent, type I 0.89 2.5E-04 1.1E-03

3560617 SNX6 sorting nexin 6 0.88 2.0E-07 5.2E-06

3766651 ERN1 endoplasmic reticulum to nucleus signaling 1 0.88 2.4E-07 5.8E-06

3296046 KCNMA1potassium large conductance calcium-activated channel, subfamily M,

alpha member 10.88 1.3E-07 3.7E-06

2349402 AMY2B amylase, alpha 2B (pancreatic) 0.88 3.3E-03 8.7E-03

3756723 KRTAP2-4 keratin associated protein 2-4 0.88 3.1E-07 7.0E-06

3023384 AHCYL2 adenosylhomocysteinase-like 2 0.88 2.2E-06 2.9E-05

2879105 SPRY4 sprouty homolog 4 (Drosophila) 0.88 3.0E-06 3.7E-05

2790062 TMEM154 transmembrane protein 154 0.88 9.5E-05 5.2E-04

2537171 FAM150B family with sequence similarity 150, member B 0.88 9.2E-08 3.0E-06

2726910 SPATA18 spermatogenesis associated 18 homolog (rat) 0.88 1.2E-06 1.9E-05

3410056 TSPAN11 tetraspanin 11 0.87 2.7E-03 7.3E-03

2417390 WLS wntless homolog (Drosophila) 0.87 5.7E-07 1.1E-05

3566949 C14ORF149 chromosome 14 open reading frame 149 0.87 1.5E-07 4.2E-06

2382467 CNIH3 cornichon homolog 3 (Drosophila) 0.87 5.9E-06 6.1E-05

3389353 CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.87 9.6E-04 3.2E-03

2734421 ARHGAP24 Rho GTPase activating protein 24 0.87 3.3E-05 2.3E-04

3238962 KIAA1217 KIAA1217 0.87 1.9E-07 4.9E-06

2489545 HK2 hexokinase 2 0.87 1.7E-06 2.4E-05

3148463 ANGPT1 angiopoietin 1 0.87 1.4E-05 1.2E-04

2923939 SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 0.87 2.3E-06 3.1E-05

2867836 GLRX glutaredoxin (thioltransferase) 0.87 1.7E-06 2.4E-05

3811459 KDSR 3-ketodihydrosphingosine reductase 0.87 2.3E-07 5.6E-06

2832447 PCDHB13 protocadherin beta 13 // protocadherin beta 13 0.86 2.3E-04 1.1E-03

2655113 KLHL24 kelch-like 24 (Drosophila) 0.86 7.6E-05 4.4E-04

2405036 BSDC1 BSD domain containing 1 0.86 7.9E-08 2.7E-06

3564790 ERO1L ERO1-like (S. cerevisiae) 0.86 5.4E-06 5.7E-05

3821159 LPPR2 lipid phosphate phosphatase-related protein type 2 0.86 2.4E-08 1.2E-06

3741456 TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.85 1.9E-03 5.7E-03

2727587 KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.85 1.8E-05 1.4E-04

2834863 ABLIM3 actin binding LIM protein family, member 3 0.85 2.9E-07 6.6E-06

3814791 PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.85 6.1E-05 3.7E-04

3347431 ELMOD1 ELMO/CED-12 domain containing 1 0.85 4.4E-06 4.9E-05

3806211 PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 0.85 2.9E-06 3.6E-05

3174121 MAMDC2 MAM domain containing 2 0.85 5.7E-06 5.9E-05

2960955 SLC17A5 solute carrier family 17 (anion/sugar transporter), member 5 0.85 2.6E-06 3.4E-05

2964231 RRAGD Ras-related GTP binding D 0.85 2.2E-07 5.4E-06

3358742 TOLLIP toll interacting protein 0.85 6.6E-07 1.2E-05

4008427 NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 0.85 6.0E-04 2.3E-03

3260265 CNNM1 cyclin M1 0.84 1.7E-05 1.4E-04

3104260 PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.84 1.6E-07 4.3E-06

3389273 CASP4 caspase 4, apoptosis-related cysteine peptidase 0.84 1.7E-07 4.6E-06

3715512 TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.84 1.3E-07 3.8E-06

3671202 CDH13 cadherin 13, H-cadherin (heart) 0.84 3.3E-07 7.3E-06

3141755 HEY1 hairy/enhancer-of-split related with YRPW motif 1 0.84 3.3E-07 7.3E-06

2359470 IVL involucrin 0.83 3.3E-04 1.4E-03

3873629 SIRPA signal-regulatory protein alpha 0.83 5.1E-07 1.0E-05

2575949 TUBA3E tubulin, alpha 3e 0.83 8.9E-03 1.9E-02

3625539 NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.83 7.6E-05 4.4E-04

3186191 ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0.83 6.4E-08 2.3E-06

2973232 C6ORF174 chromosome 6 open reading frame 174 0.83 9.3E-05 5.1E-04

3262509 GSTO1 glutathione S-transferase omega 1 0.83 1.9E-06 2.7E-05

3442854 SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.82 1.5E-07 4.2E-06

2706791 ZMAT3 zinc finger, matrin-type 3 0.82 1.2E-05 1.1E-04

3239380 THNSL1 threonine synthase-like 1 (S. cerevisiae) 0.82 4.2E-04 1.7E-03

2979246 RAET1L retinoic acid early transcript 1L 0.82 2.1E-02 3.8E-02

3892873 NTSR1 neurotensin receptor 1 (high affinity) 0.82 3.9E-06 4.4E-05

3355733 FLI1 Friend leukemia virus integration 1 0.82 2.1E-07 5.4E-06

3268274 PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide

binding specific) member 10.82 1.1E-04 6.1E-04

2739755 AP1AR adaptor-related protein complex 1 associated regulatory protein 0.82 1.7E-04 8.2E-04

3894601 FKBP1A FK506 binding protein 1A, 12kDa 0.81 1.6E-05 1.3E-04

3042881 HOXA7 homeobox A7 0.81 2.6E-05 1.9E-04

2476116 SLC30A6 solute carrier family 30 (zinc transporter), member 6 0.81 5.4E-05 3.4E-04

2414366 PPAP2B phosphatidic acid phosphatase type 2B 0.80 7.6E-08 2.6E-06

3964154 CERK ceramide kinase 0.80 1.5E-06 2.2E-05

2317434 TPRG1L tumor protein p63 regulated 1-like 0.80 7.7E-08 2.7E-06

3828949 DPY19L3 dpy-19-like 3 (C. elegans) 0.80 9.2E-05 5.1E-04

3981959 SLC16A2 solute carrier family 16, member 2 (monocarboxylic acid transporter 8) 0.80 3.0E-08 1.3E-06

3688079 NCRNA00095 non-protein coding RNA 95 0.80 2.4E-03 6.7E-03

3601051 NEO1 neogenin 1 0.80 3.2E-06 3.9E-05

3771675 ST6GALNAC2ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-

acetylgalactosaminide alpha-2,6-sialyltransferase 20.80 6.4E-08 2.3E-06

2841491 C5ORF41 chromosome 5 open reading frame 41 0.80 1.1E-03 3.6E-03

3851072 ACP5 acid phosphatase 5, tartrate resistant 0.79 3.2E-04 1.4E-03

3147173 NCALD neurocalcin delta 0.79 1.3E-06 2.0E-05

3867443 HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 0.79 2.1E-05 1.6E-04

2394817 KLHL21 kelch-like 21 (Drosophila) 0.79 3.5E-06 4.2E-05

3842755 LOC100128252 hypothetical LOC100128252 0.79 3.8E-05 2.6E-04

2832392 PCDHB16 protocadherin beta 16 0.79 6.8E-05 4.0E-04

3728571 OR4D1 olfactory receptor, family 4, subfamily D, member 1 0.79 5.7E-03 1.3E-02

2921296 AMD1 adenosylmethionine decarboxylase 1 0.78 3.4E-06 4.0E-05

3218528 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.78 3.1E-04 1.3E-03

3738629 SLC16A3 solute carrier family 16, member 3 (monocarboxylic acid transporter 4) 0.78 2.4E-08 1.2E-06

3466826 CDK17 cyclin-dependent kinase 17 0.78 8.3E-06 8.0E-05

3706439 RAP1GAP2 RAP1 GTPase activating protein 2 0.78 1.2E-05 1.0E-04

2777714 SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.78 7.3E-08 2.6E-06

2902348 MICB MHC class I polypeptide-related sequence B 0.78 2.6E-06 3.3E-05

3341539 KCTD21 potassium channel tetramerisation domain containing 21 0.78 7.9E-04 2.8E-03

3536706 LGALS3 lectin, galactoside-binding, soluble, 3 0.78 1.4E-07 3.9E-06

3222170 TNC tenascin C 0.78 8.3E-07 1.5E-05

2388525 SDCCAG8 serologically defined colon cancer antigen 8 0.77 6.1E-04 2.3E-03

2319340 SLC25A33 solute carrier family 25, member 33 0.77 2.4E-03 6.8E-03

3548929 RIN3 Ras and Rab interactor 3 0.77 8.4E-08 2.8E-06

3972025 PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.77 1.1E-05 9.7E-05

2912980 OGFRL1 opioid growth factor receptor-like 1 0.77 1.7E-04 8.4E-04

3807474 C18ORF32 chromosome 18 open reading frame 32 0.77 1.8E-05 1.5E-04

2823551 MAN2A1 mannosidase, alpha, class 2A, member 1 0.77 4.2E-04 1.7E-03

3858285 TSHZ3 teashirt zinc finger homeobox 3 0.77 3.6E-04 1.5E-03

3631214 TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) 0.77 7.5E-07 1.4E-05

3895891 ADRA1D adrenergic, alpha-1D-, receptor 0.76 8.7E-08 2.9E-06

3651955 METTL9 methyltransferase like 9 0.76 1.3E-07 3.8E-06

2545953 FNDC4 fibronectin type III domain containing 4 0.76 2.2E-08 1.1E-06

3870104 ZNF415 zinc finger protein 415 0.76 9.4E-05 5.2E-04

2969886 FYN FYN oncogene related to SRC, FGR, YES 0.76 4.5E-05 2.9E-04

3575567 FOXN3 forkhead box N3 0.76 3.4E-06 4.0E-05

3840164 ZNF610 zinc finger protein 610 0.76 2.6E-06 3.3E-05

3275042 ASB13 ankyrin repeat and SOCS box-containing 13 0.76 4.5E-07 9.2E-06

2864849 SSBP2 single-stranded DNA binding protein 2 0.76 9.9E-07 1.7E-05

2563654 EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.75 7.9E-05 4.5E-04

3345427 ENDOD1 endonuclease domain containing 1 0.75 8.1E-07 1.4E-05

3151970 MTSS1 metastasis suppressor 1 0.75 1.5E-06 2.2E-05

3840224 ZNF528 zinc finger protein 528 0.75 1.2E-04 6.2E-04

3968512 CLCN4 chloride channel 4 0.75 2.1E-06 2.9E-05

2786732 MAML3 mastermind-like 3 (Drosophila) 0.75 1.3E-05 1.2E-04

3829857 ZNF302 zinc finger protein 302 0.75 5.7E-04 2.2E-03

2493992 KCNIP3 Kv channel interacting protein 3, calsenilin 0.75 7.6E-08 2.6E-06

2832310 PCDHB3 protocadherin beta 3 0.75 9.9E-03 2.1E-02

2660029 LMLN leishmanolysin-like (metallopeptidase M8 family) 0.75 1.6E-04 7.7E-04

3410384 C12ORF35 chromosome 12 open reading frame 35 0.75 3.4E-04 1.4E-03

2372924 TROVE2 TROVE domain family, member 2 0.74 7.5E-03 1.7E-02

3752709 MYO1D myosin ID 0.74 2.5E-06 3.3E-05

3422855 GLIPR1 GLI pathogenesis-related 1 0.74 1.7E-07 4.5E-06

2362394 IFI16 interferon, gamma-inducible protein 16 0.74 6.1E-05 3.7E-04

3218067 MRPL50 mitochondrial ribosomal protein L50 0.74 1.7E-05 1.4E-04

3405748 EMP1 epithelial membrane protein 1 0.74 6.1E-07 1.2E-05

2847967 SEMA5A

sema domain, seven thrombospondin repeats (type 1 and type 1-like),

transmembrane domain (TM) and short cytoplasmic domain,

(semaphorin) 5A

0.74 5.5E-05 3.4E-04

3922100 MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78

(mouse)0.74 6.0E-04 2.3E-03

3654699 NUPR1 nuclear protein, transcriptional regulator, 1 0.74 5.4E-06 5.7E-05

3784208 DTNA dystrobrevin, alpha 0.73 1.2E-06 1.9E-05

3385951 NOX4 NADPH oxidase 4 0.73 5.8E-06 6.0E-05

3076076 SLC37A3 solute carrier family 37 (glycerol-3-phosphate transporter), member 3 0.73 1.4E-05 1.2E-04

2714644 C4ORF42 chromosome 4 open reading frame 42 0.73 5.3E-05 3.4E-04

2725332 TMEM33 transmembrane protein 33 0.73 1.3E-05 1.1E-04

3852880 EMR2 egf-like module containing, mucin-like, hormone receptor-like 2 0.73 4.9E-07 9.8E-06

2443120 DPT dermatopontin 0.73 2.0E-05 1.6E-04

3802129 SS18 synovial sarcoma translocation, chromosome 18 0.73 1.2E-04 6.5E-04

3421300 MDM2 Mdm2 p53 binding protein homolog (mouse) 0.73 2.0E-05 1.6E-04

3148582 EIF3E eukaryotic translation initiation factor 3, subunit E 0.72 6.3E-04 2.4E-03

3329793 SLC39A13 solute carrier family 39 (zinc transporter), member 13 0.72 3.9E-07 8.3E-06

2856995 ESM1 endothelial cell-specific molecule 1 0.72 1.0E-05 9.4E-05

3843275 ZNF419 zinc finger protein 419 0.72 7.0E-04 2.5E-03

3660213 CYLD cylindromatosis (turban tumor syndrome) 0.72 8.1E-06 7.8E-05

2626802 PTPRG protein tyrosine phosphatase, receptor type, G 0.72 6.1E-05 3.7E-04

2504328 GYPC glycophorin C (Gerbich blood group) 0.72 1.4E-07 3.9E-06

2327391 SESN2 sestrin 2 0.72 3.7E-07 8.0E-06

2470165 TRIB2 tribbles homolog 2 (Drosophila) 0.72 9.5E-07 1.6E-05

2331903 ZNF643 zinc finger protein 643 0.71 2.9E-03 7.7E-03

2378019 CAMK1G calcium/calmodulin-dependent protein kinase IG 0.71 2.1E-07 5.3E-06

3990727 RAB33A RAB33A, member RAS oncogene family 0.71 7.0E-05 4.1E-04

3806459 ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 0.71 4.5E-05 2.9E-04

3674199 CPNE7 copine VII 0.71 8.9E-07 1.5E-05

2637112 GAP43 growth associated protein 43 0.71 6.7E-06 6.8E-05

2371346 RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.71 9.0E-06 8.5E-05

3901041 THBD thrombomodulin 0.71 7.6E-07 1.4E-05

2832423 PCDHB10 protocadherin beta 10 0.71 8.8E-06 8.3E-05

2887164 SH3PXD2B SH3 and PX domains 2B 0.71 2.0E-05 1.6E-04

3940099 ADORA2A adenosine A2a receptor 0.71 2.8E-05 2.1E-04

3395464 ASAM adipocyte-specific adhesion molecule 0.71 1.3E-06 2.0E-05

3562003 TRAPPC6B trafficking protein particle complex 6B 0.71 3.1E-04 1.3E-03

3665949 PSKH1 protein serine kinase H1 0.71 1.1E-06 1.8E-05

3142217 PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.71 3.1E-05 2.2E-04

3512874 LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.71 4.5E-06 4.9E-05

3860450 ZNF566 zinc finger protein 566 0.71 2.1E-04 9.8E-04

3227482 FIBCD1 fibrinogen C domain containing 1 0.71 1.4E-06 2.1E-05

3782166 IMPACT Impact homolog (mouse) 0.71 6.2E-04 2.3E-03

3106243 RIPK2 receptor-interacting serine-threonine kinase 2 0.70 6.9E-05 4.1E-04

2515276 DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.70 2.4E-02 4.1E-02

3419849 TBK1 TANK-binding kinase 1 0.70 1.9E-03 5.7E-03

3788976 RAB27B RAB27B, member RAS oncogene family 0.70 3.5E-04 1.5E-03

3189932 STXBP1 syntaxin binding protein 1 0.70 3.3E-08 1.5E-06

3569200 ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.70 1.1E-04 6.0E-04

3235516 CAMK1D calcium/calmodulin-dependent protein kinase ID 0.70 5.5E-06 5.8E-05

3011838 STEAP1 six transmembrane epithelial antigen of the prostate 1 0.70 8.2E-05 4.7E-04

3326400 CAT catalase 0.70 4.1E-07 8.5E-06

3991889 FAM127A family with sequence similarity 127, member A 0.70 1.3E-06 2.0E-05

3875423 BMP2 bone morphogenetic protein 2 0.70 7.0E-06 7.0E-05

2835848 SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 0.70 1.1E-06 1.7E-05

3592401 C15ORF48 chromosome 15 open reading frame 48 0.70 2.6E-04 1.2E-03

3968122 TBL1X transducin (beta)-like 1X-linked 0.70 4.1E-06 4.6E-05

3718555 SLFN5 schlafen family member 5 0.70 2.5E-05 1.8E-04

2577028 NCKAP5 NCK-associated protein 5 0.70 3.9E-04 1.6E-03

2487082 ANTXR1 anthrax toxin receptor 1 0.70 6.4E-06 6.5E-05

2960010 LMBRD1 LMBR1 domain containing 1 0.69 2.4E-04 1.1E-03

3225855 ANGPTL2 angiopoietin-like 2 0.69 3.4E-06 4.1E-05

3204987 OR13J1 olfactory receptor, family 13, subfamily J, member 1 0.69 2.1E-03 6.1E-03

3759849 PLEKHM1pleckstrin homology domain containing, family M (with RUN domain)

member 10.69 6.6E-07 1.2E-05

2732391 CCNG2 cyclin G2 0.69 2.5E-06 3.3E-05

3469180 SLC41A2 solute carrier family 41, member 2 0.69 8.0E-04 2.8E-03

3528864 MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.69 3.3E-07 7.3E-06

2331158 AKIRIN1 akirin 1 0.69 1.3E-05 1.2E-04

3147726 SLC25A32 solute carrier family 25, member 32 0.69 1.7E-05 1.4E-04

3591963 EIF3J eukaryotic translation initiation factor 3, subunit J 0.68 1.3E-04 6.6E-04

3839057 TBC1D17 TBC1 domain family, member 17 0.68 2.9E-07 6.7E-06

3049292 IGFBP3 insulin-like growth factor binding protein 3 0.68 1.3E-05 1.2E-04

3984907 ARMCX1 armadillo repeat containing, X-linked 1 0.68 6.2E-06 6.4E-05

3403414 DPPA3 developmental pluripotency associated 3 0.68 1.2E-03 3.8E-03

2748061 TRIM2 tripartite motif-containing 2 0.68 9.8E-04 3.3E-03

3778504 RAB31 RAB31, member RAS oncogene family 0.68 1.6E-06 2.3E-05

3261165 BTRC beta-transducin repeat containing 0.68 4.1E-06 4.6E-05

3711262 HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 0.68 1.2E-04 6.2E-04

3567187 DHRS7 dehydrogenase/reductase (SDR family) member 7 0.68 1.8E-05 1.4E-04

2425400 EXTL2 exostoses (multiple)-like 2 0.68 3.2E-04 1.4E-03

4023467 ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.68 3.6E-05 2.5E-04

2780099 NHEDC2 Na+/H+ exchanger domain containing 2 0.68 1.0E-05 9.2E-05

3661152 FTO fat mass and obesity associated 0.68 2.0E-07 5.1E-06

3989089 ZBTB33 zinc finger and BTB domain containing 33 0.68 1.2E-03 3.8E-03

3353640 GRAMD1B GRAM domain containing 1B 0.67 1.1E-05 9.7E-05

2532272 ALPP alkaline phosphatase, placental 0.67 1.3E-02 2.6E-02

3690154 NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.67 3.0E-05 2.1E-04

3917204 C21ORF7 chromosome 21 open reading frame 7 0.67 6.9E-07 1.3E-05

4017381 TSC22D3 TSC22 domain family, member 3 0.67 8.9E-06 8.4E-05

3551485 EML1 echinoderm microtubule associated protein like 1 0.67 2.8E-05 2.1E-04

3115504 MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.67 5.9E-07 1.1E-05

3250990 UNC5B unc-5 homolog B (C. elegans) 0.67 1.3E-05 1.1E-04

2777447 NAP1L5 nucleosome assembly protein 1-like 5 0.67 1.0E-04 5.6E-04

3645816 ZNF75A zinc finger protein 75a 0.67 4.8E-04 1.9E-03

2988726 FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) 0.67 8.7E-07 1.5E-05

3652271 C16ORF52 chromosome 16 open reading frame 52 0.67 2.9E-05 2.1E-04

3326067 C11ORF41 chromosome 11 open reading frame 41 0.67 1.0E-03 3.3E-03

3815045 HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 0.67 4.1E-05 2.7E-04

3890109 C20ORF108 chromosome 20 open reading frame 108 0.66 2.0E-05 1.6E-04

3212008 FRMD3 FERM domain containing 3 0.66 3.0E-06 3.7E-05

3418492 TSPAN31 tetraspanin 31 0.66 5.8E-07 1.1E-05

2968652 SESN1 sestrin 1 0.66 4.1E-04 1.7E-03

2992814 GPNMB glycoprotein (transmembrane) nmb 0.66 1.0E-06 1.7E-05

3998632 PNPLA4 patatin-like phospholipase domain containing 4 0.66 4.5E-05 2.9E-04

3448152 ITPR2 inositol 1,4,5-triphosphate receptor, type 2 0.66 1.6E-03 4.7E-03

3928538 KRTAP19-5 keratin associated protein 19-5 0.66 1.6E-02 3.0E-02

3462816 PHLDA1 pleckstrin homology-like domain, family A, member 1 0.66 6.7E-08 2.4E-06

3887635 NCOA3 nuclear receptor coactivator 3 0.66 5.0E-05 3.2E-04

3061651 BET1 blocked early in transport 1 homolog (S. cerevisiae) 0.66 2.8E-04 1.2E-03

3627422 RORA RAR-related orphan receptor A 0.66 8.3E-07 1.5E-05

3419471 RPL14 ribosomal protein L14 0.66 2.6E-05 1.9E-04

2802696 FAM105A family with sequence similarity 105, member A 0.66 8.9E-04 3.0E-03

3283920 ARHGAP12 Rho GTPase activating protein 12 0.66 2.2E-03 6.2E-03

3911814 SLMO2 slowmo homolog 2 (Drosophila) 0.66 4.4E-05 2.9E-04

3807487 RPL17 ribosomal protein L17 0.65 9.6E-05 5.3E-04

2972310 SERINC1 serine incorporator 1 0.65 1.3E-03 4.0E-03

3819200 EVI5L ecotropic viral integration site 5-like 0.65 4.0E-07 8.4E-06

3565739 ATG14 ATG14 autophagy related 14 homolog (S. cerevisiae) 0.65 7.6E-05 4.4E-04

3192062 BAT2L1 HLA-B associated transcript 2-like 1 0.65 4.0E-05 2.7E-04

3250699 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.65 3.6E-07 7.8E-06

2913277 KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5 0.65 9.8E-05 5.4E-04

3736636 C1QTNF1 C1q and tumor necrosis factor related protein 1 0.65 3.8E-06 4.3E-05

3984779 HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 0.65 7.7E-05 4.5E-04

3214451 NFIL3 nuclear factor, interleukin 3 regulated 0.65 6.1E-04 2.3E-03

3230610 ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.65 8.7E-08 2.9E-06

3335338 FAM89B family with sequence similarity 89, member B 0.65 2.8E-06 3.6E-05

3868963 ETFB electron-transfer-flavoprotein, beta polypeptide 0.65 2.9E-06 3.6E-05

2977265 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.65 1.5E-03 4.5E-03

2915828 NT5E 5'-nucleotidase, ecto (CD73) 0.65 1.2E-05 1.0E-04

2970985 TSPYL4 TSPY-like 4 0.65 5.1E-07 1.0E-05

3895795 RNF24 ring finger protein 24 0.64 3.4E-07 7.6E-06

2643592 EPHB1 EPH receptor B1 0.64 7.4E-06 7.3E-05

3732230 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.64 2.3E-05 1.7E-04

3018866 DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.64 3.9E-04 1.6E-03

2949859 PBX2 pre-B-cell leukemia homeobox 2 0.64 1.6E-02 3.1E-02

2821347 ERAP2 endoplasmic reticulum aminopeptidase 2 0.64 8.8E-04 3.0E-03

3758510 ETV4 ets variant 4 0.64 1.2E-05 1.0E-04

3368748 FBXO3 F-box protein 3 0.64 1.4E-04 7.0E-04

3830051 SCN1B sodium channel, voltage-gated, type I, beta 0.64 6.7E-06 6.7E-05

3145801 TSPYL5 TSPY-like 5 0.64 1.3E-05 1.1E-04

2792420 TMEM192 transmembrane protein 192 0.64 1.8E-04 8.9E-04

2649113 TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.64 1.3E-05 1.2E-04

3712062 TRPV2 transient receptor potential cation channel, subfamily V, member 2 0.64 1.4E-06 2.1E-05

3448975 ERGIC2 ERGIC and golgi 2 0.64 2.6E-03 7.2E-03

3163818 SH3GL2 SH3-domain GRB2-like 2 0.64 3.6E-05 2.5E-04

2934308 IGF2R insulin-like growth factor 2 receptor 0.64 2.0E-06 2.8E-05

3762473 TOB1 transducer of ERBB2, 1 0.64 2.2E-06 3.0E-05

2806468 IL7R interleukin 7 receptor 0.63 1.6E-04 8.1E-04

3835467 ZNF234 zinc finger protein 234 0.63 5.5E-04 2.1E-03

3432514 OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.63 5.7E-04 2.2E-03

2583602 RBMS1 RNA binding motif, single stranded interacting protein 1 0.63 5.2E-04 2.0E-03

2849469 ANKH ankylosis, progressive homolog (mouse) 0.63 6.2E-06 6.4E-05

2832499 PCDHB15 protocadherin beta 15 // protocadherin beta 15 0.63 4.0E-05 2.7E-04

3662650 ARL2BP ADP-ribosylation factor-like 2 binding protein 0.63 1.3E-06 2.0E-05

3578069 C14ORF139 chromosome 14 open reading frame 139 0.63 7.2E-05 4.2E-04

2832325 PCDHB5 protocadherin beta 5 0.63 9.2E-05 5.1E-04

3859946 HSPB6 heat shock protein, alpha-crystallin-related, B6 0.63 3.1E-06 3.8E-05

2326496 DHDDS dehydrodolichyl diphosphate synthase 0.63 2.1E-06 2.9E-05

3215146 NINJ1 ninjurin 1 0.63 1.4E-05 1.2E-04

3188111 PTGS1prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and

cyclooxygenase)0.63 2.5E-06 3.3E-05

3878836 RIN2 Ras and Rab interactor 2 0.62 5.2E-06 5.5E-05

2992963 CCDC126 coiled-coil domain containing 126 0.62 2.1E-04 9.9E-04

3444503 TAS2R31 taste receptor, type 2, member 31 0.62 5.4E-03 1.3E-02

3318666 SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.62 2.6E-07 6.1E-06

4048764 C6ORF35 chromosome 6 open reading frame 35 0.62 2.6E-03 7.2E-03

2887490 STC2 stanniocalcin 2 0.62 7.8E-06 7.6E-05

2406139 KIAA0319L KIAA0319-like 0.62 1.3E-06 2.0E-05

3845495 REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) 0.62 2.7E-05 2.0E-04

3403567 NECAP1 NECAP endocytosis associated 1 0.62 2.8E-05 2.1E-04

3412345 TMEM117 transmembrane protein 117 0.62 6.1E-04 2.3E-03

3324713 METT5D1 methyltransferase 5 domain containing 1 0.62 2.8E-02 4.8E-02

2731636 PARM1 prostate androgen-regulated mucin-like protein 1 0.62 3.6E-06 4.2E-05

2824581 KCNN2potassium intermediate/small conductance calcium-activated channel,

subfamily N, member 20.62 1.2E-04 6.4E-04

2645387 ACPL2 acid phosphatase-like 2 0.62 1.6E-05 1.3E-04

3496916 GPR180 G protein-coupled receptor 180 0.62 1.7E-03 5.1E-03

3786471 SETBP1 SET binding protein 1 0.62 1.8E-06 2.5E-05

3214668 IARS isoleucyl-tRNA synthetase 0.61 1.8E-07 4.9E-06

3364095 CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 0.61 2.1E-05 1.6E-04

3840883 ZNF761 zinc finger protein 761 0.61 3.3E-04 1.4E-03

2979267 ULBP3 UL16 binding protein 3 0.61 1.2E-04 6.4E-04

3021158 C7ORF58 chromosome 7 open reading frame 58 0.61 2.3E-04 1.0E-03

3237548 ARL5B ADP-ribosylation factor-like 5B 0.61 7.7E-04 2.7E-03

3729014 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 0.61 1.0E-04 5.5E-04

3894322 SRXN1 sulfiredoxin 1 0.61 2.1E-05 1.6E-04

3701297 CDYL2 chromodomain protein, Y-like 2 0.61 6.1E-06 6.4E-05

2645275 SLC25A36 solute carrier family 25, member 36 0.61 6.0E-03 1.4E-02

3127775 TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.61 1.6E-06 2.4E-05

3957207 GATSL3 GATS protein-like 3 0.61 2.0E-07 5.2E-06

3764872 PTRH2 peptidyl-tRNA hydrolase 2 0.61 1.3E-04 6.5E-04

3190659 SET SET nuclear oncogene 0.61 1.0E-06 1.7E-05

3843399 ZNF134 zinc finger protein 134 0.61 1.5E-04 7.5E-04

3432678 TPCN1 two pore segment channel 1 0.61 1.4E-05 1.2E-04

2731757 THAP6 THAP domain containing 6 0.61 7.9E-04 2.8E-03

2709414 TBCCD1 TBCC domain containing 1 0.61 1.0E-03 3.3E-03

3294159 P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.61 2.8E-04 1.2E-03

2473784 EPT1 ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) 0.60 3.4E-04 1.4E-03

3352904 SC5DL sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like 0.60 1.1E-03 3.7E-03

3542063 SLC39A9 solute carrier family 39 (zinc transporter), member 9 0.60 2.0E-06 2.8E-05

3695107 TK2 thymidine kinase 2, mitochondrial 0.60 6.1E-07 1.2E-05

3204558 KIAA1539 KIAA1539 0.60 4.9E-07 9.8E-06

3842724 ZNF583 zinc finger protein 583 0.60 2.6E-03 7.1E-03

2916345 SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 0.60 2.1E-03 6.1E-03

3837504 SEPW1 selenoprotein W, 1 0.60 1.0E-05 9.5E-05

4028512 RPS4Y1 ribosomal protein S4, Y-linked 1 0.60 7.6E-05 4.4E-04

2867443 MCTP1 multiple C2 domains, transmembrane 1 0.60 5.1E-05 3.2E-04

3449700 FAM60A family with sequence similarity 60, member A 0.60 5.5E-05 3.5E-04

3047660 GLI3 GLI family zinc finger 3 0.60 4.3E-05 2.8E-04

3019793 FOXP2 forkhead box P2 0.60 6.1E-06 6.3E-05

2730746 SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4 0.60 2.1E-04 1.0E-03

3572278 NEK9 NIMA (never in mitosis gene a)- related kinase 9 0.60 1.4E-06 2.1E-05

3854756 RAB3A RAB3A, member RAS oncogene family 0.60 5.3E-05 3.3E-04

3429460 TXNRD1 thioredoxin reductase 1 0.60 1.6E-05 1.3E-04

3919033 SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.60 6.0E-04 2.3E-03

3154317 NDRG1 N-myc downstream regulated 1 0.60 8.1E-06 7.8E-05

2935475 QKI quaking homolog, KH domain RNA binding (mouse) 0.60 2.6E-04 1.2E-03

3744410 KRBA2 KRAB-A domain containing 2 0.59 1.9E-02 3.5E-02

2771718 UBA6 ubiquitin-like modifier activating enzyme 6 0.59 2.0E-03 5.8E-03

2650393 PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.59 3.8E-05 2.6E-04

2420615 LPAR3 lysophosphatidic acid receptor 3 0.59 1.1E-03 3.6E-03

3230811 DPP7 dipeptidyl-peptidase 7 0.59 1.6E-06 2.3E-05

2492064 KDM3A lysine (K)-specific demethylase 3A 0.59 5.0E-04 1.9E-03

3744800 STX8 syntaxin 8 0.59 1.8E-04 8.7E-04

3592023 B2M beta-2-microglobulin 0.59 3.6E-06 4.2E-05

3613725 NDN necdin homolog (mouse) 0.59 5.8E-05 3.6E-04

3566495 C14ORF37 chromosome 14 open reading frame 37 0.59 3.9E-05 2.6E-04

2977621 PLAGL1 pleiomorphic adenoma gene-like 1 0.59 3.0E-05 2.1E-04

3430776 ISCU iron-sulfur cluster scaffold homolog (E. coli) 0.59 1.6E-05 1.3E-04

3452231 SLC38A1 solute carrier family 38, member 1 0.59 6.6E-05 4.0E-04

3821727 ZNF136 zinc finger protein 136 0.59 7.1E-05 4.2E-04

2639225 PDIA5 protein disulfide isomerase family A, member 5 0.59 1.1E-05 9.6E-05

3058209 MAGI2membrane associated guanylate kinase, WW and PDZ domain

containing 20.59 2.9E-05 2.1E-04

3690193 ITFG1 integrin alpha FG-GAP repeat containing 1 0.59 1.3E-04 6.5E-04

2519294 FAM171B family with sequence similarity 171, member B 0.59 4.3E-03 1.1E-02

3774906 SECTM1 secreted and transmembrane 1 0.59 8.1E-06 7.8E-05

3924372 COL6A1 collagen, type VI, alpha 1 0.59 1.8E-06 2.5E-05

2946345 HIST1H2BG histone cluster 1, H2bg -0.59 3.0E-04 1.3E-03

3380996 C11ORF51 chromosome 11 open reading frame 51 -0.59 2.2E-06 3.0E-05

3250093 KIAA1279 KIAA1279 -0.59 3.0E-06 3.7E-05

3630450 AAGAB alpha- and gamma-adaptin binding protein -0.59 5.1E-05 3.2E-04

3355145 ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 -0.59 2.1E-05 1.6E-04

4019486 SEPT6 septin 6 -0.59 3.9E-06 4.4E-05

2591906 OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -0.59 2.4E-04 1.1E-03

3215701 FANCC Fanconi anemia, complementation group C -0.59 1.4E-05 1.2E-04

3445908 EPS8 epidermal growth factor receptor pathway substrate 8 -0.59 1.2E-05 1.0E-04

3436544 BRI3BP BRI3 binding protein -0.59 1.5E-05 1.3E-04

2451593 CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -0.59 2.6E-05 1.9E-04

3113456 MTBPMdm2, transformed 3T3 cell double minute 2, p53 binding protein

(mouse) binding protein, 104kDa-0.59 7.7E-04 2.7E-03

3249641 MYPN myopalladin -0.59 3.4E-07 7.5E-06

3623031 FBN1 fibrillin 1 -0.59 2.7E-05 2.0E-04

2601648 DOCK10 dedicator of cytokinesis 10 -0.59 8.3E-04 2.9E-03

2713555 KIAA0226 KIAA0226 -0.59 1.3E-06 2.0E-05

3842264 NAT14 N-acetyltransferase 14 (GCN5-related, putative) -0.60 3.1E-05 2.2E-04

2510884 ARL6IP6 ADP-ribosylation-like factor 6 interacting protein 6 -0.60 2.4E-03 6.7E-03

2835006 GRPEL2 GrpE-like 2, mitochondrial (E. coli) -0.60 2.0E-04 9.5E-04

2474977 FOSL2 FOS-like antigen 2 -0.60 4.4E-06 4.8E-05

3354879 HYLS1 hydrolethalus syndrome 1 -0.60 1.1E-04 5.8E-04

3941010 SRR SRR1 domain containing -0.60 1.5E-06 2.3E-05

3178480 NXNL2 nucleoredoxin-like 2 -0.60 5.1E-04 2.0E-03

2427074 PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -0.60 5.0E-05 3.2E-04

3028956 TAS2R39 taste receptor, type 2, member 39 -0.60 1.6E-02 3.1E-02

2903285 PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large

multifunctional peptidase 2)-0.60 2.1E-06 2.9E-05

3329206 CREB3L1 cAMP responsive element binding protein 3-like 1 -0.60 1.3E-06 2.0E-05

3719210 DHRS11 dehydrogenase/reductase (SDR family) member 11 -0.60 8.8E-06 8.4E-05

2460325 C1ORF198 chromosome 1 open reading frame 198 -0.60 6.9E-06 6.9E-05

2523689 ABI2 abl-interactor 2 -0.60 2.5E-05 1.9E-04

3094334 GPR124 G protein-coupled receptor 124 -0.60 6.3E-06 6.4E-05

3703885 SLC7A5solute carrier family 7 (cationic amino acid transporter, y+ system),

member 5-0.60 1.2E-07 3.6E-06

3671935 CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -0.60 2.8E-05 2.0E-04

2705748 NCEH1 neutral cholesterol ester hydrolase 1 -0.60 2.5E-05 1.8E-04

2812435 ERBB2IP erbb2 interacting protein -0.60 4.7E-03 1.1E-02

2475710 LCLAT1 lysocardiolipin acyltransferase 1 -0.60 1.6E-05 1.3E-04

2427791 DENND2D DENN/MADD domain containing 2D -0.60 5.8E-06 6.1E-05

3453712 RHEBL1 Ras homolog enriched in brain like 1 -0.61 5.0E-04 1.9E-03

3694657 CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.61 6.4E-06 6.6E-05

2710474 LEPREL1 leprecan-like 1 -0.61 8.8E-05 4.9E-04

2437801 ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -0.61 4.0E-06 4.6E-05

