Wednesday, March 8To

Friday, March 10, 2017

Reitz Union Auditorium and Grand BallroomUniversity of Florida, Gainesville, FL USA

PROGRAM BOOK

ADVANCES IN SKELETAL MUSCLE BIOLOGY IN HEALTH AND DISEASE

UNIVERSITY of FLORIDA

ADVANCES IN SKELETAL MUSCLE BIOLOGY IN HEALTH & DISEASE Sponsors

The conference organizers gratefully acknowledge the financial support of:

Silver:

ADVANCES IN SKELETAL MUSCLE BIOLOGY IN HEALTH AND DISEASE CONFERENCE PROGRAM

Wi-Fi: The University of Florida offers complimentary internet access to people affiliated or conducting

business with UF and UFHealth via “ufvisitor”. To connect please select “ufvisitor”, open up an internet

browser window and follow the instruction. The conference organizers are unable to provide further assistance

with connectivity.

WEDNESDAY, March 8, 2017 Reitz Union, University of Florida Time 12:30-1:30pm Grant-Writing Workshop, Ground Floor

Room G330

12:30-1:00 R Grants - Key aspects for a successful grant

Jill Rafael-Fortney, The Ohio State University, USA

1:00-1:30 Panel Question & Answer Session

Jill Rafael-Fortney, The Ohio State University, USA

Andrew Brack, University of California San Francisco, USA

Karyn Esser, University of Florida, USA

Room G320

12:30-1:00 K Grants - Key aspects for a successful grant

Amanda Taylor Boyce, NIAMS- National Institutes of Health, USA

1:00-1:30 Panel Question & Answer Session

Amanda Taylor Boyce, NIAMS- National Institutes of Health, USA

Darin Falk, University of Florida, USA (K01 recipient)

Glenn Walter, University of Florida, USA

Room G310

12:30-1:00 F Grants - Key aspects for a successful grant

Ashok Kumar, University of Louisville, USA

1:00-1:30 Panel Question & Answer Session

Ashok Kumar, University of Louisville, USA

Sue Bodine, University of California, Davis, USA

Simon Schenk, University of California, San Diego, USA

Lance Riley, University of Florida, USA (F31 recipient)

1:45pm Welcome and Opening Remarks,

Auditorium (Second Floor Reitz Union)

David S. Guzick Senior Vice President, Health Affairs President, UF Health; University of Florida

Lee Sweeney Director, UF Myology Institute; University of Florida

Andrew Judge Associate Professor and Conference Co-Chair; University of Florida

2:00pm Session Muscle Diseases: Biology & Biomarkers Chair Glenn Walter 2:00-2:25 Kevin Campbell Structural Basis of the Tight Association between the

University of Iowa Extracellular Matrix and the Sarcolemma in Skeletal USA Muscle

2:25-2:50 Jill Rafael-Fortney Mineralocorticoid signaling in acute and chronic skeletal The Ohio State University muscle injuries USA

2:50-3:15 Krista Vandenborne MR Imaging Biomarkers in Duchenne Muscular Dystrophy University of Florida USA

3:15-3:40 Michael Hughes RNA-seq reveals extraordinary diversity between skeletal Washington University muscle tissues USA

Short talks selected from abstracts (4 min presentations with no questions) 3:40-3:44 Isabelle Richards Investigation of the penultimate domain of titin using the

INSERM UMR951 CRISPR/Cas9 system: implication for LGMD2A, France TMD/LGMD2J and DM1

3:45-3:49 Silvia Castagnaro Beclin 1 is required for skeletal muscle homeostasis and its

University of Padova deficiency leads to muscular dystrophy Italy

3:50-3:54 Hannah Spaulding Impaired autophagic flux in dystrophic muscle augments

Iowa State University extracellular autophagosome release USA

3:55-3:59 Jia Li ACE-2494, a systemically-acting GDF ligand trap,

Acceleron Pharma attenuates muscle weakness in murine models of USA neurodegeneration, muscular dystrophy, and disuse

atrophy

4:00-4:04 James Thomas Disruption of Prenatal RNA Splicing Patterns and Altered University of Florida Myogenesis in Congenital Myotonic Dystrophy USA

