Social Determinant and NCD

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    The Equity & Socialdeterminants of NCD(Cardiovasculardisease, Diabetics),Tobacco case and TB*

    Disampaikan oleh:

    Yayi Suryo Prabandari

    Prodi S2 IKM

    FK UGM

    Referensi utama:

    Blas, E., & Kurup, A.S. 2010. Equity,

    social determinants and public

    health programmes. Switzerlands:

    WHO

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    LO learning objectives

    Setelah mengikuti sesi ini mahasiswa akan

    mampu memahami dan mengidentifikasi

    beban sakit, determinan sosial dan equity:

    - PTM (Penyakit kardiovaskular dandiabetes),

    - TB dan

    - Kasus penggunaan tembakau

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    Social Determinant

    (Marmot) Social gradient

    Unemployment

    Stress

    Social support Early life

    Addiction

    Social exclusion

    Food

    Work and

    Transport

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    What is meant by social gradient?

    The poorest of the poor, around the world, have the worst

    health. Within countries, the evidence shows that in general thelower an individuals socioeconomic position the worse their

    health. There is a social gradient in health that runs from top to

    bottom of the socioeconomic spectrum. This is a global

    phenomenon, seen in low, middle and high income countries. The social gradient in health means that health inequities affect

    everyone.

    For example, if you look at under-5 mortality rates by levels of

    household wealth you see that within counties the relationbetween socioeconomic level and health is graded. The poorest

    have the highest under-5 mortality rates, and people in the

    second highest quintile of household wealth have higher

    mortality in their offspring than those in the highest quintile.

    This is the social gradient in health.

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    The Meaning of social exclusion

    Social exclusion(Sociology):

    the failure of society to provide certain

    individuals and groups with those rights

    and benefits normally available to its

    members, such as employment, adequate

    housing, health care, education and

    training, etc.

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    The Meaning of social exclusionThe report draws attention to an important distinction between social

    exclusion used to describe a state experienced by particular groups of people(common in policy discourse) as opposed to the relational approach adopted by

    the SEKN. From this perspective exclusion is viewed as a dynamic, multi-

    dimensional process driven by unequal power relationships. In the SEKN

    conceptual model exclusionary processes operate along and interact across

    four main dimensions - economic, political, social and cultural - and at different

    levels including individual, household, group, community, country and global

    regional levels. These exclusionary processes create a continuum of

    inclusion/exclusion characterised by an unjust distribution of resources and

    unequal access to the capabilities and rights required to:

    Create conditions necessary for entire populations to meet and go beyond

    basic needs.

    Enable participatory and cohesive social systems.

    Value diversity.

    Guarantee peace and human rights.

    Sustain environmental systems.

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    Health inequality and inequity

    Health inequalities can be defined as differences inhealth status or in the distribution of health

    determinants between different population groups.

    For example, differences in mobility between elderly

    people and younger populations or differences inmortality rates between people from different social

    classes. It is important to distinguish between inequality

    in health and inequity.

    Some health inequalities are attributable to biologicalvariations or free choice and others are attributable to

    the external environment and conditions mainly outside

    the control of the individuals concerned.

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    Health inequality and inequity

    In the first case it may be impossible or

    ethically or ideologically unacceptable to

    change the health determinants and so the

    health inequalities are unavoidable.

    In the second, the uneven distribution may be

    unnecessary and avoidable as well as unjust

    and unfair, so that the resulting health

    inequalities also lead to inequity in health.

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    Penentu Sosial Kesehatan (WHO)

    Penghasilan

    Status sosialPendidikan

    STATUS

    SEHAT

    What are the social 'determinants' of health?

    The social determinants of health are the circumstances in which people are born, grow

    up, live, work and age, and the systems put in place to deal with illness. These

    circumstances are in turn shaped by a wider set of forces: economics, social policies,

    and politics.