3485863 EXOSC8 exosome component 8 -0.61 5.2E-05 3.3E-04

2644461 ARMC8 armadillo repeat containing 8 -0.61 1.8E-04 8.9E-04

3042973 HOXA11 homeobox A11 -0.61 5.6E-06 5.8E-05

2785282 SCLT1 sodium channel and clathrin linker 1 -0.61 5.5E-04 2.1E-03

2847292 NSUN2 NOP2/Sun domain family, member 2 -0.61 3.2E-06 3.9E-05

3309755 C10ORF119 chromosome 10 open reading frame 119 -0.61 9.3E-07 1.6E-05

3417184 SUOX sulfite oxidase -0.61 1.4E-06 2.2E-05

3534785 PPIL5 peptidylprolyl isomerase (cyclophilin)-like 5 -0.61 1.6E-05 1.3E-04

2360206 ATP8B2 ATPase, class I, type 8B, member 2 -0.61 1.0E-05 9.4E-05

2584904 SLC38A11 solute carrier family 38, member 11 -0.61 8.0E-05 4.6E-04

3643938 TMEM204 transmembrane protein 204 -0.61 1.1E-06 1.8E-05

2752006 SAP30 Sin3A-associated protein, 30kDa -0.61 4.3E-05 2.8E-04

3390180 KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2 -0.62 1.7E-04 8.2E-04

3865635 DMPK dystrophia myotonica-protein kinase -0.62 6.3E-06 6.5E-05

2697490 CEP70 centrosomal protein 70kDa -0.62 7.6E-04 2.7E-03

3833757 SNRPA small nuclear ribonucleoprotein polypeptide A -0.62 4.0E-06 4.5E-05

3733065 MAP2K6 mitogen-activated protein kinase kinase 6 -0.62 3.0E-05 2.2E-04

3361531 OR10A3 olfactory receptor, family 10, subfamily A, member 3 -0.62 3.6E-03 9.2E-03

2739792 ALPK1 alpha-kinase 1 -0.62 1.2E-05 1.1E-04

3907524 PLTP phospholipid transfer protein -0.62 1.4E-07 4.1E-06

3505937 CENPJ centromere protein J -0.62 4.1E-04 1.7E-03

3601511 ISLR immunoglobulin superfamily containing leucine-rich repeat -0.62 1.8E-04 8.8E-04

3380901 NUMA1 nuclear mitotic apparatus protein 1 -0.62 1.8E-07 4.7E-06

2791894 FSTL5 follistatin-like 5 -0.62 7.1E-03 1.6E-02

3333247 FADS2 fatty acid desaturase 2 -0.63 1.4E-06 2.1E-05

3350830 TAGLN transgelin -0.63 5.3E-07 1.0E-05

2738723 HADH hydroxyacyl-CoA dehydrogenase -0.63 2.3E-05 1.7E-04

3387483 MTMR2 myotubularin related protein 2 -0.63 2.2E-05 1.7E-04

3744463 MYH10 myosin, heavy chain 10, non-muscle -0.63 2.9E-04 1.3E-03

3904566 DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) -0.63 7.1E-06 7.1E-05

3199790 PSIP1 PC4 and SFRS1 interacting protein 1 -0.63 1.8E-04 8.8E-04

3754227 MYO19 myosin XIX -0.63 4.4E-05 2.9E-04

2664452 ANKRD28 ankyrin repeat domain 28 -0.63 6.1E-04 2.3E-03

2407478 FHL3 four and a half LIM domains 3 -0.63 4.8E-06 5.2E-05

3976519 RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.63 1.5E-07 4.2E-06

3251298 CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 -0.63 7.2E-07 1.3E-05

3822195 NACC1nucleus accumbens associated 1, BEN and BTB (POZ) domain

containing-0.63 1.3E-07 3.9E-06

2980258 MTRF1L mitochondrial translational release factor 1-like -0.63 2.4E-03 6.7E-03

3838118 RUVBL2 RuvB-like 2 (E. coli) -0.63 7.3E-06 7.3E-05

3401197 C12ORF32 chromosome 12 open reading frame 32 -0.63 1.9E-06 2.7E-05

3223425 CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.63 1.2E-04 6.2E-04

3466556 NTN4 netrin 4 -0.63 4.0E-03 1.0E-02

2835576 SYNPO synaptopodin -0.64 2.4E-06 3.2E-05

2359764 SNAPIN SNAP-associated protein -0.64 4.3E-05 2.8E-04

3304004 NPM3 nucleophosmin/nucleoplasmin 3 -0.64 4.6E-06 5.0E-05

3355056 FOXRED1 FAD-dependent oxidoreductase domain containing 1 -0.64 1.3E-04 6.6E-04

3417531 COQ10A coenzyme Q10 homolog A (S. cerevisiae) -0.64 1.9E-05 1.5E-04

3281703 PRTFDC1 phosphoribosyl transferase domain containing 1 -0.64 2.1E-06 2.9E-05

2454935 ANGEL2 angel homolog 2 (Drosophila) -0.64 1.9E-05 1.5E-04

3845909 LMNB2 lamin B2 -0.64 1.2E-06 1.9E-05

3023149 FLNC filamin C, gamma -0.64 1.3E-06 2.0E-05

3065740 RELN reelin -0.64 2.6E-04 1.2E-03

2328868 HDAC1 histone deacetylase 1 -0.64 2.4E-06 3.2E-05

3322717 GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa -0.64 9.6E-06 8.8E-05

3373724 SSRP1 structure specific recognition protein 1 -0.64 3.5E-07 7.7E-06

3510066 POSTN periostin, osteoblast specific factor -0.64 6.6E-04 2.4E-03

2730714 DCK deoxycytidine kinase -0.64 2.7E-03 7.3E-03

3633048 EDC3 enhancer of mRNA decapping 3 homolog (S. cerevisiae) -0.64 1.9E-06 2.7E-05

2343231 NEXN nexilin (F actin binding protein) -0.65 4.8E-03 1.2E-02

2877314 CDC23 cell division cycle 23 homolog (S. cerevisiae) -0.65 1.6E-05 1.3E-04

3388785 MMP10 matrix metallopeptidase 10 (stromelysin 2) -0.65 1.4E-03 4.4E-03

2358993 TUFT1 tuftelin 1 -0.65 9.1E-06 8.6E-05

2885099 NUDCD2 NudC domain containing 2 -0.65 1.5E-05 1.3E-04

3226644 ZDHHC12 zinc finger, DHHC-type containing 12 -0.65 4.8E-07 9.7E-06

2890148 HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.65 1.3E-04 6.6E-04

2474681 GPN1 GPN-loop GTPase 1 -0.65 5.7E-06 6.0E-05

2945741 FAM65B family with sequence similarity 65, member B -0.65 4.3E-05 2.8E-04

3405440 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.65 1.8E-04 8.8E-04

3235414 SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) -0.65 3.6E-05 2.5E-04

3150715 DSCC1 defective in sister chromatid cohesion 1 homolog (S. cerevisiae) -0.65 1.5E-04 7.3E-04

2364381 RGS4 regulator of G-protein signaling 4 -0.66 1.7E-05 1.4E-04

2352804 OLFML3 olfactomedin-like 3 -0.66 4.9E-07 9.8E-06

2769947 CLOCK clock homolog (mouse) -0.66 4.9E-04 1.9E-03

2902633 MSH5 mutS homolog 5 (E. coli) -0.66 5.9E-07 1.1E-05

3653398 TNRC6A trinucleotide repeat containing 6A -0.66 4.8E-04 1.9E-03

2523045 FZD7 frizzled homolog 7 (Drosophila) -0.66 9.0E-06 8.5E-05

2827057 GRAMD3 GRAM domain containing 3 -0.66 2.9E-05 2.1E-04

3144973 RAD54B RAD54 homolog B (S. cerevisiae) -0.66 2.3E-06 3.1E-05

2439842 TAGLN2 transgelin 2 -0.66 7.9E-08 2.7E-06

2948564 MDC1 mediator of DNA-damage checkpoint 1 -0.66 7.4E-07 1.4E-05

2742134 SPATA5 spermatogenesis associated 5 -0.66 2.9E-05 2.1E-04

3373845 SLC43A3 solute carrier family 43, member 3 -0.66 3.9E-06 4.4E-05

2943874 KIF13A kinesin family member 13A -0.67 2.6E-04 1.2E-03

2642887 CCRL1 chemokine (C-C motif) receptor-like 1 -0.67 2.6E-02 4.4E-02

3044129 GGCT gamma-glutamylcyclotransferase -0.67 1.7E-04 8.2E-04

2406064 SFPQ splicing factor proline/glutamine-rich -0.67 7.5E-06 7.4E-05

3665997 DUS2L dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) -0.67 9.4E-06 8.7E-05

3739108 FN3KRP fructosamine 3 kinase related protein -0.67 1.4E-05 1.2E-04

3991698 HPRT1 hypoxanthine phosphoribosyltransferase 1 -0.67 7.8E-05 4.5E-04

3628832 DAPK2 death-associated protein kinase 2 -0.67 1.3E-06 2.0E-05

2336650 PODN podocan -0.67 3.2E-06 3.8E-05

2961177 COL12A1 collagen, type XII, alpha 1 -0.67 7.7E-04 2.7E-03

2668351 UBP1 upstream binding protein 1 (LBP-1a) -0.67 5.1E-06 5.5E-05

2655476 AP2M1 adaptor-related protein complex 2, mu 1 subunit -0.67 1.6E-05 1.3E-04

3723005 FZD2 frizzled homolog 2 (Drosophila) -0.67 3.8E-07 8.2E-06

2336539 ZYG11A zyg-11 homolog A (C. elegans) -0.67 2.1E-05 1.6E-04

2491676 VAMP5 vesicle-associated membrane protein 5 (myobrevin) -0.67 1.1E-06 1.8E-05

3328389 EXT2 exostosin 2 -0.67 7.8E-08 2.7E-06

3529951 NYNRIN NYN domain and retroviral integrase containing -0.67 2.5E-05 1.9E-04

3176999 RMI1 RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) -0.67 7.8E-04 2.8E-03

2452405 NUAK2 NUAK family, SNF1-like kinase, 2 -0.68 2.7E-05 2.0E-04

3633578 CSPG4 chondroitin sulfate proteoglycan 4 -0.68 8.6E-07 1.5E-05

2347023 CCDC18 coiled-coil domain containing 18 -0.68 1.0E-03 3.4E-03

2674526 NICN1 nicolin 1 -0.68 7.8E-06 7.6E-05

2379754 SMYD2 SET and MYND domain containing 2 -0.68 3.4E-06 4.0E-05

2531779 ARMC9 armadillo repeat containing 9 -0.68 7.0E-06 7.0E-05

2440476 F11R F11 receptor -0.68 2.8E-05 2.1E-04

3947096 CCDC134 coiled-coil domain containing 134 -0.68 1.6E-06 2.4E-05

2856634 ARL15 ADP-ribosylation factor-like 15 -0.68 4.0E-04 1.6E-03

2403557 SNORA44 small nucleolar RNA, H/ACA box 44 -0.68 2.4E-05 1.8E-04

3428783 DRAM1 DNA-damage regulated autophagy modulator 1 -0.68 2.8E-06 3.5E-05

3190463 ODF2 outer dense fiber of sperm tails 2 -0.68 1.0E-06 1.7E-05

2610707 HRH1 histamine receptor H1 -0.68 3.7E-05 2.5E-04

2519577 COL3A1 collagen, type III, alpha 1 -0.68 4.7E-05 3.0E-04

3129465 INTS9 integrator complex subunit 9 -0.68 3.6E-06 4.3E-05

2949471 NEU1 sialidase 1 (lysosomal sialidase) -0.68 9.8E-07 1.7E-05

2944491 MBOAT1 membrane bound O-acyltransferase domain containing 1 -0.68 2.8E-06 3.5E-05

3860208 ALKBH6 alkB, alkylation repair homolog 6 (E. coli) -0.68 2.8E-05 2.1E-04

3714896 FAM27L family with sequence similarity 27-like -0.68 1.2E-02 2.4E-02

3245682 MAPK8 mitogen-activated protein kinase 8 -0.68 1.8E-05 1.5E-04

3182781 SMC2 structural maintenance of chromosomes 2 -0.68 7.0E-04 2.5E-03

4024160 ATP11C ATPase, class VI, type 11C -0.69 8.5E-04 2.9E-03

3432467 OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.69 9.3E-06 8.7E-05

3855358 HOMER3 homer homolog 3 (Drosophila) -0.69 2.4E-06 3.2E-05

2348757 HIAT1 hippocampus abundant transcript 1 -0.69 1.2E-05 1.1E-04

2723710 PGM2 phosphoglucomutase 2 -0.69 2.3E-05 1.7E-04

2352743 DCLRE1B DNA cross-link repair 1B -0.69 4.0E-04 1.7E-03

3416278 HOXC11 homeobox C11 -0.69 3.5E-05 2.4E-04

3962678 PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.69 2.6E-07 6.1E-06

3708961 WRAP53 WD repeat containing, antisense to TP53 -0.69 8.1E-06 7.8E-05

2863964 ARSB arylsulfatase B -0.69 7.0E-06 7.0E-05

3817501 CHAF1A chromatin assembly factor 1, subunit A (p150) -0.69 1.9E-05 1.5E-04

3102372 SULF1 sulfatase 1 -0.69 2.2E-04 1.0E-03

3088213 SH2D4A SH2 domain containing 4A -0.70 2.6E-07 6.2E-06

2344888 CYR61 cysteine-rich, angiogenic inducer, 61 -0.70 9.9E-07 1.7E-05

2858023 PLK2 polo-like kinase 2 -0.70 5.7E-05 3.6E-04

3858852 RHPN2 rhophilin, Rho GTPase binding protein 2 -0.70 4.4E-04 1.8E-03

3757329 JUP junction plakoglobin -0.70 1.3E-06 2.0E-05

2766492 C4ORF34 chromosome 4 open reading frame 34 -0.70 5.6E-05 3.5E-04

3232979 AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1;

20-alpha (3-alpha)-hydroxysteroid dehydrogenase)-0.70 2.0E-03 5.7E-03

3236448 SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -0.70 5.8E-05 3.6E-04

3323052 NAV2 neuron navigator 2 -0.70 9.9E-07 1.7E-05

3683377 GPRC5B G protein-coupled receptor, family C, group 5, member B -0.70 2.1E-05 1.6E-04

2562198 TGOLN2 trans-golgi network protein 2 -0.70 1.8E-06 2.5E-05

3418610 XRCC6BP1 XRCC6 binding protein 1 -0.71 1.4E-07 4.1E-06

3415368 KRT86 keratin 86 -0.71 8.4E-05 4.7E-04

3896200 PCNA proliferating cell nuclear antigen -0.71 1.1E-05 1.0E-04

2389789 SCCPDH saccharopine dehydrogenase (putative) -0.71 6.6E-06 6.7E-05

2638467 GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -0.71 4.2E-05 2.8E-04

2999755 AEBP1 AE binding protein 1 -0.71 2.2E-07 5.5E-06

4054204 APOD apolipoprotein D -0.71 5.5E-05 3.5E-04

2880292 DPYSL3 dihydropyrimidinase-like 3 -0.71 5.0E-06 5.4E-05

3258260 EXOC6 exocyst complex component 6 -0.71 4.0E-05 2.7E-04

3707095 ARRB2 arrestin, beta 2 -0.71 1.0E-05 9.3E-05

2688813 CCDC80 coiled-coil domain containing 80 -0.71 2.6E-07 6.2E-06

3994710 MAMLD1 mastermind-like domain containing 1 -0.71 5.2E-06 5.5E-05

3464747 KITLG KIT ligand -0.72 4.7E-04 1.9E-03

3433538 RNFT2 ring finger protein, transmembrane 2 -0.72 4.0E-06 4.5E-05

3604006 ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.72 1.9E-07 4.9E-06

2394784 NOL9 nucleolar protein 9 -0.72 2.8E-06 3.5E-05

2458289 LBR lamin B receptor -0.72 2.0E-04 9.6E-04

2902574 LY6G5B lymphocyte antigen 6 complex, locus G5B -0.72 4.9E-06 5.3E-05

3635125 MTHFS5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-

ligase)-0.72 5.2E-06 5.5E-05

3645253 SRRM1 serine/arginine repetitive matrix 2 -0.72 1.3E-05 1.1E-04

3683037 ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.72 2.5E-07 6.0E-06

3469319 APPL2adaptor protein, phosphotyrosine interaction, PH domain and leucine

zipper containing 2-0.72 5.4E-07 1.1E-05

2553911 SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) -0.72 5.4E-05 3.4E-04

3367338 KIF18A kinesin family member 18A -0.72 1.5E-04 7.4E-04

3223646 PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -0.72 7.7E-07 1.4E-05

3855596 NR2C2AP nuclear receptor 2C2-associated protein -0.73 3.6E-05 2.5E-04

2413519 HSPB11 heat shock protein family B (small), member 11 -0.73 9.7E-06 8.9E-05

3772187 EPR1 effector cell peptidase receptor 1 (non-protein coding) -0.73 3.1E-04 1.3E-03

3010082 PHTF2 putative homeodomain transcription factor 2 -0.73 2.8E-04 1.2E-03

3917563 KRTAP1-5 keratin associated protein 15-1 -0.73 1.4E-05 1.2E-04

3456081 RARG retinoic acid receptor, gamma -0.73 4.4E-07 9.1E-06

3205488 ZBTB5 zinc finger and BTB domain containing 5 -0.73 3.6E-06 4.2E-05

2519480 GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.73 4.6E-05 3.0E-04

3539499 RHOJ ras homolog gene family, member J -0.73 2.6E-06 3.3E-05

2929870 STXBP5 syntaxin binding protein 5 (tomosyn) -0.74 1.6E-04 8.0E-04

2560286 LOXL3 lysyl oxidase-like 3 -0.74 2.9E-08 1.3E-06

3929038 C21ORF45 chromosome 21 open reading frame 45 -0.74 8.3E-08 2.8E-06

2695941 TOPBP1 topoisomerase (DNA) II binding protein 1 -0.74 3.4E-04 1.4E-03

2353237 VANGL1 vang-like 1 (van gogh, Drosophila) -0.74 2.3E-05 1.8E-04

3447694 BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.74 3.3E-04 1.4E-03

3863811 PSG6 pregnancy specific beta-1-glycoprotein 6 -0.74 2.0E-03 5.9E-03

2654091 USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -0.74 4.9E-06 5.3E-05

2388794 ZNF238 zinc finger protein 238 -0.74 8.2E-06 7.9E-05

2426951 PSRC1 proline/serine-rich coiled-coil 1 -0.75 4.2E-06 4.7E-05

2375784 NCRNA00260 non-protein coding RNA 260 -0.75 3.7E-05 2.6E-04

3866276 SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.75 7.6E-07 1.4E-05

3904594 C20ORF117 chromosome 20 open reading frame 117 -0.75 2.3E-06 3.1E-05

2634058 FAM55C family with sequence similarity 55, member C -0.75 4.1E-05 2.8E-04

2844709 CNOT6 CCR4-NOT transcription complex, subunit 6 -0.75 4.3E-05 2.8E-04

2884623 C1QTNF2 C1q and tumor necrosis factor related protein 2 -0.76 8.0E-05 4.6E-04

3850676 KANK2 KN motif and ankyrin repeat domains 2 -0.76 2.9E-07 6.7E-06

2924330 TPD52L1 tumor protein D52-like 1 -0.76 2.2E-04 1.0E-03

2542795 SDC1 syndecan 1 -0.76 1.3E-06 2.0E-05

3268669 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) -0.76 8.4E-07 1.5E-05

2609347 LMCD1 LIM and cysteine-rich domains 1 -0.76 3.9E-05 2.6E-04

3960685 DMC1DMC1 dosage suppressor of mck1 homolog, meiosis-specific

homologous recombination (yeast)-0.76 1.1E-05 9.6E-05

3080283 XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -0.76 7.0E-04 2.5E-03

3015442 PILRB paired immunoglobin-like type 2 receptor beta -0.76 1.8E-06 2.5E-05

3168255 HRCT1 histidine rich carboxyl terminus 1 -0.76 2.9E-05 2.1E-04

2371547 C1ORF21 chromosome 1 open reading frame 21 -0.76 1.5E-05 1.3E-04

2684851 VGLL3 vestigial like 3 (Drosophila) -0.76 3.6E-03 9.3E-03

3770699 MIF4GD MIF4G domain containing -0.76 3.9E-07 8.4E-06

2836451 MFAP3 microfibrillar-associated protein 3 -0.76 2.2E-04 1.0E-03

3757917 PTRF polymerase I and transcript release factor -0.76 4.3E-08 1.8E-06

2352758 HIPK1 homeodomain interacting protein kinase 1 -0.76 3.8E-06 4.4E-05

2444451 CENPL centromere protein L -0.76 4.3E-06 4.8E-05

2796484 CASP3 caspase 3, apoptosis-related cysteine peptidase -0.76 1.8E-05 1.5E-04

3976797 SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -0.76 2.7E-04 1.2E-03

3414846 DAZAP2 DAZ associated protein 2 -0.77 1.8E-07 4.8E-06

2786567 C4ORF49 chromosome 4 open reading frame 49 -0.77 2.4E-06 3.2E-05

3764738 SKA2 spindle and kinetochore associated complex subunit 2 -0.77 7.9E-06 7.7E-05

3625761 MNS1 meiosis-specific nuclear structural 1 -0.77 9.5E-05 5.2E-04

3901851 ABHD12 abhydrolase domain containing 12 -0.77 1.9E-06 2.7E-05

3167553 IL11RA interleukin 11 receptor, alpha -0.77 2.1E-07 5.3E-06

3465248 LUM lumican -0.77 8.1E-04 2.8E-03

3658925 ORC6 origin recognition complex, subunit 6 -0.77 2.0E-07 5.2E-06

3562746 C14ORF106 chromosome 14 open reading frame 106 -0.77 5.5E-05 3.5E-04

3726691 ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.77 2.2E-08 1.1E-06

3007438 POM121 POM121 membrane glycoprotein -0.77 1.8E-02 3.4E-02

2944068 DEK DEK oncogene -0.78 2.7E-04 1.2E-03

2366422 ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.78 1.0E-05 9.4E-05

3907111 TOMM34 translocase of outer mitochondrial membrane 34 -0.78 6.8E-08 2.4E-06

3074857 PTN pleiotrophin -0.78 3.7E-04 1.6E-03

2591643 COL5A2 collagen, type V, alpha 2 -0.78 6.6E-05 4.0E-04

3628498 CA12 carbonic anhydrase XII -0.78 1.6E-06 2.3E-05

2514122 LASS6 LAG1 homolog, ceramide synthase 6 -0.78 1.1E-05 9.7E-05

2857416 IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) -0.78 7.3E-04 2.6E-03

2334319 TOE1 target of EGR1, member 1 (nuclear) -0.79 3.5E-06 4.1E-05

2757319 SLBP stem-loop binding protein -0.79 1.8E-05 1.4E-04

2829947 TGFBI transforming growth factor, beta-induced, 68kDa -0.79 9.8E-08 3.1E-06

3103293 RDH10 retinol dehydrogenase 10 (all-trans) -0.79 2.1E-05 1.6E-04

3854218 HAUS8 HAUS augmin-like complex, subunit 8 -0.79 1.8E-04 8.6E-04

2836242 GRIA1 glutamate receptor, ionotropic, AMPA 1 -0.79 2.7E-06 3.5E-05

3415668 TENC1 tensin like C1 domain containing phosphatase (tensin 2) -0.79 9.3E-08 3.0E-06

2533493 SH3BP4 SH3-domain binding protein 4 -0.79 2.1E-08 1.1E-06

2429261 NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -0.80 4.8E-06 5.2E-05

3318967 OR10A2 olfactory receptor, family 10, subfamily A, member 2 -0.80 1.2E-02 2.4E-02

3722770 C17ORF53 chromosome 17 open reading frame 53 -0.80 2.8E-06 3.5E-05

3923218 RRP1B ribosomal RNA processing 1 homolog B (S. cerevisiae) -0.80 8.0E-07 1.4E-05

2779486 H2AFZ H2A histone family, member Z -0.80 2.1E-07 5.3E-06

3599709 GLCE glucuronic acid epimerase -0.80 2.7E-05 2.0E-04

3677315 PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -0.81 1.0E-06 1.7E-05

2904663 FANCE Fanconi anemia, complementation group E -0.81 4.2E-06 4.7E-05

3168385 GLIPR2 GLI pathogenesis-related 2 -0.81 1.1E-07 3.4E-06

3766621 ICAM2 intercellular adhesion molecule 2 -0.81 3.6E-06 4.2E-05

2429466 NGF nerve growth factor (beta polypeptide) -0.81 1.1E-05 1.0E-04

2852274 MTMR12 myotubularin related protein 12 -0.82 3.8E-06 4.4E-05

2719617 BST1 bone marrow stromal cell antigen 1 -0.82 7.7E-07 1.4E-05

3557791 FAM158A family with sequence similarity 158, member A -0.82 2.0E-06 2.8E-05

2340819 TCTEX1D1 Tctex1 domain containing 1 -0.82 3.0E-05 2.2E-04

3403168 C1S complement component 1, s subcomponent -0.82 7.0E-06 7.0E-05

3327906 API5 apoptosis inhibitor 5 -0.82 1.1E-05 1.0E-04

2334646 RAD54L RAD54-like (S. cerevisiae) -0.82 5.1E-05 3.2E-04

3318009 RRM1 ribonucleotide reductase M1 -0.83 7.3E-06 7.2E-05

4000944 RBBP7 retinoblastoma binding protein 7 -0.83 2.2E-07 5.5E-06

2905069 KCTD20 potassium channel tetramerisation domain containing 20 -0.83 2.6E-05 1.9E-04

3593147 DUT deoxyuridine triphosphatase -0.83 2.3E-05 1.8E-04

3279058 ACBD7 acyl-CoA binding domain containing 7 -0.83 4.3E-05 2.8E-04

3708074 XAF1 XIAP associated factor 1 -0.83 3.7E-05 2.5E-04

2324341 NBPF3 neuroblastoma breakpoint family, member 3 -0.83 2.5E-06 3.3E-05

3308489 KIAA1598 KIAA1598 -0.83 5.0E-05 3.2E-04

3056414 RFC2 replication factor C (activator 1) 2, 40kDa -0.83 4.0E-05 2.7E-04

3634811 CTSH cathepsin H -0.83 6.3E-06 6.5E-05

2953852 MED20 mediator complex subunit 20 -0.83 4.3E-05 2.8E-04

3413278 TMEM106C transmembrane protein 106C -0.84 1.9E-06 2.7E-05

3748798 MFAP4 microfibrillar-associated protein 4 -0.84 2.4E-08 1.2E-06

3012019 CLDN12 claudin 12 -0.84 5.1E-05 3.2E-04

3995633 BGN biglycan -0.84 1.4E-07 4.0E-06

3907234 SDC4 syndecan 4 -0.84 3.8E-08 1.6E-06

2674808 TRAIP TRAF interacting protein -0.84 1.4E-05 1.2E-04

3060245 SLC25A40 solute carrier family 25, member 40 -0.84 3.4E-05 2.4E-04

2907671 PTK7 PTK7 protein tyrosine kinase 7 -0.84 9.9E-09 6.5E-07

3645477 PAQR4 progestin and adipoQ receptor family member IV -0.84 5.0E-05 3.2E-04

2549565 SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.84 3.4E-05 2.4E-04

3724197 NSF N-ethylmaleimide-sensitive factor -0.85 2.7E-07 6.3E-06

3576284 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.85 4.3E-06 4.8E-05

3862273 PRR13 proline rich 13 -0.85 2.0E-05 1.6E-04

3476012 MPHOSPH9 M-phase phosphoprotein 9 -0.85 5.4E-05 3.4E-04

2330075 EIF2C1 eukaryotic translation initiation factor 2C, 1 -0.85 3.8E-06 4.4E-05

3723071 DBF4B DBF4 homolog B (S. cerevisiae) -0.85 9.9E-07 1.7E-05

2412799 ORC1 origin recognition complex, subunit 1 -0.86 5.5E-05 3.5E-04

3903146 E2F1 E2F transcription factor 1 -0.86 7.3E-06 7.3E-05

2950277 HLA-DMA major histocompatibility complex, class II, DM alpha -0.86 4.0E-07 8.4E-06

3548152 TDP1 tyrosyl-DNA phosphodiesterase 1 -0.86 4.3E-07 8.8E-06

2402459 STMN1 stathmin 1 -0.86 7.9E-08 2.7E-06

2350922 GSTM4 glutathione S-transferase mu 4 -0.87 2.0E-06 2.8E-05

3250055 DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 -0.87 1.9E-05 1.5E-04

3651018 CP110 CP110 protein -0.87 6.3E-04 2.4E-03

2361154 SYT11 synaptotagmin XI -0.87 1.9E-07 5.1E-06

3226592 WDR34 WD repeat domain 34 -0.87 1.9E-06 2.7E-05

2327482 RCC1 regulator of chromosome condensation 1 -0.88 3.4E-06 4.0E-05

3149843 RAD21 RAD21 homolog (S. pombe) -0.88 3.0E-06 3.7E-05

3274758 AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2;

bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)-0.88 2.1E-04 9.7E-04

2750594 SC4MOL sterol-C4-methyl oxidase-like -0.88 5.7E-05 3.6E-04

2696309 AMOTL2 angiomotin like 2 -0.88 1.3E-07 3.8E-06

2351004 GSTM5 glutathione S-transferase mu 5 -0.88 1.5E-04 7.4E-04

2529627 KCNE4 potassium voltage-gated channel, Isk-related family, member 4 -0.89 6.1E-04 2.3E-03

3866898 LIG1 ligase I, DNA, ATP-dependent -0.89 4.0E-06 4.5E-05

3261923 AS3MT arsenic (+3 oxidation state) methyltransferase -0.89 4.1E-05 2.7E-04

2353773 TTF2 transcription termination factor, RNA polymerase II -0.89 4.5E-06 5.0E-05

3556966 HAUS4 HAUS augmin-like complex, subunit 4 -0.89 3.4E-06 4.0E-05

3318390 TRIM6-TRIM34 TRIM6-TRIM34 readthrough -0.89 8.7E-08 2.9E-06

3427352 NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -0.89 2.6E-04 1.2E-03

4012142 ERCC6Lexcision repair cross-complementing rodent repair deficiency,

complementation group 6-like-0.89 9.6E-07 1.6E-05

3340161 PPME1 protein phosphatase methylesterase 1 -0.89 1.1E-08 7.0E-07

2471316 GEN1 Gen homolog 1, endonuclease (Drosophila) -0.90 1.1E-04 5.8E-04

2697721 PRR23C proline rich 23C -0.90 9.9E-04 3.3E-03

3439178 PXMP2 peroxisomal membrane protein 2, 22kDa -0.90 1.1E-06 1.8E-05

3435362 KNTC1 kinetochore associated 1 -0.90 8.3E-06 7.9E-05

3831062 WDR62 WD repeat domain 62 -0.90 3.2E-06 3.9E-05

4009238 SMC1A structural maintenance of chromosomes 1A -0.91 3.7E-06 4.3E-05

3394183 H2AFX H2A histone family, member X -0.91 4.5E-07 9.2E-06

3479181 POLE polymerase (DNA directed), epsilon -0.91 1.0E-05 9.3E-05

2951567 FKBP5 FK506 binding protein 5 -0.91 1.3E-06 2.0E-05

3852691 DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 -0.91 7.9E-06 7.7E-05

3340269 POLD3 polymerase (DNA-directed), delta 3, accessory subunit -0.91 2.9E-05 2.1E-04

3558118 DHRS1 dehydrogenase/reductase (SDR family) member 1 -0.91 1.2E-07 3.5E-06

3565206 BMP4 bone morphogenetic protein 4 -0.91 5.2E-08 2.0E-06

3414885 SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 -0.91 1.3E-07 3.8E-06

3192912 C9ORF96 chromosome 9 open reading frame 96 -0.92 1.5E-04 7.4E-04

2902844 CFB complement factor B -0.92 2.1E-07 5.3E-06

3333358 INCENP inner centromere protein antigens 135/155kDa -0.92 4.2E-06 4.7E-05

2840002 CCDC99 coiled-coil domain containing 99 -0.92 3.8E-05 2.6E-04

3716664 SUZ12P suppressor of zeste 12 homolog pseudogene -0.92 8.7E-06 8.2E-05

3573994 C14ORF145 chromosome 14 open reading frame 145 -0.92 1.1E-05 9.8E-05

3050367 FIGNL1 fidgetin-like 1 -0.92 3.8E-05 2.6E-04

2441043 OLFML2B olfactomedin-like 2B -0.92 2.1E-07 5.3E-06

2330687 ZC3H12A zinc finger CCCH-type containing 12A -0.92 3.1E-06 3.8E-05

3204692 C9ORF100 chromosome 9 open reading frame 100 -0.93 4.0E-07 8.4E-06

3601348 LOXL1 lysyl oxidase-like 1 -0.93 4.3E-08 1.7E-06

7385547 CCL2 chemokine (C-C motif) ligand 2 -0.93 5.5E-06 5.8E-05

3550485 VRK1 vaccinia related kinase 1 -0.93 6.8E-07 1.3E-05

3417146 CDK2 cyclin-dependent kinase 2 -0.93 7.8E-07 1.4E-05

3415576 KRT18 keratin 18 -0.93 1.6E-06 2.3E-05

2334404 NASP nuclear autoantigenic sperm protein (histone-binding) -0.93 2.8E-07 6.4E-06

3258910 HELLS helicase, lymphoid-specific -0.93 1.9E-05 1.5E-04

2966587 SIM1 single-minded homolog 1 (Drosophila) -0.94 3.1E-05 2.2E-04

2402416 C1ORF135 chromosome 1 open reading frame 135 -0.94 6.3E-05 3.8E-04

4000370 FANCB Fanconi anemia, complementation group B -0.94 1.4E-06 2.1E-05

3598721 ZWILCH Zwilch, kinetochore associated, homolog (Drosophila) -0.94 2.2E-06 3.0E-05

2516023 CDCA7 cell division cycle associated 7 -0.95 2.9E-07 6.6E-06

2384268 HIST3H2BB histone cluster 3, H2bb -0.95 9.1E-05 5.1E-04

2587961 CHN1 chimerin (chimaerin) 1 -0.96 8.0E-07 1.4E-05

2948547 NRM nurim (nuclear envelope membrane protein) -0.96 7.7E-07 1.4E-05

3850660 SPC24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) -0.96 4.4E-06 4.9E-05

3399545 NCAPD3 non-SMC condensin II complex, subunit D3 -0.96 2.1E-06 2.9E-05

2948630 IER3 immediate early response 3 -0.96 5.1E-07 1.0E-05

3758317 BRCA1 breast cancer 1, early onset -0.96 3.0E-06 3.7E-05

4019900 CUL4B cullin 4B -0.96 1.9E-06 2.7E-05

3905145 TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyl-

transferase)-0.97 7.7E-07 1.4E-05

3443226 MFAP5 microfibrillar associated protein 5 -0.97 3.4E-07 7.5E-06

3827218 RPSAP58 ribosomal protein SA pseudogene 58 -0.97 3.3E-03 8.7E-03

3468743 NT5DC3 5'-nucleotidase domain containing 3 -0.97 4.0E-07 8.4E-06

2625907 FLNB filamin B, beta -0.97 4.0E-08 1.7E-06

2373693 LHX9 LIM homeobox 9 -0.97 8.3E-08 2.8E-06

2911413 PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.98 2.1E-07 5.3E-06

2369339 RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.98 1.9E-05 1.5E-04

2946324 HIST1H3D histone cluster 1, H3d -0.98 3.4E-06 4.0E-05

3013255 PEG10 paternally expressed 10 -0.98 1.1E-05 9.6E-05

3362852 MRVI1 murine retrovirus integration site 1 homolog -0.98 2.9E-06 3.6E-05

3850069 DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.98 8.2E-08 2.8E-06

2732844 ANXA3 annexin A3 -0.99 8.5E-07 1.5E-05

3875195 MCM8 minichromosome maintenance complex component 8 -0.99 2.2E-05 1.7E-04

2888674 MXD3 MAX dimerization protein 3 -0.99 5.5E-07 1.1E-05

3970476 SCML1 sex comb on midleg-like 1 (Drosophila) -1.00 7.1E-06 7.1E-05

3127334 REEP4 receptor accessory protein 4 -1.00 7.0E-07 1.3E-05

3748400 USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene) -1.00 7.7E-03 1.7E-02

3410614 FGD4 FYVE, RhoGEF and PH domain containing 4 -1.01 4.6E-06 5.0E-05

3904747 RBL1 retinoblastoma-like 1 (p107) -1.01 4.8E-06 5.2E-05

2743315 PHF17 PHD finger protein 17 -1.01 9.1E-08 3.0E-06

3556990 JUB jub, ajuba homolog (Xenopus laevis) -1.01 1.5E-08 8.8E-07

3607698 C15ORF42 chromosome 15 open reading frame 42 -1.02 2.4E-07 5.9E-06

3204463 FANCG Fanconi anemia, complementation group G -1.02 4.0E-06 4.5E-05

3137875 GGHgamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl

hydrolase)-1.02 4.3E-06 4.8E-05

2364155 UHMK1 U2AF homology motif (UHM) kinase 1 -1.02 6.6E-06 6.7E-05

2458338 ENAH enabled homolog (Drosophila) -1.02 2.1E-05 1.6E-04

3097152 MCM4 minichromosome maintenance complex component 4 -1.02 4.5E-07 9.2E-06

3293724 C10ORF54 chromosome 10 open reading frame 54 -1.02 5.7E-06 5.9E-05

2709486 RFC4 replication factor C (activator 1) 4, 37kDa -1.02 1.4E-06 2.1E-05

2584134 FAP fibroblast activation protein, alpha -1.03 8.7E-05 4.9E-04

3760268 ARL17A ADP-ribosylation factor-like 17A -1.03 1.0E-03 3.4E-03

3335029 POLA2 polymerase (DNA directed), alpha 2 (70kD subunit) -1.03 7.8E-06 7.7E-05

2548617 CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -1.03 8.2E-07 1.4E-05

3145107 CCNE2 cyclin E2 -1.04 8.0E-05 4.6E-04

3383227 GAB2 GRB2-associated binding protein 2 -1.04 1.2E-08 7.4E-07

3240012 MASTL microtubule associated serine/threonine kinase-like -1.04 2.5E-07 6.1E-06

2571510 IL1B interleukin 1, beta -1.04 1.8E-03 5.3E-03

3770632 SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) -1.05 1.4E-05 1.2E-04

3203935 KIF24 kinesin family member 24 -1.05 1.1E-06 1.8E-05

2522916 CDK15 cyclin-dependent kinase 15 -1.05 9.2E-07 1.6E-05

2477203 VIT vitrin -1.05 1.8E-06 2.6E-05

3299504 ACTA2 actin, alpha 2, smooth muscle, aorta -1.05 4.0E-08 1.7E-06

2622696 SEMA3Bsema domain, immunoglobulin domain (Ig), short basic domain,

secreted, (semaphorin) 3B-1.05 2.3E-06 3.1E-05

3154185 TMEM71 transmembrane protein 71 -1.05 1.9E-06 2.7E-05

3367036 CCDC34 coiled-coil domain containing 34 -1.06 3.0E-06 3.7E-05

2511432 GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -1.06 8.3E-07 1.5E-05

2715076 WHSC1 Wolf-Hirschhorn syndrome candidate 1 -1.07 1.7E-08 9.3E-07

3920003 CHAF1B chromatin assembly factor 1, subunit B (p60) -1.07 5.1E-06 5.5E-05

2813442 CENPH centromere protein H -1.07 2.3E-09 2.6E-07

3354210 SPA17 sperm autoantigenic protein 17 -1.08 4.2E-06 4.7E-05

3059667 SEMA3Dsema domain, immunoglobulin domain (Ig), short basic domain,

secreted, (semaphorin) 3D-1.08 6.4E-03 1.5E-02

3302187 ARHGAP19 Rho GTPase activating protein 19 -1.08 1.7E-06 2.5E-05

3415320 KRT7 keratin 7 -1.08 1.5E-05 1.3E-04

2649367 PTX3 pentraxin 3, long -1.08 2.2E-06 3.0E-05

3817602 TNFAIP8L1 tumor necrosis factor, alpha-induced protein 8-like 1 -1.08 2.7E-05 2.0E-04

3484497 FRY furry homolog (Drosophila) -1.09 1.2E-05 1.0E-04

3405515 APOLD1 apolipoprotein L domain containing 1 -1.09 5.9E-07 1.1E-05

2634027 CEP97 centrosomal protein 97kDa -1.09 1.2E-05 1.1E-04

3880827 GINS1 GINS complex subunit 1 (Psf1 homolog) -1.10 6.0E-08 2.2E-06

3333226 FEN1 flap structure-specific endonuclease 1 -1.10 5.2E-07 1.0E-05

2518272 ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -1.10 7.9E-05 4.6E-04