4:05-4:09 Andreas Patsalos Macrophage BACH1, a heme regulated transcriptional

University of Debrecen repressor, controls HMOX1 and skeletal muscle Hungary regeneration

4:10 - 4:45pm Coffee Break, North Hallway

Coffee, tea, and light snacks provided

Holmes-Huxley Lecture 4:45 – 5:45 Kenneth Holmes Muscle Contraction

Professor Fellow of the Royal Society Former Leader of Biophysics at the Max-Planck Institute for Medical Research, Heidelberg, Germany

6:00pm Reception and Poster Viewing, Grand Ballroom

THURSDAY, March 9, 2017 Auditorium, Reitz Union, University of Florida Time 7:45am Coffee, Tea, and Pastries 8:00am Session Mechanisms of Muscle Wasting Chair Denis Guttridge

8:00-8:25 Chris Adams Investigating Mechanisms and Treatment of Skeletal

University of Iowa Muscle Atrophy USA 8:25-8:50 Marco Sandri Novel signaling pathways that control muscle mass and Venetian Institute of force Molecular Medicine Italy

8:50-9:15 Teresa Zimmers Organ crosstalk and molecular mechanisms of muscle Indiana University wasting in pancreatic cancer cachexia USA 9:15-9:40 Robert Jackman The use of transcription factor reporters to guide the study Boston University of skeletal muscle atrophy USA Short talks selected from abstracts (4 min presentations with no questions) 9:40-9:44 Sarah Judge Pancreatic cancer patients display progressive skeletal

University of Florida muscle pathology USA

9:45-9:49 Guohua Zhang Lewis lung carcinoma induces muscle wasting by activating

University of Texas Toll-like receptor 4 Health Science Center USA

9:50-9:54 Martin Connolly miR-424: a potential regulator of muscle wasting and

Imperial College London anabolic resistance in COPD and ICU-associated wasting England

9:55-9:59 David Hammers Supraphysiological levels of GDF11 induce severe striated

University of Florida muscle atrophy USA

10:00am Coffee Break and Poster Viewing Coffee, tea, and light snacks provided 10:30am Session Muscle Force Transmission and EC-Coupling Chair Lee Sweeney

10:30-10:55 Lars Larsson Bench to bedside research on critical illness myopathy Karolinska Institute (CIM) and ventilator induced diaphragm muscle Sweden dysfunction (VIDD): Mechanisms and intervention strategies

10:55-11:20 Jane Kent In Vivo Human Skeletal Muscle Energetics and Fatigue University of Massachusetts USA

11:20-11:45 Eduardo Rios Calsequestrin: myth and reality of a unique calcium store Rush University USA 11:45-12:10 Anne Houdusse Mechanistic and Structural Basis for Allosteric Tuning of Institut Curie Myosin by highly specific Activators and Inhibitors of France Force Generation

Short talks selected from abstracts (4 min presentations with no questions) 12:10-12:14 Darin Falk Optogenetic therapy for skeletal muscle University of Florida USA

12:15-12:19 Scott Bowen Diaphragm alterations in a cardiometabolic obese rat Leipzig University model of heart failure with preserved ejection fraction Germany (HFpEF) are not reversed by exercise training

12:20-12:24 Rizwan Qaisar Oxidative stress induced dysregulation of excitation-

Oklahoma Medical contraction coupling contributes to muscle weakness Research Foundation

USA

12:25-12:29 Daria Neyroud Effects of Three Weeks of Wingate-Type High-Intensity

University of Lausanne Interval Training On Muscle Fatigue and Ryr1 Expression Switzerland

12:30-2:30pm Poster Session I– Grand Ballroom

Beverages and boxed lunches provided 2:30pm Session Nutrition and Muscle Metabolism Chair Bret Goodpaster

2:30-2:55 Daniel Kelly Mitochondrial Remodeling Relevant to Exercise and Sanford Burnham Prebys Disease Medical Discovery Institute USA

2:55-3:20 Teresa Davis Regulation of Postnatal Muscle Protein Synthesis by Baylor College of Medicine Nutrition USA

3:20-3:45 Suzette Pereira Role of HMB in addressing age-related muscle loss

Abbott Nutrition USA

Short talks selected from abstracts (4 min presentations with no questions) 3:45-3:49 Adam Black High-fat diets enriched with varying fatty acid compositions