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    PenyakitKardiovaskular

    CVD

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    Perbandingan trend kematianNCD/PTM dan Penyakit Infeksi di

    Low dan Middle Income Country

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    DALYs = Disability

    Adjusted Life Years

    The sum of years of

    potential life lost due to

    premature

    mortality and the years

    of productive life lost

    due to disability.

    Beban SakitMayor (10penyakit dan

    injuries) diNegaraberkembangdng kematiantinggi dan

    rendah sertanegara maju

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    Statusperkem-bangan

    ekonomi ,kematiandanbebansakit

    CVD

    i i

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    Status perkembangan ekonomi dan prevalensi faktorrisiko CVD di WHO sub region

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    Conceptual framework for understanding health inequities, pathways and entry-points

    Age Economic development, urbanization, globalizationa

    Lifetime exposure to advertising of fast foods, tobacco, vehicle use,

    disposable income, urban infrastructure, physical inactivity, high

    calorie intake, high salt intake, high saturated fat diet, tobacco use.

    lack of control over life and work, high deprivation neighbourhoods

    Raised cholesterol, raised blood sugar, raised blood

    pressure, overweight, obesityb, lack of access to healthinformation, health services, social support and welfare

    assistance, poor health care-seeking behaviour

    Higher incidence, frequent recurrences,

    higher case fatality, comorbiditiesb

    High out-of-pocket expenditure, poor adherence, lower survival, loss

    of employment, loss of productivity and income, social and financial

    consequences, entrenchment in poverty, disability, poor quality of life

    b

    Social context

    Differential

    exposure

    Differentialvulnerability

    Differential

    outcomes

    Differential

    consequences

    Social stratificationa

    Social devripationa

    Unemployment

    Literacy

    Deprived neighbourhoods

    Adverse intrauterine life

    Less access to:

    Health services

    Early detection

    Healthy foodb

    Povertyb

    OvercrowdingPoor housing

    Rheumatic heart

    disease

    chagas disease

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    Determinants of the economic developmentand summary prevalence ofcardiovascular risk factors in WHO subregions:

    a. Government policies: Influencing socialcapital, infrastructure, transport,agriculture, food

    b. Health policies at macro, health system

    and micro levelsc. Individual, household and community

    factors: use of health services, dietarypractices, lifestyle

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    Main patterns of social gradientsassociated with CVDMain Patterns Examples

    Changing

    direction of

    gradient

    In the past CVD was considered to be a disease of affluent countries

    and the affluent in low-income countries. While CVD trends are

    declining in development countries, the impact of urbanization and

    mechanization has resulted in rising trends of CVD in developing

    countries. With economic development the prevalence of

    cardiovascular risk factors will shift from higher socioeconomic

    groups in these countries to lower socioeconomic groups, as has

    been the case in developed countries (94)

    Monotonous The risk of late detection of CVD and cardiovascular risk factors and

    consequent worse health outcomes is higher among people from low

    socioeconomic groups due to poor access to health care. This

    gradient exists in both rich and poor countries (95, 96)

    Bottom-end People with coronary heart disease of a lower socioeconomic status

    are more likely to be smokers and more likely to be obese than

    others. They usually have higher levels of comorbidity and

    depression and lower self-efficacy expectations, and are less likely to

    participate in cardiac rehabilitation programmes (97)

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    Main patterns o socia gra ientsassociated with CVDMain

    Patterns

    Examples

    Top-end In some countries, upper-class people gain preferential

    access to services even within publicly-funded health care

    systems compared to those with lower incomes or less

    education (98)

    Threshold Some types of CVD, such as chagas disease andrheumatic heart disease, are associated with extreme

    poverty due to poor housing, malnutrition and

    overcrowding (5, 6)

    Clustering In low-and middle-income countries cardiovascular risk

    profiles are more unhealthy in urban in rural populationsbecause of the cumulative effects of higher exposure to

    tobacco promotion, unhealthy food and fewer opportunities

    for physical activity due to urban infrastructure (2.32)