3329983 PTPRJ protein tyrosine phosphatase, receptor type, J -1.10 2.2E-07 5.5E-06

2339414 USP1 ubiquitin specific peptidase 1 -1.11 6.0E-05 3.7E-04

3715489 TMEM97 transmembrane protein 97 -1.11 2.1E-07 5.3E-06

3403015 ENO2 enolase 2 (gamma, neuronal) -1.12 3.7E-07 8.1E-06

2802681 LOC100133299 GALI1870 -1.12 7.7E-04 2.7E-03

2565902 ANKRD36B ankyrin repeat domain 36B -1.14 1.3E-02 2.6E-02

3972093 POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -1.14 4.5E-06 4.9E-05

3530982 G2E3 G2/M-phase specific E3 ubiquitin protein ligase -1.14 1.4E-06 2.1E-05

2898597 GMNN geminin, DNA replication inhibitor -1.14 1.1E-07 3.4E-06

3464967 GALNT4UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactos-

aminyl-transferase 4 (GalNAc-T4)-1.15 2.3E-07 5.6E-06

3563395 POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit) -1.15 3.9E-07 8.4E-06

2957126 MCM3 minichromosome maintenance complex component 3 -1.15 7.1E-06 7.1E-05

2584787 COBLL1 COBL-like 1 -1.16 1.4E-05 1.2E-04

2652675 ECT2 epithelial cell transforming sequence 2 oncogene -1.16 5.1E-06 5.5E-05

2720584 SLIT2 slit homolog 2 (Drosophila) -1.16 2.9E-07 6.7E-06

2783715 MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -1.16 3.2E-06 3.9E-05

2899171 HIST1H1E histone cluster 1, H1e -1.16 3.5E-08 1.5E-06

3257246 IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -1.16 3.0E-07 6.8E-06

2406420 CLSPN claspin -1.17 8.1E-06 7.8E-05

3433747 RFC5 replication factor C (activator 1) 5, 36.5kDa -1.17 1.1E-06 1.8E-05

3119213 LY6K lymphocyte antigen 6 complex, locus K -1.17 2.2E-05 1.7E-04

3311832 ADAM12 ADAM metallopeptidase domain 12 -1.18 1.0E-07 3.2E-06

3741997 ANKFY1 ankyrin repeat and FYVE domain containing 1 -1.18 2.8E-08 1.3E-06

2947081 HIST1H4L histone cluster 1, H4l -1.18 5.8E-07 1.1E-05

2674762 UBA7 ubiquitin-like modifier activating enzyme 7 -1.18 8.1E-10 1.5E-07

3757970 PSMC3IP PSMC3 interacting protein -1.19 2.9E-07 6.7E-06

3319937 WEE1 WEE1 homolog (S. pombe) -1.19 3.3E-09 3.2E-07

3095766 GINS4 GINS complex subunit 4 (Sld5 homolog) -1.20 4.3E-07 8.8E-06

2947077 HIST1H3I histone cluster 1, H3i -1.20 3.5E-07 7.6E-06

3178583 CKS2 CDC28 protein kinase regulatory subunit 2 -1.20 1.4E-07 4.1E-06

2462160 NID1 nidogen 1 -1.20 4.5E-08 1.8E-06

4022781 FAM122B family with sequence similarity 122B -1.20 1.3E-06 2.0E-05

2928461 GPR126 G protein-coupled receptor 126 -1.21 3.8E-06 4.3E-05

3704980 FANCA Fanconi anemia, complementation group A -1.21 9.3E-08 3.0E-06

2451043 LMOD1 leiomodin 1 (smooth muscle) -1.21 1.3E-06 2.0E-05

2946353 HIST1H1D histone cluster 1, H1d -1.21 5.5E-06 5.8E-05

2754937 TLR3 toll-like receptor 3 -1.21 2.0E-06 2.8E-05

2661992 OXTR oxytocin receptor -1.22 1.1E-06 1.8E-05

3821908 RNASEH2A ribonuclease H2, subunit A -1.22 3.2E-07 7.3E-06

3929775 DONSON downstream neighbor of SON -1.22 9.4E-07 1.6E-05

2425118 SASS6 spindle assembly 6 homolog (C. elegans) -1.22 4.7E-05 3.0E-04

2510464 TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -1.22 3.5E-06 4.2E-05

3649811 NDE1 nudE nuclear distribution gene E homolog 1 (A. nidulans) -1.23 1.2E-07 3.6E-06

3457824 TIMELESS timeless homolog (Drosophila) -1.23 1.1E-06 1.8E-05

3414739 METTL7A methyltransferase like 7A -1.23 4.3E-09 3.8E-07

3331903 FAM111B family with sequence similarity 111, member B -1.23 2.0E-05 1.6E-04

2783207 PRSS12 protease, serine, 12 (neurotrypsin, motopsin) -1.24 9.5E-08 3.0E-06

3415744 IGFBP6 insulin-like growth factor binding protein 6 -1.24 1.3E-08 7.8E-07

2780172 CENPE centromere protein E, 312kDa -1.24 3.5E-05 2.4E-04

3455261 KRT81 keratin 81 -1.24 4.6E-09 4.0E-07

3802602 CDH2 cadherin 2, type 1, N-cadherin (neuronal) -1.24 2.2E-08 1.1E-06

2326410 CCDC21 coiled-coil domain containing 21 -1.24 5.7E-07 1.1E-05

3428845 C12ORF48 chromosome 12 open reading frame 48 -1.25 9.9E-09 6.5E-07

3810542 CCBE1 collagen and calcium binding EGF domains 1 -1.26 7.7E-08 2.7E-06

2686458 ABI3BP ABI family, member 3 (NESH) binding protein -1.26 6.8E-07 1.3E-05

3817698 UHRF1 ubiquitin-like with PHD and ring finger domains 1 -1.26 4.7E-08 1.8E-06

3944147 MCM5 minichromosome maintenance complex component 5 -1.27 8.1E-07 1.4E-05

3765580 BRIP1 BRCA1 interacting protein C-terminal helicase 1 -1.27 1.4E-06 2.1E-05

2434129 HIST2H2AB histone cluster 2, H2ab -1.27 2.8E-06 3.6E-05

2899223 HIST1H2AE histone cluster 1, H2ae -1.27 3.9E-06 4.5E-05

3000905 C7ORF69 chromosome 7 open reading frame 69 -1.27 1.2E-06 1.9E-05

2709606 RPL39L ribosomal protein L39-like -1.27 2.5E-07 6.0E-06

3809826 ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -1.28 8.3E-08 2.8E-06

2427007 SORT1 sortilin 1 -1.28 3.1E-08 1.4E-06

3458133 PRIM1 primase, DNA, polypeptide 1 (49kDa) -1.28 3.8E-07 8.2E-06

4045643 S100A16 S100 calcium binding protein A16 -1.28 2.6E-09 2.7E-07

3748323 SHMT1 serine hydroxymethyltransferase 1 (soluble) -1.28 4.8E-06 5.2E-05

3655628 KIF22 kinesin family member 22 -1.29 6.2E-07 1.2E-05

3887049 UBE2C ubiquitin-conjugating enzyme E2C -1.29 9.3E-07 1.6E-05

3509411 MAB21L1 mab-21-like 1 (C. elegans) -1.29 1.2E-08 7.5E-07

3598959 SMAD3 SMAD family member 3 -1.30 2.2E-09 2.5E-07

2905404 PIM1 pim-1 oncogene -1.30 2.3E-07 5.6E-06

3168409 CCIN calicin -1.30 6.5E-06 6.6E-05

3493391 C13ORF34 chromosome 13 open reading frame 34 -1.30 6.2E-08 2.3E-06

2980241 FBXO5 F-box protein 5 -1.30 1.1E-06 1.8E-05

2941784 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -1.31 3.1E-09 3.1E-07

2700365 TM4SF1 transmembrane 4 L six family member 1 -1.31 1.9E-06 2.7E-05

2748163 MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) -1.32 3.1E-05 2.2E-04

2899102 HIST1H3C histone cluster 1, H3c -1.33 1.3E-07 3.9E-06

2413423 TMEM48 transmembrane protein 48 -1.33 4.8E-08 1.9E-06

2877257 BRD8 bromodomain containing 8 -1.33 3.3E-08 1.4E-06

2902178 TCF19 transcription factor 19 -1.33 1.5E-06 2.2E-05

2899768 HIST1H4I histone cluster 1, H4i -1.34 7.2E-06 7.1E-05

2691575 POLQ polymerase (DNA directed), theta -1.34 2.8E-07 6.5E-06

3504691 ZDHHC20 zinc finger, DHHC-type containing 20 -1.34 1.9E-07 5.1E-06

2435005 SELENBP1 selenium binding protein 1 -1.34 5.7E-09 4.5E-07

2946232 HIST1H1C histone cluster 1, H1c -1.34 4.0E-07 8.4E-06

2640855 MCM2 minichromosome maintenance complex component 2 -1.35 5.0E-07 9.9E-06

3499132 ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -1.35 2.9E-08 1.3E-06

3235789 MCM10 minichromosome maintenance complex component 10 -1.35 2.7E-07 6.3E-06

2451200 UBE2T ubiquitin-conjugating enzyme E2T (putative) -1.36 2.1E-08 1.1E-06

2879166 FGF1 fibroblast growth factor 1 (acidic) -1.36 7.3E-09 5.5E-07

3757108 KRT19 keratin 19 -1.37 9.6E-07 1.6E-05

2434319 ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -1.37 8.5E-06 8.1E-05

2946208 HIST1H4B histone cluster 1, H4b -1.38 1.2E-05 1.0E-04

3608298 BLM Bloom syndrome, RecQ helicase-like -1.38 1.5E-07 4.1E-06

3485074 RFC3 replication factor C (activator 1) 3, 38kDa -1.38 1.5E-08 8.4E-07

2598099 BARD1 BRCA1 associated RING domain 1 -1.38 4.1E-07 8.5E-06

2945882 CMAHcytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-N-

acetylneuraminate monooxygenase) pseudogene-1.38 2.2E-07 5.6E-06

3257338 KIF20B kinesin family member 20B -1.38 1.3E-06 2.0E-05

2397025 DHRS3 dehydrogenase/reductase (SDR family) member 3 -1.38 1.1E-08 6.9E-07

3452478 AMIGO2 adhesion molecule with Ig-like domain 2 -1.39 1.5E-07 4.2E-06

3405587 GPRC5A G protein-coupled receptor, family C, group 5, member A -1.40 2.2E-09 2.6E-07

2946219 HIST1H2AB histone cluster 1, H2ab -1.40 8.5E-06 8.1E-05

2899243 HIST1H4F histone cluster 1, H4f -1.40 4.7E-06 5.1E-05

2946364 HIST1H3F histone cluster 1, H3f -1.40 3.6E-06 4.2E-05

2900091 HIST1H2AL histone cluster 1, H2al -1.41 7.7E-08 2.7E-06

2981912 EZR ezrin -1.41 7.1E-08 2.5E-06

2858592 DEPDC1B DEP domain containing 1B -1.42 1.1E-07 3.2E-06

2946215 HIST1H3B histone cluster 1, H3b -1.42 1.1E-07 3.2E-06

2946194 HIST1H1A histone cluster 1, H1a -1.43 1.6E-05 1.4E-04

3063685 MCM7 minichromosome maintenance complex component 7 -1.43 9.3E-07 1.6E-05

2388219 EXO1 exonuclease 1 -1.44 2.5E-07 6.0E-06

3651509 ERI2 ERI1 exoribonuclease family member 2 -1.44 9.3E-09 6.2E-07

2947040 HIST1H2AJ histone cluster 1, H2aj -1.47 9.2E-04 3.1E-03

2577896 MCM6 minichromosome maintenance complex component 6 -1.47 7.2E-08 2.5E-06

3445028 GPR19 G protein-coupled receptor 19 -1.47 2.3E-04 1.1E-03

2946268 HIST1H2BC histone cluster 1, H2bc -1.47 2.5E-05 1.9E-04

3377423 CDCA5 cell division cycle associated 5 -1.47 1.2E-06 1.9E-05

3874438 CDC25B cell division cycle 25 homolog B (S. pombe) -1.47 7.6E-09 5.5E-07

2975655 FAM54A family with sequence similarity 54, member A -1.48 6.6E-07 1.2E-05

2742985 PLK4 polo-like kinase 4 -1.48 2.1E-06 2.9E-05

3962165 CENPM centromere protein M -1.48 3.3E-06 4.0E-05

2899772 HIST1H2AH histone cluster 1, H2ah -1.48 2.3E-05 1.7E-04

2473284 CENPO centromere protein O -1.48 1.2E-06 1.9E-05

2675936 POC1A POC1 centriolar protein homolog A (Chlamydomonas) -1.49 2.0E-06 2.8E-05

2900059 HIST1H2BM histone cluster 1, H2bm -1.49 2.7E-07 6.3E-06

3726375 EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) -1.49 2.5E-07 6.0E-06

3728964 PRR11 proline rich 11 -1.49 1.2E-09 1.7E-07

2711034 C3ORF59 chromosome 3 open reading frame 59 -1.50 3.8E-09 3.5E-07

2652027 CLDN11 claudin 11 -1.50 7.7E-09 5.6E-07

2899206 HIST1H2BF histone cluster 1, H2bf -1.51 9.2E-08 3.0E-06

3706753 GSG2 germ cell associated 2 (haspin) -1.51 3.6E-07 7.9E-06

3540136 HSPA2 heat shock 70kDa protein 2 -1.51 3.1E-10 9.8E-08

3444043 OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -1.51 1.1E-06 1.8E-05

2411228 STIL SCL/TAL1 interrupting locus -1.52 2.0E-08 1.1E-06

3342426 C11ORF82 chromosome 11 open reading frame 82 -1.52 2.0E-09 2.4E-07

3438061 GPR133 G protein-coupled receptor 133 -1.52 1.9E-09 2.4E-07

2900051 HIST1H3H histone cluster 1, H3h -1.53 4.0E-07 8.4E-06

3415857 ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) -1.53 7.1E-08 2.5E-06

3595979 CCNB2 cyclin B2 -1.53 7.6E-09 5.5E-07

3186966 TLR4 toll-like receptor 4 -1.53 5.7E-07 1.1E-05

2474240 KHK ketohexokinase (fructokinase) -1.53 2.0E-06 2.8E-05

3151534 ATAD2 ATPase family, AAA domain containing 2 -1.55 7.4E-07 1.4E-05

2600689 EPHA4 EPH receptor A4 -1.55 5.0E-08 1.9E-06

2739160 CCDC109B coiled-coil domain containing 109B -1.55 4.2E-07 8.7E-06

3286602 CXCL12 chemokine (C-X-C motif) ligand 12 -1.57 2.0E-11 2.7E-08

3591704 WDR76 WD repeat domain 76 -1.57 5.0E-09 4.2E-07

4007689 KCND1 potassium voltage-gated channel, Shal-related subfamily, member 1 -1.57 8.3E-09 5.8E-07

3044597 PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -1.59 2.6E-08 1.2E-06

3703112 GINS2 GINS complex subunit 2 (Psf2 homolog) -1.59 2.0E-07 5.2E-06

3460467 RPSAP52 ribosomal protein SA pseudogene 52 -1.59 3.7E-09 3.5E-07

3150289 SAMD12 sterile alpha motif domain containing 12 -1.60 1.2E-06 1.9E-05

2946319 HIST1H4D histone cluster 1, H4d -1.61 3.0E-06 3.7E-05

3427767 TMPO thymopoietin -1.63 2.1E-09 2.5E-07

2363852 FCRLA Fc receptor-like A -1.63 5.5E-07 1.1E-05

3401804 RAD51AP1 RAD51 associated protein 1 -1.63 2.6E-08 1.2E-06

2335922 CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -1.63 4.3E-07 8.9E-06

3078348 EZH2 enhancer of zeste homolog 2 (Drosophila) -1.64 9.7E-08 3.1E-06

2650199 SMC4 structural maintenance of chromosomes 4 -1.64 5.7E-07 1.1E-05

2946369 HIST1H3G histone cluster 1, H3g -1.64 1.1E-07 3.3E-06

2899095 HIST1H4A histone cluster 1, H4a -1.65 8.3E-05 4.7E-04

3402571 NCAPD2 non-SMC condensin I complex, subunit D2 -1.65 1.0E-09 1.6E-07

3791896 SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 -1.67 1.3E-08 7.9E-07

2859667 CENPK centromere protein K -1.67 1.2E-06 2.0E-05

3910785 AURKA aurora kinase A -1.67 2.0E-10 9.2E-08

2900116 HIST1H2BO histone cluster 1, H2bo -1.68 4.5E-08 1.8E-06

2522212 SGOL2 shugoshin-like 2 (S. pombe) -1.68 1.2E-06 2.0E-05

3590086 RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) -1.69 5.1E-08 1.9E-06

3454223 RACGAP1 Rac GTPase activating protein 1 -1.69 1.5E-09 2.1E-07

3365776 E2F8 E2F transcription factor 8 -1.69 2.3E-09 2.6E-07

4052881 FAM72D family with sequence similarity 72, member D -1.70 9.5E-08 3.0E-06

3619945 OIP5 Opa interacting protein 5 -1.70 1.0E-09 1.6E-07

3710823 MYOCD myocardin -1.70 1.1E-06 1.8E-05

2877990 TMEM173 transmembrane protein 173 -1.71 3.2E-10 9.8E-08

2720251 NCAPG non-SMC condensin I complex, subunit G -1.71 3.1E-07 7.1E-06

2378937 DTL denticleless homolog (Drosophila) -1.73 1.4E-07 4.0E-06

3936913 CDC45 cell division cycle 45 homolog (S. cerevisiae) -1.73 1.1E-07 3.5E-06

2454444 NEK2 NIMA (never in mitosis gene a)-related kinase 2 -1.73 8.2E-09 5.8E-07

3984655 CENPI centromere protein I -1.73 1.5E-08 8.5E-07

2687979 KIAA1524 KIAA1524 -1.74 2.4E-07 5.9E-06

3934695 PTTG1 pituitary tumor-transforming 1 interacting protein -1.74 1.6E-07 4.3E-06

2899146 HIST1H4C histone cluster 1, H4c -1.74 3.4E-08 1.5E-06

3707950 FAM64A family with sequence similarity 64, member A -1.74 8.3E-10 1.5E-07

3644764 CCNF cyclin F -1.74 1.4E-07 3.9E-06

3290210 ZWINT ZW10 interactor -1.75 4.2E-08 1.7E-06

3821263 CNN1 calponin 1, basic, smooth muscle -1.76 5.4E-10 1.3E-07

3720896 CDC6 cell division cycle 6 homolog (S. cerevisiae) -1.76 2.2E-08 1.1E-06

2840036 DOCK2 dedicator of cytokinesis 2 -1.77 2.6E-09 2.7E-07

2571457 CKAP2L cytoskeleton associated protein 2-like -1.78 1.6E-07 4.3E-06

2798915 TRIP13 thyroid hormone receptor interactor 13 -1.78 8.5E-09 5.9E-07

3413875 TROAP trophinin associated protein (tastin) -1.78 4.4E-08 1.8E-06

2350714 SYPL2 synaptophysin-like 2 -1.78 1.2E-06 1.9E-05

3442475 C1R complement component 1, r subcomponent -1.79 7.4E-09 5.5E-07

3291435 RTKN2 rhotekin 2 -1.80 7.3E-07 1.3E-05

3604147 KIAA1199 KIAA1199 -1.80 1.0E-06 1.7E-05

3490655 CKAP2 cytoskeleton associated protein 2 -1.80 1.1E-08 7.0E-07

2870889 C5ORF13 chromosome 5 open reading frame 13 -1.81 3.5E-07 7.6E-06

2752725 NEIL3 nei endonuclease VIII-like 3 (E. coli) -1.82 6.4E-09 5.0E-07

2408189 PPT1 palmitoyl-protein thioesterase 1 -1.82 1.4E-11 2.2E-08

3504617 SKA3 spindle and kinetochore associated complex subunit 3 -1.84 2.5E-08 1.2E-06

2450345 KIF14 kinesin family member 14 -1.84 8.0E-07 1.4E-05

2874371 FBN2 fibrillin 2 -1.84 4.9E-08 1.9E-06

3788049 SKA1 spindle and kinetochore associated complex subunit 1 -1.84 1.1E-08 7.0E-07

3881443 TPX2 TPX2, microtubule-associated, homolog (Xenopus laevis) -1.85 1.5E-10 7.6E-08

3136888 TOX thymocyte selection-associated high mobility group box -1.86 1.7E-08 9.4E-07

3607510 FANCI Fanconi anemia, complementation group I -1.86 2.8E-08 1.3E-06

3949055 GTSE1 G-2 and S-phase expressed 1 -1.87 1.1E-08 7.1E-07

3886223 MYBL2 v-myb myeloblastosis viral oncogene homolog (avian)-like 2 -1.87 3.5E-09 3.4E-07

3168508 MELK maternal embryonic leucine zipper kinase -1.87 5.7E-09 4.5E-07

3223687 PHF19 PHD finger protein 19 -1.88 1.8E-09 2.3E-07

3744263 AURKB aurora kinase B -1.89 5.3E-09 4.3E-07

2610241 FANCD2 Fanconi anemia, complementation group D2 -1.90 1.1E-08 6.9E-07

2416218 ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -1.90 6.9E-07 1.3E-05

2806517 SKP2 S-phase kinase-associated protein 2 (p45) -1.92 3.1E-10 9.8E-08

2914777 TTK TTK protein kinase -1.92 2.0E-07 5.2E-06

2877378 CDC25C cell division cycle 25 homolog C (S. pombe) -1.93 2.5E-06 3.2E-05

3474104 CIT citron (rho-interacting, serine/threonine kinase 21) -1.94 1.1E-09 1.6E-07

3689880 SHCBP1 SHC SH2-domain binding protein 1 -1.97 1.0E-09 1.6E-07

2947063 HIST1H2AK histone cluster 1, H2ak -1.98 6.4E-08 2.3E-06

3599811 KIF23 kinesin family member 23 -1.99 2.5E-09 2.7E-07

3082181 NCAPG2 non-SMC condensin II complex, subunit G2 -2.00 3.9E-09 3.6E-07

3590014 CASC5 cancer susceptibility candidate 5 -2.00 4.2E-08 1.7E-06

2796510 MLF1IP MLF1 interacting protein -2.01 2.2E-08 1.1E-06

3635903 DNM1P41 DNM1 pseudogene 41 -2.01 1.1E-02 2.3E-02

3752258 EVI2B ecotropic viral integration site 2B -2.02 3.4E-08 1.5E-06

2899090 HIST1H3A histone cluster 1, H3a -2.02 1.8E-08 9.8E-07

3250146 SRGN serglycin -2.03 1.5E-10 7.6E-08

2604254 HJURP Holliday junction recognition protein -2.04 5.4E-10 1.3E-07

2747190 DCLK2 doublecortin-like kinase 2 -2.05 1.1E-09 1.7E-07

2714955 TACC3 transforming, acidic coiled-coil containing protein 3 -2.05 6.7E-09 5.2E-07

2620256 KIF15 kinesin family member 15 -2.07 1.5E-08 8.8E-07

3008019 ELN elastin -2.09 1.9E-09 2.4E-07

3593575 SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -2.09 7.3E-10 1.5E-07

3515965 DIAPH3 diaphanous homolog 3 (Drosophila) -2.09 3.1E-08 1.4E-06

2947095 HIST1H3J histone cluster 1, H3j -2.09 9.3E-07 1.6E-05

3736290 BIRC5 baculoviral IAP repeat-containing 5 -2.09 7.0E-09 5.3E-07

3772158 TK1 thymidine kinase 1, soluble -2.10 5.2E-10 1.3E-07

2378325 SERTAD4 SERTA domain containing 4 -2.10 7.0E-10 1.4E-07

3776139 NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae) -2.11 2.0E-08 1.1E-06

2838656 HMMR hyaluronan-mediated motility receptor (RHAMM) -2.11 4.8E-08 1.9E-06

3248289 CDK1 cyclin-dependent kinase 1 -2.12 9.4E-08 3.0E-06

3775842 TYMS thymidylate synthetase -2.13 3.7E-09 3.5E-07

2665572 SGOL1 shugoshin-like 1 (S. pombe) -2.13 4.5E-08 1.8E-06

3587457 ARHGAP11A Rho GTPase activating protein 11A -2.13 9.9E-08 3.1E-06

3589697 BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) -2.16 2.8E-10 9.8E-08

2451693 FMOD fibromodulin -2.17 9.4E-10 1.6E-07

2784113 CCNA2 cyclin A2 -2.17 2.2E-10 9.7E-08

3091475 SCARA3 scavenger receptor class A, member 3 -2.17 4.6E-12 1.4E-08

3463727 LIN7A lin-7 homolog A (C. elegans) -2.18 5.5E-10 1.3E-07

3590388 NUSAP1 nucleolar and spindle associated protein 1 -2.18 2.3E-09 2.6E-07

3428268 GAS2L3 growth arrest-specific 2 like 3 -2.18 8.7E-11 7.6E-08

3653072 PLK1 polo-like kinase 1 -2.19 4.5E-10 1.2E-07

3756193 TOP2A topoisomerase (DNA) II alpha 170kDa -2.19 1.8E-08 9.7E-07

2494484 NCAPH non-SMC condensin I complex, subunit H -2.23 1.7E-09 2.2E-07

3980560 KIF4A kinesin family member 4A -2.23 7.7E-10 1.5E-07

3852565 ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) -2.24 9.0E-09 6.1E-07

3023883 CPA4 carboxypeptidase A4 -2.24 2.7E-08 1.3E-06

2449559 ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.25 7.3E-07 1.3E-05

3884892 FAM83D family with sequence similarity 83, member D -2.25 3.8E-11 4.4E-08

3090697 CDCA2 cell division cycle associated 2 -2.26 2.8E-09 2.8E-07

2379863 CENPF centromere protein F, 350/400kDa (mitosin) -2.26 1.7E-07 4.5E-06

2813414 CCNB1 cyclin B1 -2.27 9.0E-10 1.6E-07

3639031 PRC1 protein regulator of cytokinesis 1 -2.28 6.1E-11 6.2E-08

3440598 FOXM1 forkhead box M1 -2.30 1.9E-09 2.4E-07

2334098 KIF2C kinesin family member 2C -2.31 1.4E-08 7.9E-07

2364438 NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) -2.31 2.4E-09 2.6E-07

2827185 LMNB1 lamin B1 -2.31 2.2E-09 2.6E-07

3258168 KIF11 kinesin family member 11 -2.32 3.5E-08 1.5E-06

2333136 CDC20 cell division cycle 20 homolog (S. cerevisiae) -2.34 2.5E-10 9.8E-08

2324084 CDA cytidine deaminase -2.36 9.5E-10 1.6E-07

2473991 CENPA centromere protein A -2.37 2.7E-10 9.8E-08

3129149 PBK PDZ binding kinase -2.40 4.4E-09 3.8E-07

3756911 KRT34 keratin 34 -2.41 3.0E-10 9.8E-08

3565663 DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.42 1.4E-10 7.6E-08

3629103 KIAA0101 KIAA0101 -2.42 1.1E-09 1.6E-07

2997376 ANLN anillin, actin binding protein -2.44 1.5E-09 2.1E-07

2438282 IQGAP3 IQ motif containing GTPase activating protein 3 -2.45 5.4E-10 1.3E-07

3442322 CDCA3 cell division cycle associated 3 -2.45 7.3E-09 5.5E-07

2947073 HIST1H1B histone cluster 1, H1b -2.45 1.9E-08 1.0E-06

3750785 SPAG5 sperm associated antigen 5 -2.45 1.6E-10 8.0E-08

3312490 MKI67 antigen identified by monoclonal antibody Ki-67 -2.50 6.3E-10 1.3E-07

2469252 RRM2 ribonucleotide reductase M2 -2.52 4.2E-09 3.7E-07

2585933 SPC25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) -2.54 6.4E-10 1.3E-07

3945545 APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -2.56 2.9E-10 9.8E-08

2570616 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) -2.57 5.5E-10 1.3E-07

3258444 CEP55 centrosomal protein 55kDa -2.59 4.3E-10 1.2E-07

3536336 CDKN3 cyclin-dependent kinase inhibitor 3 -2.63 9.0E-12 2.1E-08

2793951 HMGB2 high-mobility group box 2 -2.63 5.7E-09 4.5E-07

2330773 CDCA8 cell division cycle associated 8 -2.65 1.6E-09 2.1E-07

4041113 KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.72 4.6E-09 4.0E-07

2417528 DEPDC1 DEP domain containing 1 -2.72 5.1E-08 1.9E-06

2946225 HIST1H2BB histone cluster 1, H2bb -2.81 2.2E-06 2.9E-05

3209726 ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.95 7.3E-09 5.5E-07

2830638 KIF20A kinesin family member 20A -2.96 2.8E-12 1.4E-08

3381817 UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -2.98 4.5E-12 1.4E-08

1153 protein coding genes (1012 up and 141 down) were identified as significantly differentially expressed in BS cells using the following cutoff:

absolute expression ratio (ER) ≥ 1.5 and false discovery rate (FDR) < 0.05. Thus significantly differentially expressed genes have log2 expression

values of ≥|0.59|.