Pennsylvania State University have differential effects on skeletal muscle Troponin T pre- USA mRNA alternative splicing

3:50-3:54 Jinhee Kim Metal transporter ZIP14 (SLC39A14) is critical to University of Florida inflammatory responses and atrophy prevention in murine USA skeletal muscle

3:55-4:25pm Coffee Break and Poster Viewing

Coffee, tea, and light snacks provided 4:25- 4:50 Simon Schenk Acetyltransferases and muscle metabolism

University of California San Diego, USA

4:50 - 5:15 Carol Witczak Glucose Transporters & Skeletal Muscle Growth East Carolina University USA Short talks selected from abstracts (4 min presentations with no questions) 5:15 - 5:19 Joshua Drake Skeletal muscle Ulk1 is required for metabolic adaptation

University of Virginia to exercise training USA 5:20 - 5:24 Andrea Armani Transcription Factor EB controls metabolic flexibility

University of Padua during exercise Italy

Pre- and post-doctoral trainee data blitz (2 min presentations with no questions) 5:25 - 6:00 Chair: Leonardo Ferreira

Poster 3. An MRI Investigation of Trunk Muscle Involvement and Effects on Expiratory Function in Duchenne Muscular Dystrophy. Alison Barnard; Donovan Lott; Rebecca Willcocks; Sean Forbes; William Triplett; Abhinandan Batra; Barbara Smith; Krista Vandenborne; Glenn Walter Poster 29. Spectrin repeat 2 through hinge 2 impacts functionality of miniaturized dystrophin constructs. Lindsay, Angus; Lowe, Dawn A.; Duan, Dongsheng; Judge, Luke M.; Chamberlain, Jeffery S.; Ervasti, James M. Poster 30. Muscle ULK1 and ULK2 modulate different aspects of autophagy and are required for atrophy during fasting. Mere, Caleb; Fuqua, Jordan; Blomme, Jay; de Melo, Vitor; Kronemberger, Ana; Lira, Vitor Poster 59. TRB3 Regulates Protein Turnover in Mouse Skeletal Muscle. Choi, Ran Hee, McConahay, Abigail, Hardee, Justin P., Carson, James A., Hirshman, Michael F., Goodyear, Laurie J., Koh, Ho-jin Poster 86. Differential sensitivity to the lack of extracellular signal-regulated kinases 1/2 in murine fast- and slow twitch muscles. Wang, Shuo; Seaberg Bonnie; Paez-Colasante, Ximena; Rimer, Mendell Poster 90. Muscle-specific knockdown of Numb and Numb-like protein reduces in situ tetanic and twitch force production in mouse gastrocnemius muscle. Graham, Zachary A.; De Gasperia, Rita; Harlow, Lauren; Bauman, William A.; Brotto, Marco; Cardozo, Christopher P. Poster 91. MicroRNA-31 and Aging: Impact on the force transfer apparatus in skeletal muscle. Hughes, David C., Ebert, Scott M., Marcotte, George R., Juo, Natalie., Adams, Christopher M. and Baar, Keith Poster 104. Seven-days of hindlimb suspension in voluntary wheel running mice results in substantial insulin resistance, soleus muscle atrophy and intramyocellular ceramide accumulation. McKenzie, Alec I.; Reidy, Paul T.; Nelson, Daniel S.; Mulvey, Jade L.; Brunker, Preston T.; Lindsay, Catherine C.; Yonemura, Nikol M.; Drummond, Micah J.