    Dichotomous In some populations women are much less exposed to

    certain cardiovascular risk factors, such as tobacco, due tocultural inhibitions (99)

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    Inequity and CVD : social determinants and pathwaysentry-points for interventions and information needsPriority public

    health

    conditionslevel

    Social

    determinants

    and pathways

    Main entry-points Interventions Measurement

    Socio-

    economic

    context

    and position

    (entry-pointsand

    Intervention

    are common

    To other areas

    of health

    Social status

    Education

    Occupation

    Poverty

    Parents social

    class

    Ageing of

    populations

    Poor

    governance

    Define,

    institutionalize

    Protect, and

    enforce human

    rights toeducation,

    employment,

    living conditions

    and health

    Redistribution of

    power andresources in

    populations

    Universal primary

    education

    Programmes to

    alleviate

    undernutrition inwomen of

    childbearing age and

    pregnant women

    Tax-financed public

    services, including

    education and healthMultifaceted poverty

    reduction strategies

    at country level,

    including

    employment

    opportunity

    Access to

    employment

    opportunities,

    poverty alleviation

    schemes andeducation

    Level of

    investment in

    interventions that

    improve health

    (including

    cardiovascular

    health) that lie

    outside the health

    sector

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    Inequity and CVD : social determinants and pathwaysentry-points for interventions and information needsPriority

    public

    health

    conditions

    level

    Social

    determinantsand pathways

    Main entry-

    points

    Interventions Measurement

    Differential

    exposure

    Poor living conditions

    in childhood

    Community structures

    Control over life andwork

    Attitudes towards

    health

    Marketing

    Television exposure

    Psychosocial and work

    stress

    Unemployment

    High-deprivation

    health services

    Health-related

    behaviours

    Residence:urban/rural

    Strengthen

    positive and

    counteract

    negative health

    effects of

    modernization

    Community

    infrastructure

    development

    Reduce

    affordability of

    harmful products

    Increase

    availability of and

    accessibility to

    health food

    International trade agreements

    that promote availability and

    affordability of healthy foods

    International agreements onmarketing of food to children

    Use tobacco tax for promotion

    of health of the population

    Develop urban infrastructures

    to facilitate physical activity

    Government legislation and

    regulation, e.g. tobaccoadvertising and pricing

    Voluntary agreement with

    industry, e.g. trans fats and salt

    in processed food

    User-friendly food labelling to

    help customers to make healthy

    food choices

    Information on policies

    and structural

    environment measures

    conducive to healthy

    behaviour, e.g. tobacco

    cessation, consumption

    of fruits and vegetables,

    reduce salt in processed

    food, regular physical

    activity

    Information on

    legislative andregulatory frameworks

    to support healthy

    behaviour

    Measurement of gaps in

    implementation of

    policies and legislative

    and regulatoryframeworks

    Priority Social Main entry Interventions Measurement

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    Priority

    public

    health

    conditions

    level

    Social

    determinants and

    pathways

    Main entry-

    points

    Interventions Measurement

    Differen-

    tial

    vulnera-

    bility

    Access to

    education

    Comorbidity

    Lack of social

    support

    Access to welfare

    assistance

    Health care-

    seeking behavioursAccessibility of

    health services

    Undernutrition

    Physical inactivity

    Access to health

    education

    Gender

    Subsidize

    healthy items

    to make

    healthy

    choices easy

    choices

    Compensate

    for lack of

    opportunities

    Empower

    people

    Provide healthy meals free or

    subsidize to schoolchildren

    Subsidize fruits and vegetables in

    worksite canteens and restaurants

    Facilitate a price structure of food

    commodities to promote health, e.g.