Table S2C. Common significantly differentially expressed mRNAs in BS and BLM-depleted cells

BS vs NM BLM vs NS3299504 ACTA2 actin, alpha 2, smooth muscle, aorta -1.46 -1.05

3311832 ADAM12 ADAM metallopeptidase domain 12 0.90 -1.18

3927480 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.93 2.31

2921296 AMD1 adenosylmethionine decarboxylase 1 0.65 0.78

2664452 ANKRD28 ankyrin repeat domain 28 0.88 -0.63

2997376 ANLN anillin, actin binding protein 1.17 -2.44

3638607 ANPEP alanyl (membrane) aminopeptidase 0.91 1.18

3327906 API5 apoptosis inhibitor 5 0.87 -0.823469319 APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 0.67 -0.72

3237548 ARL5B ADP-ribosylation factor-like 5B 0.59 0.61

3683037 ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.70 -0.72

2510884 ARL6IP6 ADP-ribosylation-like factor 6 interacting protein 6 0.74 -0.60

2531779 ARMC9 armadillo repeat containing 9 0.69 -0.68

3395464 ASAM adipocyte-specific adhesion molecule 0.72 0.71

3809826 ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.89 -1.28

3592023 B2M beta-2-microglobulin 0.64 0.59

3921933 BACE2 beta-site APP-cleaving enzyme 2 -0.65 1.06

3061651 BET1 blocked early in transport 1 homolog (S. cerevisiae) 1.10 0.66

3807474 C18ORF32 chromosome 18 open reading frame 32 1.17 0.77

2711034 C3ORF59 chromosome 3 open reading frame 59 0.77 -1.50

2766492 C4ORF34 chromosome 4 open reading frame 34 0.83 -0.70

2714644 C4ORF42 chromosome 4 open reading frame 42 0.69 0.73

2870889 C5ORF13 chromosome 5 open reading frame 13 0.92 -1.81

3021158 C7ORF58 chromosome 7 open reading frame 58 1.22 0.61

3162529 C9ORF150 chromosome 9 open reading frame 150 0.63 1.49

3781531 CABLES1 Cdk5 and Abl enzyme substrate 1 -0.59 1.67

2840002 CCDC99 coiled-coil domain containing 99 0.72 -0.92

7385547 CCL2 chemokine (C-C motif) ligand 2 0.82 -0.93

2642887 CCRL1 chemokine (C-C motif) receptor-like 1 0.96 -0.67

2913694 CD109 CD109 molecule 0.85 1.61

2548617 CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.95 -1.03

3466826 CDK17 cyclin-dependent kinase 17 0.72 0.78

3984655 CENPI centromere protein I 0.59 -1.73

3490655 CKAP2 cytoskeleton associated protein 2 0.73 -1.80

2652027 CLDN11 claudin 11 1.63 -1.50

3012019 CLDN12 claudin 12 1.04 -0.84

2769947 CLOCK clock homolog (mouse) 0.68 -0.66

3821263 CNN1 calponin 1, basic, smooth muscle -1.33 -1.76

3599495 CORO2B coronin, actin binding protein, 2B 0.60 0.97

4019900 CUL4B cullin 4B 0.62 -0.96

3771642 CYGB cytoglobin -0.69 1.47

2686023 DCBLD2 discoidin, CUB and LCCL domain containing 2 1.64 0.95

2397025 DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.66 -1.38

3865635 DMPK dystrophia myotonica-protein kinase -0.83 -0.62

2601648 DOCK10 dedicator of cytokinesis 10 0.93 -0.59

3812074 DSEL dermatan sulfate epimerase-like 1.64 1.25

2515276 DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.64 0.70

4004819 DYNLT3 dynein, light chain, Tctex-type 3 0.84 1.40

3148582 EIF3E eukaryotic translation initiation factor 3, subunit E 0.69 0.72

3591963 EIF3J eukaryotic translation initiation factor 3, subunit J 0.65 0.68

3403015 ENO2 enolase 2 (gamma, neuronal) -0.71 -1.12

3445908 EPS8 epidermal growth factor receptor pathway substrate 8 1.00 -0.59

2812435 ERBB2IP erbb2 interacting protein 1.00 -0.60

3448975 ERGIC2 ERGIC and golgi 2 0.82 0.64

3039177 ETV1 ets variant 1 0.82 1.41

2816459 F2R coagulation factor II (thrombin) receptor 1.59 1.04

4022781 FAM122B family with sequence similarity 122B 0.60 -1.20

2584134 FAP fibroblast activation protein, alpha 0.72 -1.03

3043936 FKBP14 FK506 binding protein 14, 22 kDa 0.81 1.27

2451693 FMOD fibromodulin -1.10 -2.17

2545953 FNDC4 fibronectin type III domain containing 4 -0.64 0.76

2523045 FZD7 frizzled homolog 7 (Drosophila) 0.75 -0.66

3047660 GLI3 GLI family zinc finger 3 0.65 0.60

2992814 GPNMB glycoprotein (transmembrane) nmb 1.33 0.66

3405587 GPRC5A G protein-coupled receptor, family C, group 5, member A 0.79 -1.40

2351004 GSTM5 glutathione S-transferase mu 5 -1.00 -0.88

3151086 HAS2 hyaluronan synthase 2 1.86 1.27

3058944 HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.18 1.99

2946232 HIST1H1C histone cluster 1, H1c -0.96 -1.34

2899171 HIST1H1E histone cluster 1, H1e -0.67 -1.16

2977265 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.60 0.65

2890148 HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.72 -0.653984779 HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 0.86 0.65

Log2(ER)Gene Description

Gene

Symbol

Probe Set

ID

3991698 HPRT1 hypoxanthine phosphoribosyltransferase 1 0.71 -0.67

3168255 HRCT1 histidine rich carboxyl terminus 1 -0.69 -0.76

3214668 IARS isoleucyl-tRNA synthetase 0.89 0.61

2362394 IFI16 interferon, gamma-inducible protein 16 1.23 0.74

4018729 IL13RA2 interleukin 13 receptor, alpha 2 0.81 1.20

2857416 IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 1.70 -0.78

2806468 IL7R interleukin 7 receptor 1.02 0.63

3601511 ISLR immunoglobulin superfamily containing leucine-rich repeat -0.61 -0.62

3690193 ITFG1 integrin alpha FG-GAP repeat containing 1 0.70 0.59

3630736 ITGA11 integrin, alpha 11 -1.21 1.04

2809245 ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.23 1.76

3296046 KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 1.62 0.88

3390180 KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2 0.73 -0.62

3629103 KIAA0101 KIAA0101 0.66 -2.42

2830638 KIF20A kinesin family member 20A 0.74 -2.96

3464747 KITLG KIT ligand 1.10 -0.72

3756911 KRT34 keratin 34 -1.14 -2.41

2458289 LBR lamin B receptor 0.77 -0.72

2960010 LMBRD1 LMBR1 domain containing 1 0.66 0.69

2451043 LMOD1 leiomodin 1 (smooth muscle) -0.61 -1.21

3850501 LOC147727 hypothetical LOC147727 0.67 0.92

2902574 LY6G5B lymphocyte antigen 6 complex, locus G5B 0.75 -0.72

2823551 MAN2A1 mannosidase, alpha, class 2A, member 1 0.88 0.77

3097152 MCM4 minichromosome maintenance complex component 4 0.76 -1.02

3421300 MDM2 Mdm2 p53 binding protein homolog (mouse) 0.80 0.73

3414739 METTL7A methyltransferase like 7A 0.61 -1.23

3651955 METTL9 methyltransferase like 9 0.63 0.76

3443226 MFAP5 microfibrillar associated protein 5 -2.09 -0.97

2649723 MFSD1 major facilitator superfamily domain containing 1 1.02 1.00

3143660 MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.97 1.65

3218067 MRPL50 mitochondrial ribosomal protein L50 0.96 0.74

2705748 NCEH1 neutral cholesterol ester hydrolase 1 0.80 -0.60

3887635 NCOA3 nuclear receptor coactivator 3 0.74 0.66

2394784 NOL9 nucleolar protein 9 0.71 -0.72

3724197 NSF N-ethylmaleimide-sensitive factor 0.70 -0.85

2915828 NT5E 5'-nucleotidase, ecto (CD73) 0.98 0.65

3590388 NUSAP1 nucleolar and spindle associated protein 1 0.79 -2.18

3134922 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.60 0.99

3013255 PEG10 paternally expressed 10 0.80 -0.98

3462816 PHLDA1 pleckstrin homology-like domain, family A, member 1 1.12 0.66

3010082 PHTF2 putative homeodomain transcription factor 2 0.66 -0.73

3732230 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.60 0.64

3252036 PLAU plasminogen activator, urokinase 0.94 0.98

3728964 PRR11 proline rich 11 0.80 -1.49

3126191 PSD3 pleckstrin and Sec7 domain containing 3 0.90 0.95

2649367 PTX3 pentraxin 3, long 1.48 -1.08

2626167 PXK PX domain containing serine/threonine kinase 1.20 1.32

2935475 QKI quaking homolog, KH domain RNA binding (mouse) 0.71 0.60

2369339 RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.60 -0.98

2583602 RBMS1 RNA binding motif, single stranded interacting protein 1 1.13 0.63

2371346 RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.65 0.71

2614120 RPL15 ribosomal protein L15 0.77 1.06

3318009 RRM1 ribonucleotide reductase M1 0.60 -0.83

2752006 SAP30 Sin3A-associated protein, 30kDa 0.64 -0.61

2750594 SC4MOL sterol-C4-methyl oxidase-like 1.26 -0.88

3352904 SC5DL sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like 0.70 0.60

2389789 SCCPDH saccharopine dehydrogenase (putative) 0.64 -0.71

3907234 SDC4 syndecan 4 0.59 -0.84

3774906 SECTM1 secreted and transmembrane 1 1.26 0.59

3059464 SEMA3Asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin)

3A1.28 0.91

2847967 SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane

domain (TM) and short cytoplasmic domain, (semaphorin) 5A1.08 0.74

3592755 SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.62 1.10

3936951 SEPT5 septin 5 -0.62 1.19

2972310 SERINC1 serine incorporator 1 0.84 0.65

3190659 SET SET nuclear oncogene 1.18 0.61

2406064 SFPQ splicing factor proline/glutamine-rich 1.19 -0.67

3764738 SKA2 spindle and kinetochore associated complex subunit 2 1.09 -0.77

3768412 SLC16A6 solute carrier family 16, member 6 (monocarboxylic acid transporter 7) 0.85 3.66

2960955 SLC17A5 solute carrier family 17 (anion/sugar transporter), member 5 0.84 0.85

3147726 SLC25A32 solute carrier family 25, member 32 0.67 0.69

2319340 SLC25A33 solute carrier family 25, member 33 0.86 0.77

3060245 SLC25A40 solute carrier family 25, member 40 0.73 -0.84

2476116 SLC30A6 solute carrier family 30 (zinc transporter), member 6 0.65 0.81

2349043 SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.92 0.90

2701927 SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 0.80 0.60

3919033 SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 2.59 0.60

2786322 SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 1.76 2.01

3718555 SLFN5 schlafen family member 5 1.23 0.70

2720584 SLIT2 slit homolog 2 (Drosophila) 1.49 -1.16

3598959 SMAD3 SMAD family member 3 0.64 -1.30

3766960 SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1.45 0.96

2403557 SNORA44 small nucleolar RNA, H/ACA box 44 0.59 -0.68

3560617 SNX6 sorting nexin 6 0.82 0.88

3519309 SPRY2 sprouty homolog 2 (Drosophila) 1.00 1.81

2879105 SPRY4 sprouty homolog 4 (Drosophila) 0.83 0.88

3802129 SS18 synovial sarcoma translocation, chromosome 18 0.70 0.73

3355145 ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 -0.76 -0.59

2402459 STMN1 stathmin 1 0.59 -0.86

3770632 SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 1.88 -1.05

3716664 SUZ12P suppressor of zeste 12 homolog pseudogene 0.71 -0.92

2361154 SYT11 synaptotagmin XI 0.89 -0.87

3350830 TAGLN transgelin -1.10 -0.63

2649113 TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.95 0.64

2925590 TMEM200A transmembrane protein 200A 0.61 1.33

2725332 TMEM33 transmembrane protein 33 0.73 0.73

3427767 TMPO thymopoietin 0.65 -1.63

3449068 TMTC1 transmembrane and tetratricopeptide repeat containing 1 1.63 0.89

3653398 TNRC6A trinucleotide repeat containing 6A 0.71 -0.66

3762473 TOB1 transducer of ERBB2, 1 0.63 0.64

3145149 TP53INP1 tumor protein p53 inducible nuclear protein 1 0.72 1.06

3429460 TXNRD1 thioredoxin reductase 1 0.63 0.60

3775842 TYMS thymidylate synthetase 0.66 -2.13

2364155 UHMK1 U2AF homology motif (UHM) kinase 1 0.91 -1.02

2491676 VAMP5 vesicle-associated membrane protein 5 (myobrevin) -0.71 -0.67

2477203 VIT vitrin 0.73 -1.05

3319937 WEE1 WEE1 homolog (S. pombe) 0.60 -1.19

2417390 WLS wntless homolog (Drosophila) 0.99 0.87

3708074 XAF1 XIAP associated factor 1 -0.86 -0.83

3075531 ZC3HAV1L zinc finger CCCH-type, antiviral 1-like 0.93 1.06

3801943 ZNF521 zinc finger protein 521 0.79 1.61

Cutoff for significantly differentially expressed mRNAs: absolute expression ratio (ER) ≥ 1.5 and false discovery rate (FDR) < 0.05. Thus significantly differentially expressed genes have log2 expression values of ≥|0.59|.

Up-regulated mRNAs are highlighted in red and down-regulated mRNAs are highlighted in green.

Table S3. Gene Set Enrichment Analysis (GESA) detail

p-value

(intersect)

p-value

(GSEA)

p-value

(intersect)

p-value

(GSEA)

RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 3.6E-45 8.4E-03 4.4E-24 6.4E-03

SENESE_HDAC3_TARGETS_UP 9.4E-39 6.0E-04 3.5E-12 1.0E-04

CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 2.2E-38 3.1E-03 1.3E-22 1.0E-04

SENESE_HDAC1_TARGETS_UP 1.4E-29 3.0E-04 7.2E-11 1.0E-04

ONKEN_UVEAL_MELANOMA_UP 4.5E-23 5.5E-03 n.s. 1.0E-04

NUYTTEN_NIPP1_TARGETS_DN 6.1E-23 1.0E-04 6.5E-13 1.0E-04

ACEVEDO_LIVER_CANCER_UP 8.6E-22 8.0E-03 n.s. 4.0E-04

BORCZUK_MALIGNANT_MESOTHELIOMA_UP 7.3E-21 6.1E-03 n.s. 1.0E-04

JIANG_HYPOXIA_NORMAL 1.4E-19 7.0E-04 n.s. 1.0E-04

KIM_ALL_DISORDERS_CALB1_CORR_UP 1.7E-19 9.1E-03 n.s. 1.0E-04

GENTILE_UV_HIGH_DOSE_DN 5.3E-17 3.7E-03 5.8E-12 1.0E-04

GRUETZMANN_PANCREATIC_CANCER_UP 9.2E-17 4.1E-03 1.1E-11 1.0E-04

BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 3.3E-16 4.7E-03 n.s. 1.0E-04

LAIHO_COLORECTAL_CANCER_SERRATED_UP 3.7E-16 6.3E-03 n.s. 1.0E-04

FORTSCHEGGER_PHF8_TARGETS_DN 7.1E-16 3.3E-03 n.s. 1.0E-04

THUM_SYSTOLIC_HEART_FAILURE_UP 4.2E-15 2.2E-03 n.s. 1.0E-04

MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 5.0E-14 5.3E-03 n.s. 3.3E-03

MARTINEZ_RB1_AND_TP53_TARGETS_UP 5.1E-14 3.0E-04 n.s. 1.0E-04

WANG_TUMOR_INVASIVENESS_DN 1.6E-13 1.2E-03 n.s. 1.0E-04

MARTINEZ_TP53_TARGETS_UP 1.7E-13 4.0E-04 n.s. 1.0E-04

DURCHDEWALD_SKIN_CARCINOGENESIS_DN 3.3E-13 7.0E-04 n.s. 1.0E-04

NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 3.7E-13 9.6E-03 n.s. 1.0E-04

FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 1.2E-12 5.5E-03 n.s. 1.0E-04

TOOKER_GEMCITABINE_RESISTANCE_DN 4.1E-12 9.0E-04 n.s. 1.0E-04

JI_RESPONSE_TO_FSH_DN 5.9E-12 2.1E-03 n.s. 3.7E-03

WANG_LMO4_TARGETS_UP 1.3E-11 5.0E-03 n.s. 5.9E-03

RODRIGUES_THYROID_CARCINOMA_DN 1.6E-11 2.3E-03 n.s. 1.0E-04

ONDER_CDH1_TARGETS_1_DN 2.9E-11 1.2E-03 n.s. 1.0E-03

MARTINEZ_RB1_TARGETS_UP 4.0E-11 2.9E-03 n.s. 1.0E-04

ALONSO_METASTASIS_UP 7.7E-11 6.1E-03 n.s. 1.0E-04

BROWNE_HCMV_INFECTION_14HR_DN 3.5E-10 3.0E-03 n.s. 1.0E-04

CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 4.3E-10 7.1E-03 n.s. 8.0E-04

LU_EZH2_TARGETS_DN 2.0E-09 4.3E-03 8.3E-09 2.0E-04

DAZARD_RESPONSE_TO_UV_SCC_UP 2.1E-09 4.6E-03 n.s. 2.0E-04

HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 2.8E-09 5.5E-03 n.s. 1.0E-04

BENPORATH_NANOG_TARGETS 3.3E-09 5.6E-03 1.7E-11 1.0E-04

KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 3.8E-09 3.2E-03 n.s. 1.0E-04

JIANG_HYPOXIA_VIA_VHL 4.7E-09 1.0E-03 n.s. 1.6E-03

SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 1.1E-08 6.4E-03 n.s. 1.0E-04

BENPORATH_NOS_TARGETS n.s. 1.0E-04 5.3E-11 1.0E-04

p-value

(intersect)

p-value

(GSEA)

p-value

(intersect)

p-value

(GSEA)

PID_ERBB1_DOWNSTREAM_PATHWAY 5.2E-07 2.3E-03 n.s. 1.0E-04

BIOCARTA_TEL_PATHWAY 9.0E-06 1.0E-03 n.s. 1.0E-04

PID_RET_PATHWAY 1.4E-05 2.0E-04 n.s. 1.0E-04

PID_TGFBRPATHWAY 4.0E-05 3.5E-03 n.s. 6.7E-03

PID_MET_PATHWAY 4.6E-05 2.1E-03 n.s. 1.0E-04

REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 5.4E-05 1.7E-03 3.5E-02 6.3E-03

REACTOME_ACTIVATION_OF_RAC 9.8E-05 2.6E-03 n.s. 4.0E-04

REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 1.1E-04 3.0E-04 3.5E-02 1.0E-04

BIOCARTA_AT1R_PATHWAY 1.3E-04 3.5E-03 n.s. 1.0E-04

REACTOME_SIGNALING_BY_NOTCH 1.6E-04 8.2E-03 1.4E-02 1.0E-04

PID_EPHBFWDPATHWAY 1.8E-04 3.3E-03 n.s. 3.6E-03

REACTOME_SEMAPHORIN_INTERACTIONS 1.8E-04 6.7E-03 4.7E-02 1.0E-04

REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 2.0E-04 8.6E-03 n.s. 1.0E-04

REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION 2.7E-04 3.0E-04 1.5E-02 1.0E-04

BIOCARTA_AGR_PATHWAY 3.6E-04 6.7E-03 n.s. 4.0E-04

REACTOME_SIGNALING_BY_EGFR_IN_CANCER 4.3E-04 6.2E-03 n.s. 2.0E-04

C2: CGP (chemical and genetic perturbations, 3402 gene sets):

cut-off p-value (intersect) < 10E-8

BS vs. NM BLM vs. NS

C2: CP (canonical pathways, 1320 gene sets): cut-off p-value (intersect) < 0.05

BS vs. NM BLM vs. NS

PID_ILK_PATHWAY 5.1E-04 7.5E-03 n.s. 1.0E-04

PID_NFAT_3PATHWAY 5.2E-04 4.0E-04 n.s. 1.0E-04

BIOCARTA_ARF_PATHWAY 5.6E-04 1.6E-03 3.7E-02 1.0E-04

BIOCARTA_SPRY_PATHWAY 5.6E-04 2.0E-04 n.s. 1.0E-04

PID_A6B1_A6B4_INTEGRIN_PATHWAY 6.2E-04 4.8E-03 n.s. 1.0E-04

PID_FGF_PATHWAY 2.7E-03 4.1E-03 n.s. 2.0E-04

REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING 4.4E-03 2.0E-03 n.s. 2.4E-03

KEGG_CHRONIC_MYELOID_LEUKEMIA 7.8E-03 9.3E-03 n.s. 1.0E-04

ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 8.9E-03 5.4E-03 n.s. 5.3E-03

PID_P53REGULATIONPATHWAY 1.4E-02 1.2E-03 n.s. 1.0E-04

BIOCARTA_PTDINS_PATHWAY 1.6E-02 2.8E-03 n.s. 1.0E-04

PID_INTEGRIN_A4B1_PATHWAY 1.7E-02 3.9E-03 n.s. 1.0E-04

REACTOME_METABOLISM_OF_CARBOHYDRATES 2.1E-02 5.0E-03 n.s. 1.0E-04

PID_P38GAMMADELTAPATHWAY 3.2E-02 5.8E-03 4.7E-02 1.0E-04

PID_ERBB1_INTERNALIZATION_PATHWAY 4.7E-02 6.0E-04 n.s. 1.0E-04

REACTOME_SIGNALLING_BY_NGF n.s. 8.8E-03 1.6E-02 1.0E-04

p-value

(intersect)

p-value

(GSEA)

p-value

(intersect)

p-value

(GSEA)

MIR-224 5.1E-14 1.0E-04 5.8E-05 1.0E-04

MIR-17-5P,MIR-20A,MIR-106A,MIR-106B,MIR-20B,MIR-519D 9.6E-11 1.2E-03 2.7E-05 1.0E-04

MIR-124A 1.2E-10 1.7E-03 n.s. 2.9E-03

MIR-1,MIR-206 2.4E-10 9.0E-04 6.2E-04 1.0E-04

MIR-9 1.0E-09 7.0E-04 4.0E-04 1.0E-04

MIR-320 5.4E-09 1.9E-03 1.7E-02 9.0E-04

MIR-409-3P 2.6E-07 6.0E-03 1.7E-02 1.0E-04

MIR-520F 8.0E-06 2.8E-03 6.7E-04 1.0E-04

MIR-520G,MIR-520H 8.0E-05 2.6E-03 4.3E-04 1.0E-04

MIR-518C 8.6E-05 6.8E-03 n.s. 1.0E-04

MIR-365 1.8E-04 2.7E-03 n.s. 8.5E-03

MIR-519E 3.2E-04 3.7E-03 3.9E-02 6.2E-03

MIR-221,MIR-222 5.8E-04 1.7E-03 n.s. 4.0E-04

MIR-199A,MIR-199B 6.1E-04 3.5E-03 n.s. 1.1E-03

MIR-93,MIR-302A,MIR-302B,MIR-302C,MIR-302D,MIR-372,MIR-373,MIR-520E,MIR-

520A,MIR-526B,MIR-520B,MIR-520C,MIR-520D2.3E-03 7.0E-04 4.2E-03 1.0E-04

MIR-212,MIR-132 3.4E-03 7.2E-03 n.s. 1.0E-04

MIR-136 9.5E-03 2.9E-03 n.s. 4.0E-04

MIR-150 1.2E-02 1.9E-03 n.s. 1.0E-04

p-value

(intersect)

p-value

(GSEA)

p-value

(intersect)

p-value

(GSEA)

MGGAAGTG_V$GABP_B 3.4E-06 6.4E-03 n.s. 3.0E-04

TTANTCA_UNKNOWN 1.2E-05 5.0E-04 1.6E-05 7.0E-04

SMTTTTGT_UNKNOWN 6.5E-05 1.6E-03 2.6E-03 1.0E-04

V$MYB_Q5_01 2.2E-04 3.1E-03 4.7E-03 1.0E-04

V$SRF_C 1.2E-03 4.2E-03 n.s. 1.0E-04

V$USF_Q6 1.3E-03 3.9E-03 n.s. 1.0E-04

GCTNWTTGK_UNKNOWN 1.4E-03 6.1E-03 7.6E-03 1.0E-04

V$CHOP_01 1.7E-03 5.2E-03 n.s. 1.2E-03

TGCGCANK_UNKNOWN 2.3E-03 9.0E-03 4.6E-02 1.0E-04

YGCGYRCGC_UNKNOWN 3.2E-03 3.8E-03 n.s. 1.0E-04

V$FOXO1_02 3.3E-03 5.8E-03 2.9E-06 1.0E-04

V$E4BP4_01 3.6E-03 7.0E-04 2.0E-02 7.6E-03

ATGGYGGA_UNKNOWN 6.4E-03 1.6E-03 4.3E-02 1.8E-03

V$CREB_Q2_01 7.2E-03 1.0E-04 n.s. 1.0E-04

V$E4F1_Q6 1.0E-02 5.1E-03 n.s. 1.0E-04

V$HTF_01 1.6E-02 4.7E-03 6.0E-03 1.0E-04

V$NRF1_Q6 3.2E-02 1.7E-03 n.s. 1.0E-04

V$HIF1_Q3 4.0E-02 7.0E-04 2.1E-02 1.0E-04

V$BRN2_01 n.s. 9.7E-03 3.1E-03 6.1E-03

V$FREAC7_01 n.s. 9.0E-04 3.8E-03 1.0E-03

V$LXR_Q3 n.s. 4.2E-03 1.3E-02 1.0E-04

C3: MIR (microRNA targets, 221 gene sets): cut-off p-value (intersect) < 0.05

BS vs. NM BLM vs. NS

C3: TFT (transcriptional factor targets, 615 gene sets):

cut-off p-value (intersect) < 0.05

BS vs. NM BLM vs. NS

p-value

(intersect)

p-value

(GSEA)

p-value

(intersect)

p-value

(GSEA)

MODULE_15 9.3E-04 1.8E-03 2.9E-09 1.0E-04

MODULE_56 1.7E-02 5.6E-03 n.s. 3.7E-03

MODULE_147 3.4E-06 7.3E-03 n.s. 1.0E-04

MODULE_166 1.5E-02 3.5E-03 n.s. 9.1E-03

MODULE_256 3.1E-02 2.0E-04 n.s. 1.0E-04

MODULE_69 n.s. 9.5E-03 9.2E-03 1.0E-04

MODULE_136 n.s. 9.2E-03 4.5E-02 1.0E-04

p-value

(intersect)

p-value

(GSEA)

p-value

(intersect)

p-value

(GSEA)

MORF_RAB6A 8.0E-10 9.1E-03 n.s. 5.2E-03

GCM_BCL2L1 1.7E-02 2.7E-03 n.s. 1.0E-04

p-value

(intersect)

p-value

(GSEA)

p-value

(intersect)

p-value

(GSEA)

MACROMOLECULAR_COMPLEX_ASSEMBLY 1.2E-06 2.2E-03 n.s. 1.0E-04

REGULATION_OF_METABOLIC_PROCESS 4.4E-06 3.0E-03 n.s. 1.4E-03

CELLULAR_COMPONENT_ASSEMBLY 6.1E-06 2.5E-03 n.s. 1.0E-04

REGULATION_OF_CELLULAR_METABOLIC_PROCESS 7.9E-06 2.7E-03 n.s. 2.7E-03

TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWA

Y8.5E-05 6.0E-03

n.s.

2.0E-04

REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION_AND_BIOGENESI

S8.6E-05 2.5E-03

n.s.

1.0E-04

POSITIVE_REGULATION_OF_CELLULAR_PROCESS 9.8E-05 6.9E-03 n.s. 1.0E-04

PROTEIN_KINASE_CASCADE 1.4E-04 9.4E-03 n.s. 1.0E-04

REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SI

GNALING_PATHWAY1.6E-04 8.3E-03 3.0E-03

1.0E-04

ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY 3.1E-04 1.0E-04 1.9E-02 1.0E-04

BIOPOLYMER_MODIFICATION 4.9E-04 5.5E-03 n.s. 1.0E-04

NEGATIVE_REGULATION_OF_TRANSCRIPTION 7.5E-04 5.3E-03 n.s. 1.0E-04

NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION_AND_

BIOGENESIS1.2E-03 6.8E-03 n.s.

1.0E-04

VESICLE_MEDIATED_TRANSPORT 1.5E-03 5.8E-03 n.s. 1.0E-04

NEGATIVE_REGULATION_OF_NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_

NUCLEIC_ACID_METABOLIC_PROCESS1.9E-03 8.4E-03 3.6E-02

1.0E-04

REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE 5.9E-03 8.6E-03 4.0E-02 1.0E-04

POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE 8.6E-03 9.7E-03 2.5E-02 1.0E-04

REGULATION_OF_TRANSFERASE_ACTIVITY 1.9E-02 2.5E-03 3.7E-02 1.0E-04

REGULATION_OF_PROTEIN_KINASE_ACTIVITY 2.6E-02 2.4E-03 n.s. 1.0E-04

REGULATION_OF_KINASE_ACTIVITY 2.9E-02 2.5E-03 n.s. 1.0E-04

REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY n.s. 9.7E-03 n.s. 1.0E-04

NEGATIVE_REGULATION_OF_CELL_ADHESION n.s. 9.2E-03 n.s. 1.0E-04

p-value

(intersect)

p-value

(GSEA)

p-value

(intersect)

p-value

(GSEA)

ER_GOLGI_INTERMEDIATE_COMPARTMENT 1.3E-06 4.0E-04 n.s. 1.0E-04

p-value

(intersect)

p-value

(GSEA)

p-value

(intersect)

p-value

(GSEA)

GTPASE_ACTIVITY 1.6E-04 8.2E-03 n.s. 1.0E-04

SMAD_BINDING 6.3E-03 4.6E-03 n.s. 1.0E-04

PROTEIN_KINASE_ACTIVITY 7.2E-03 2.8E-03 1.7E-02 1.0E-04

TRANSITION_METAL_ION_BINDING 1.2E-02 7.6E-03 n.s. 1.0E-04

NUCLEOTIDE_BINDING 2.8E-02 1.0E-03 4.0E-02 1.0E-04

PURINE_NUCLEOTIDE_BINDING 2.8E-02 1.2E-03 n.s. 1.0E-04

PURINE_RIBONUCLEOTIDE_BINDING 4.1E-02 1.5E-03 n.s. 1.0E-04

S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY n.s. 3.9E-03 6.6E-03 9.1E-03

C5: MF (GO molecular function, 396 gene sets): cut-off p-value (intersect) < 0.05

BS vs. NM BLM vs. NS

BLM vs. NS

C4: CM (cancer modules, 431 gene sets): cut-off p-value (intersect) < 0.05

BS vs. NM BLM vs. NS

C4: CGN (cancer gene neighborhoods, 427 gene sets):

cut-off p-value (intersect) < 0.05

BS vs. NM BLM vs. NS

C5: BP (GO Biological Process Ontology, 825 gene sets):

cut-off p-value (intersect) < 0.05

BS vs. NM BLM vs. NS

C5: CC (GO cellular component, 233 gene sets): cut-off p-value (intersect) <

0.05

BS vs. NM

p-value

(intersect)

p-value

(GSEA)

p-value

(intersect)

p-value

(GSEA)

CAMP_UP.V1_DN 2.1E-10 2.0E-04 1.3E-02 8.0E-04

STK33_UP 2.3E-09 3.8E-03 2.3E-08 1.0E-04

p-value

(intersect)

p-value

(GSEA)

p-value

(intersect)

p-value

(GSEA)

GSE17721_12H_VS_24H_POLYIC_BMDM_UP 1.0E-13 2.6E-03 9.2E-03 1.0E-04

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP 2.8E-11 1.8E-03 n.s. 2.0E-04

GSE22886_NAIVE_VS_MEMORY_TCELL_DN 2.8E-11 1.0E-03 1.8E-04 1.0E-04

GSE17721_CTRL_VS_GARDIQUIMOD_0.5H_BMDM_UP 3.9E-11 7.0E-04 n.s. 1.0E-04

GSE17721_0.5H_VS_4H_PAM3CSK4_BMDM_DN 4.6E-11 5.5E-03 3.4E-02 7.0E-04

GSE10239_MEMORY_VS_KLRG1HIGH_EFF_CD8_TCELL_DN 7.7E-11 9.6E-03 1.6E-07 1.0E-04

GSE20715_WT_VS_TLR4_KO_LUNG_UP 4.8E-09 8.8E-03 n.s. 4.0E-04

GSE17721_POLYIC_VS_PAM3CSK4_4H_BMDM_DN 7.4E-09 1.0E-03 n.s. 1.0E-04

GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP 1.1E-08 9.1E-03 3.3E-03 9.0E-04

GSE22886_NAIVE_BCELL_VS_DC_DN 4.4E-08 7.6E-03 n.s. 1.0E-04

GSE27786_BCELL_VS_NKCELL_DN 9.6E-08 3.2E-03 n.s. 4.4E-03

GSE339_EX_VIVO_VS_IN_CULTURE_CD4POS_DC_DN 9.6E-08 3.7E-03 n.s. 3.2E-03

GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_4MONTH_POST_DX_UP 9.6E-08 4.2E-03 1.9E-02 1.0E-04

GSE22886_NAIVE_CD8_TCELL_VS_MEMORY_TCELL_DN 1.2E-07 7.0E-04 5.8E-05 1.0E-04

GSE17721_LPS_VS_POLYIC_16H_BMDM_UP 1.8E-07 4.2E-03 4.7E-02 7.0E-03

GSE17721_POLYIC_VS_CPG_16H_BMDM_DN 1.8E-07 3.9E-03 n.s. 1.0E-04

GSE3982_MAST_CELL_VS_NKCELL_UP 1.8E-07 9.1E-03 n.s. 1.0E-04

GSE17721_POLYIC_VS_GARDIQUIMOD_1H_BMDM_DN 2.4E-07 4.0E-03 n.s. 2.0E-04

GSE22886_NAIVE_TCELL_VS_NEUTROPHIL_UP 2.4E-07 8.5E-03 n.s. 4.4E-03

GSE39820_TGFBETA1_IL6_VS_TGFBETA1_IL6_IL23A_TREATED_CD4_TCELL_UP 4.4E-07 3.0E-04 n.s. 1.0E-04

GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_HET_TCONV_UP 4.4E-07 1.0E-04 n.s. 1.0E-04

GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDM_DN 6.4E-07 1.6E-03 2.0E-04 1.0E-04

GSE17721_POLYIC_VS_GARDIQUIMOD_4H_BMDM_DN 6.4E-07 1.9E-03 n.s. 1.0E-04

GSE17721_POLYIC_VS_CPG_2H_BMDM_DN 9.3E-07 9.8E-03 n.s. 6.0E-04

GSE3982_EOSINOPHIL_VS_NKCELL_UP 1.2E-06 6.7E-03 6.6E-03 1.0E-04

GSE3982_BASOPHIL_VS_CENT_MEMORY_CD4_TCELL_UP 1.7E-06 1.5E-03 2.0E-03 1.0E-04

GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP 2.2E-06 1.0E-03 1.7E-02 1.0E-04

GSE13484_UNSTIM_VS_YF17D_VACCINE_STIM_PBMC_UP 2.4E-06 3.9E-03 n.s. 3.0E-03

GSE17721_LPS_VS_GARDIQUIMOD_16H_BMDM_DN 2.7E-06 5.4E-03 6.1E-04 1.0E-04

GSE17721_CTRL_VS_LPS_4H_BMDM_UP 4.5E-06 8.6E-03 4.5E-02 1.0E-04

GSE9037_CTRL_VS_LPS_4H_STIM_BMDM_UP 5.0E-06 9.5E-03 n.s. 1.0E-04

GSE11057_NAIVE_VS_CENT_MEMORY_CD4_TCELL_DN 5.6E-06 9.7E-03 n.s. 1.0E-04

GSE12845_IGD_NEG_BLOOD_VS_DARKZONE_GC_TONSIL_BCELL_DN 6.2E-06 7.5E-03 n.s. 2.0E-04

GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_DN 7.7E-06 9.0E-04 5.4E-03 1.0E-04

GSE29618_BCELL_VS_PDC_DAY7_FLU_VACCINE_DN 1.7E-05 4.6E-03 4.7E-03 1.0E-04

GSE11057_NAIVE_VS_EFF_MEMORY_CD4_TCELL_DN 1.8E-05 7.3E-03 5.0E-03 1.0E-04

GSE14308_TH17_VS_NAIVE_CD4_TCELL_UP 2.0E-05 2.5E-03 2.6E-03 2.7E-03

GSE20366_TREG_VS_NAIVE_CD4_TCELL_UP 2.0E-05 3.6E-03 2.1E-06 1.0E-04

GSE13484_12H_UNSTIM_VS_YF17D_VACCINE_STIM_PBMC_UP 2.1E-05 6.7E-03 n.s. 8.5E-03

GSE17721_CPG_VS_GARDIQUIMOD_6H_BMDM_DN 2.1E-05 6.1E-03 n.s. 1.0E-04

GSE17721_LPS_VS_PAM3CSK4_16H_BMDM_DN 2.8E-05 1.9E-03 1.6E-03 1.0E-04

GSE360_L_DONOVANI_VS_B_MALAYI_LOW_DOSE_MAC_UP 3.7E-05 1.8E-03 4.7E-02 3.9E-03

GSE7764_NKCELL_VS_SPLENOCYTE_UP 5.5E-05 7.6E-03 1.9E-02 1.0E-04

GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN 8.0E-05 2.6E-03 6.3E-05 1.0E-04

GSE7764_IL15_NK_CELL_24H_VS_SPLENOCYTE_DN 9.7E-05 6.5E-03 2.0E-03 1.0E-04

GSE13484_UNSTIM_VS_3H_YF17D_VACCINE_STIM_PBMC_DN 1.1E-04 6.8E-03 n.s. 1.3E-03

GSE9037_WT_VS_IRAK4_KO_LPS_4H_STIM_BMDM_UP 1.2E-04 9.3E-03 9.2E-03 4.0E-04

GSE17721_POLYIC_VS_GARDIQUIMOD_16H_BMDM_UP 1.5E-04 7.8E-03 n.s. 2.3E-03

GSE13229_MATURE_VS_INTMATURE_NKCELL_DN 1.5E-04 3.3E-03 n.s. 9.6E-03

GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_UP 1.5E-04 1.0E-04 n.s. 1.0E-04

GSE37416_CTRL_VS_12H_F_TULARENSIS_LVS_NEUTROPHIL_UP 2.2E-04 3.0E-03 7.6E-03 1.0E-04

GSE36476_CTRL_VS_TSST_ACT_72H_MEMORY_CD4_TCELL_YOUNG_UP 2.4E-04 8.0E-04 n.s. 1.0E-04

GSE3982_MAST_CELL_VS_CENT_MEMORY_CD4_TCELL_UP 2.6E-04 7.2E-03 4.4E-03 1.0E-04

GSE17721_LPS_VS_PAM3CSK4_6H_BMDM_UP 2.9E-04 1.4E-03 n.s. 1.0E-04

GSE27786_CD4_TCELL_VS_NKCELL_DN 2.9E-04 6.0E-04 n.s. 1.0E-04

GSE16522_MEMORY_VS_NAIVE_ANTI_CD3CD28_STIM_CD8_TCELL_UP 3.4E-04 2.8E-03 n.s. 1.0E-04

C7: Immunologic signatures (1910 gene sets): cut-off p-value (intersect) < 0.05

BS vs. NM BLM vs. NS

C6: Oncogenic signatures (189 gene sets): cut-off p-value (intersect) < 0.05

BS vs. NM BLM vs. NS

GSE9650_NAIVE_VS_EXHAUSTED_CD8_TCELL_DN 3.4E-04 5.9E-03 2.7E-03 1.0E-04

GSE24634_NAIVE_CD4_TCELL_VS_DAY10_IL4_CONV_TREG_DN 4.0E-04 1.0E-03 1.1E-10 1.0E-04

GSE3982_MAC_VS_TH2_UP 4.0E-04 3.5E-03 n.s. 2.8E-03

GSE24142_ADULT_VS_FETAL_DN3_THYMOCYTE_UP 4.7E-04 5.0E-03 7.1E-03 5.0E-04

GSE20366_CD103_KLRG1_DP_VS_DN_TREG_DN 5.3E-04 6.9E-03 1.7E-04 1.0E-04

GSE360_CTRL_VS_M_TUBERCULOSIS_MAC_UP 5.7E-04 1.9E-03 n.s. 1.0E-04

GSE17721_LPS_VS_GARDIQUIMOD_12H_BMDM_DN 6.2E-04 3.1E-03 n.s. 1.0E-04

GSE27786_NKTCELL_VS_MONO_MAC_UP 6.4E-04 8.6E-03 n.s. 1.0E-04

GSE3982_EOSINOPHIL_VS_MAC_DN 6.7E-04 2.6E-03 n.s. 1.0E-04

GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN 8.5E-04 9.0E-04 n.s. 1.0E-04

GSE12845_IGD_POS_BLOOD_VS_NAIVE_TONSIL_BCELL_DN 9.1E-04 5.1E-03 2.1E-02 3.3E-03

GSE17721_LPS_VS_PAM3CSK4_4H_BMDM_UP 9.9E-04 3.7E-03 1.3E-02 1.0E-04

GSE360_CTRL_VS_B_MALAYI_LOW_DOSE_DC_UP 1.0E-03 4.0E-04 n.s. 2.0E-04

GSE17721_12H_VS_24H_GARDIQUIMOD_BMDM_DN 1.5E-03 4.2E-03 n.s. 1.3E-03

GSE9650_EFFECTOR_VS_EXHAUSTED_CD8_TCELL_DN 2.0E-03 2.2E-03 7.2E-04 1.0E-04

GSE27786_NKTCELL_VS_ERYTHROBLAST_UP 2.1E-03 2.6E-03 n.s. 1.0E-04

GSE24634_TREG_VS_TCONV_POST_DAY3_IL4_CONVERSION_DN 2.2E-03 3.2E-03 3.4E-03 1.0E-04

GSE17721_PAM3CSK4_VS_GADIQUIMOD_1H_BMDM_DN 3.2E-03 7.2E-03 n.s. 2.5E-03

GSE27786_ERYTHROBLAST_VS_MONO_MAC_DN 3.2E-03 8.3E-03 n.s. 1.0E-04

GSE3982_MAST_CELL_VS_MAC_DN 3.2E-03 8.3E-03 n.s. 2.0E-04

GSE3982_CTRL_VS_PMA_STIM_EOSINOPHIL_UP 3.5E-03 6.5E-03 n.s. 2.0E-04

GSE32423_IL7_VS_IL4_MEMORY_CD8_TCELL_UP 4.2E-03 8.0E-04 1.1E-04 1.0E-04

GSE17721_LPS_VS_CPG_12H_BMDM_UP 4.5E-03 9.1E-03 3.9E-02 1.0E-04

GSE13484_12H_VS_3H_YF17D_VACCINE_STIM_PBMC_UP 5.9E-03 2.0E-04 n.s. 1.0E-04

GSE17721_LPS_VS_GARDIQUIMOD_8H_BMDM_UP 5.9E-03 3.5E-03 4.7E-02 1.0E-04

GSE39820_CTRL_VS_IL1B_IL6_IL23A_CD4_TCELL_UP 5.9E-03 6.8E-03 1.8E-04 1.0E-04

GSE360_CTRL_VS_B_MALAYI_HIGH_DOSE_MAC_UP 6.2E-03 2.0E-04 n.s. 2.0E-04

GSE360_DC_VS_MAC_B_MALAYI_LOW_DOSE_UP 7.1E-03 3.7E-03 n.s. 4.0E-04

GSE32423_IL7_VS_IL7_IL4_MEMORY_CD8_TCELL_UP 7.2E-03 1.1E-03 2.3E-03 1.0E-04

GSE17721_LPS_VS_POLYIC_16H_BMDM_DN 7.5E-03 1.3E-03 n.s. 1.0E-04

GSE5463_CTRL_VS_DEXAMETHASONE_TREATED_THYMOCYTE_DN 8.0E-03 4.7E-03 2.9E-03 6.8E-03

GSE3982_NEUTROPHIL_VS_BASOPHIL_UP 8.6E-03 1.9E-03 n.s. 2.0E-04

GSE30962_ACUTE_VS_CHRONIC_LCMV_SECONDARY_INF_CD8_TCELL_UP 9.2E-03 8.1E-03 1.2E-02 1.0E-04

GSE17721_LPS_VS_CPG_4H_BMDM_DN 9.8E-03 5.1E-03 n.s. 2.0E-04

GSE36476_YOUNG_VS_OLD_DONOR_MEMORY_CD4_TCELL_72H_TSST_ACT_DN 1.0E-02 9.5E-03 n.s. 1.0E-03

GSE360_HIGH_VS_LOW_DOSE_B_MALAYI_DC_UP 1.1E-02 5.4E-03 n.s. 1.8E-03

GSE11864_CSF1_VS_CSF1_IFNG_PAM3CYS_IN_MAC_UP 1.1E-02 1.5E-03 n.s. 1.0E-04

GSE24142_EARLY_THYMIC_PROGENITOR_VS_DN3_THYMOCYTE_FETAL_UP 1.2E-02 7.0E-04 n.s. 1.0E-04

GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_YOUNG_UP 1.4E-02 2.0E-03 1.8E-02 8.0E-04

GSE17721_LPS_VS_PAM3CSK4_8H_BMDM_DN 1.6E-02 9.1E-03 n.s. 5.0E-04

GSE27786_CD8_TCELL_VS_MONO_MAC_DN 2.0E-02 7.0E-04 3.6E-04 1.0E-04

GSE17974_0.5H_VS_72H_UNTREATED_IN_VITRO_CD4_TCELL_UP 2.8E-02 4.6E-03 n.s. 1.0E-04

GSE37416_CTRL_VS_6H_F_TULARENSIS_LVS_NEUTROPHIL_UP 4.2E-02 1.1E-03 n.s. 3.8E-03

GSE360_DC_VS_MAC_UP 4.8E-02 6.8E-03 n.s. 3.3E-03

GSE17721_CTRL_VS_POLYIC_1H_BMDM_UP 5.0E-02 6.3E-03 n.s. 1.0E-04

Note:

p-value (intersect) is the p-value of a hypergeometric test for genes that were in common between BS-NM and BLM-NS data and were represented in statistically

significant genesets.

p-value (GSEA) is the p-value of the Gene Set Enrichment Analysis (GSEA).

n.s.: not significant at the cut-off p-value (intersect). Common genesets between BS vs. NM and BLM vs. NS are highlighted in bold type.

