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Sistem Penghantaran ObatMutakhir

(Advanced Drug Delivery)

Dr. Ahmad Kharis Nugroho, Apt.

Dr.rer.nat. Ronny MartienC.M. Ratna Rini N., M.Pharm., Apt.

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Drug delivery (system)?

Vehicle? Dosage form?

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Ultimate goal of drug

delivery ?To deliver the active pharmacological

ingredients to the site of action,

safely, efficiently and effectively

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2 aspects of controlled release

1. Spatial placement site specific

targeting delivery

2. Temporal delivery rate / time

efficiency

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Delivery design consideration

Disease/abnormalities determination Type and goal of therapy

Criteria for ideal system

Route of administration physiological

condition

Natural barrier anticipation

Possibility of modification or combinationof delivery

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Points to concern

Challenges (read: barriers) of delivery Ideal system

Technology development

Critical factors

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Type of drug delivery

Conventional drug delivery

Immediate - Continuous release

Advanced drug delivery Controlled release

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General purposes of study

To gain better understanding of advanceddrug delivery

To distinguish the delivery systems based

on the unique mechanisms

To identify the critical factors on thedelivery system studied

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Competence Indicators

Students can explain the role of drugdelivery system in encouraging patient-oriented therapy

Students are capable to distinguish theadvanced drug delivery systems based onthe mechanism of delivery and release

Students are able to identify the criticalfactors of the delivery systems learnt

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Conscience to develop

The objectiveness in accessing information Critical and logical thinking

The importance of communication and

team work/collaboration spirit

Self confidence to decide the right things

Imagination leading to creativity

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Compassion held

Willingly to contribute to the transfer ofcorrect information about drug deliverysystem

Highly motivated to design the drugdelivery system which fully concerns onpatients overall condition

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Menu

Week Agenda PIC

I-II Nanotechnology delivery Dr. Ronny

Martien

III-IV Nanotech on cancer

chemotherapy strategies

Dr. Ronny

Martien

V-VII Transdermal delivery Dr. AkhmadKharis, Apt.

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MenuWeek Agenda PIC to guide

Mid exam

VIII-X Pulmonary and nasal

delivery

Iin, M.Pharm,

Apt

XI-

XIII

Oral Modified Delivery Iin,

M.Pharm,Apt

Final exam

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Schedule description

Dr. Akhmad Kharis, Apt. and Dr. RonnyMartien will teach on weekdays schedule forall classes

Saturday classes are only carried out if Dr.Akhmad Kharis, Apt. is not available to givelectures on weekdays due to must-to-doagendas on Gadjah Mada University (there

will be notification)

Learning with Iin, M.Pharm will start aftermid exam for 6 weeks

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Distribution of assessment

I:K:R =50% : 25% : 25%

Description of I mark: Final exam : max 30

Assignment & presentation : max 20 (10 forpresentation, 10 for discussion)

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Learning together

guided by bu iin

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Activity class discussion

A class is divided into 9 groups@2assignments

Iin, M.Pharm:

Pulmonary drug delivery (3)

Nasal delivery (1)

Sustained delivery & Pulsatile delivery (2)

Oral macromolecular delivery (3)

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Iin, M.Pharm:

Pulmonary drug delivery (3) 2 meetings

Anatomy and physiology of lung, lung naturaldefense and physical factors affecting drugdisposition

Design of pulmonary delivery system

Exuberra review

Nasal delivery (1) 1 meeting

Anatomy of nose and reason behind delivery

Design of nasal delivery systemReview on pulmonary and nasal delivery

Sustained delivery & pulsatile delivery (2) 1

meeting

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Oral macromolecular delivery (3) 2

meetings (+review and reflection) Strategy to overcome enzymatic barriers

Role of penetration enhancers

Strategy to overcome efflux pump

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Aspects to discuss

Concept of deliveryDescription of either the anatomy and

physiology of the site of action or thephysiological barriers

The purpose of the delivery system

The unique mechanism of the system

What critical factors to concern and why?

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Handout

Use slides of Power Point (use 3 slides/page

no more than 8 pages)

No plagiarism!!!

If you refer to any articles or figures, always

refer on a right manner (with acknowledgement)and the statement of only for learningpurposes

Handout should be copied and distributed at

least one day before class If the handout needs to be revised, revision will

be done after class

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Recommended references

See the SPO folder on Filey!