    lower price for low-fat milk

    Improve early case detection of

    individuals with diabetes andhypertension by targeting vulnerable

    groups, e.g. deprived neighbourhoods,

    slum dwellers

    Improve population access to health

    promotion by targeting vulnerable

    groups in health education

    programmes

    Combine poverty reduction strategies

    with incentives utilization of preventive

    services, e.g. conditional cash

    transfers, vouchers

    Provide social insurance and fee

    examinations for basic preventive and

    curative health interventions

    Education and employmentopportunities for women

    Access to media,

    e.g. print, radio and

    television and

    health education

    programmes

    broadcast through

    these media

    Affordability of

    fruits. vegetables

    and low-fat fooditems

    Population

    coverage of

    screening and early

    detection of high-

    risk groups

    Access to treatmentand follow-up

    including to

    essential drugs,

    basic technologies

    and special

    interventions, e.g.

    bypass surgery

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    Priority

    public

    health

    conditio

    ns level

    Social determinants

    and pathways

    Main entry-

    points

    Interventions Measurement

    Differen-

    tial

    health

    care out-

    comes

    Cost to appropriate car

    Differential utilization

    by patients

    Prescription practices

    not based on evidence

    Poor adherence

    Discriminating services

    Poor access to essential

    medicines

    Frequent recurrences

    and hospitalizationsLife stress and social

    isolation

    Lack of education

    Comorbidity

    Medical

    Procedures

    Provider

    practices:

    compensate

    fordifferential

    outcomes

    Increase awareness among

    providers of ethical norms and

    patient rights

    Provide universal access to a

    package of essential CVD

    interventions through a primaryhealth care approach

    Provide incentives within public

    and private health systems to

    increase equity in outcomes, e.g.

    fees and bonuses for

    disadvantaged groupsProvide dedicated services for

    particular groups, e.g. smoking

    cessation programmes for

    people in deprived

    neighbourhoods

    Access to essential

    medicines and

    basic technologies

    in primary health

    care

    Levels ofpopulation

    coverage related

    to essential CVD

    interventions

    Support for

    smoking cessationfor high-risk

    groups among low

    socioeconomic

    segments of the

    population

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    Priority

    public

    healthconditio

    ns level

    Social determinants

    and pathways

    Main entry-

    points

    Interventions Measurement

    Differen

    tial

    consequ

    ences

    Lower survival and

    worse outcomes

    Loss of employment

    Social and financial

    consequences

    Lack of access to

    welfare assistance

    Heavy health

    expenditure

    Lack of safety nets

    Social and

    physical

    access

    Policies and environments

    in worksites to reduce

    differential consequences

    Increase access of services

    for people with specific

    health conditions, e.g.

    cardiac rehabilitation

    Improve referral links to

    social welfare and healtheducation services

    Social and

    economic

    effects of health

    outcomes

    Access to

    cardiac

    rehabilitation

    Policies for

    linking healthand social

    welfare

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    Prevention and Control of NCD :public health model

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    Diabetes

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    Estimasi jumlah penderita Diabetes

    di negara maju & berkembang

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    Prevalensi Komplikasi Diabetes

    Overview of diabetes-

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    Overview of diabetesrelated pathwaysSocial

    stratification

    Industrialization,

    urbanization

    and globalization

    Social

    norms

    Local food

    environments

    Urban

    infrastructuresEnvironments

    Promoting

    Tobacco use

    Ageing

    Population

    Social

    Context

    Differential

    exposure

    Access to and type of

    health care, including

    Self-management

    Excess calories

    and poor diet

    Physical

    inactivity

    Genes andearly life

    experienceSmoking Old age

    Diabetes incidence,

    glucose control,

    blood pressure control

    and lipid control

    Diabetes complications

    and premature mortality

    Differential

    vulnerability

    Differential

    consequences

    Differential

    care outcome

    Costs for health

    And social care

    Qualityof life

    Loss ofincome

    Obesity

    Obesogenic environment

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    TOB CCOC SE

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    Prevalensi Perokok berdasarkan WHO region

    St tus ekonomi d n isiko kem ti n di

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    `Status ekonomi dan risiko kematian dibeberapa negara