Table S4. Significantly differentially expressed miRNAs identified in BS or BLM-depleted fibroblasts

p-value FDR Expression Ratio p-value FDR Expression Ratio

hsa-miR-181a-5p 5.85E-03 3.34E-02 2.60 3.42E-02 n.s. n.s.

hsa-miR-595 8.04E-04 1.03E-02 2.13 n.s. n.s. n.s.

hsa-miR-30a-5p 1.93E-03 1.76E-02 2.12 n.s. n.s. n.s.

hsa-miR-30d-5p 2.43E-03 2.00E-02 1.90 n.s. n.s. n.s.

hsa-miR-155-5p 1.67E-02 6.62E-02 1.90 3.99E-02 n.s. n.s.

hsa-miR-29b-3p 2.90E-02 9.94E-02 1.85 n.s. n.s. n.s.

hsa-miR-412 2.21E-03 1.89E-02 1.83 n.s. n.s. n.s.

hsa-miR-130a-3p 5.19E-03 3.16E-02 1.79 4.70E-03 9.23E-02 n.s.

hsa-miR-320a 5.32E-04 7.67E-03 1.75 n.s. n.s. n.s.

hsa-miR-484 3.17E-03 2.12E-02 1.73 n.s. n.s. n.s.

hsa-miR-29c-3p 1.44E-02 6.06E-02 1.72 n.s. n.s. n.s.

hsa-miR-634 2.77E-03 2.05E-02 1.68 1.22E-02 n.s. n.s.

hsa-miR-26b-5p 6.29E-03 3.39E-02 1.68 n.s. n.s. n.s.

hsa-miR-34a-5p 1.10E-02 4.93E-02 1.67 n.s. n.s. n.s.

hsa-miR-199a-5p 2.14E-02 8.25E-02 1.63 1.52E-05 3.04E-03 -1.68hsa-miR-328 1.66E-02 6.62E-02 1.63 n.s. n.s. n.s.

hsa-miR-29a-3p 2.38E-02 8.67E-02 1.62 4.43E-02 n.s. n.s.

hsa-miR-130b-3p 2.69E-02 9.34E-02 1.56 n.s. n.s. n.s.

hsa-miR-103a-3p 5.81E-03 3.34E-02 1.51 n.s. n.s. n.s.

hsa-miR-143-3p 7.17E-03 3.64E-02 -2.35 5.93E-04 3.16E-02 -1.68hsa-miR-499a-5p 2.50E-03 2.00E-02 -2.05 n.s. n.s. n.s.

hsa-miR-92b-3p 3.14E-03 2.12E-02 -1.92 n.s. n.s. n.s.

hsa-miR-145-5p 8.59E-04 1.03E-02 -1.89 3.96E-03 8.55E-02 -2.22hsa-let-7c 6.76E-05 2.65E-03 -1.88 n.s. n.s. n.s.

hsa-let-7b-5p 5.27E-07 1.44E-04 -1.88 3.27E-02 n.s. n.s.

hsa-miR-632 5.12E-04 7.67E-03 -1.87 n.s. n.s. n.s.

hsa-let-7e-5p 2.55E-05 1.40E-03 -1.86 5.01E-03 9.23E-02 n.s.

hsa-miR-129-5p 6.51E-03 3.43E-02 -1.85 n.s. n.s. n.s.

hsa-miR-636 1.88E-05 1.29E-03 -1.73 n.s. n.s. n.s.

hsa-let-7d-5p 7.92E-05 2.67E-03 -1.71 3.51E-03 7.79E-02 1.80hsa-let-7g-5p 3.48E-03 2.22E-02 -1.71 n.s. n.s. n.s.

hsa-miR-638 2.77E-03 2.05E-02 -1.71 n.s. n.s. n.s.

hsa-miR-365a-3p 9.65E-03 4.48E-02 -1.70 n.s. n.s. n.s.

hsa-let-7a-5p 6.86E-06 9.40E-04 -1.70 n.s. n.s. n.s.

hsa-miR-99a-5p 9.30E-03 4.39E-02 -1.66 1.50E-03 5.03E-02 1.59hsa-let-7f-5p 9.91E-04 1.10E-02 -1.61 n.s. n.s. n.s.

hsa-miR-193a-5p 4.69E-04 7.67E-03 -1.57 n.s. n.s. n.s.

hsa-miR-152 1.48E-02 6.14E-02 -1.55 n.s. n.s. n.s.

hsa-miR-221-3p 4.04E-02 n.s. n.s. 6.18E-05 7.06E-03 2.50hsa-miR-107 2.27E-02 8.48E-02 n.s. 2.61E-05 3.48E-03 2.37hsa-miR-495 n.s. n.s. n.s. 1.51E-03 5.03E-02 2.03hsa-miR-24-3p n.s. n.s. n.s. 2.97E-04 1.83E-02 1.83hsa-let-7i-5p 1.36E-03 1.43E-02 n.s. 2.40E-05 3.48E-03 1.67hsa-miR-409-3p n.s. n.s. n.s. 5.79E-03 9.53E-02 1.56hsa-miR-382-5p n.s. n.s. n.s. 2.59E-03 6.91E-02 1.53hsa-miR-210 3.16E-04 6.00E-03 n.s. 3.16E-03 7.44E-02 -3.38hsa-miR-15a-5p n.s. n.s. n.s. 5.01E-03 9.23E-02 -2.69hsa-miR-629-5p n.s. n.s. n.s. 5.08E-03 9.23E-02 -2.51hsa-miR-15b-5p n.s. n.s. n.s. 1.09E-05 3.04E-03 -2.26hsa-miR-196a-5p 3.59E-02 n.s. n.s. 2.48E-03 6.83E-02 -1.72hsa-miR-16-5p n.s. n.s. n.s. 1.15E-05 3.04E-03 -1.70hsa-miR-25-3p n.s. n.s. n.s. 9.48E-04 4.21E-02 -1.59

A total of 38 (19 up and 19 down) miRNAS were identified as significantly differentially expressed in BS fibroblasts, and 19 (9 up and

10 down) miRNAs in BLM-depleted human fibroblasts using the following cut-off: absolute expression ratio ≥ 1.5 and false discovery rate

(FDR) < 0.1.

Cancer/disease associated miRNAs annotated in MalaCards: The Human Malady Compendium (http://www.malacards.org/) are highlighted

in bold italic font.

miRBase IDBS vs. NM BLM vs. NS

Table S5: Experimentally validated targets of miRNAs significantly altered in BS or BLM-depleted cells.

change in miRNA expression

miRBase ID BS vs NM BLM vs NS Validated Targets

hsa-miR-143-3p ↓ down  ↓ down AKT1 BCL2 COL1A1 DNMT3A FHIT FNDC3B FSCN1 HK2 HRAS KRAS MACC1 MAPK7 MDM2 MMP13 MYO6 SERPINE1

hsa-miR-145-5p ↓ down  ↓ down 

ADAM17 BNIP3 CBFB CDH2 CDK4 CDKN1A CLINT1 CPEB4 CTGF DDX17 EIF4E ERG F11R FLI1 FSCN1 FZD7 HDAC2 HOXA9 IFNB1 IGF1R ILK IRS1 IRS2 ITGB8 KLF4 KRT7 MDM2 MUC1 MYC MYO5A MYO6 MYRF NANOG NEDD9 NRAS PAK4 POU5F1 PPM1D PPP3CA ROBO2 RTKN SERPINE1 SOCS7 SOX2 STAT1 SWAP70 TIRAP TMOD3 VEGFA YES1

hsa-miR-199a-5p ↑ up  ↓ down CAV1 DDR1 EDN1 ERBB2 EZH2 GPR78 IKBKB LIF MAP3K11 SIRT1 SMAD4 SMARCA2 SULT1E1 UNG

hsa-let-7d-5p ↓ down  ↑ up  APP DICER1 HMGA2 IL13 MPL PDGFA SLC11A2

hsa-miR-99a-5p ↓ down  ↑ up  FGFR3 IGR1R MTOR RAVER2 SERPINE1 

hsa-miR-181a-5p ↑ up n.s.

ATM BCL2 BCL2L11 CDKN1B CDX2 DDIT4 DUSP5 DUSP6 FOS GATA6 GPR78 HIPK2 HRAS KAT2B KLF6 MCL1 MTMR3 NLK NOTCH1 PLAG1 PRAP1 PROX1 PTPN11 PTPN22 RALA SIRT1 XIAP ZNF763

hsa-miR-595 ↑ up n.s. PARD6A

hsa-miR-30a-5p ↑ up n.s. ABL1 AVEN BECN1 DTL FOXD1 NEUROD1 NOTCH1 PIK3CD PRDM1 RUNX2 SEPT7 SMAD1 TNRC6A TUBB4B

hsa-miR-30d-5p ↑ up  n.s. CASP3 EZH2 GNAI2 GPR78 RUNX2 SMAD1 TP53

hsa-miR-155-5p ↑ up  n.s.

ACTR2 AGO4 AGTR1 ANAPC16 APAF1 APC ARFIP1 ARID2 ARL15 ARL6IP5 ARMC2 ARPC3 BACH1 BCL6 C16orf62 C17orf80 C3orf18 CAB39 CARD11 CARHSP1 CBR4 CCDC41 CCDC82 CD68 CDC40 CEBPB CEP41 CHD9 CIAPIN1 CLUAP1 CSNK1A1 CYP2U1 CYR61 DCUN1D2 DET1 DHX40 E2F2 EDN1 ETS1 EXOSC2 FAM135A FAM177A1 FAM199X FAM91A1 FGF7 FLI1 FOXO3 GABARAPL1 GATM GCFC2 GCSAM GOLT1B GPM6B HAL HBP1 HERC4 HIVEP2 ICAM1 IFNGR1 IGJ IKBKE IL13RA1 IL17RB IL8 INPP5D INPP5F INTS6 JARID2 JUN KBTBD2 KDM3A KIAA0430 KLHL5 KRAS KRCC1 LCORL LDOC1 LIN7C LNX2 LRIF1 LRRC59 MAP3K10 MAP3K14 MASTL MATR3 MBNL3 MCM8 MECP2 MEF2A MEIS1 MITF MLH1 MORC3 MPP5 MRPL18 MRPS27 MSH2 MSH6 MSI2 MYB MYBL1 MYD88 MYO10 MYO1D NARS NFATC2IP NOS3 NOVA1 OLR1 PAK2 PALD1 PBRM1 PCDH9 PDLIM5 PHC2 PHF14 PHF17 PICALM PKIA PKN2 PLS1 POLE3 PRKAR1A RAB11FIP2 RAC1 RAPGEF2 RBAK RHEB RHOA RUNX2 SAP30L SDCBP SECISBP2 SELE SKI SLC33A1 SLC35F2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMARCA4 SOCS1 SPI1 SSX2IP TAB2 TAF5L TBC1D14 TBC1D8B TBCA TCF12 TLE4 TM6SF1 TOMM20 TP53INP1 TRAK1 TRIP13 TSHZ3 TSPAN14 TTF1 UBQLN1 UBTD2 UPF2 UQCRFS1 VPS18 WBP1L WEE1 WHSC1L1 WWC1 YWHAZ ZIC3 ZNF248 ZNF254 ZNF28 ZNF493 ZNF561 ZNF611 ZNF652 ZNF83

hsa-miR-29b-3p ↑ up  n.s.

ADAM12 BACE1 BCL2 BMP1 CDC42 CDK6 COL1A1 COL3A1 COL4A1 COL5A3 CTNNBIP1 DNAJB11 DNMT1 DNMT3A DNMT3B DUSP2 ESR1 FGA FGB FGG FOS GRN HDAC4 IFNG IMPDH1 MCL1 MMP15 MMP2 MMP24 MYCN NASP NCOA3 NID1 NKIRAS2 PPP1R13B PTEN RAX S100B SFPQ SP1 TBX21 TCL1A TET1 VEGFA

hsa-miR-412 ↑ up n.s.  ACVR1C

hsa-miR-130a-3p ↑ up n.s. APP ATG2B ATXN1 CSF1 DICER1 ESR1 HOXA10 HOXA5 IFITM1 KLF4 MAFB MEOX2 PPARG RUNX3 SMAD4 TAC1

hsa-miR-320a ↑ up n.s.  AQP1 AQP4 HSPB6 MAPK1 MCL1 NPR1 TAC1 TFRC

hsa-miR-484 ↑ up n.s.  FIS1

hsa-miR-29c-3p ↑ up n.s. 

BACE1 BCL2 CDC42 CDK6 COL15A1 COL1A1 COL1A2 COL21A1 COL3A1 COL4A1 COL4A2 COL7A1 DNMT3A DNMT3B FBN1 FGA FGB FGG GAPDH IGFBP1 LAMC1 MCL1 MMP15 MMP24 MYCN PPP1R13B SPARC SRSF10 TDG TFAP2C WNT4

hsa-miR-634 ↑ up n.s.  not available (n.a.)

hsa-miR-26b-5p ↑ up n.s.  ABCA1 ARL4C CCNE1 CDK6 EPHA2 PTGS2

hsa-miR-34a-5p ↑ up n.s. 

ACSL1 ACSL4 AXIN2 AXL BCL2 BMP7 CCL22 CCND1 CCND3 CCNE2 CD44 CDC25A CDK4 CDK6 CDKN2A CDKN2C CEBPB DLL1 E2F1 E2F3 EPHA5 FOSL1 FOXP1 GRM7 HDAC1 HNF4A IFNB1 IMPA1 IMPDH2 JAG1 KLB LDHA LEF1 MAGEA12 MAGEA2 MAGEA3 MAGEA6 MAP2K1 MAP3K9 MET MTA2 MYB MYC MYCN NANOG NOTCH1 NOTCH2 PDGFRA PEA15 PPP1R10 SIRT1 SOX2 SPI1 STX1A SYT1 TP53 ULBP2 VAMP2 VEGFA WNT1 YY1 ZAP70

hsa-miR-328 ↑ up n.s.  ABCG2 BACE1 CD44 H2AFX PTPRJ

hsa-miR-29a-3p ↑ up n.s. 

ABL1 ADAMTS9 BACE1 BCL2 BCL7A CD276 CDC42 CDK6 COL4A1 COL4A2 CPEB3 CPEB4 DICER1 DKK1 DNMT3A DNMT3B FGA FGB FGG GLUL HBP1 IMPDH1 ITGA11 ITIH5 KREMEN2 LPL MCL1 MYCN NASP NAV3 PIK3R1 PPM1D PPP1R13B PTEN PXDN RAN S100B SFRP2 TNFAIP3

hsa-miR-130b-3p ↑ up n.s.  CSF1 DICER1 PPARG RUNX3 TP53INP1 UVRAG ZEB1

hsa-miR-103a-3p ↑ up n.s. CAV1 CCNE1 CDK2 CREB1 CYP2C8 DAPK1 DICER1 GPD1 ID2 KLF4 PTEN TIMP3

hsa-miR-499a-5p ↓ down n.s. FOXO4 PDCD4 SOX6

hsa-miR-92b-3p ↓ down n.s. CDKN1C NLK PRMT5 SLC15A1

hsa-let-7c-5p ↓ down  n.s. BCL2L1 COPS6 COPS8 DICER1 GPS1 HMGA2 MPL MYC NRAS TGFBR1 TRIM71

hsa-let-7b-5p ↓ down  n.s. ACTG1 CCNA1 CCNA2 CCND1 CCND2 CDC34 CDK6 CYP2J2 DICER1 HMGA2 IFNB1 LIN28A LIN28B MTPN NR2E1 PRDM1 RPIA

hsa-miR-632 ↓ down n.s. PRDX6

hsa-let-7e-5p ↓ down  n.s.  EIF3J HMGA2 MPL MYCN SMC1A WNT1 

hsa-miR-129-5p ↓ down n.s. FMR1 NOTCH1 UBE2F

hsa-miR-636 ↓ down n.s. n.a.

hsa-let-7g-5p ↓ down  n.s. BCL2L1 BMI1 CDKN2A COL1A2 HMGA2 IGF2BP1 IL13 KRAS MYC

hsa-miR-638 ↓ down n.s. OSCP1

hsa-miR-365a-3p ↓ down n.s. BCL2 CCND1 IL6

hsa-let-7a-5p ↓ down  n.s.

AGO4 APP CASP3 CASP8 CASP9 CCND2 CDKN1A DICER1 E2F1 E2F2 EGFR FOXA1 HAS2 HMGA1 HMGA2 HRAS IGF2 IL6 ITGB3 KRAS LIN28A MPL MYC NF2 NKIRAS2 NR1I2 NRAS PRDM1 RAVER2 TMED7 TRIM71 UHRF2 VDR

hsa-let-7f-5p ↓ down  n.s. COPS6 COPS8 CYP19A1 GPS1 IL13 KLK6 KLK10 MPL PRDM1 SLC5A5

hsa-miR-193a-5p ↓ down n.s.  TP73

hsa-miR-152 ↓ down n.s.  DMNT1 HLA-G IGF1R IRS1 TGFA

hsa-miR-221-3p n.s. ↑ up 

ARIH2 BBC3 BMF BNIP3 BNIP3L BRAP CDKN1B CDKN1C CERS2 CORO1A CREBZF DDIT4 DICER1 DKK2 DVL2 ESR1 FMR1 FOS FOXO3 HMGXB4 ICAM1 KIT MEOX2 MYBL1 NAIP PTEN SELE TBK1 TCEAL1 TICAM1 TIMP3 TMED7 TNFSF10 TP53 USP18 ZEB2

hsa-miR-107 n.s.  ↑ up ARNT BACE1 CCNE1 CDCA4 CDK6 CHRM1 CRKL CYP2C8 DAPK1 DICER1 FBXW7 GRN HIF1A KLF4 MYB NFIA NOTCH2 PLAG1 PTEN RAB1B VEGFA

hsa-miR-495 n.s. ↑ up  MEIS1 PBX3

hsa-miR-24-3p n.s. ↑ up 

ACVR1B ARHGAP19 AURKB BCL2L11 BRCA1 CCNA2 CDK1 CDK4 CDKN1B CDKN2A CHEK1 CNDP2 CORO1A DEDD DHFR DHFRP1 DND1 E2F2 FAF1 FEN1 FURIN H2AFX HNF4A MAPK14 MCM10 MCM4 MLEC MYC NOTCH1 PAK4 PCNA POLD1 PTPN9 PTPRF SH3PXD2A ST7L STX16 TGFB1 TMED7 TRIB3 ZNF217

hsa-let-7i-5p n.s. ↑ up  COPS6 COPS8 GPS1 IL13 SOCS1 TLR4

hsa-miR-409-3p n.s. ↑ up  ANG FGA FGB FGG IFNG PHF10

hsa-miR-382-5p n.s.  ↑ up n.a.

hsa-miR-210 n.s. ↓ down 

ABCB9 ACVR1B AIFM3 APC ATP11C BDNF CASP8AP2 CBX1 CDK10 CHD9 CLASP2 CPEB2 DDAH1 DENND6A E2F3 EFNA3 ELK3 FGFRL1 GPD1L HECTD1 HOXA1 HOXA3 HOXA9 ISCU KIAA1161 MDGA1 MIB1 MID1IP1 MNT MRE11A NCAM1 NIPBL NPTX1 P4HB PIM1 PTAR1 PTPN1 RAD52 SEH1L SERTAD2 SMCHD1 TNPO1 TP53I11 UBQLN1 VMP1 XIST XPA

hsa-miR-15a-5p n.s. ↓ down AKT3 APP BACE1 BCL2 BMI1 BRCA1 CADM1 CCND1 CCND2 CCNE1 CDC25A CHUK DMTF1 IFNG MYB PURA RECK TMEM184B TP53 TSPYL2 UCP2 VEGFA WNT3A

hsa-miR-629-5p n.s. ↓ down  HNF4A

hsa-miR-15b-5p n.s. ↓ down  BCL2 CCND1 CCNE1 EIF4A1 IFNG PURA RECK VEGFA

hsa-miR-196a-5p n.s.  ↓ down  ANXA1 BACH1 CDKN1B HMOX1 HOXA5 HOXA7 HOXB7 HOXB8 HOXC8 HOXD8 KRT5 S100A9 SPRR2C

hsa-miR-16-5p n.s. ↓ down 

ACVR2A AKT3 ARL2 BCL2 BMI1 BRCA1 CADM1 CAPRIN1 CCND1 CCND3 CCNE1 CCNT2 CDK6 CHUK HMGA1 IFNG MYB NCOR2 PIM1 PPM1D PTGS2 PURA TP53 TPPP3 UNG VEGFA WNT3A ZYX

hsa-miR-25-3p n.s. ↓ down BCL2L11 CCL26 CDH1 CDKN1C EZH2 KAT2B KLF4 MDM2 PRMT5 SMAD7 TP53

Validated miRNA target search was performed on miRNAs significantly changed in BS or BLM-depleted human fibroblasts (Table S5) using miRTarBase (v4.4, http://mirtarbase.mbc.nctu.edu.tw/)(16). Only target genes validated by strong experimental assays such as reporter assay or Western blot were listed.

Figure S5: qPCR verification of miRNA expression levels determined by microarray.

The log2expression values for indicated microRNAs are plotted against the qRT-PCR -ΔCt

values (ΔCt = CtmiRNA - CtRNU66). Each dot represents a primary fibroblast cell line (red = BS,

black = NM). Shown are the regression line as well as the P- and R2 values (coefficient of

determination) for the correlation. Methodological details are in the Supplementary materials.

hsa-miR-181a

6 7 8 9 10 11 12-6

-4

-2

0

2

4

log2 array expression value hsa-miR-181a

qR

T-P

CR

exp

ressio

n v

alu

e (C

tU66-C

t m

iR-1

81a)

R2=0.786

P < 0.001

hsa-miR-181c

6 7 8 9 10 11-8

-6

-4

-2

0

log2 array expression value hsa-miR-181c

qR

T-P

CR

exp

ressio

n v

alu

e (C

tU66-C

t m

iR-1

81c)

R2=0.621

P < 0.001

hsa-miR-155

8 10 12 14 16-6

-4

-2

0

2

log2 array expression value hsa-miR-155

qR

T-P

CR

exp

ressio

n v

alu

e (C

tU66-C

t m

iR-1

55)

R2=0.798

P < 0.001

hsa-miR-181b

8 10 12 14-4

-2

0

2

4

log2 array expression value hsa-miR-181b

qR

T-P

CR

exp

ressio

n v

alu

e (C

tU66-C

t m

iR-1

81b

)

R2=0.911

P < 0.001

hsa-miR-181d

6 8 10 12 14-2

0

2

4

log2 array expression value hsa-miR-181d

qR

T-P

CR

exp

ressio

n v

alu

e (C

tU66-C

t m

iR-1

81d

)

R2=0.815

P < 0.001

hsa-miR-34a

6 7 8 9 10-2

0

2

4

log2 array expression value hsa-miR-34a

qR

T-P

CR

exp

ressio

n v

alu

e (C

tU66-C

t m

iR-3

4a)

R2=0.594

P < 0.001

Supplementary Figure S6: G4 motif frequencies and enrichment near transcription start sites and intron 1 boundaries of genes with altered expression in BLMdepleted cells. (A) G4 motif frequencies as a function of location in genes up- and down-regulated in BLM-depleted cells. G4 motif counts are shown for non-transcribed strands (NT) and transcribed strands (TS) over the 250 bp ± gene transcription start sites (TSSs) and exon 1/intron 1 5ʹ boundaries for genes whose expression was up- or downregulated (red and blue curves, respectively) versus the comparable distributions for 1,000 randomly-selected gene sets of equal size drawn from the pool of all genes on expression arrays. Gray areas indicate average G4 motif frequencies among all genes surveyed on expression arrays. (B) False Discovery Rates (FDR) of observed G4 motif frequencies compared to 1,000 randomly selected gene sets. ns: non-significant (FDR >0.05)

Table S6. Hypergeometric test of miRNA targeting vs. significantly altered mRNA expression

miRBase ID

BS-NM

miR

direction

BLM-NS

miR

direction

num

validated

targets

DEG targets

DOWN

in BS-NM

total DEG

DOWN in

BS-NM

fraction

altered as

predicted

p-value intersect genes

hsa-miR-199a-5p up down 15 0 141 1

hsa-miR-181a-5p up n.s. 28 0 141 1

hsa-miR-595 up n.s. 1 0 141 1

hsa-miR-30a-5p up n.s. 14 0 141 1

hsa-miR-30d-5p up n.s. 7 0 141 1

hsa-miR-155-5p up n.s. 183 0 141 1

hsa-miR-29b-3p up n.s. 44 1 141 0.023 4.985E-02 MMP24

hsa-miR-412 up n.s. 1 0 141 1

hsa-miR-130a-3p up n.s. 23 0 141 1

hsa-miR-320a up n.s. 8 0 141 1

hsa-miR-484 up n.s. 1 1 141 1.000 0 FIS1

hsa-miR-29c-3p up n.s. 31 1 141 0.032 2.623E-02 MMP24

hsa-miR-26b-5p up n.s. 6 0 141 1

hsa-miR-34a-5p up n.s. 63 0 141 1

hsa-miR-328 up n.s. 5 0 141 1

hsa-miR-29a-3p up n.s. 47 1 141 0.021 5.608E-02 ITGA11

hsa-miR-130b-3p up n.s. 7 0 141 1

hsa-miR-103a-3p up n.s. 12 0 141 1

UP

in BS-NM

UP

in BS-NM

hsa-miR-143-3p down down 15 2 1012 0.133 5.346E-02 FNDC3B, MDM2

hsa-let-7d-5p down up 7 0 1012 1

hsa-miR-99a-5p down up 5 0 1012 1

hsa-miR-499a-5p down n.s. 3 0 1012 1

hsa-miR-92b-3p down n.s. 4 0 1012 1

hsa-let-7c-5p down n.s. 11 0 1012 1

hsa-let-7b-5p down n.s. 24 2 1012 0.083 1.625E-01 BIRC6, PDGFRA

hsa-miR-632 down n.s. 1 0 1012 1

hsa-let-7e-5p down n.s. 6 1 1012 0.167 4.372E-02 EIF3J

hsa-miR-129-5p down n.s. 7 1 1012 0.143 5.888E-02 BMPR2

hsa-let-7g-5p down n.s. 10 0 1012 1

hsa-miR-638 down n.s. 1 0 1012 1

hsa-miR-365a-3p down n.s. 3 0 1012 1

hsa-let-7a-5p down n.s. 44 4 1012 0.091 1.122E-01 EGFR, HAS2, SLC20A1, TMED7

hsa-let-7f-5p down n.s. 15 0 1012 1

hsa-miR-193a-5p down n.s. 1 0 1012 1

hsa-miR-152 down n.s. 5 1 1012 0.200 3.031E-02 IRS1

hsa-miR-145-5p down down 50 10 1012 0.200 1.169E-04CLINT1, DDX17, FZD7, HDAC2,

HOXA9, IRS1, MDM2, MYO5A,

DOWN

in BLM-NS

DOWN

in BLM-NShsa-let-7d-5p down up 7 0 752 1

hsa-miR-99a-5p down up 5 0 752 1

hsa-miR-221-3p n.s. up 38 1 752 0.026 4.959E-01 CDKN1B

hsa-miR-107 n.s. up 21 0 752 1

hsa-miR-495 n.s. up 2 0 752 1

hsa-let-7i-5p n.s. up 6 1 752 0.167 2.514E-02 TLR4

hsa-miR-409-3p n.s. up 6 0 752 1

hsa-miR-24-3p n.s. up 54 12 752 0.222 3.747E-07

ARHGAP19, AURKB, BRCA1, CDK1,

CDKN1B, E2F1, FEN1, H2AFX,

MCM10, MCM4, PCNA, RRM2

UP

in BLM-NS

UP

in BLM-NShsa-miR-143-3p down down 15 2 580 0.133 1.259E-02 FSCN1, MDM2

hsa-miR-145-5p down down 50 4 580 0.080 2.542E-02 FLI1, FSCN1, MDM2, MYC

hsa-miR-199a-5p up down 15 0 580 1

hsa-miR-210 n.s. down 47 2 580 0.043 2.079E-01 BDNF, ISCU

hsa-miR-15a-5p n.s. down 29 2 580 0.069 7.176E-02 CADM1, CCND2

hsa-miR-629-5p n.s. down 1 0 580 1

hsa-miR-15b-5p n.s. down 8 0 580 1

hsa-miR-196a-5p n.s. down 14 2 580 0.143 1.032E-02 BACH1, HOXA7

hsa-miR-16-5p n.s. down 34 2 580 0.059 1.042E-01 CADM1, PTGS2

hsa-miR-25-3p n.s. down 11 1 580 0.091 5.041E-02 MDM2

Table S6a: Selected target genes differentially expressed in BS and BLM depleted cells

BS cells

Gene FunctionmRNA

expressionApoptosis BIRC6 anti-apoptotic up

FIS1 pro-apoptotic down

p53 pathway MDM2 negative regulator of p53 up

Growth factor

receptor/oncogeneEGFR EGF receptor

up

PDGFRA PDGF receptor up

FZD7 Wnt signaling component up

MYCplays an important role in cell cycle progression,

apoptosis and cellular transformation.up

FLI1 proto-oncogene up

Insulin signaling IRS1 insulin receptor signaling up

BLM depleted cells

Gene FunctionmRNA

expression

p53 pathway MDM2 negative regulator of p53 up

Oncogene MYCplays an important role in cell cycle progression,

apoptosis and cellular transformation.up

FLI1 proto-oncogene? up

DNA replication & DNA

damage responseBRCA1 DNA damage response and repair down

FEN1 DNA replication and repair down

H2AFX DNA damage response and repair down

MCM4 DNA replication down

MCM10 DNA replication and repair down

PCNA DNA replication down

RRM2 DNA replication down

Cell cycle control CDK1 Regulation of cell cycle progression. down

CDKN1B Inhibition of cell cycle progression. down

E2F1 Involved in cell cycle regulation or in DNA replication. down

Table 7A: Differentially Expressed Genes in BS patients vs NM that have at least one G4 motif in each regionRegion

Regulation

G4 Strand Either NT T Either NT T Either NT T Either NT T Either NT T Either NT T

Gene AAK1 ACBD3 ACSL3 ACAN ADA ACAN AAK1 AAK1 ACTR10 ACAN ADA ACAN AAK1 AAK1 ACBD3 ADA ADA ADARB1

Symbols ACBD3 ACTR10 ADAM10 ACTC1 ADARB1 ACTC1 ACTR10 ACTR3 ACVR1 ADA ADARB1 ADAMTSL1 ACBD3 ACSL3 ACTR10 ADARB1 ADARB1 AKR1B1

ACSL3 ACTR3 ADAMTS5 ADA ADD2 ADAMTSL1 ACTR3 ADAM10 ADD3 ADAMTSL1 ALOX12 AKR1B1 ACSL3 ACTR3 ACTR3 ADD2 ADD2 ALOX12

ACTR10 ADAMTS5 ADNP ADAMTSL1 ALDH1B1 AIP ACVR1 ADD3 ADNP ADARB1 ATP6V0B BAD ACTR10 ADD3 ADAM10 AKR1B1 AKR1B1 BAD

ACTR3 ADD3 AFF4 ADARB1 ALDOC ALOX12 ADAM10 AGPAT3 AGFG1 AKR1B1 BACE2 C10orf10 ACTR3 AFF4 ADNP ALOX12 ALOX12 C1QTNF5

ADAM10 AGPAT3 AGPAT3 ADD2 ALOX12 BAD ADD3 AHDC1 AGPAT3 ALOX12 BAD CABLES1 ADAM10 AGFG1 AGPAT3 ATP6V0B ATP6V0B CABLES1

ADD3 AHDC1 ANKRD13A AIP BAD C10orf10 ADNP AHNAK2 AHNAK2 ATP6V0B C12orf57 CRLF1 ADD3 AGPAT3 AHNAK2 BACE2 BACE2 CALB2

ADNP AHNAK2 ANKRD36B ALDH1B1 C10orf10 CABLES1 AGFG1 ANKRD13A ANKRD13A BACE2 C1QTNF5 CYGB ADNP AHDC1 AHR BAD C12orf57 CRLF1

AFF4 AHR ANXA7 ALDOC CD24 CALB2 AGPAT3 ANPEP ANXA7 BAD CIB1 CYP4A22 AFF4 AHNAK2 ANKRD13A C12orf57 CABLES1 ENO2

AGFG1 AK3 AP1G1 ALOX12 COMP CIB1 AHDC1 ANXA7 APH1B C10orf10 CRLF1 DMPK AGFG1 AK3 APH1B C1QTNF5 CIB1 FDXACB1

AGPAT3 ANKRD36B APBB2 BAD CRLF1 CYGB AHNAK2 APPBP2 ARCN1 C12orf57 EIF6 ENO2 AGPAT3 ANKRD13A APPL2 CABLES1 CNN1 FUOM

AHDC1 ANKRD50 APH1B C10orf10 DMPK DMPK ANKRD13A ARHGAP21 ARHGEF12 C1QTNF5 FAM101A FNDC4 AHDC1 ANKRD36B ARL6IP1 CALB2 CRLF1 GPC4