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    `

    Malaysia

    2.90%

    Indonesia

    46.16%

    Myanmar

    8.73%

    Philippines

    16.62%

    Singapore

    0.39%

    Thailand

    7.74%

    Viet Nam

    14.11%

    Lao PDR

    1.23%

    Brunei

    0.04%Cambodia

    2.07%

    Tobacco Consumption in ASEAN

    3rdin the world

    S ki l

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    ``Smoking prevalence

    in Indonesia

    *Kosen, Aryastami, Usman, Karyana, Konas Presentation IAKMI XI, 2010** Ministry of Health, Basic Health Research, 2007 ( prevalence of > 10 years old)

    *** Ministry of Health, Basic Health Research, 2010 (prevalence of > 15 years old)

    Year Male Female Total

    1995* 53.9 1.7 27.2

    2001* 62.9 1.4 31.8

    2004* 63.0 5.0 35.0

    2007** 65.3 5.1 35.4

    2010*** 65.9 4.2 34.7

    Indonesia is

    3rd rank theworlds

    leading

    tobacco

    consuming

    nations with

    146.860.000

    population is

    smoker

    2001 2004

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    2001 2004Keluarga

    miskin

    pemilik

    kartu sehat

    Keluarga

    miskin yang

    TIDAK

    memiliki

    kartu sehat

    Keluarga

    miskin

    pemilik

    kartu sehat

    Keluarga

    miskin yang

    TIDAK

    memiliki

    kartu sehatStatus merokok:

    - Tidak

    - Ya 35,8864,1235,48

    64,5232,88

    67,12 36,2563,75Pernah merokok

    - Tidak

    - Ya 80,0020,00 82,1117,89 - -Merokok di

    dalam rumah

    - Tidak

    - Ya4,92

    95,08

    5,83

    94,17

    15.33

    84,67

    14,78

    85.22Rata-rata mulaimerokok 18,67 18,58 17,34 17,61Rata-rata jumlah

    rokok yang

    dihisap perhari10,05 10,14 8,32 8,37

    Mayoritas

    perokok adalah

    keluarga miskin

    Umur mulai

    merokok semakin

    muda

    Jumlah rokok

    yang dihisap

    berkurang

    Susenas 2001 & 2004*

    N P i i P t P k k

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    No Propinsi Persentase Perokok2001 2004Keluarga

    miskin

    pemilik

    kartu sehat

    Keluarga miskin

    yang TIDAK

    memiliki kartu

    sehat

    Keluarga

    miskin

    pemilik

    kartu sehat

    Keluarga miskin

    yang TIDAK

    memiliki kartu

    sehat1 NAD N.A N.A 66,40 60,622 Sumut 60,00 62,96 58,33 60,083 Sumbar 83,33 67,68 47,06 55,614 Riau 100,00 75,61 25,00 50,005 Jambi 77,78 66,28 33,33 66,676 Sumsel 44,44 67,33 64,71 78,617 Bengkulu 78,57 67,30 52,63 74,518 Lampung 76,09 74,90 86,09 75,159 Kep.Babel 100,00 65,00 100,00 30,5610 DKI Jkt 100,00 55,00 0,00 33,3311 Jabar 56,04 72,25 62,79 69,8412 Jateng 69,59 62,43 65,87 62,6913 DI Yogya 54,55 50,31 62,07 56,3414 Jatim 58,67 63,97 64,85 63,9915 Banten 25,00 78,92 46,15 70,42

    Indonesia 64,12 64,52 67,12 63,75Susenas 2001 & 2004*

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    ``Rokok dan Remaja Indonesia

    1986: perokok usia 10-14 tahun

    dan 15-19 tahun sebesar 0.6% dan13.2%

    1995: prevalensinya menjadi 1.1%

    dan 22.6% pada usia yang sama*

    Riset Kesehatan Dasar pada tahun2007 dan dilanjutkan Riskesdas

    2010 menunjukkan peningkatan

    perokok usia 15-24 tahun, dari

    24.6% menjadi 26.6% Perokok pemula di Indonesia juga

    semakin muda, dari rata-rata 17,4

    tahun menjadi 14-15 tahun

    (*Suhardi, 1997; **Riskesdas, 2007;Riskesdas 2010)

    K kt i tik l

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    `

    2000 2009

    Laki-laki%

    Perem-puan %

    Laki-laki%

    Perem-puan %

    Status

    sekolah

    Negeri 45 56 39 54

    Swasta disamakan/

    Akreditasi A

    33 27 57 43

    Swasta diakui/Akreditasi B

    22 17 4 3

    Umur < 14 tahun 9 13 41 34

    15 tahun 55 65 15 23

    > 16 tahun 36 22 44 43

    Uang

    saku

    < Rp. 2000,- 54 48 2 1

    Rp. 2000,- --

    Rp. 5000,-

    44 49 53 53

    > Rp. 5000,- 2 3 45 46

    Karakteristik sampel

    Hasil Penelitian : Prevalensi Perokok

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    2000(%)

    2009(%)

    Non perokok 35

    Perokok eksperimen 30Perokok teratur 35

    Non perokok 68

    Perokok eksperimen 10Perokok teratur 22

    Non perokok 77Perokok eksperimen 30Perokok teratur 6

    Non perokok 96

    Perokok eksperimen 2Perokok teratur 2

    `Hasil Penelitian Prevalensi PerokokPelajar di Kota Yogya

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    2000(%)

    2009(%)

    Teman non perokok: 10

    Teman perokok 1/ > 1: 90Ayah perokok : 65

    Ibu perokok : 8Kakak laki-laki perokok: 43

    Teman non perokok: 17

    Teman perokok 1/ > 1: 75

    Ayah perokok: 78

    Ibu perokok:4Kakak laki-laki perokok: 31

    Teman non perokok: 26

    Teman perokok 1/>1: 74

    Ayah perokok : 65Ibu perokok: 6

    Kakak laki-laki perokok: 38

    Teman non perokok: 33

    Teman perokok 1 / >1: 61Ayah perokok:82

    Ibu perokok: 2

    Kakak laki-laki perokok:36

    `Hasil Penelitian : Smoker Social etwork

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    `Tobacco use initiation during

    adolescence

    Ability to resist peer pressure

    Adequate awareness of tobaccos harms

    Scepticism about smoking prevention

    Prevalence of social problems

    Co-occurring psychological or psychiatric

    School performance

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    Differential exposure. These vulnerabilities arecompounded by the differential exposure ofdisadvantage young people to pressures withinthe physical and social environment thatencourage the uptake of tobacco use anddiscourage successful quitting. These include:

    Preponderance of adults who model tobaccouse

    Prevalence of peer smoking

    Availability of tobacco products

    Targeted advertising and promotion

    Paucity of environments supportive of beingtobacco free

    `Tobacco use initiation during

    adolescence

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    `Faktor penyebab

    remaja merokok

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    `Tobacco use cessation or continuation

    during adulthood

    Higher levels of nicotine addition

    Low self-efficacy and greater perceived

    barriers to quitting

    Higher levels of stress Co-occurring health and other problems

    Working conditions

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    `Differential exposure

    Social norms permissive to smoking

    Lack of social and instrumental

    support to quit

    Availability of cigarettes, and

    advertising where allowed (see

    above)

    Barriers to affordable cessation

    services

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    `

    Strengthening implementation of the WHO Framework

    Convention on Tobacco Control with a Social determinants

    approach

    While overall prevalence of tobacco use hasreduced significantly in much of the developedword, this is not evidenced across all populationsubgroups, including young people and lower

    socioeconomic groups Few countries, even in the developed world, have

    fully implemented the range of tobacco controlmeasures outlined in the Convention, includingmechanisms to enforce compliance

    In many developing countries, whereimplementation to tobacco control measures lagsbehind the developed world, tobacco use isactually increasing