AHNAK2 ANLN API5 CABLES1 FNDC4 ENO2 ANPEP ARHGAP29 ARL6IP1 CABLES1 FIS1 FUOM AHNAK2 ANKRD50 ARL6IP6 CIB1 CYGB KCNK6

AHR ANPEP ARCN1 CALB2 GSTM5 FMOD ANXA7 ARL5B ASAP1 CIB1 FSTL3 IDH2 AHR ANPEP ASAP2 CNN1 CYP4A22 LRRC3

AK3 ARL5B ARHGAP18 CD24 GUK1 FNDC4 APH1B ARL6IP6 ASAP2 CRLF1 FUOM LMOD1 AK3 ANXA7 ATMIN CRLF1 DHRS3 MEI1

ANKRD13A ARL6IP6 ARHGAP29 CIB1 IFI30 FSTL3 APPBP2 ARPP19 ATG3 CYGB FXYD1 LRRC3 ANKRD13A AP3B1 ATP1B3 CYGB DMPK MRPS11

ANKRD36B ARPP19 ARHGEF12 COMP LBH FUOM ARCN1 ASAP1 ATP6AP2 CYP4A22 GSTM5 NPAS1 ANKRD36B APH1B ATP8B1 CYP4A22 EIF6 MSRB2

ANKRD50 ARRDC3 ARL6IP6 CRLF1 MANBAL GADD45B ARHGAP21 ASAP2 ATP6V1A DMPK HAPLN3 RASD2 ANKRD50 APPL2 AZIN1 DHRS3 FAM101A NPAS1

ANPEP ASAP2 ASAP2 CYGB MCAM GJD2 ARHGAP29 ASPH ATP8B1 EIF6 ID3 RHOD ANPEP ARHGAP21 BCAP29 DMPK FIS1 NPR3

ANXA7 ASH1L ATF2 DMPK MMP24 GPC4 ARHGEF12 ATMIN BAG2 ENO2 IFI30 SCARF2 ANXA7 ARHGAP29 BMPR2 EIF6 FMOD NTMT1

AP3B1 ASPH ATG3 ENO2 MSRB1 IDH2 ARL5B ATP2C1 BCAP29 FAM101A IRF6 SDHC AP3B1 ARL6IP5 BTBD1 ENO2 FNDC4 NXPH3

APH1B ATF2 ATP6V1A FMOD MSRB2 ITGA11 ARL6IP1 ATP5L BICC1 FIS1 KCNK6 SELM APH1B ASAP1 BTF3L4 FAM101A FSTL3 PGK1

APPL2 ATMIN AZIN1 FNDC4 MYL6 KRT34 ARL6IP6 ATP6AP2 BIRC6 FNDC4 LRRC3 SEPT5 APPL2 ASH1L C12orf23 FDXACB1 FUOM RASD2

ARHGAP21 ATP1B3 BICC1 FSTL3 NDRG2 LIMK2 ARPP19 ATP8B1 BMPR2 FSTL3 MANBAL SLC38A5 ARHGAP21 ASPH CAB39 FIS1 FXYD1 SDHC

ARHGAP29 ATP2A2 BIRC2 FUOM NOTCH3 LRRC3 ASAP1 BAG2 BZW1 FUOM MMP24 SNTA1 ARHGAP29 ATMIN CACHD1 FMOD GADD45B SEL1L3

ARL6IP1 ATP2C1 BIRC6 GADD45B NPAS1 MCAM ASAP2 BCAP29 C12orf75 FXYD1 MSRB1 ST3GAL4 ARL6IP1 ATP1B3 CALCOCO2 FNDC4 GSTM5 SELM

ARL6IP5 ATP8B1 BMP2K GJD2 NPR3 MMP24 ASPH BET1 C3orf58 GSTM5 MSRB2 TAGLN ARL6IP5 ATP2A2 CAMK2D FSTL3 GUK1 SEPT5

ARL6IP6 AZIN1 BRCC3 GPC4 NXPH3 MYL6 ATG3 BIRC2 CACHD1 HAPLN3 MYL6 TMEM141 ARL6IP6 ATP5L CAMSAP2 FUOM HAPLN3 SLC4A3

ASAP1 BAG2 BZW1 GSTM5 POLR2G NDRG2 ATMIN BMP2K CACNA2D1 ID3 NDRG2 TMEM9 ASAP1 ATP6AP2 CAPRIN1 FXYD1 HSPB7 TMEM9

ASAP2 BICC1 C12orf75 GUK1 PTPRN NPAS1 ATP2C1 BTBD1 CALCOCO2 IDH2 NDUFA13 UXT ASAP2 AZIN1 CAPZA2 GADD45B IFI30 YBX1

ASH1L BMPR2 C3orf17 IDH2 RPS4X NPR3 ATP5L C12orf23 CAMSAP2 IFI30 NOTCH3 YBX1 ASH1L B2M CAV2 GPC4 IRF6

ASPH BOD1 C3orf58 IFI30 SCARF2 PODNL1 ATP6AP2 C12orf75 CAST IRF6 NXPH3 ASPH BCAP29 CCDC6 GSTM5 ISLR

ATMIN C12orf23 CACHD1 ITGA11 SEL1L3 POLE4 ATP6V1A C3orf17 CAV1 KCNK6 ORMDL2 ATMIN BET1 CCT6A GUK1 LMOD1

ATP1B3 C12orf75 CACNA2D1 KRT34 SELM PTPRN ATP8B1 C5orf51 CCDC6 LMOD1 PGK1 ATP1B3 BIRC2 CEP170 HAPLN3 LRRC3

ATP2A2 C5orf51 CAMSAP2 LBH SEPT5 RASD2 BAG2 CA5B CD44 LRRC3 PODNL1 ATP2A2 BIRC6 CHAMP1 HSPB7 MMP24

ATP5L CA5B CANX LIMK2 SLC4A3 RHOD BCAP29 CAB39 CD9 MANBAL POLR2G ATP5L BLOC1S6 CLIC4 IFI30 MSRB1

ATP6AP2 CALCOCO2 CCDC25 LRRC3 SPRYD3 SCARF2 BET1 CALCOCO2 CDC42EP3 MMP24 RNASE3 ATP6AP2 BMS1 CLINT1 IRF6 MYL6

ATP8B1 CAMSAP2 CCDC6 MANBAL ST3GAL4 SDF2 BICC1 CAMK2D CDV3 MSRB1 RPS4X ATP8B1 BTBD1 CLOCK ISLR NDRG2

AZIN1 CANX CCT6A MCAM SEPT5 BIRC2 CAMSAP2 CFL2 MSRB2 SCARF2 AZIN1 BZW1 CMTM6 KCNK6 NDUFA13

B2M CAPZA2 CD46 MMP24 SGCA BIRC6 CANX CLIC4 MYL6 SGCA B2M C12orf23 CNEP1R1 LMOD1 NOTCH3

BCAP29 CAST CDC42EP3 MSRB1 SLC38A5 BMP2K CAST CLMP NDRG2 SLC4A3 BCAP29 C12orf75 CNOT4 LRRC3 NPR3

BET1 CAV2 CDK17 MSRB2 SLC4A3 BMPR2 CAV1 CLOCK NDUFA13 SNTA1 BET1 C3orf17 COPB1 MEI1 NXPH3

BIRC2 CD47 CDV3 MYL6 SNTA1 BTBD1 CAV2 CMPK1 NOTCH3 SPRYD3 BIRC2 C3orf58 COPS2 MMP24 ORMDL2

BIRC6 CD9 CFL2 NDRG2 ST3GAL4 BZW1 CD44 CNEP1R1 NPAS1 ST3GAL4 BIRC6 C5orf15 COX16 MRPS11 PODNL1

BLOC1S6 CDK17 CHAMP1 NOTCH3 TAGLN C12orf23 CD47 CPEB2 NXPH3 TMEM141 BLOC1S6 C5orf51 CREBBP MSRB1 POLE4

BMPR2 CLMP CHIC2 NPAS1 TMEM141 C12orf75 CDK12 CPNE3 ORMDL2 TMEM9 BMPR2 C9orf47 CSNK2A1 MSRB2 POLR2G

BMS1 CLOCK CLDN11 NPR3 UXT C3orf17 CEP170 CREBBP PGK1 UQCRQ BMS1 CA5B CTBP1-AS2 MYL6 PSMB5

BTBD1 CNEP1R1 CLIC4 NXPH3 VAMP5 C3orf58 CFL2 CTBP1-AS2 PODNL1 UXT BTBD1 CACNA2D1 CUL3 NDRG2 PTPRN

BTF3L4 COLEC12 CLMP PODNL1 C5orf51 CHAMP1 CUL4B POLR2G VAMP5 BTF3L4 CAMK2D DCUN1D1 NDUFA13 RGS16

BZW1 CORO2B CLOCK POLE4 CA5B CLOCK CYBRD1 RASD2 BZW1 CAPN2 DCUN1D5 NOTCH3 RHOD

C12orf23 COX20 CNOT11 POLR2G CAB39 CMTM6 DCTN6 RHOD C12orf23 CAST DDX1 NPAS1 RNASE3

C12orf75 CREBBP CNOT4 PTPRN CACHD1 CNEP1R1 DCUN1D1 RNASE3 C12orf75 CAV1 DDX17 NPR3 RPS4X

C3orf17 CST4 CNOT7 RASD2 CACNA2D1 CNOT1 DDX3X RPS4X C3orf17 CCAR1 DDX3X NTMT1 SCARF2

C3orf58 CTBP1-AS2 CPNE3 RHOD CALCOCO2 CNOT11 DNAJC10 SCARF2 C3orf58 CCDC6 DHX9 NXPH3 SDF2

C5orf15 CTHRC1 CRK RPS4X CAMK2D CNOT4 DNAJC3 SDHC C5orf15 CCNG1 DNAJC3 ORMDL2 SEL1L3

C5orf51 CUL1 CUL3 SCARF2 CAMSAP2 CNOT7 DPP4 SELM C5orf51 CCNT1 DYNC1H1 PGK1 SGCA

C9orf47 DARS CUL4B SDF2 CANX COLEC12 DPYD SEPT5 C9orf47 CCT6A DYNLT3 PODNL1 SLC4A3

CA5B DCBLD1 CYP1B1 SEL1L3 CAST COPB1 DSTNP2 SGCA CA5B CD109 EDEM1 POLE4 SNTA1

First 250bp of Intron 1

DownUp

TSS to +250 bp

Up Down Up Down

-250 bp to TSS

CAB39 DCTN4 DCTN6 SELM CAV1 COX20 DTX3L SLC38A5 CAB39 CD47 EGFR POLR2G SPRYD3

CACHD1 DDX5 DCUN1D1 SEPT5 CAV2 CRK EFNA5 SLC4A3 CACHD1 CD9 EGR1 PSMB5 ST3GAL4

CACNA2D1 DEGS1 DDX3X SGCA CCDC6 CSNK2A1 EGR1 SNTA1 CACNA2D1 CDC42EP3 EIF2AK2 PTPRN TMEM141

CALCOCO2 DERL2 DHX9 SLC38A5 CD44 CTHRC1 EIF2S1 SPRYD3 CALCOCO2 CDK17 EIF2S1 RASD2 TMEM9

CAMK2D DNAJC13 DIRC2 SLC4A3 CD47 CUL1 EIF4G2 ST3GAL4 CAMK2D CDV3 ENY2 RGS16 TRAPPC4

CAMSAP2 DNMBP DNAJC10 SNTA1 CD9 DARS ERP44 TAGLN CAMSAP2 CEP170 EPB41L2 RHOD UQCRQ

CAPN2 DPYD DOCK10 SPRYD3 CDC42EP3 DCBLD2 F2R TMEM141 CAPN2 CFL2 ERBB2IP RNASE3 VAMP5

CAPRIN1 DR1 DPYD ST3GAL4 CDK12 DCUN1D5 F3 TMEM9 CAPRIN1 CHAMP1 F3 RPS4X WFDC1

CAPZA2 DTX3L DSEL TAGLN CDV3 DDX6 FAM208A UQCRQ CAPZA2 CHIC2 FERMT2 SCARF2 YBX1

CAST DYNLL1 DTX3L TMEM141 CEP170 DEGS1 FBXO28 UXT CAST CKAP2 FGF2 SDF2

CAV1 EDA2R EFNA5 UXT CFL2 DERL2 G3BP1 VAMP5 CAV1 CKAP5 FNDC3A SDHC

CAV2 EDEM1 EGFR VAMP5 CHAMP1 DHX15 GDI2 YBX1 CAV2 CLIC4 FNDC3B SEL1L3

CCAR1 EGR1 EIF2AK2 CLIC4 DHX9 GFPT1 CCAR1 CLOCK G3BP1 SELM

CCDC6 EHBP1 EIF2S3 CLMP DIRC2 GLUD1 CCDC6 CLTC GBE1 SEPT5

CCNG1 EIF2AK2 EIF3A CLOCK DNAJC13 GNAQ CCNG1 CMPK1 GJC1 SGCA

CCNT1 EIF3A EIF3J CMPK1 DNMBP GNG11 CCNT1 CMTM6 GLT8D1 SLC4A3

CCT6A EIF5 EIF3M CMTM6 DOCK10 GNS CCT6A CNIH1 GLUD1 SNTA1

CD109 ELK3 EIF5 CNEP1R1 DPYD GOLT1B CD109 CNOT1 GMPS SPRYD3

CD47 EPB41L2 EPS8 CNOT1 DSEL GPBP1 CD47 CNOT4 GNAQ ST3GAL4

CD9 F2R ERBB2IP CNOT11 DYNLL1 GSPT1 CD9 CNOT7 GNPTAB TMEM141

CDC42EP3 F3 ERP44 CNOT4 EDEM1 GSR CDC42EP3 COLEC12 GNS TMEM9

CDK17 FAM208A FAM13B CNOT7 EHBP1 HDAC2 CDK17 COPB1 GSK3B TRAPPC4

CDV3 FAM35A FAM208A COLEC12 EIF2AK2 HECTD1 CDV3 COPB2 GSPT1 UQCRQ

CEP170 FAM91A1 FAM86C1 COPB1 EIF2S3 HELZ CEP170 COX20 HELZ VAMP5

CFL2 FBXO30 FASN COX20 EIF5 HERC4 CFL2 CPEB2 HERPUD2 WFDC1

CHAMP1 FERMT2 FBXL3 CPEB2 EPB41L2 HIF1A CHAMP1 CREBBP HGF YBX1

CHIC2 FGF2 FERMT2 CPNE3 ERLIN1 IARS CHIC2 CRK HIBADH

CKAP2 FNDC3A FGF2 CREBBP ERRFI1 IARS2 CKAP2 CSNK2A1 HIF1A

CKAP5 FOXJ3 FST CRK ETV1 INSIG1 CKAP5 CUL3 HNRNPA2B1

CLIC4 GFPT1 FUBP3 CSNK2A1 F3 ISCA1 CLIC4 CYB5B HNRNPH2

CLINT1 GLI3 GDAP2 CTBP1-AS2 FAM122B ITGB1 CLINT1 CYBRD1 HNRNPR

CLOCK GMFB GFPT1 CTHRC1 FAM208A ITM2B CLOCK CYP1B1 IDE

CLTC GMPS GLI3 CUL1 FAM35A KCMF1 CLTC DARS IL6ST

CMPK1 GNAQ GLUD1 CUL4B FAM86C1 KCNMA1 CMPK1 DCAF6 ITFG1

CMTM6 GNG12 GNAQ CYBRD1 FAM91A1 KIAA0196 CMTM6 DCBLD1 JKAMP

CNEP1R1 GPR39 GNPNAT1 DARS FASN KIAA1430 CNEP1R1 DCBLD2 KCMF1

CNIH1 GSK3B GNPTAB DCBLD2 FBXL3 KIF5B CNIH1 DCTN6 KCNMA1

CNOT1 GSPT1 GNS DCTN6 FBXO10 KPNA3 CNOT1 DCUN1D1 KDELC2

CNOT4 HEATR1 GSPT1 DCUN1D1 FBXO30 KPNB1 CNOT4 DDX1 KHDRBS1

CNOT7 HELZ HAS2 DCUN1D5 FERMT2 LARP4B CNOT7 DDX3X KIAA0196

COLEC12 HERC4 HBS1L DDX3X FGF2 LBR COLEC12 DDX47 KIAA0430

COPB1 HGF HECTD1 DDX6 FOXJ3 LHFPL2 COPB1 DDX5 KPNB1

COPB2 HHIPL2 HERC4 DEGS1 FUBP3 LIPA COPB2 DDX6 LARP4B

COPS2 HIVEP2 HIVEP2 DERL2 FZD6 LMAN1 COPS2 DEGS1 LBR

COX16 HPRT1 HNRNPK DHX15 G3BP1 LMBRD1 COX16 DERL2 LMAN1

COX20 HS2ST1 HNRNPR DHX9 GDAP2 LPIN1 COX20 DHX15 LMBRD1

CPEB2 HSD17B12 HP1BP3 DIRC2 GFPT1 LRPPRC CPEB2 DHX9 LRPPRC

CREBBP HSP90AA1 HSP90AA1 DNAJC10 GJC1 LY6G5B CREBBP DIP2B LRRC8C

CRK IDH3A IARS2 DNAJC13 GMFB MAN1A1 CRK DNAJC10 LY6G5B

CSNK2A1 IGF2BP2 IKBIP DNAJC3 GNAQ MAP3K7 CSNK2A1 DNAJC13 MAN1A1

CTBP1-AS2 IL6ST IMPAD1 DNMBP GNG12 MAPK1 CTBP1-AS2 DNAJC3 MAN2A1

CUL3 INPP4B INSIG1 DOCK10 GNPNAT1 MAPK1IP1L CUL3 DNMBP MAP3K7

CYB5B INSIG1 ISCA1 DPP4 GPR39 MB21D2 CYB5B DPYD MAP4K4

CYBRD1 IQGAP1 ITGA2 DPYD HDHD1 ME1 CYBRD1 DYNC1I2 MAPK1

CYP1B1 ITGA2 ITGB1 DSEL HELZ MET CYP1B1 DYNLT3 MATR3

DARS JAK1 ITM2B DSTNP2 HEXB MMD DARS EDEM1 MCFD2

DCAF6 JUN KCNMA1 DTX3L HHIPL2 MRGPRF DCAF6 EFNA5 MCM4

DCBLD1 KCMF1 KDELC2 DYNLL1 HMGCR MRPL45 DCBLD1 EGR1 MDFIC

DCBLD2 KCNMA1 KHDRBS1 EDEM1 HNRNPH2 MRPS6 DCBLD2 EHBP1 ME1

DCTN6 KDELC2 KIAA0196 EFNA5 HNRNPK MSL2 DCTN6 EIF2AK2 MEIS2

DCUN1D1 LARP4B KIAA0430 EGR1 HOXA9 MTDH DCUN1D1 EIF2S3 METTL9

DCUN1D5 LBR KIAA1430 EHBP1 HPRT1 MYO1B DCUN1D5 EIF3H MINPP1

DDX1 LHFP KIAA1715 EIF2AK2 HPS3 MYO5A DDX1 EIF3J MMADHC

DDX17 LHFPL2 KITLG EIF2S1 HS2ST1 NAMPT DDX17 EIF5 MMD

DDX3X LINC00152 KPNA4 EIF2S3 HSD17B12 NCKAP1 DDX3X ELK3 MOB1B

DDX47 LOC150381 KPNB1 EIF4G2 HSP90AA1 NCOA4 DDX47 ELOVL5 MYO1B

DDX5 LPAR1 LAMB1 EIF5 IDH3A NF1 DDX5 EPB41L2 NABP1

DDX6 LPP LAPTM4A EPB41L2 IGF2BP2 NFAT5 DDX6 EPS8 NARS

DEGS1 LRRC8C LHFP ERLIN1 IKBIP NNT DEGS1 ERRFI1 NCOA4

DERL2 MAN2A1 LHFPL2 ERP44 IMPAD1 NONO DERL2 EXOC5 NPTX1

DHX15 MAP1LC3B LIMA1 ERRFI1 INSIG1 NPEPPS DHX15 F2R NR1D2

DHX9 MDFIC LMAN1 ETV1 IQGAP1 NPTN DHX9 F3 NREP

DIP2B MED13 LOC150381 F2R ITCH NR1D2 DIP2B FAM126A NRP1

DNAJC10 MET LPIN1 F3 ITFG1 NR3C1 DNAJC10 FAM35A NSF

DNAJC13 METTL7A LYSMD3 FAM122B ITGB1 NREP DNAJC13 FAM86C1 NT5C2

DNAJC3 MFN1 MALAT1 FAM208A JUN NRP1 DNAJC3 FAM91A1 NT5E

DNMBP MFSD1 MAML2 FAM35A KCMF1 NT5C2 DNMBP FAM96A NUCKS1

DPYD MGST1 MAN1A1 FAM86C1 KIAA0430 NUP98 DPYD FASN NUP98

DYNC1H1 MMD MAP1B FAM91A1 KIAA1033 OCIAD1 DYNC1H1 FBXL3 PAPOLA

DYNC1I2 MOB1A MAP1LC3B FASN KIAA1430 OSMR DYNC1I2 FBXO10 PATL1

DYNLT3 MOB1B MAP4K4 FBXL3 KIAA1715 PAK2 DYNLT3 FBXO28 PAXBP1

EDEM1 MRGPRF MAP4K5 FBXO10 KITLG PANK3 EDEM1 FERMT2 PBX3

EFNA5 MRPS6 MARCH7 FBXO28 KPNA4 PANX1 EFNA5 FNDC3A PCNX

EGFR MYO5A MCL1 FBXO30 LDHB PAPOLA EGFR FNDC3B PDCD6IP

EGR1 NABP1 MCM4 FERMT2 LHFPL2 PATL1 EGR1 FOXJ3 PITPNB

EHBP1 NF1 MDFIC FGF2 LIMA1 PBX1 EHBP1 FUBP3 PITPNC1

EIF2AK2 NMT2 MDM2 FOXJ3 LOC150381 PDGFC EIF2AK2 FZD6 PKN2

EIF2S1 NR1D2 ME1 FUBP3 LPAR1 PITPNB EIF2S1 G3BP1 PPP3CA

EIF2S3 NR3C1 MED13 FZD6 LPIN1 PITPNC1 EIF2S3 GBE1 PPP6C

EIF3H NREP MED13L G3BP1 LRPPRC PLS3 EIF3H GDAP2 PPP6R3

EIF3J NRP1 MET GDAP2 LRRC37BP1 PPP1CC EIF3J GDI2 PREPL

EIF5 NT5C2 METAP2 GDI2 LRRC8C PPP1R12A EIF5 GFPT1 PRKAR1A

ELK3 NTNG1 METTL9 GFPT1 LY6G5B PPP2CA ELK3 GJC1 PRKCA

ELOVL5 OCIAD1 MKLN1 GJC1 MAN2A1 PPP2R2A ELOVL5 GMFB PRR14L

ENY2 OSBPL8 MMADHC GLUD1 MAP4K4 PPP2R5E ENY2 GNG12 PSMD1

EPB41L2 OSMR MMD GMFB MAPK1IP1L PPP3CA EPB41L2 GNPNAT1 PTBP1

EPS8 PABPN1 MMGT1 GNAQ MB21D2 PPP6R3 EPS8 GOLT1B PXN

ERBB2IP PAK2 MOB1B GNG11 MCFD2 PREPL ERBB2IP GPRC5A PYGL

ERRFI1 PANK3 MRPL45 GNG12 MED1 PRICKLE1 ERRFI1 GSPT1 QKI

EXOC5 PAPD4 MRPL50 GNPNAT1 MED13 PRKAR1A EXOC5 HDAC2 RAB14

F2R PBX1 MSL2 GNS MED13L PRKCA F2R HDHD1 RAB23

F3 PCYOX1 MTDH GOLT1B MKLN1 PRR14L F3 HELZ RAB3GAP2

FAM126A PDGFC MYO1B GPBP1 MMD PRRC2C FAM126A HERC4 RAB7A

FAM35A PERP NABP1 GPR39 MMP16 PSMA4 FAM35A HERPUD2 RANBP9

FAM86C1 PGRMC1 NAMPT GSPT1 MOB1A PTBP1 FAM86C1 HHIPL2 RARS

FAM91A1 PHLDA1 NF1 GSR MRGPRF PTBP3 FAM91A1 HIATL1 RASSF8

FAM96A PIGX NFAT5 HDAC2 MSL2 PTP4A1 FAM96A HMGCR REV3L

FASN PIK3R1 NNT HDHD1 MTRR PTPN14 FASN HNRNPH2 RNF130

FBXL3 PLAG1 NPEPPS HECTD1 NAE1 PTPRK FBXL3 HNRNPK ROBO1

FBXO10 PPP1R12A NUDT21 HELZ NAMPT RAB10 FBXO10 HNRNPR RRAGC

FBXO28 PPP3CA NUP155 HERC4 NCKAP1 RAB3B FBXO28 HOXA9 RTN4

FERMT2 PPP6C NUP98 HEXB NFE2L2 RAB7A FERMT2 HPRT1 RYK

FGF2 PPP6R3 ORC3 HHIPL2 NOL9 RAB8B FGF2 HSP90AA1 S100A10

FNDC3A PRKDC PAIP2 HIF1A NR1D2 RAC1 FNDC3A HSP90B1 SAP30

FNDC3B PRR14L PAK2 HMGCR NRD1 RAP2A FNDC3B HSPH1 SCAF8

FOXJ3 PRRC1 PDGFC HNRNPH2 NSF RCN1 FOXJ3 IDE SCAMP1

FUBP3 PSD3 PEG10 HNRNPK NT5C2 RCN2 FUBP3 IDH3A SCCPDH

FZD6 PSMD1 PERP HOXA9 NTNG1 REEP3 FZD6 IFI16 SEC63

G3BP1 PSME4 PGM3 HPRT1 NUCKS1 REV3L G3BP1 IFNAR1 SEPT10

GBE1 PTBP1 PHTF2 HPS3 NXF1 RGMB GBE1 INPP4B SERINC1

GDAP2 PTBP3 PIGX HS2ST1 OSBPL8 RNF11 GDAP2 INSIG1 SERPINE2

GDI2 PTP4A2 PKN2 HSD17B12 PABPN1 RNF130 GDI2 IQGAP1 SERTAD2

GFPT1 PUM2 PLAG1 HSP90AA1 PAIP2 RPS27L GFPT1 ITCH SFT2D1

GJC1 PVRL3 PLS3 IARS PANK3 RTN4 GJC1 ITGA2 SFT2D2

GLT8D1 PXN PPCS IARS2 PANX1 SCAF8 GLT8D1 ITGB1 SFXN1

GLUD1 PYGL PPP1CC IDH3A PAPOLA SCARB2 GLUD1 ITM2B SGCE

GMFB QKI PPP2CA IGF2BP2 PATL1 SCCPDH GMFB KCMF1 SH3BGRL

GMPS RAB10 PPP2R2A IKBIP PBX1 SDCCAG3 GMPS KIAA0196 SKAP2

GNAQ RAB1A PPP2R5E IMPAD1 PCNX SEMA3C GNAQ KIAA1033 SLC25A33

GNG12 RAB23 PRDM8 INSIG1 PIGX SEMA5A GNG12 KIAA1715 SLC30A1

GNPNAT1 RAB2A PRICKLE1 IQGAP1 PITPNB SEMA6D GNPNAT1 KIF5B SLC30A5

GNPTAB RAB5A PRKAA1 ISCA1 PITPNC1 SEPT10 GNPTAB KITLG SLC44A1

GNS RAB8B PRKCA ITCH POLR2B SERINC1 GNS KMT2E SLC9A6

GOLT1B RAC1 PSD3 ITFG1 POMK SERTAD2 GOLT1B KPNA3 SLC9A7

GPRC5A RALGPS2 PSMA4 ITGB1 PPP1CB SETD5 GPRC5A KPNA4 SLFN5

GSK3B RAP2A PTPN14 ITM2B PPP1CC SFPQ GSK3B KPNB1 SMAD3

GSPT1 RAP2B PTX3 JUN PPP1R12A SFT2D1 GSPT1 LAMP2 SMAD4

HDAC2 RASSF8 PXN KCMF1 PPP6C SFT2D2 HDAC2 LAPTM4A SMAD5

HDHD1 RBFOX2 PYGL KCNMA1 PPP6R3 SKAP2 HDHD1 LARP4B SNX3

HELZ REEP3 QKI KIAA0196 PRKDC SLC20A1 HELZ LBR SNX6

HERC4 RGL1 RAB1A KIAA0430 PROS1 SLC35F5 HERC4 LHFPL2 SOCS5

HERPUD2 RHOBTB3 RAB21 KIAA1033 PRR14L SLC5A3 HERPUD2 LIMA1 SPATS2L

HGF ROBO1 RAB23 KIAA1430 PSD3 SLC9A1 HGF LMBRD1 SPIN1

HHIPL2 RRAGC RAB2A KIAA1715 PSMD1 SLC9A6 HHIPL2 LOC150381 SPPL2A

HIATL1 RSPRY1 RAB5A KIF5B PSME4 SLC9A7 HIATL1 LPAR1 SPRED1

HIBADH RYBP RANBP9 KITLG PTBP1 SLFN5 HIBADH LPCAT2 SPRY2

HIF1A SAP30 RAP2B KPNA3 PTBP3 SMAD2 HIF1A LPIN1 SRGAP1

HMGCR SAR1B RBMS1 KPNA4 PUM2 SMAD3 HMGCR LRCH3 STK38

HNRNPA2B1 SBF2 RBPJ KPNB1 PVRL3 SMARCA1 HNRNPA2B1 LRPPRC STMN1

HNRNPH2 SCAF8 RCN1 LARP4B PXK SMNDC1 HNRNPH2 LRRC37BP1 STOM

HNRNPK SCARB2 REEP3 LBR PXN SNX6 HNRNPK LRRC8C STT3B

HNRNPR SDC4 REV3L LDHB RAB10 SOCS5 HNRNPR LSM6 SUB1

HOXA9 SDCBP RFX7 LHFPL2 RAB21 SPRED1 HOXA9 LUC7L2 SUMO2

HPRT1 SEC63 RPS27L LIMA1 RAB8B SSFA2 HPRT1 LURAP1L SUPT16H

HSP90AA1 SEL1L RTN4 LIPA RAP2A SSR1 HSP90AA1 LUZP6 SUZ12P1

HSP90B1 SEMA5A RYBP LMAN1 RAP2B STARD3NL HSP90B1 LY6G5B SYPL1

HSPH1 SERPINE2 RYK LMBRD1 RASA1 STK38 HSPH1 MAN2A1 TBL1XR1

IDE SERTAD2 SAMD8 LOC150381 RASSF8 STMN1 IDE MAP1LC3B TCEB3

IDH3A SET SDCBP LPAR1 RBMS1 STOM IDH3A MAP4K4 TCP1

IFI16 SETD5 SDCCAG3 LPIN1 REEP3 SUB1 IFI16 MAP4K5 TEAD1

IFNAR1 SFT2D1 SEC22B LRPPRC RFX7 SUCLG2 IFNAR1 MAPK1 TFDP1

IL6ST SFT2D2 SEC23A LRRC37BP1 RNF11 SUPT20H IL6ST MAPK1IP1L TFRC

INPP4B SFXN1 SECTM1 LRRC8C RNF146 SUZ12 INPP4B MASP1 TGFBR3

INSIG1 SGCB SEMA5A LY6G5B ROBO1 SYPL1 INSIG1 MATR3 TIMP2

IQGAP1 SGCE SEMA6D MAN1A1 RPF2 TAB2 IQGAP1 MCM4 TM9SF3

ITCH SHOC2 SEPT10 MAN2A1 RRAGC TCEB3 ITCH MDFIC TMED2

ITFG1 SLAIN2 SEPT11 MAP3K7 RRM1 TCF12 ITFG1 MDM2 TMEM260

ITGA2 SLC16A6 SEPT7 MAP4K4 RSPRY1 TEAD1 ITGA2 MED1 TMEM50B

ITGB1 SLC20A1 SERBP1 MAPK1 RUNX1 TFDP1 ITGB1 MED13 TMEM9B

ITM2B SLC35A5 SF3B14 MAPK1IP1L RYK TGFBR3 ITM2B MED13L TMPO

JKAMP SLC38A2 SFT2D2 MB21D2 S100A10 TIMP2 JKAMP MEIS2 TNPO1

KCMF1 SLC44A1 SLAIN2 MCFD2 SAMD8 TIPARP KCMF1 MET TOP1

KCNMA1 SLC5A3 SLC17A5 ME1 SAR1A TM9SF2 KCNMA1 METTL9 TPBG

KDELC2 SMAD2 SLC25A33 MED1 SBF2 TMED5 KDELC2 MKLN1 TRA2A

KHDRBS1 SMAD3 SLC30A1 MED13 SC5D TMED7 KHDRBS1 MOB1A TRAM1

KIAA0196 SMARCA1 SLC30A7 MED13L SCAF8 TMEM123 KIAA0196 MRGPRF UACA

KIAA0430 SOAT1 SLC9A6 MET SCARB2 TMEM14B KIAA0430 MRPS6 UBE2R2

KIAA1033 SOCS6 SLC9A7 MKLN1 SDC4 TMEM19 KIAA1033 MTMR6 UBXN4

KIAA1715 SPSB1 SMAD2 MMD SDCCAG3 TMEM243 KIAA1715 MTRR UBXN7

KIF5B SQLE SMAD3 MMP16 SEC23A TMEM30A KIF5B MYO1B UGDH

KITLG SRSF2 SMAD5 MOB1A SEC62 TMEM55A KITLG MYO5A UHMK1

KMT2E SSB SMURF2 MRGPRF SEC63 TMEM87B KMT2E NAA50 VAPA

KPNA3 STK17A SNX6 MRPL45 SEPT7 TMEM9B KPNA3 NAE1 VEZF1

KPNA4 STK38 SOCS5 MRPS6 SET TNFAIP3 KPNA4 NAMPT VPS35

KPNB1 STMN1 SOCS6 MSL2 SFT2D1 TNFRSF11B KPNB1 NARS VTA1

LAMP2 STOM SPATS2L MTDH SFXN1 TOB1 LAMP2 NCKAP1 WBP11

LAPTM4A STX2 SPIN1 MTRR SGCB TPP2 LAPTM4A NCL WDR82

LARP4B STYX SPRY2 MYO1B SGCE TRPS1 LARP4B NF1 WEE1

LBR SUCLG2 SPSB1 MYO5A SHOC2 TUSC3 LBR NFAT5 XRCC5

LHFPL2 SUZ12 SQLE NAE1 SLC16A6 TWIST1 LHFPL2 NMT2 YME1L1

LIMA1 SYPL1 SRPK1 NAMPT SLC17A5 TXNL1 LIMA1 NNT YTHDF1

LMAN1 SYT14 SS18 NCKAP1 SLC20A1 UBE2D1 LMAN1 NPEPPS ZBTB2

LMBRD1 TAB2 SSFA2 NCOA4 SLC25A32 UBE2R2 LMBRD1 NPTN ZC3H11A

LOC150381 TAF9 STK17B NF1 SLC25A46 UBE3C LOC150381 NR3C1 ZC3H7A

LPAR1 TAOK1 STOM NFAT5 SLC30A5 UGCG LPAR1 NRP1 ZC3HAV1L

LPCAT2 TCEB3 STX2 NFE2L2 SLC35A5 USP14 LPCAT2 NSF ZDHHC2

LPIN1 TCF12 SUCLG2 NNT SLC35F5 VHL LPIN1 NSMAF ZFR

LRCH3 TFAP2C SUPT16H NOL9 SMAD2 VPS35 LRCH3 NT5C2 ZNF521

LRPPRC TIMP2 SUPT20H NONO SMAD4 WBP11 LRPPRC NTNG1 ZNF655

LRRC37BP1 TMEM165 SUZ12P1 NPEPPS SMARCA1 WDR82 LRRC37BP1 NUFIP2 ZYG11B

LRRC8C TMEM243 SYT14 NPTN SNAPC3 WNK1 LRRC8C NUP98

LSM6 TMTC1 TAB2 NR1D2 SNX6 WSB1 LSM6 NUSAP1

LUC7L2 TNFAIP3 TAF9 NR3C1 SOCS5 YTHDC1 LUC7L2 NXF1

LURAP1L TOB1 TAOK1 NRD1 SOCS6 ZBED5 LURAP1L PABPN1

LUZP6 TOP1 TBL1XR1 NREP SPATS2L ZBTB2 LUZP6 PANK3

LY6G5B TPBG TBX3 NRP1 SPIN1 ZC3H7A LY6G5B PAPOLA

MAN1A1 TRIP12 TCEB3 NSF SPRED1 ZDHHC2 MAN1A1 PATL1

MAN2A1 TRPS1 TCF12 NT5C2 SPSB1 ZFAND5 MAN2A1 PCMTD1

MAP1LC3B TSPAN5 TFDP1 NTNG1 SRPK1 ZFP36L2 MAP1LC3B PCYOX1

MAP3K7 TUBB4A TFRC NUCKS1 SS18 ZFR MAP3K7 PDCD6IP

MAP4K4 TWIST1 TGFBR3 NUP98 SSFA2 ZMIZ1 MAP4K4 PDS5A

MAP4K5 UACA TMED7 NXF1 STAM2 ZNF148 MAP4K5 PGM3

MAPK1 UBE2D1 TMEM123 OCIAD1 STARD3NL ZNF521 MAPK1 PGRMC1

MAPK1IP1L UBE2R2 TMEM14B OSBPL8 STK17A ZYG11B MAPK1IP1L PHLDA1

MASP1 UBXN7 TMEM50B OSMR STMN1 MASP1 PIGK

MATR3 UGCG TMEM55A PABPN1 STOM MATR3 PIGX

MCFD2 USO1 TMEM87B PAIP2 STX2 MCFD2 PITPNC1

MCM4 USP53 TMEM9B PAK2 STYX MCM4 PLS3

MDFIC VEZF1 TNFRSF11B PANK3 SUPT16H MDFIC POLR2B

MDM2 VPS35 TPP2 PANX1 SUZ12 MDM2 POMK

ME1 WEE1 TPT1 PAPOLA SUZ12P1 ME1 PPP1CB

MED1 WLS TSPAN5 PATL1 TAB2 MED1 PPP1CC

MED13 WNK1 TUBB4A PBX1 TACC1 MED13 PPP1R12A

MED13L YAP1 UACA PCNX TAF9 MED13L PPP2R2A

MEIS2 ZBTB2 UBE2R2 PDGFC TAOK1 MEIS2 PPP2R5E

MET ZC3HAV1 UBL3 PIGX TBL1XR1 MET PPP6R3

METTL9 ZDHHC2 UGDH PITPNB TCEB3 METTL9 PRICKLE1

MINPP1 ZIC1 UHMK1 PITPNC1 TCP1 MINPP1 PRKAA1

MKLN1 ZNF655 USP14 PLS3 TFDP1 MKLN1 PRNP

MMADHC ZYG11B USP34 POLR2B TFRC MMADHC PRRC2C

MMD VEZF1 POMK TGFBR3 MMD PSD3

MOB1A WDR26 PPP1CB TIMP2 MOB1A PSMA4

MOB1B WDR82 PPP1CC TIPRL MOB1B PSMD1

MRGPRF WNK1 PPP1R12A TMEM165 MRGPRF PSME4

MRPS6 XPO1 PPP2CA TMEM19 MRPS6 PTBP1

MTMR6 YTHDF1 PPP2R2A TMEM248 MTMR6 PTP4A1

MTRR YWHAB PPP2R5E TMEM260 MTRR PTP4A2

MYO1B ZC3H11A PPP3CA TMX3 MYO1B PTPN14

MYO5A ZC3HAV1L PPP6C TNPO1 MYO5A PTPRK

NAA50 ZDHHC2 PPP6R3 TNRC6A NAA50 PUM1

NABP1 ZFAND5 PREPL TOB1 NABP1 PUM2

NAE1 ZFP36L2 PRICKLE1 TPBG NAE1 PVRL3

NAMPT ZFR PRKAR1A TRIP12 NAMPT PXK

NARS ZMYM4 PRKCA TSPAN5 NARS PXN

NCKAP1 PRKDC TTPAL NCKAP1 PYGL

NCL PROS1 TUBB4A NCL QKI

NCOA4 PRR14L UBE3C NCOA4 RAB14

NF1 PRRC2C UBXN7 NF1 RAB1A

NFAT5 PSD3 UCHL3 NFAT5 RAB21

NMT2 PSMA4 UFD1L NMT2 RAB23

NNT PSMD1 UGDH NNT RAB2A

NPEPPS PSME4 UGP2 NPEPPS RAB3B

NPTN PTBP1 USP34 NPTN RAB5A

NPTX1 PTBP3 USP53 NPTX1 RAB8B

NR1D2 PTP4A1 VEZF1 NR1D2 RAC1

NR3C1 PTPN14 VPS35 NR3C1 RALGPS2

NREP PTPRK WLS NREP RANBP9

NRP1 PUM2 YAP1 NRP1 RAP2A

NSF PVRL3 YTHDF1 NSF RB1

NSMAF PXK ZBTB2 NSMAF RBFOX2

NT5C2 PXN ZC3H11A NT5C2 RBMS1

NT5E RAB10 ZC3H7A NT5E RCN2

NTNG1 RAB21 ZDHHC2 NTNG1 REEP3

NUCKS1 RAB3B ZFP36L2 NUCKS1 RFX7

NUFIP2 RAB7A ZFR NUFIP2 RGL1

NUP98 RAB8B ZMIZ1 NUP98 RNF146

NUSAP1 RAC1 ZMPSTE24 NUSAP1 RPF2

NXF1 RAP2A ZMYM4 NXF1 RPS24

PABPN1 RAP2B ZNF655 PABPN1 RRAGC

PANK3 RASA1 ZSCAN20 PANK3 RSPRY1

PAPOLA RASSF8 PAPOLA RUNX1

PATL1 RBMS1 PATL1 RYK

PAXBP1 RCN1 PAXBP1 S100A10

PBX3 RCN2 PBX3 SAMD8

PCMTD1 REEP3 PCMTD1 SAP30

PCNX REV3L PCNX SAR1A

PCYOX1 RFX7 PCYOX1 SBF2

PDCD6IP RGMB PDCD6IP SC5D

PDS5A RNF11 PDS5A SCAF8

PGM3 RNF130 PGM3 SCCPDH

PGRMC1 RNF146 PGRMC1 SDAD1

PHLDA1 ROBO1 PHLDA1 SDC4

PIGK RPF2 PIGK SDCBP

PIGX RPS27L PIGX SEC23A

PITPNB RRAGC PITPNB SEC24D

PITPNC1 RRM1 PITPNC1 SEC62

PKN2 RSPRY1 PKN2 SECTM1

PLS3 RTN4 PLS3 SEPT11

POLR2B RUNX1 POLR2B SEPT7

POMK RYK POMK SERBP1

PPP1CB S100A10 PPP1CB SERPINE2

PPP1CC SAMD8 PPP1CC SERTAD2

PPP1R12A SAR1A PPP1R12A SET

PPP2R2A SBF2 PPP2R2A SETD5

PPP2R5E SC5D PPP2R5E SF3B14

PPP3CA SCAF8 PPP3CA SFPQ

PPP6C SCARB2 PPP6C SFT2D1

PPP6R3 SCCPDH PPP6R3 SFXN1

PREPL SDC4 PREPL SGCB

PRICKLE1 SDCCAG3 PRICKLE1 SGMS2

PRKAA1 SEC23A PRKAA1 SHOC2

PRKAR1A SEC62 PRKAR1A SKA2

PRKCA SEC63 PRKCA SLAIN2

PRNP SEMA3C PRNP SLC17A5

PRR14L SEMA5A PRR14L SLC20A1

PRRC2C SEMA6D PRRC2C SLC25A33

PSD3 SEPT10 PSD3 SLC25A40

PSMA4 SEPT7 PSMA4 SLC25A46

PSMD1 SERINC1 PSMD1 SLC30A7

PSME4 SERTAD2 PSME4 SLC35F5

PTBP1 SET PTBP1 SLC38A2

PTP4A1 SETD5 PTP4A1 SLC39A6

PTP4A2 SFPQ PTP4A2 SLC5A3

PTPN14 SFT2D1 PTPN14 SLIT2

PTPRK SFT2D2 PTPRK SMAD2

PUM1 SFXN1 PUM1 SMAD3

PUM2 SGCB PUM2 SMARCA1

PVRL3 SGCE PVRL3 SMNDC1

PXK SHOC2 PXK SMURF2

PXN SKAP2 PXN SNX6

PYGL SLC16A6 PYGL SOAT1

QKI SLC17A5 QKI SOCS5

RAB14 SLC20A1 RAB14 SOCS6

RAB1A SLC25A32 RAB1A SPATS2L

RAB21 SLC25A46 RAB21 SPDL1

RAB23 SLC30A5 RAB23 SPIN1

RAB2A SLC35A5 RAB2A SPPL2A

RAB3B SLC35F5 RAB3B SPSB1

RAB3GAP2 SLC5A3 RAB3GAP2 SRPK1

RAB5A SLC9A1 RAB5A SRSF2

RAB7A SLC9A6 RAB7A SRSF3

RAB8B SLC9A7 RAB8B SRSF5

RAC1 SLFN5 RAC1 SS18

RALGPS2 SMAD2 RALGPS2 SSFA2

RANBP9 SMAD3 RANBP9 STAT1

RAP2A SMAD4 RAP2A STEAP1B

RARS SMARCA1 RARS STK17A

RASSF8 SMNDC1 RASSF8 STMN1

RB1 SNAPC3 RB1 STX2

RBFOX2 SNX6 RBFOX2 SUB1

RBMS1 SOCS5 RBMS1 SUZ12P1

RCN2 SOCS6 RCN2 SYT11

REEP3 SPATS2L REEP3 TAB2

REV3L SPIN1 REV3L TAF9

RFX7 SPRED1 RFX7 TAOK1

RGL1 SPSB1 RGL1 TBL1XR1

RNF130 SRPK1 RNF130 TCEB3

RNF146 SS18 RNF146 TCF12

ROBO1 SSFA2 ROBO1 TCP1

RPF2 SSR1 RPF2 TEAD1

RPS24 STAM2 RPS24 TERF1

RRAGC STARD3NL RRAGC TFDP1

RSPRY1 STK17A RSPRY1 TFG

RTN4 STK38 RTN4 TFRC

RUNX1 STMN1 RUNX1 TIPARP

RYK STOM RYK TM9SF2

S100A10 STX2 S100A10 TMED2

SAMD8 STYX SAMD8 TMEM106B

SAP30 SUB1 SAP30 TMEM165

SAR1A SUCLG2 SAR1A TMEM209

SBF2 SUPT16H SBF2 TMEM248

SC5D SUPT20H SC5D TMEM33

SCAF8 SUZ12 SCAF8 TMPO

SCAMP1 SUZ12P1 SCAMP1 TMTC1

SCCPDH SYPL1 SCCPDH TMX3

SDAD1 TAB2 SDAD1 TNFAIP3

SDC4 TACC1 SDC4 TNPO1

SDCBP TAF9 SDCBP TNRC6A

SEC23A TAOK1 SEC23A TOB1

SEC24D TBL1XR1 SEC24D TPP2

SEC62 TCEB3 SEC62 TPT1

SEC63 TCF12 SEC63 TRAK2

SECTM1 TCP1 SECTM1 TRAM1

SEPT10 TEAD1 SEPT10 TRIP12

SEPT11 TFDP1 SEPT11 TRPM7

SEPT7 TFRC SEPT7 TRPS1

SERBP1 TGFBR3 SERBP1 TUBB4A

SERINC1 TIMP2 SERINC1 TUSC3

SERPINE2 TIPARP SERPINE2 TYMS

SERTAD2 TIPRL SERTAD2 UBE2D1

SET TM9SF2 SET UBE2R2

SETD5 TMED5 SETD5 UBE3C

SF3B14 TMED7 SF3B14 UBQLN1

SFPQ TMEM123 SFPQ UBXN7

SFT2D1 TMEM14B SFT2D1 UCHL3

SFT2D2 TMEM165 SFT2D2 UFD1L

SFXN1 TMEM19 SFXN1 UGCG

SGCB TMEM243 SGCB UGDH

SGCE TMEM248 SGCE USO1

SGMS2 TMEM260 SGMS2 USP14

SH3BGRL TMEM30A SH3BGRL USP34

SHOC2 TMEM55A SHOC2 USP9X

SKA2 TMEM87B SKA2 VAPA

SKAP2 TMEM9B SKAP2 VEZF1

SLAIN2 TMX3 SLAIN2 VPS35

SLC17A5 TNFAIP3 SLC17A5 WAC

SLC20A1 TNFRSF11B SLC20A1 WDR26

SLC25A33 TNPO1 SLC25A33 WRB

SLC25A40 TNRC6A SLC25A40 WSB1

SLC25A46 TOB1 SLC25A46 XPO1

SLC30A1 TPBG SLC30A1 XRCC5

SLC30A5 TPP2 SLC30A5 YAP1

SLC30A7 TRIP12 SLC30A7 YTHDC1

SLC35F5 TRPS1 SLC35F5 YTHDF1

SLC38A2 TSPAN5 SLC38A2 ZBTB2

SLC39A6 TTPAL SLC39A6 ZC3H11A

SLC44A1 TUBB4A SLC44A1 ZC3H7A

SLC5A3 TUSC3 SLC5A3 ZC3HAV1

SLC9A6 TWIST1 SLC9A6 ZC3HAV1L

SLC9A7 TXNL1 SLC9A7 ZFAND5

SLFN5 UBE2D1 SLFN5 ZFR

SLIT2 UBE2R2 SLIT2 ZMIZ1

SMAD2 UBE3C SMAD2 ZMYM4

SMAD3 UBXN7 SMAD3 ZNF148

SMAD4 UCHL3 SMAD4 ZNF706

SMAD5 UFD1L SMAD5 ZSCAN20

SMARCA1 UGCG SMARCA1

SMNDC1 UGDH SMNDC1

SMURF2 UGP2 SMURF2

SNX3 USP14 SNX3

SNX6 USP34 SNX6

SOAT1 USP53 SOAT1

SOCS5 VEZF1 SOCS5

SOCS6 VHL SOCS6

SPATS2L VPS35 SPATS2L

SPDL1 WBP11 SPDL1

SPIN1 WDR82 SPIN1

SPPL2A WLS SPPL2A

SPRED1 WNK1 SPRED1

SPRY2 WSB1 SPRY2

SPSB1 YAP1 SPSB1

SRGAP1 YTHDC1 SRGAP1

SRPK1 YTHDF1 SRPK1

SRSF2 ZBED5 SRSF2

SRSF3 ZBTB2 SRSF3

SRSF5 ZC3H11A SRSF5

SS18 ZC3H7A SS18

SSFA2 ZDHHC2 SSFA2

STAT1 ZFAND5 STAT1

STEAP1B ZFP36L2 STEAP1B

STK17A ZFR STK17A

STK38 ZMIZ1 STK38

STMN1 ZMPSTE24 STMN1

STOM ZMYM4 STOM

STT3B ZNF148 STT3B

STX2 ZNF521 STX2

SUB1 ZNF655 SUB1

SUMO2 ZSCAN20 SUMO2

SUPT16H ZYG11B SUPT16H

SUZ12P1 SUZ12P1

SYPL1 SYPL1

SYT11 SYT11

TAB2 TAB2

TAF9 TAF9

TAOK1 TAOK1

TBL1XR1 TBL1XR1

TCEB3 TCEB3

TCF12 TCF12

TCP1 TCP1

TEAD1 TEAD1

TERF1 TERF1

TFDP1 TFDP1

TFG TFG

TFRC TFRC

TGFBR3 TGFBR3

TIMP2 TIMP2

TIPARP TIPARP

TM9SF2 TM9SF2

TM9SF3 TM9SF3

TMED2 TMED2

TMEM106B TMEM106B

TMEM165 TMEM165

TMEM209 TMEM209

TMEM248 TMEM248

TMEM260 TMEM260

TMEM33 TMEM33

TMEM50B TMEM50B

TMEM9B TMEM9B

TMPO TMPO

TMTC1 TMTC1

TMX3 TMX3

TNFAIP3 TNFAIP3

TNPO1 TNPO1

TNRC6A TNRC6A

TOB1 TOB1

TOP1 TOP1

TPBG TPBG

TPP2 TPP2

TPT1 TPT1

TRA2A TRA2A

TRAK2 TRAK2

TRAM1 TRAM1

TRIP12 TRIP12

TRPM7 TRPM7

TRPS1 TRPS1

TUBB4A TUBB4A

TUSC3 TUSC3

TYMS TYMS

UACA UACA

UBE2D1 UBE2D1

UBE2R2 UBE2R2

UBE3C UBE3C

UBQLN1 UBQLN1

UBXN4 UBXN4

UBXN7 UBXN7

UCHL3 UCHL3

UFD1L UFD1L

UGCG UGCG

UGDH UGDH

UHMK1 UHMK1

USO1 USO1

USP14 USP14

USP34 USP34

USP9X USP9X

VAPA VAPA

VEZF1 VEZF1

VPS35 VPS35

VTA1 VTA1

WAC WAC

WBP11 WBP11

WDR26 WDR26

WDR82 WDR82

WEE1 WEE1

WRB WRB

WSB1 WSB1

XPO1 XPO1

XRCC5 XRCC5

YAP1 YAP1

YME1L1 YME1L1

YTHDC1 YTHDC1

YTHDF1 YTHDF1

ZBTB2 ZBTB2

ZC3H11A ZC3H11A

ZC3H7A ZC3H7A

ZC3HAV1 ZC3HAV1

ZC3HAV1L ZC3HAV1L

ZDHHC2 ZDHHC2

ZFAND5 ZFAND5

ZFR ZFR

ZMIZ1 ZMIZ1

ZMYM4 ZMYM4

ZNF148 ZNF148

ZNF521 ZNF521

ZNF655 ZNF655

ZNF706 ZNF706

ZSCAN20 ZSCAN20

ZYG11B ZYG11B

Table S7B: Differentially Expressed Genes in response to shBLM compared to shNS filtered against NS-Control that have at least one G4 motif in each regionRegion

Regulation

G4 Strand Either NT T Either NT T Either NT T Either NT T Either NT T Either NT T

Gene ABCA2 ABCA2 ABLIM3 AAGAB AAGAB ABCC3 ABCA2 ACP5 ABCA2 ABCC3 ABCC3 ABI2 ABCA2 ACP5 ABCA2 ABCC3 ABCC3 ABHD12

Symbols ABLIM3 ACP5 ADAMTS5 ABCC3 ABCC3 ABI2 ABLIM3 ACPL2 ABLIM3 ABHD12 ABHD12 ACBD7 ABLIM3 ACPL2 ABLIM3 ABHD12 ABHD12 ACBD7

ACP5 ACPL2 ADRA1D ABHD12 ABHD12 AEBP1 ACP5 ADRA1D ADRA1D ABI2 ABI2 AEBP1 ACP5 AKIRIN1 ADRA1D ABI2 ABI2 ANAPC15

ACPL2 ADAMTS5 ALPP ABI2 ABI2 ANKFY1 ACPL2 AHCYL2 AHCYL2 ACBD7 ACBD7 AJUBA ACPL2 ANKRD29 AFF3 ACBD7 ACBD7 ANXA3

ADRA1D AHCYL2 ANGPTL4 AEBP1 AGO1 ANKRD36B ADRA1D ANKRD29 ANGPTL2 AEBP1 AGO1 ANAPC15 ADRA1D ANPEP ALPP AEBP1 AEBP1 APOBEC3B

AFF3 AKIRIN1 ANK2 AGO1 ALKBH6 API5 AHCYL2 ANPEP ANGPTL4 AGO1 AJUBA APOBEC3B AFF3 ANTXR1 ANKH AGO1 AGO1 APPL2

AKIRIN1 ALPP ANKH ALKBH6 AMOTL2 ARHGEF39 ANGPTL2 AP1AR ANKH AJUBA ALKBH6 ARHGEF39 AKIRIN1 ARHGAP12 ANKRD52 ALKBH6 ALKBH6 ARL6IP1

ALPP ANGPTL2 ANKRD29 AMOTL2 ANKRD36B ARNT2 ANGPTL4 ARHGAP24 ANKRD52 ALKBH6 AMOTL2 ARL6IP1 ALPP ARHGAP24 ARNTL ALPK1 ALPK1 ARMC8

ANKH ANKRD52 ANTXR1 ANKFY1 ANLN BGN ANKH ARL5B ANTXR1 AMOTL2 ANKFY1 ARNT2 ANKH ARL2BP ATG4D AMOTL2 AMOTL2 ARNT2

ANKRD29 ANPEP ARHGAP12 ANKRD36B ANXA3 BIRC5 ANKRD29 ARNTL AREG ANAPC15 ANXA3 AS3MT ANKRD29 ASB13 BDNF ANAPC15 ANKFY1 ARSB

ANKRD52 AP1AR ASB13 ANLN ARRB2 C1orf21 ANKRD52 ASB13 ASB13 ANKFY1 AP2M1 ASF1B ANKRD52 B2M BMP2 ANKFY1 ANKRD36B AS3MT

ANPEP ARL5B ATG14 ANXA3 AS3MT C9orf96 ANPEP ATP6V1D ATG4D ANXA3 ARHGAP19 ATP8B1 ANPEP B3GALNT2 CABLES1 ANKRD36B AP2M1 ASF1B

ANTXR1 ARNTL BACH1 API5 ATP8B1 CDA ANTXR1 BACE2 BDNF AP2M1 ARNT2 BGN ANTXR1 BACE2 CBX6 ANXA3 APPL2 ATP8B1

ARHGAP12 ATG4D CABLES1 ARHGEF39 AUNIP CDC20 AP1AR BAMBI BMP2 APOBEC3B ARRB2 BIRC5 ARHGAP12 BAMBI CCDC126 AP2M1 ARHGAP19 BGN

ARHGAP24 B3GALNT2 CADM1 ARNT2 BGN CDC23 AREG BDNF CABLES1 ARHGAP19 ATP8B1 BRI3BP ARHGAP24 BDNF CCDC68 APOBEC3B ARHGEF2 BIRC5

ARL2BP BACH1 CCDC68 ARRB2 BMP4 CDC42EP3 ARHGAP24 BET1 CAMK1D ARHGEF39 ATP8B2 C17orf53 ARL2BP BET1 CDYL2 APPL2 ARHGEF39 C1orf21

ARNTL BSDC1 CDK17 AS3MT BRI3BP CDCA5 ARL5B C16orf52 CBX6 ARL6IP1 AUNIP C1orf21 ARNTL BMP2 CHORDC1 ARHGAP19 ARL15 CASP3

ASB13 C16orf52 CERK ATP8B1 C1orf21 CDH11 ARNTL CBX6 CCDC68 ARNT2 AURKA CA12 ASB13 BTRC CHRM2 ARHGEF2 ARMC8 CCNB2

ATG4D CADM1 CLMP AUNIP C9orf96 CDH2 ASB13 CCNG2 CERK ARRB2 BRI3BP CASP3 ATG4D C16orf52 CLCN5 ARHGEF39 ARRB2 CCNF

B2M CAMK1D COL6A1 BGN CASP3 CDK5RAP2 ATG4D CDYL2 CHRM2 AS3MT BUB1 CDC42EP3 B2M CABLES1 CREBRF ARL15 ATP8B2 CDCA3

B3GALNT2 CAT CPNE7 BIRC5 CCNF CENPM ATP6V1D CHORDC1 CLCN5 ASF1B C10orf54 CDCA8 B3GALNT2 CADM1 CTBP1-AS2 ARL6IP1 AUNIP CDCA8

BACE2 CCND2 CRYL1 BMP4 CDCA3 CHST3 BACE2 CPNE7 CLDN1 ATP8B1 C1QTNF2 CDH2 BACE2 CAMK1D CTSO ARMC8 AURKA CENPA

BAMBI CDK17 CYGB BRI3BP CDCA8 CIT BAMBI CREBRF CLMP ATP8B2 CCBE1 CENPA BAMBI CAT CYLD ARNT2 BRI3BP CEP85

BDNF CDYL2 CYLD C1orf21 CDH11 CKS2 BDNF CRYL1 CPNE7 AUNIP CCNF CHN1 BDNF CBX6 CYP2R1 ARRB2 BST1 CERS6

BET1 CHORDC1 DPP7 C9orf96 CDK2 CLDN11 BET1 CYLD CREBRF AURKA CDC20 CIT BET1 CD109 DPP7 ARSB BUB1 CHST3

BMP2 CLCN4 DPY19L3 CASP3 CHST3 CRISPLD2 BMP2 CYP2A6 CRYL1 BGN CDC45 COL12A1 BMP2 CDH13 DYNLT3 AS3MT BUB3 CIT

BTRC CLMP DSEL CCNF CNOT6 CSPG4 C16orf52 CYP2R1 CTBP1-AS2 BIRC5 CDH11 CREB3L1 BTRC CDK17 EIF1AX ASF1B C10orf54 CNOT6

C16orf52 CORO2B EIF3J CDA COL5A2 CTSH CABLES1 DCBLD2 CTSO BRI3BP CDK2 CUL4B C16orf52 CDYL2 EIF4EBP2 ATP8B1 C17orf53 COL12A1

CABLES1 CPNE7 EIF4EBP2 CDC20 CRISPLD2 CUL4B CAMK1D DHDDS CYGB BUB1 CDK5RAP2 CXCL12 CABLES1 CERK EML1 ATP8B2 C1orf198 CYR61

CADM1 CTBP1-AS2 ELMOD1 CDC23 CSPG4 CXCL12 CBX6 DHRS7 DPP7 C10orf54 CENPO CYR61 CADM1 COL6A1 EPT1 AUNIP C1orf21 DHRS11

CAMK1D CYP2R1 EML1 CDC42EP3 CXCL12 DAPK2 CCDC68 DSEL EIF4EBP2 C17orf53 CFB DMPK CAMK1D CPNE7 ETFB AURKA C1QTNF2 E2F1

CAT DHDDS ENDOD1 CDCA3 DAPK2 DCLK2 CCNG2 EIF4EBP2 ELMOD1 C1orf21 CHAF1A DNMT1 CAT CREBRF ETV4 BGN CASP3 ELN

CBX6 DOCK4 ERN1 CDCA5 DAZAP2 DHRS1 CDYL2 ERO1L EPHB1 C1QTNF2 CIT DOCK2 CBX6 CRYL1 FAM150B BIRC5 CCNA2 ENAH

CCDC126 DPP7 FAM105A CDCA8 DHRS11 DMPK CERK ETFB EPT1 CA12 CKS2 DRAM1 CCDC126 CYGB FAM171A2 BRI3BP CCNF ENO2

CCDC68 DPY19L3 FAM127A CDH11 DMPK E2F1 CHORDC1 ETV1 EREG CASP3 CNOT6 ELN CCDC68 CYLD FAM171B BST1 CDC20 FANCA

CD109 DUSP4 FAM171A2 CDH2 DOCK2 ELN CHRM2 EVI5L ETFB CCBE1 CSPG4 ENO2 CD109 CYP2A6 FAM210B BUB1 CDC42EP3 FBN2

CDH13 ELMOD1 FAM171B CDK2 DONSON ENAH CLCN5 FAM105A ETV4 CCNF CTSH FAM65B CDH13 CYP2R1 FIBCD1 BUB3 CDC45 FHL3

CDK17 EPHA5 FAM19A3 CDK5RAP2 DRAM1 ENO2 CLDN1 FAM150B EVI5L CDC20 DAPK2 FHL3 CDK17 DCBLD2 FLI1 C10orf54 CDCA8 FLNC

CDYL2 EPHB1 FAM210B CENPM E2F1 EPS8 CLMP FAM171A2 F2R CDC42EP3 DBF4B FLNC CDYL2 DHDDS FSCN1 C17orf53 CDH11 FOSL2

CERK ERAP2 FAM89B CHST3 ELN EZR CPNE7 FAM210B FAM105A CDC45 DDX21 FOXM1 CERK DHRS7 FYN C1orf198 CDH2 GPR126

CHORDC1 ERO1L FBXL19-AS1 CIT ENAH FAM27L CREBRF FAM89B FAM171B CDCA8 DDX39A FRY CHORDC1 DNAJB9 GCOM1 C1orf21 CDK5RAP2 HADH

CHRM2 ETV4 FNDC4 CKS2 FADS2 FAM65B CRYL1 FBXO3 FAM210B CDH11 DHRS11 FSTL5 CHRM2 DTNA HCN2 C1QTNF2 CENPO HIAT1

CLCN5 EVI5L FSCN1 CLDN11 FANCA FAM83D CTBP1-AS2 FEZ1 FIBCD1 CDH2 DOCK2 FZD2 CLCN5 DUSP6 HGF CASP3 CHAF1A HOXA11

COL6A1 F2R FTO CNOT6 FBN1 FANCC CTSO FKBP1A FNDC4 CDK2 DONSON GAB2 COL6A1 DYNC1I2 HIPK2 CCNA2 CHN1 IER3

CPNE7 F2RL1 FYN COL5A2 FHL3 FANCE CYGB FLI1 FOXP2 CDK5RAP2 ERI2 GINS4 CPNE7 DYNLT3 HMGA2 CCNB2 CIT IGFBP6

CREBRF FAM150B G0S2 CRISPLD2 FLNB FBN2 CYLD GAP43 GCOM1 CENPA ESPL1 GSG2 CREBRF E2F7 HNRNPH2 CCNF CKS2 INCENP

CRYL1 FAM171A2 GCOM1 CSPG4 FLNC FEN1 CYP2A6 GCOM1 GFPT2 CENPO EZR HAUS4 CRYL1 EIF2AK3 IGF2 CDC20 CNN1 INTS9

CTBP1-AS2 FAM210B GFPT2 CTSH FOSL2 FLNB CYP2R1 GM2A GM2A CFB F11R HIAT1 CTBP1-AS2 EIF3J INA CDC42EP3 CNOT6 KANK2

CTSO FAM89B GLI3 CUL4B FOXRED1 FLNC DCBLD2 GRB10 GPR137B CHAF1A FADS2 HOXA11 CTSO EPHA5 ISCU CDC45 CREB3L1 KRT7

CYGB FBXO3 GM2A CXCL12 FZD2 FMOD DHDDS GSTO1 HCN2 CHN1 FANCA ICAM2 CYGB EPT1 ITFG1 CDCA3 CSPG4 LBR

CYLD FEZ1 GRB10 DAPK2 GINS2 FN3KRP DHRS7 GTF2B HEY1 CIT FBN1 IER3 CYLD EREG ITGA6 CDCA8 CTSH LOXL1

CYP2A6 FLI1 GTF2B DAZAP2 GLIPR2 FOXM1 DPP7 HCN2 HIPK2 CKS2 FEN1 JADE1 CYP2A6 EVI5L ITGA8 CDH11 DAPK2 LY6G5B

CYP2R1 FNDC4 HAS2 DCLK2 GPR124 GAB2 DSEL HEY1 HMGA2 CNOT6 FGD4 JUP CYP2R1 F2R ITPR2 CDH2 DAZAP2 LY6K

DCBLD2 FOXN3 HCN2 DHRS1 GPRC5B GALNT4 EIF4EBP2 HNRNPH2 HSD17B10 COL12A1 FN3KRP KCND1 DCBLD2 F2RL1 KCNJ15 CDK5RAP2 DBF4B MCM4

DHDDS FSCN1 HEY1 DHRS11 GSTM5 GLIPR2 ELMOD1 IMPACT IARS CREB3L1 FOSL2 KIAA0226 DHDDS FAM105A KCNMA1 CENPA DDX21 MIF4GD

DHRS7 GATSL3 HIPK2 DMPK HDAC1 GPR126 EPHB1 ITFG1 IGF2 CSPG4 FOXRED1 KIAA1598 DHRS7 FAM150B KDM3A CENPO DDX39A MSH5

DNAJB9 GCOM1 HIVEP2 DOCK2 HIAT1 GSG2 EPT1 IVL IGF2R CTSH FZD2 KPNA2 DNAJB9 FAM171A2 KDSR CEP85 DHRS11 MYBL2

DPP7 GFPT2 HSD17B10 DONSON HPRT1 H2AFZ EREG JAM2 ISCU CUL4B GAB2 KRT7 DPP7 FAM171B LAMA1 CERS6 DHRS3 NEU1

-250 bp to TSS TSS to +250 bp First 250bp of Intron 1

Up Down Up Down Up Down

DTNA GLI3 IGF2 DRAM1 HSPB11 HAUS8 ERO1L KCNIP3 ITGA6 CXCL12 GINS2 LBR DTNA FAM89B LMBRD1 CHAF1A DMPK NID1

DUSP6 GPR137B IGF2R E2F1 IGFBP6 HOMER3 ETFB KCNQ5 ITGA8 CYR61 GINS4 LCLAT1 DUSP6 FBXO3 LPPR2 CHN1 DNMT1 NREP

DYNC1I2 GRB10 IGFBP3 ELN ITGA4 HOXC11 ETV1 KCTD21 JAM2 DAPK2 GLIPR2 LMNB1 DYNC1I2 FIBCD1 LTBP1 CHST3 DOCK2 NSF

DYNLT3 GSTO1 IMPACT ENAH KANK2 HRH1 ETV4 KDM3A KCNC4 DBF4B GSTM4 LMOD1 DYNLT3 FKBP1A MAN2A1 CIT DRAM1 NUDCD2

E2F7 HCN2 INA ENO2 KCND1 IGFBP6 EVI5L KIAA1217 KCNJ15 DDX21 GSTM5 LOXL1 E2F7 FLI1 MAPRE3 CKS2 DUT NXNL2

EIF1AX HEY1 ISCU EPS8 KHK JADE1 F2R KIAA1551 KCNMA1 DDX39A GTF2H1 LY6G5B EIF1AX FNDC4 METTL9 CNN1 E2F1 ORC6

EIF2AK3 HGF ITGA11 EZR KIAA0226 KIAA1199 FAM105A LCE2A KCNQ5 DHRS11 GTSE1 MB21D2 EIF2AK3 FRMD3 MICB CNOT6 ENAH PACSIN2

EIF3J HIST1H4H ITGA2 FADS2 KIAA1199 KIF13A FAM150B LGALS3 KDSR DMPK HADH MCM7 EIF3J FYN MTSS1 COL12A1 EPS8 PAQR4

EIF4EBP2 HIVEP2 ITPR2 FAM27L KIF22 KPNA2 FAM171A2 LMLN KIAA1217 DNMT1 HAUS4 MIF4GD EIF4EBP2 GATSL3 NEK9 CREB3L1 ERI2 PGM2