    S l i i dd i

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    `Structural interventions addressing

    socioeconomic context and position in society

    a. Entry-point: reducing availability of tobacco andtobacco productsa. Price and tax measures to reduce the demand for

    tobacco (Article 6 of the WHO Framework Conventionon Tobacco Control)

    b. Elimination of illicit trade in tobacco products (article 15

    of FCTC)c. Prohibition of sales to minors (Article 6 of the WHO

    Framework Convention on Tobacco Control)

    b. Entry-point: increasing the acceptability oftobacco control as a global public good

    c. Entry-point: enhancing accessibility to tobaccocontrol

    St t l i t ti dd i

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    `Structural interventions addressing

    differential exposure

    Entry-point: increasing the availability ofenvironments supportive of tobacco control

    Entry-point: reducing the social acceptability oftobacco use

    Banning tobacco adversiting, promotion andsponsorship (article 13 of FCTC)

    Packaging and labelling of tobacco products (Article IIof the WHO Framework Convention on TobaccoControl)

    Other interventions to reduce the acceptability oftobacco use: promoting tobacco-free role models

    Entry-point: regulating tobacco productdisclosures

    Entry-point: increasing accessibility to cessationsupport

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    `

    a. Entry-point: increasing availability ofinformation

    b. Entry-point: reducing the acceptability oftobacco use within populations

    c. Entry-point: tying tobacco control interventionsinto community development and andempowerment initiatives

    Intervention addressing differential health careoutcomes and consequences:

    provision of cessation services

    `Structural interventions addressingdifferential vulnerability

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    CURRENT GLOBAL TB CONTROL

    STRATEGY TARGETS

    Prevention starts with cure

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    a. Access barriers

    b. Barriers to successful treatment

    c. The social and economic burden

    of TB

    d. Strategic response to address

    access and adherence barriers

    `Reaching the poor with effectivecurative interventions

    `

    Framework for downstream risk factors and upstream determinants of TB, and related entry-points for interventions

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    Weak and inequitable economic

    Social and environmental policy

    Globalization, migration,

    Urbanization, demographic transition

    Weak healthsystem, poor access

    Inappropriate

    health seeking

    Poverty, low socioeconomicstatus, low education

    Inappropriate

    health seeking

    Active TB

    cases in

    community

    Crowding,

    Poor

    ventilation

    Tobacco

    smoke, air

    population

    HIV, malnutrition, lung

    diseases, diabetes,

    alcoholism, etc

    Age. Sex

    and genetic

    factors

    High-level contact with

    infectious droplets

    Impaired host

    defence

    Exposure Infection Active disease Consequences

    Indicates where national TB programmes could intervene jointly with other Disease control programmes within the general health care system

    Indicates entry-point for interventions outside the health system

    Indicates where the current global TB control strategy has its main focus

    Downstream

    Upstream

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    `Upstream determinants

    Causal pathways linking

    socioeconomic status and TB risk

    Gender differentiation in TB incidence

    and risk factor profile

    Urbanization and poverty

    Demographic changes

    Changing lifestyles

    Poor physical environment

    Fragmented health system

    `Relative risk, prevalence and population attributable fraction of selected

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    downstream risk factors for TB in 22 High TB Burden Countries

    Area riset yg

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    `Area riset yg

    direkomendasikan untuk TB

    basic epidemiological research to furtherestablish association and causality of TB riskfactors, including interactions between the riskfactors;

    refined and country-specific analyses of

    population attributable fractions of different riskfactors, accounting for interaction andheterogeneity across countries;

    multilevel analysis to explain causal pathwayslinking low socioeconomic status with higher

    risk of TB;

    A i t yg di kom d ik

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    analysis of factors determining variations in TBburden and historical change in TB burdenacross countries and across geographicalareas within countries;

    modelling of impact on future TB burden of

    different scenarios for socioeconomic changeand change in risk factor exposure inpopulation

    `Area riset yg direkomendasikanuntuk TB

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    Terima kasih atas perhatiannya`