EML1 HMGA2 KCNC4 FAM65B KRT19 KRT34 FAM171B LPAR3 KLHDC3 DOCK2 HDAC1 MRVI1 EML1 GCOM1 NETO2 CSPG4 ESPL1 PHF19

EPHA5 HOXA7 KCNMA1 FAM83D KRT7 KRT7 FAM210B LPHN2 KLHL21 DONSON HIST1H4L MYBL2 EPHA5 GDPD1 NOX4 CTSH EXT2 PKMYT1

EPT1 IGF2R KCNN2 FANCA LBR LIG1 FAM89B LTBP1 LAMA1 DRAM1 HJURP NACC1 EPT1 GLRX NT5E CYR61 FAM64A PLK2

EREG IL1RN KIAA0319L FANCC LMCD1 LMCD1 FBXO3 LYPLA1 LMBRD1 ELN HLA-DMA NAT14 EREG GPR137B PARD6G DAPK2 FANCA PLTP

ETFB ITGA2 KLHDC3 FANCE LOXL3 LOXL1 FEZ1 M6PR LPAR3 ENO2 HMGB2 NAV2 ETFB GRB10 PBX2 DAZAP2 FANCC PODN

ETV4 ITGA6 KLHL21 FBN1 MCM2 MCM2 FIBCD1 MAN2A1 LPPR2 ERI2 HOMER3 NREP ETV4 GSTO1 PITPNC1 DBF4B FBN1 POLA2

EVI5L ITGA8 KLHL24 FBN2 METTL7A MCM4 FKBP1A MAPRE3 LTBP1 ESPL1 HPRT1 NT5DC3 EVI5L GTF2B PLEKHM1 DDX21 FBN2 PPME1

F2R JARID2 LAMA1 FEN1 MIF4GD MCM7 FLI1 MCTP1 LYPLA1 EZR HSPA2 NTN4 F2R HCN2 PNPLA4 DDX39A FEN1 PTRF

F2RL1 KCNIP3 LGALS3 FHL3 MTHFS MCMBP FNDC4 MICB M6PR F11R HSPB11 NYNRIN F2RL1 HIPK2 PODXL DHRS11 FHL3 PXMP2

FAM105A KCNMA1 LONRF1 FLNB MTMR12 MTHFS FOXP2 MME MAP3K7CL FADS2 IGFBP6 OLFML2B FAM105A HMGA2 POPDC3 DHRS3 FLNB RDH10

FAM150B KCNQ5 LPPR2 FLNC MYH10 MTRF1L GAP43 MMP16 MAPRE3 FAM65B INCENP ORC6 FAM150B HNRNPH2 PPAP2B DMPK FLNC SAMD12

FAM171A2 KIAA0319L LTBP1 FMOD NACC1 MXD3 GCOM1 MTURN MCTP1 FANCA IQGAP3 PACSIN2 FAM171A2 HOXA7 PPAP2C DNMT1 FMOD SAP30

FAM171B KIT M6PR FN3KRP NCAPD3 MYBL2 GFPT2 MYC MSC FBN1 ITGA4 PHF19 FAM171B HSPB6 PSTPIP2 DOCK2 FN3KRP SCCPDH

FAM210B KLHL21 MAGEH1 FOSL2 NDE1 MYOCD GM2A NCALD MTURN FEN1 KANK2 PIM1 FAM210B IFI16 PTGS1 DRAM1 FOXM1 SELENBP1

FAM89B LAMA1 MAGI2 FOXM1 NEU1 NAT14 GPR137B NEDD4 NF2 FGD4 KHK PKMYT1 FAM89B IGF2 QKI DUT GAB2 SHCBP1

FBXO3 LONRF1 MDM2 FOXRED1 NGF NDE1 GRB10 NEK9 NFIL3 FHL3 KIAA0226 PLTP FBXO3 IGFBP3 QPCT E2F1 GINS2 SLBP

FIBCD1 LPAR3 METTL9 FZD2 NID1 NID1 GSTO1 NEO1 NUDT11 FLNC KIF22 PRC1 FIBCD1 INA RAB31 ELN GINS4 SLC4A8

FKBP1A LYPLA1 MRPL50 GAB2 NPM3 NT5DC3 GTF2B NETO2 OGFRL1 FN3KRP KIF4A PRR23C FKBP1A ITGA2 REXO1 ENAH GLCE SMAD3

FLI1 MAN2A1 MSC GALNT4 NRAS NYNRIN HCN2 NF2 P2RX5 FOSL2 KPNA2 PRSS12 FLI1 ITPR2 RGS2 ENO2 GLIPR2 SNRPA

FNDC4 MARVELD1 MTURN GINS2 NREP OLFML2B HEY1 NKIRAS2 PARD6G FOXM1 KRT18 RARG FNDC4 IVL RIN3 EPS8 GPR124 SORT1

FRMD3 MFSD1 MX1 GLIPR2 NSUN2 PCNA HIPK2 NPC1 PARM1 FOXRED1 LMNB1 RDH10 FRMD3 KCNC4 RORA ERI2 GPRC5A SPA17

FSCN1 MICB MYC GPR124 NT5DC3 PEG10 HMGA2 NTSR1 PIP5K1C FRY LOXL3 RPL39L FSCN1 KCNIP3 RRAGD ESPL1 GPRC5B SRRM2

FYN MME MYO1D GPR126 NTN4 PIM1 HNRNPH2 NUPR1 PITPNC1 FSTL5 LY6G5B RRM2 FYN KCNN2 SCN1B EXT2 GSTM4 STMN1

GATSL3 MX1 NDN GPRC5B NUAK2 POC1A HSD17B10 OCM2 PLEKHM1 FZD2 MB21D2 SAMD12 GATSL3 KCTD21 SEMA6A FAM64A GSTM5 SUMO2

GCOM1 NAP1L5 NEDD4 GSG2 NUMA1 POLE IARS OSBPL1A PODXL GAB2 MCM2 SCCPDH GCOM1 KDM3A SEPT5 FANCA GTF2H1 SUZ12P1

GDPD1 NCALD NEK9 GSTM5 NXNL2 PRC1 IGF2 PARD6G PPARG GINS2 MCM5 SCML1 GDPD1 KIAA0319L SEPW1 FANCC GTSE1 SYPL2

GLRX NETO2 NEO1 H2AFZ NYNRIN PTK7 IGF2R PBX2 PPM1L GINS4 MDC1 SDC1 GLRX KIAA1551 SERINC1 FBN1 HAUS4 TACC3

GPR137B NF2 NETO2 HAUS8 PCNA PTRF IMPACT PDIA5 PRSS35 GLIPR2 MIF4GD SELENBP1 GPR137B KIT SESN2 FBN2 HDAC1 TGOLN2

GRB10 NFIL3 NFIL3 HDAC1 PDE1C RAD54L ISCU PDP2 PTPRG GSG2 MTFR2 SFPQ GRB10 KLHDC3 SFRP1 FEN1 HIPK1 TK1

GSTO1 NINJ1 NUDT11 HIAT1 PHF19 RARG ITFG1 PIP5K1C RAB31 GSTM4 MTHFS SH2D4A GSTO1 KLHL21 SH3PXD2B FHL3 HJURP TMEM204

GTF2B NKIRAS2 PAG1 HOMER3 PKMYT1 RBBP7 ITGA6 PITPNC1 RGS2 GSTM5 MTMR12 SLC1A5 GTF2B LAMA4 SLC16A2 FLNB HMGB2 TMEM97

HCN2 NOG PARD6G HOXC11 PRSS12 RNFT2 ITGA8 PNPLA4 RIN3 GTF2H1 MXD3 SLC4A8 HCN2 LCE2A SLC16A3 FLNC HOMER3 TOMM34

HGF NPC1 PBX2 HPRT1 PTK7 SAMD12 IVL POPDC3 RRAGD GTSE1 MYH10 SMAD3 HGF LIMS1 SLC25A33 FMOD HOXC11 TPD52L1

HIPK2 NRIP3 PDP2 HRH1 PTPRJ SCARA3 JAM2 PPAP2C SCN1B HADH NACC1 SSRP1 HIPK2 LMBRD1 SLC25A51 FN3KRP HPRT1 TRIP13

HMGA2 NTSR1 PIP5K1C HSPB11 PTRF SCML1 KCNC4 PPARG SEMA5A HAUS4 NAT14 ST3GAL4 HMGA2 LMLN SLC26A2 FOSL2 HRH1 UCP2

HNRNPH2 OSBPL1A PLAGL1 IGFBP6 PXMP2 SDC1 KCNIP3 PRKG2 SEMA6A HDAC1 NCAPH STMN1 HNRNPH2 LONRF1 SLC35F3 FOXM1 HSPB11 UHMK1

HOXA7 P4HA1 PLEKHM1 ITGA4 RARG SEC61A2 KCNJ15 PSD3 SEMA6D HIAT1 NDC1 STXBP5 HOXA7 LPAR3 SLC37A2 GAB2 IGFBP6 VANGL1

HSPB6 PAPPA PMAIP1 JADE1 RDH10 SEMA3B KCNMA1 PTGFRN SEPT5 HIST1H4L NDE1 TACC3 HSPB6 LPHN2 SLC37A3 GINS2 INTS9 WDR62

IFI16 PARD6G PODXL KANK2 RHPN2 SH3BP4 KCNQ5 PTGS1 SEPW1 HJURP NEK2 TAGLN IFI16 LPPR2 SLC39A13 GINS4 IQGAP3 WEE1

IGF2 PARM1 POPDC3 KCND1 RPL39L SHMT1 KCTD21 PTPRU SERINC1 HLA-DMA NEU1 TGFBI IGF2 LTBP1 SLFN5 GLCE ISLR ZDHHC12

IGFBP3 PHLDA1 PPAP2C KHK RRM2 SLBP KDM3A PXK SESN2 HMGB2 NGF TK1 IGFBP3 LURAP1L SNX6 GLIPR2 JADE1

INA PMAIP1 PPARG KIAA0226 S100A16 SLC1A5 KDSR QPCT SFRP1 HOMER3 NID1 TNFAIP8L1 INA LYPLA1 SPRY2 GPR124 JUP

ISCU PODXL PPP1R3C KIAA1199 SAP30 SLC4A8 KIAA1217 RAB27B SH3GL2 HOXA11 NOL9 TOE1 ISCU MAGI2 ST6GALNAC2 GPR126 KANK2

ITFG1 PPM1L PRKG2 KIF13A SCARA3 SMAD3 KIAA1551 RAP1GAP2 SH3PXD2B HPRT1 NPM3 TRIM6-TRIM34 ITFG1 MAML3 STEAP3 GPRC5A KIAA0226

ITGA2 PRKG1 PRSS35 KIF22 SDC4 SOGA1 KLHDC3 RBMS1 SIRPA HSPA2 NRAS UCP2 ITGA2 MAN2A1 STXBP1 GPRC5B KIAA1598

ITGA6 PSD3 PSD3 KPNA2 SEC61A2 ST3GAL4 KLHL21 REXO1 SLC16A3 HSPB11 NSF VANGL1 ITGA6 MAPRE3 SULF2 GSTM4 KIF23

ITGA8 PSTPIP2 PSKH1 KRT19 SEPT6AG3L5P-PVRIG2P-PILAMA1 RIN3 SLC37A3 ICAM2 NT5DC3 ZDHHC12 ITGA8 MCTP1 TBC1D17 GSTM5 KPNA2

ITPR2 PTGFRN QKI KRT34 SERTAD4 SUZ12P1 LCE2A RPS6KA3 SLC38A1 IER3 NXNL2 ITPR2 MDM2 TBCCD1 GTF2H1 KRT18

IVL PTGS1 RBMS1 KRT7 SHCBP1 SYPL2 LGALS3 RRAGD SLC39A13 IGFBP6 NXPE3 IVL METTL9 TK2 GTSE1 KRT19

KCNC4 PTGS2 REXO1 LBR SKP2 TAGLN LMBRD1 RRM2B SLC5A3 INCENP NYNRIN KCNC4 MICB TLE3 HADH LBR

KCNIP3 PTPRU RIN3 LIG1 SLC38A11 TAGLN2 LMLN RTN4RL1 SLC6A15 IQGAP3 ORC6 KCNIP3 MSC TMED4 HAUS4 LMNB2

KCNJ15 QKI RIPK2 LMCD1 SLC43A3 TGFBI LPAR3 SATB1 SLFN5 ITGA4 PGM2 KCNJ15 MTSS1 TMEM117 HDAC1 LMOD1

KCNMA1 QPCT RNF24 LOXL1 SLC7A5 TGM2 LPHN2 SC5D SNX6 JADE1 PKMYT1 KCNMA1 MTURN TOX2 HIAT1 LOXL3

KCNN2 RAB31 SATB1 LOXL3 SMAD3 TK1 LPPR2 SCN1B SRXN1 JUP POC1A KCNN2 MYO1D TPRG1L HIPK1 LY6G5B

KCTD21 RAB33A SATB2 MCM2 SNRPA TRIM6-TRIM34 LTBP1 SEPT3 ST6GALNAC2 KANK2 PODN KCTD21 NCALD TRAPPC6B HJURP MCM2

KDM3A RAP1GAP2 SCN1B MCM4 SOGA1 UCP2 LYPLA1 SEPW1 STEAP3 KCND1 PRC1 KDM3A NEDD4 TSHZ3 HMGB2 MCM4

KDSR RASGRF2 SECTM1 MCM7 SORT1 UHMK1 M6PR SET STMN3 KHK PSMA5 KDSR NEO1 TUBA3E HOMER3 MCM5

KIAA0319L RGL1 SEMA5A MCMBP SPA17 VAMP5 MAN2A1 SLC16A2 STXBP1 KIAA0226 PSMB9 KIAA0319L NETO2 USF2 HOXA11 MCM7

KIAA1551 RNF24 SEMA6D METTL7A SPAG5 XRCC6BP1 MAP3K7CL SLC16A6 TIPARP KIAA1598 PSMC3IP KIAA1551 NFIL3 UXS1 HOXC11 MCMBP

KIT RPS6KA3 SEPT5 MIF4GD ST3GAL4 ZBTB5 MAPRE3 SLC17A5 TMED4 KIF22 PSRC1 KIT NINJ1 ZC3HAV1L HPRT1 MDC1

KLHDC3 SEMA5A SEPW1 MTHFS STMN1 ZC3H12A MCTP1 SLC25A32 TMEM158 KIF4A PTK7 KLHDC3 NPC1 ZNF521 HRH1 MIF4GD

KLHL21 SEPT3 SETBP1 MTMR12 SUV39H1 ZDHHC12 MICB SLC25A51 TOB1 KPNA2 PTPRJ KLHL21 NTM ZNF610 HSPB11 MTMR12

LAMA1 SEPT5 SIRPA MTRF1L SYNPO MME SLC2A3 TOX2 KRT18 PTTG1IP LAMA1 OCM2 IER3 MXD3

LAMA4 SEPW1 SLC17A5 MXD3 TACC3 MMP16 SLC35A1 TSHZ3 KRT7 PXMP2 LAMA4 P2RX5 IGFBP6 MYBL2

LCE2A SET SLC25A33 MYBL2 TDP1 MSC SLC37A2 TSPAN11 LBR RACGAP1 LCE2A PAPPA INCENP MYH10

LIMS1 SETBP1 SLC30A7 MYH10 TGFBI MTURN SLC37A3 TUBA3E LCLAT1 RAD51 LIMS1 PCMTD1 INTS9 NACC1

LMBRD1 SH3PXD2B SLC35F3 MYOCD TGM2 MYC SLC38A1 UBA6 LMNB1 RARG LMBRD1 PDIA5 IQGAP3 NASP

LMLN SLC16A2 SLC38A1 NACC1 TMEM204 NCALD SLC39A13 USF2 LMOD1 RBBP7 LMLN PDK3 ISLR NAT14

LONRF1 SLC16A3 SLC39A13 NAT14 UBP1 NEDD4 SLC4A4 UST LOXL1 RHPN2 LONRF1 PDP2 JADE1 NAV2

LPAR3 SLC16A6 SLC4A4 NCAPD3 VANGL1 NEK9 SLMO2 UXS1 LOXL3 RNASEH2A LPAR3 PHLDA1 JUP NBPF3

LPHN2 SLC5A3 SLC6A15 NDE1 WEE1 NEO1 SMPD1 VLDLR LY6G5B RPSAP52 LPHN2 PIP5K1C KANK2 NCAPD3

LPPR2 SLC6A15 SMPD1 NEU1 ZDHHC12 NETO2 SNX6 ZNF460 MB21D2 RPSAP58 LPPR2 PITPNC1 KIAA0226 NCAPH

LTBP1 SLMO2 SMURF2 NGF NF2 SRXN1 ZNF521 MCM2 RRM2 LTBP1 PMAIP1 KIAA1598 NDC1

LURAP1L SMPD1 SNCA NID1 NFIL3 SS18 ZNF583 MCM5 RUVBL2 LURAP1L PNPLA4 KIF23 NGF

LYPLA1 SOGA3 SNX6 NPM3 NKIRAS2 SSBP2 MCM7 S100A16 LYPLA1 PPAP2C KPNA2 NID1

MAGI2 SSBP2 SPRY2 NRAS NPC1 ST6GALNAC2 MDC1 SDC1 MAGI2 PPARG KRT18 NPM3

MAML3 STC2 SRXN1 NREP NTSR1 STEAP3 MIF4GD SDC4 MAML3 PRKG2 KRT19 NSF

MAN2A1 STEAP3 SS18 NSUN2 NUDT11 SULF2 MRVI1 SEC61A2 MAN2A1 PSD3 KRT7 NSUN2

MAPRE3 TBK1 ST8SIA5 NT5DC3 NUPR1 TAPBP MTFR2 SEMA3B MAPRE3 PTGFR LBR NTN4

MCTP1 THBD STC2 NTN4 OCM2 TCP11L2 MTHFS SEPT6 MCTP1 PTGFRN LMNB2 NUMA1

MDM2 TMED4 STMN3 NUAK2 OGFRL1 TMC7 MTMR12 SERTAD4 MDM2 PTPRG LMOD1 NUSAP1

METTL9 TMEM117 STXBP1 NUMA1 OSBPL1A TMED4 MXD3 SH2D4A METTL9 PXK LOXL1 NXNL2

MICB TMEM158 TAPBP NXNL2 P2RX5 TMEM117 MYBL2 SH3BP4 MICB QKI LOXL3 OIP5

MSC TMEM192 TBCCD1 NYNRIN PARD6G TMOD2 MYH10 SHCBP1 MSC RAB33A LY6G5B ORC6

MTSS1 TMOD2 THBD OLFML2B PARM1 TOB1 NACC1 SHMT1 MTSS1 RAB3A LY6K OXTR

MTURN TMTC1 TLE3 PCNA PBX2 TOLLIP NAT14 SLBP MTURN RAET1L MCM2 PAQR4

MYO1D TNC TMEM158 PDE1C PDIA5 TPRG1L NAV2 SMYD2 MYO1D RAP1GAP2 MCM4 PDE1C

NCALD TOB1 TMOD2 PEG10 PDP2 TRIB2 NCAPH SNAPIN NCALD RBMS1 MCM5 PGM2

NEDD4 TPRG1L TNFAIP1 PHF19 PIP5K1C TSPAN11 NDC1 SOGA1 NEDD4 RGL1 MCM7 PHF19

NEK9 TRIB2 TSC22D3 PIM1 PITPNC1 TUBA3E NDE1 SORT1 NEK9 RIN3 MCMBP PIM1

NEO1 TSC22D3 TSHZ3 PKMYT1 PLEKHM1 UBA6 NEK2 ST3GAL4 NEO1 RPL17 MDC1 PLK2

NETO2 TSPAN11 TSPAN11 POC1A PNPLA4 ULBP3 NEU1 STMN1 NETO2 RPS6KA3 MIF4GD POC1A

NFIL3 TXNIP UBA6 POLE PODXL UST NGF SUOX NFIL3 RRAGD MSH5 PODN

NINJ1 ULBP3 UNC5B PRC1 POPDC3 VLDLR NID1 SUV39H1 NINJ1 RTN4RL1 MTMR12 POLE

NOX4 USF2 VLDLR PRSS12 PPAP2C VSTM4 NOL9 SUZ12P1 NOX4 SC5D MXD3 PRC1

NPC1 VSTM4 ZBTB33 PTK7 PPARG WLS NPM3 SYPL2 NPC1 SCN1B MYBL2 PRSS12

NT5E WLS ZC3HAV1L PTPRJ PPM1L ZMAT3 NRAS TENC1 NT5E SECTM1 MYH10 PSMA5

NTM ZNF528 PTRF PRKG2 ZNF136 NREP TGM2 NTM SEPW1 NACC1 PSMB9

OCM2 ZNF583 PXMP2 PRSS35 ZNF566 NSF TNRC6A OCM2 SET NASP PSMC3IP

P2RX5 ZNF610 RAD54L PSD3 NT5DC3 TROAP P2RX5 SFXN3 NAT14 PSRC1

PAPPA RARG PTGFRN NTN4 UBP1 PAPPA SIRPA NAV2 PTK7

PARD6G RBBP7 PTGS1 NXNL2 USP6 PARD6G SLC16A2 NBPF3 PTPRJ

PBX2 RDH10 PTPRG NXPE3 VAMP5 PBX2 SLC16A3 NCAPD3 PTRF

PCMTD1 RHPN2 PTPRU NYNRIN ZBTB5 PCMTD1 SLC17A5 NCAPH PTTG1IP

PDIA5 RNFT2 PXK OLFML2B ZC3H12A PDIA5 SLC25A33 NDC1 PXMP2

PDK3 RPL39L QPCT ORC6 ZDHHC12 PDK3 SLC25A36 NEU1 RACGAP1

PDP2 RRM2 RAB27B PACSIN2 ZWINT PDP2 SLC25A51 NGF RAD54L

PHLDA1 S100A16 RAB31 PGM2 ZYG11A PHLDA1 SLC26A2 NID1 RBBP7

PIP5K1C SAMD12 RAP1GAP2 PHF19 PIP5K1C SLC30A7 NPM3 RDH10

PITPNC1 SAP30 RBMS1 PIM1 PITPNC1 SLC35A1 NREP RFC2

PLEKHM1 SCARA3 REXO1 PKMYT1 PLEKHM1 SLC35F3 NSF RHPN2

PMAIP1 SCML1 RGS2 PLTP PMAIP1 SLC37A2 NSUN2 RNASEH2A

PNPLA4 SDC1 RIN3 POC1A PNPLA4 SLC37A3 NTN4 RPS6KA5

PODXL SDC4 RPS6KA3 PODN PODXL SLC38A1 NUDCD2 RPSAP52

POPDC3 SEC61A2 RRAGD PRC1 POPDC3 SLC4A4 NUMA1 RPSAP58

PPAP2B SEMA3B RRM2B PRR23C PPAP2B SLC5A3 NUSAP1 RRM2

PPAP2C SEPT6 RTN4RL1 PRSS12 PPAP2C SLC6A15 NXNL2 RRP1B

PPARG SERTAD4 SATB1 PSMA5 PPARG SMPDL3A OIP5 RUVBL2

PRKG2 SH3BP4 SC5D PSMB9 PRKG2 SMURF2 ORC6 S100A16

PSD3 SHCBP1 SCN1B PSMC3IP PSD3 SNX6 OXTR SAP30

PSTPIP2 SHMT1 SEMA5A PSRC1 PSTPIP2 SOGA3 PACSIN2 SCCPDH

PTGFR SKP2 SEMA6A PTK7 PTGFR SRPX PAQR4 SDC1

PTGFRN SLBP SEMA6D PTPRJ PTGFRN SS18 PDE1C SDC4

PTGS1 SLC1A5 SEPT3 PTTG1IP PTGS1 SSBP2 PGM2 SEC61A2

PTPRG SLC38A11 SEPT5 PXMP2 PTPRG ST6GALNAC2 PHF19 SEMA3B

PXK SLC43A3 SEPW1 RACGAP1 PXK STEAP1 PIM1 SEPT6

QKI SLC4A8 SERINC1 RAD51 QKI STMN2 PKMYT1 SERTAD4

QPCT SLC7A5 SESN2 RARG QPCT STMN3 PLK2 SFPQ

RAB31 SMAD3 SET RBBP7 RAB31 TIPARP PLTP SH2D4A

RAB33A SNRPA SFRP1 RDH10 RAB33A TMC7 POC1A SH3BP4

RAB3A SOGA1 SH3GL2 RHPN2 RAB3A TMEM117 PODN SHCBP1

RAET1L SORT1 SH3PXD2B RNASEH2A RAET1L TMEM192 POLA2 SHMT1

RAP1GAP2 SPA17 SIRPA RPL39L RAP1GAP2 TMEM33 POLE SLBP

RBMS1 SPAG5 SLC16A2 RPSAP52 RBMS1 TMOD2 PPME1 SLC1A5

REXO1 ST3GAL4 SLC16A3 RPSAP58 REXO1 TMTC1 PRC1 SLC43A3

RGL1 STAG3L5P-PVRIG2P-PILRB SLC16A6 RRM2 RGL1 TNFAIP1 PRSS12 SLC4A8

RGS2 STMN1 SLC17A5 RUVBL2 RGS2 TNFRSF10A PSMA5 SLC7A5

RIN3 SUV39H1 SLC25A32 S100A16 RIN3 TNFRSF21 PSMB9 SLIT2

RORA SUZ12P1 SLC25A51 SAMD12 RORA TOB1 PSMC3IP SMAD3

RPL17 SYNPO SLC2A3 SCCPDH RPL17 TOLLIP PSRC1 SMYD2

RPS6KA3 SYPL2 SLC35A1 SCML1 RPS6KA3 TPRG1L PTK7 SNAPIN

RRAGD TACC3 SLC37A2 SDC1 RRAGD TRIB2 PTPRJ SOGA1

RTN4RL1 TAGLN SLC37A3 SDC4 RTN4RL1 TSPAN31 PTRF SORT1

SC5D TAGLN2 SLC38A1 SEC61A2 SC5D TUBA3E PTTG1IP SPAG5

SCN1B TDP1 SLC39A13 SELENBP1 SCN1B UBA6 PXMP2 SRRM2

SECTM1 TGFBI SLC4A4 SEMA3B SECTM1 ULBP3 RACGAP1 SSRP1

SEMA6A TGM2 SLC5A3 SEPT6 SEMA6A UNC5B RAD54L ST3GAL4

SEPT5 TK1 SLC6A15 SERTAD4 SEPT5 USF2 RBBP7 STMN1

SEPW1 TMEM204 SLFN5 SFPQ SEPW1 VLDLR RDH10 STXBP5

SERINC1 TRIM6-TRIM34 SLMO2 SH2D4A SERINC1 VSTM4 RFC2 SUOX

SESN2 UBP1 SMPD1 SH3BP4 SESN2 ZBTB33 RHPN2 SUV39H1

SET UCP2 SNX6 SHCBP1 SET ZC3HAV1L RNASEH2A SUZ12P1

SFRP1 UHMK1 SRXN1 SHMT1 SFRP1 ZNF136 RPS6KA5 SYT11

SFXN3 VAMP5 SS18 SLBP SFXN3 ZNF234 RPSAP52 TENC1

SH3PXD2B VANGL1 SSBP2 SLC1A5 SH3PXD2B ZNF566 RPSAP58 TGFBI

SIRPA WEE1 ST6GALNAC2 SLC4A8 SIRPA RRM2 TGM2

SLC16A2 XRCC6BP1 STEAP3 SMAD3 SLC16A2 RRP1B TIMELESS

SLC16A3 ZBTB5 STMN3 SMYD2 SLC16A3 RUVBL2 TNRC6A

SLC17A5 ZC3H12A STXBP1 SNAPIN SLC17A5 S100A16 TROAP

SLC25A33 ZDHHC12 SULF2 SOGA1 SLC25A33 SAMD12 TYMS

SLC25A36 TAPBP SORT1 SLC25A36 SAP30 VAMP5

SLC25A51 TCP11L2 SSRP1 SLC25A51 SCCPDH WDR34

SLC26A2 TIPARP ST3GAL4 SLC26A2 SDC1 XRCC6BP1

SLC30A7 TMC7 STMN1 SLC30A7 SDC4 ZC3H12A

SLC35A1 TMED4 STXBP5 SLC35A1 SEC61A2 ZWINT

SLC35F3 TMEM117 SUOX SLC35F3 SELENBP1

SLC37A2 TMEM158 SUV39H1 SLC37A2 SEMA3B

SLC37A3 TMOD2 SUZ12P1 SLC37A3 SEPT6

SLC38A1 TOB1 SYPL2 SLC38A1 SERTAD4

SLC39A13 TOLLIP TACC3 SLC39A13 SFPQ

SLC4A4 TOX2 TAGLN SLC4A4 SH2D4A

SLC5A3 TPRG1L TENC1 SLC5A3 SH3BP4

SLC6A15 TRIB2 TGFBI SLC6A15 SHCBP1

SLFN5 TSHZ3 TGM2 SLFN5 SHMT1

SMPDL3A TSPAN11 TK1 SMPDL3A SLBP

SMURF2 TUBA3E TNFAIP8L1 SMURF2 SLC1A5

SNX6 UBA6 TNRC6A SNX6 SLC43A3

SOGA3 ULBP3 TOE1 SOGA3 SLC4A8

SPRY2 USF2 TRIM6-TRIM34 SPRY2 SLC7A5

SRPX UST TROAP SRPX SLIT2

SS18 UXS1 UBP1 SS18 SMAD3

SSBP2 VLDLR UCP2 SSBP2 SMYD2

ST6GALNAC2 VSTM4 USP6 ST6GALNAC2 SNAPIN

STEAP1 WLS VAMP5 STEAP1 SNRPA

STEAP3 ZMAT3 VANGL1 STEAP3 SOGA1

STMN2 ZNF136 ZBTB5 STMN2 SORT1

STMN3 ZNF460 ZC3H12A STMN3 SPA17

STXBP1 ZNF521 ZDHHC12 STXBP1 SPAG5

SULF2 ZNF566 ZWINT SULF2 SRRM2

TBC1D17 ZNF583 ZYG11A TBC1D17 SSRP1

TBCCD1 TBCCD1 ST3GAL4

TIPARP TIPARP STMN1

TK2 TK2 STXBP5

TLE3 TLE3 SUMO2

TMC7 TMC7 SUOX

TMED4 TMED4 SUV39H1

TMEM117 TMEM117 SUZ12P1

TMEM192 TMEM192 SYPL2

TMEM33 TMEM33 SYT11

TMOD2 TMOD2 TACC3

TMTC1 TMTC1 TENC1

TNFAIP1 TNFAIP1 TGFBI

TNFRSF10A TNFRSF10A TGM2

TNFRSF21 TNFRSF21 TGOLN2

TOB1 TOB1 TIMELESS

TOLLIP TOLLIP TK1

TOX2 TOX2 TMEM204

TPRG1L TPRG1L TMEM97

TRAPPC6B TRAPPC6B TNRC6A

TRIB2 TRIB2 TOMM34

TSHZ3 TSHZ3 TPD52L1

TSPAN31 TSPAN31 TRIP13

TUBA3E TUBA3E TROAP

UBA6 UBA6 TYMS

ULBP3 ULBP3 UCP2

UNC5B UNC5B UHMK1

USF2 USF2 VAMP5

UXS1 UXS1 VANGL1

VLDLR VLDLR WDR34

VSTM4 VSTM4 WDR62

ZBTB33 ZBTB33 WEE1

ZC3HAV1L ZC3HAV1L XRCC6BP1

ZNF136 ZNF136 ZC3H12A

ZNF234 ZNF234 ZDHHC12

ZNF521 ZNF521 ZWINT

ZNF566 ZNF566

ZNF610 ZNF610

Table S8: G4 statistic for genes significantly altered in BS and BLM-depleted cells Extended G4 Statistics for genes regulated in BS patients compared to Normal control

Region -250bp to TSS

Regulation Up or Down N=1138

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 575 870 1.51 350 442 1.26 326 428 1.31

Random Genes 531.78 807.26 1.52 322.23 407.13 1.26 310.25 398.93 1.29

SD(Random) 16.41 30.03 0.03 15.33 20.99 0.03 14.5 21.39 0.03

FDR Rand > Reg 0.006 0.021 0.57 0.045 0.05 0.495 0.147 0.081 0.18

FDR Rand < Reg 0.994 0.982 0.43 0.962 0.955 0.506 0.871 0.922 0.821

Region -250bp to TSS

Regulation Up N=1000

G4 Motif Strand Either T NT

Statistics

# With

G4 Total # G4s G4s per gene

# With

G4 Total # G4s

G4s per

gene # With G4 Total # G4s

G4s per

gene

Regulated Genes 505 741 1.47 302 371 1.23 288 370 1.28

Random Genes 467.86 710.25 1.52 282.76 356.71 1.26 273.63 351.42 1.28

SD(Random) 15.44 27.7 0.03 14.12 20.38 0.03 13.54 19.34 0.03

FDR Rand > Reg 0.004 0.145 0.935 0.087 0.228 0.855 0.164 0.189 0.491

FDR Rand < Reg 0.998 0.864 0.065 0.919 0.785 0.145 0.854 0.828 0.509

Region -250bp to TSS

Regulation Down N=138

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 70 129 1.84 48 71 1.48 38 58 1.53

Random Genes 64.52 98.06 1.52 38.68 48.74 1.26 37.66 48.42 1.29

SD(Random) 5.73 10.31 0.09 5.03 7.24 0.09 5.27 7.42 0.09

FDR Rand > Reg 0.188 0.001 0.001 0.042 0.003 0.004 0.514 0.109 0.003

FDR Rand < Reg 0.844 0.999 0.999 0.972 0.998 0.996 0.562 0.918 0.997

Region TSS to +250

Regulation Up or Down N=1138

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 577 829 1.44 303 359 1.18 377 470 1.25

Random Genes 536.45 771.84 1.44 262.73 319.64 1.22 365.46 454.18 1.24

SD(Random) 16.32 27.08 0.03 13.37 17.71 0.03 16.06 21.57 0.02

FDR Rand > Reg 0.007 0.019 0.525 0.001 0.013 0.868 0.256 0.243 0.424

FDR Rand < Reg 0.993 0.982 0.475 0.999 0.989 0.132 0.76 0.776 0.577

Region TSS to +250

Regulation Up N=1000

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 507 721 1.42 272 319 1.17 328 402 1.23

Random Genes 472.1 679.64 1.44 231.06 280.98 1.22 320.73 398.9 1.24

SD(Random) 15.58 26.87 0.03 12.95 17.77 0.03 14.35 19.57 0.03

FDR Rand > Reg 0.015 0.068 0.724 0.001 0.024 0.912 0.329 0.458 0.767

FDR Rand < Reg 0.987 0.934 0.276 0.999 0.978 0.088 0.692 0.564 0.233

Region TSS to +250

Regulation Down N=138

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 70 108 1.54 31 40 1.29 49 68 1.39

Random Genes 64.94 93.33 1.44 31.73 38.61 1.22 44.41 55.15 1.24

SD(Random) 5.75 9.83 0.08 4.83 6.58 0.09 5.5 7.59 0.07

FDR Rand > Reg 0.222 0.084 0.089 0.599 0.429 0.183 0.235 0.06 0.031

FDR Rand < Reg 0.825 0.938 0.913 0.477 0.636 0.824 0.818 0.953 0.969

Region First 250bp of Intron 1

Regulation Up or Down N=1117

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 689 1110 1.61 288 355 1.23 541 755 1.4

Random Genes 621.33 958.77 1.54 251.32 314.89 1.25 476.63 645.96 1.36

SD(Random) 16.11 30.78 0.03 13.42 18.83 0.03 16.55 26 0.03

FDR Rand > Reg 0.001 <0.001 0.013 0.002 0.015 0.735 <0.001 <0.001 0.076

FDR Rand < Reg 1 1 0.987 0.999 0.986 0.265 1 1 0.924

Region TSS to +250

Regulation Up N=987

G4 Motif Strand Either T NT

Statistics

# With

G4 Total # G4s G4s per gene

# With

G4 Total # G4s

G4s per

gene # With G4 Total # G4s

G4s per

gene

Regulated Genes 605 973 1.61 258 317 1.23 474 656 1.38

Random Genes 548.96 847.84 1.54 222.21 278.74 1.25 421.25 570.87 1.36

SD(Random) 15.21 29.55 0.03 13.23 18.25 0.03 14.84 23.96 0.03

FDR Rand > Reg 0.001 <0.001 0.018 0.002 0.021 0.76 <0.001 <0.001 0.177

FDR Rand < Reg 0.999 1 0.982 0.998 0.983 0.24 1 1 0.823

Region TSS to +250

Regulation Down N=130

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 84 137 1.63 30 38 1.27 67 99 1.48

Random Genes 72.45 112.03 1.55 29.49 36.99 1.25 55.78 75.7 1.36

SD(Random) 5.78 11.18 0.09 4.75 6.66 0.1 5.5 8.7 0.08

FDR Rand > Reg 0.027 0.018 0.177 0.489 0.447 0.438 0.02 0.002 0.083

FDR Rand < Reg 0.981 0.986 0.823 0.599 0.6 0.57 0.985 0.999 0.917

   

Extended G4 Statistics for genes with altered regulation in BLM-depleted compared to NS shRNA depleted human fibroblasts filtered to remove NS shRNA vs Control

Region -250bp to TSS

Regulation Up or Down N=1067

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 508 777 1.53 296 381 1.29 303 396 1.31

Random Genes 498.04 756.25 1.52 302.94 382 1.26 292.01 375.44 1.29

SD(Random) 15.93 28.62 0.03 14.61 20.8 0.03 13.61 20.13 0.03

FDR Rand > Reg 0.286 0.231 0.357 0.701 0.538 0.187 0.218 0.146 0.247

FDR Rand < Reg 0.734 0.776 0.644 0.32 0.492 0.813 0.806 0.866 0.754

Region -250bp to TSS

Regulation Up N=547

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 281 425 1.51 167 216 1.29 164 209 1.27

Random Genes 255.3 387.14 1.52 155.32 195.94 1.26 150.09 193.22 1.29

SD(Random) 11.22 20.47 0.05 10.27 13.87 0.04 10.06 14.39 0.04

FDR Rand > Reg 0.007 0.034 0.533 0.137 0.088 0.213 0.087 0.144 0.626

FDR Rand < Reg 0.996 0.971 0.467 0.884 0.92 0.787 0.924 0.874 0.377

Region -250bp to TSS

Regulation Down N=520

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 227 352 1.55 129 165 1.28 139 187 1.35

Random Genes 243.04 369.82 1.52 147.49 186.43 1.26 142.16 182.93 1.29

SD(Random) 11.06 20.1 0.05 10.65 14.55 0.04 10.12 14.51 0.05

FDR Rand > Reg 0.928 0.823 0.258 0.962 0.942 0.35 0.643 0.395 0.113

FDR Rand < Reg 0.081 0.188 0.742 0.049 0.066 0.651 0.39 0.624 0.887

Region TSS to +250

Regulation Up or Down N=1067

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 515 722 1.4 256 307 1.2 341 415 1.22

Random Genes 504.37 726.39 1.44 246.26 299.79 1.22 342.37 425.46 1.24

SD(Random) 15.1 26.31 0.03 13.76 17.88 0.03 15.25 21.14 0.03

FDR Rand > Reg 0.233 0.564 0.906 0.259 0.334 0.742 0.55 0.692 0.84

FDR Rand < Reg 0.786 0.449 0.094 0.767 0.68 0.261 0.48 0.325 0.16

Region TSS to +250

Regulation Up N=547

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 258 369 1.43 142 174 1.23 166 195 1.17

Random Genes 257.97 372.22 1.44 126.71 154.17 1.22 175.93 219.15 1.25

SD(Random) 11.16 19.37 0.04 10.3 13.18 0.04 11.18 14.93 0.03

FDR Rand > Reg 0.531 0.586 0.625 0.079 0.072 0.414 0.828 0.952 0.983

FDR Rand < Reg 0.501 0.439 0.378 0.933 0.931 0.586 0.197 0.054 0.017

Region TSS to +250

Regulation Down N=520

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 257 353 1.37 114 133 1.17 175 220 1.26

Random Genes 245.38 353.43 1.44 120.16 146.26 1.22 166.94 207.55 1.24

SD(Random) 11.27 19.18 0.04 9.95 13.11 0.04 10.56 14.49 0.04

FDR Rand > Reg 0.167 0.523 0.943 0.742 0.854 0.885 0.242 0.213 0.361

FDR Rand < Reg 0.861 0.501 0.057 0.283 0.16 0.122 0.783 0.81 0.643

Region First 250bp of Intron 1

Regulation Up or Down N=997

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 586 900 1.54 236 294 1.25 454 606 1.33

Random Genes 554.75 858.11 1.55 224.01 280.62 1.25 424.97 575.54 1.35

SD(Random) 15.56 29.17 0.03 12.86 17.74 0.03 14.98 23.61 0.03

FDR Rand > Reg 0.024 0.074 0.642 0.193 0.237 0.569 0.029 0.094 0.748

FDR Rand < Reg 0.98 0.928 0.358 0.83 0.779 0.432 0.975 0.915 0.253

Region TSS to +250

Regulation Up N=514

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 294 451 1.53 129 162 1.26 222 289 1.3

Random Genes 286.33 442.69 1.55 115.36 144.55 1.25 220.07 298.6 1.36

SD(Random) 10.52 19.96 0.04 9.33 12.77 0.05 11.01 17.38 0.04

FDR Rand > Reg 0.237 0.35 0.602 0.082 0.095 0.463 0.445 0.729 0.932

FDR Rand < Reg 0.79 0.667 0.398 0.932 0.917 0.538 0.582 0.293 0.069

Region TSS to +250

Regulation Down N=483

G4 Motif Strand Either T NT

Statistics # With

G4 Total # G4s G4s per gene # With

G4 Total # G4s G4s per

gene # With G4 Total # G4s G4s per

gene

Regulated Genes 292 449 1.54 107 132 1.23 232 317 1.37

Random Genes 268.24 414.51 1.55 109.12 136.8 1.25 206.07 278.79 1.35

SD(Random) 10.81 21.07 0.05 8.7 12.28 0.05 10.64 16.86 0.04

FDR Rand > Reg 0.012 0.048 0.558 0.627 0.664 0.656 0.007 0.017 0.373

FDR Rand < Reg 0.99 0.955 0.442 0.419 0.361 0.346 0.994 0.986 0.627