Poster 116. Regional muscle architectural adaptations to concentric and eccentric training reflect different activation of mechanosensitive focal adhesion kinase. Franchi, Martino Poster 125. Muscle IGF-I Production is Critical for Functional Recovery of Skeletal Muscle Following Disuse Atrophy. Ray A. Spradlin, George Vassilakos, Michael Matheny, Hanqin Lei, Matan Ozery, Elisabeth R. Barton Poster 129. Age-Related Changes in Muscle Mass: Evidence For A Common Aging Signature? Baehr, Leslie M., Marcotte, George M., Marshall, Andrea G., West, Daniel W.D., Baar, Keith, and Bodine, Sue C. Poster 133. Mitochondrial respiratory capacity of skeletal muscle is related to physical function in older adults with obesity. Distefano, Giovanna; Standley, Robert A.; Coen, Paul M.; and Goodpaster, Bret H. Poster 142. Examining the transitional extracellular matrix in aged and young human skeletal muscle following lengthening contractions. Sorensen, Jacob R., Holland, Alex, Sutton, Chris, Parcell, Allen C., Hyldahl, Robert D. Poster 144. MnSod deficiency causes significant mitochondrial abnormalities and contractile dysfunction in skeletal muscle but does not result in muscle atrophy. Ahn, Bumsoo, Pharaoh, Gavin, Ranjit Rojina, Bhaskaran, Shylesh, Van Remmen, Holly Poster 147. gp130 Regulation of Muscle Mitochondrial Dynamics During Cancer Cachexia. Dennis K. Fix, Justin P. Hardee, Song Gao, Brandon N. VanderVeen, James A. Carson 6:00pm Presentation of Foreign Trainee Travel Awards

Scott Bowen, Leipzig University – Heart Center, Leipzig, Germany

Silvia Castagnaro, University of Padova, Padova, Italy

Martin Connolly, Imperial College, London, England

Giulia Favaro, University of Padova, Padova, Italy

Andreas Patsalos, University of Debrecan, Debrecan, Hungary

7:00pm Dinner at the Swamp Restaurant; The speakers will be dining at the Swamp Restaurant and we encourage all attendees to dine there also so that informal interactions can continue.

FRIDAY, March 10, 2017 Auditorium, Reitz Union, University of Florida Time 7:45am Coffee, Tea, and Pastries 8:00am Session Muscle Hypertrophy and

Mechanotransduction Chair Sue Bodine 8:30-8:25 Troy Hornberger Using Global Phosphoproteomics to Understand How University of Wisconsin Mechanical Signals Regulate Skeletal Muscle Mass Madison,

USA 8:25-8:50 Gustavo Nader Ribosomal Control of Skeletal Muscle Mass Pennsylvania State University USA 8:50-9:15 Paul Gregorevic Exploring the significance of BMP signaling in muscle Baker IDI Heart and Diabetes Institute

Australia 9:15-9:40 Markus Ruegg Hero or villain? The role of mTORC1 in muscle University of Basel proteostasis Switzerland

Short talks selected from abstracts (4 min presentations with no questions) 9:40-9:44 Sajedah Hindi Essential role of TAK1 signalosome in skeletal muscle

University of Louisville growth and maintenance USA 9:45-9:49 Robbert van der Pijl Diaphragm hypertrophy following passive stretch: a role

University of Arizona/ for titin-based mechanosensing Vrije Universiteit Amsterdam USA/Netherlands

9:50-9:54 Joshua Butcher Muscle Hypertrophy as a Novel Buffer against Obesity-

Augusta University Derived Hypertension USA

9:55-9:59 Bradley Gordon Castration Suppresses the Absolute Anabolic Response

University of Central Florida following High Frequency Muscle Contractions USA 10:00-10:30am Coffee Break and Poster Viewing

Coffee, tea, and light snacks provided

10:30am Session Skeletal Muscle Aging: Metabolism and Function Chair Karyn Esser 10:30-10:55 Luigi Ferrucci Mechanisms for the decline of muscle quality with aging in National Institute of Aging humans USA 10:55-11:20 Andrew Brack Skeletal Muscle Stem Cells: Regeneration and Aging University of California San Francisco, USA 11:20-11:45 Judd Aiken Latent mitochondrial DNA deletion mutations drive

University of Alberta muscle fiber loss at old age Canada

11:45-12:10 Osvaldo Delbono Sympathetic Nervous System and Skeletal Muscle Wake Forest University Innervation with Aging USA Short talks selected from abstracts (4 min presentations with no questions) 12:10-12:14 Paul Coen The Impact of Chronological Age and Physical Activity on

Florida Hospital, Mitochondrial Energetics, Exercise Efficiency and Skeletal Translational Research Muscle Performance Institute for Metabolism and Diabetes USA

12:15-12:19 Marita Wallace The influence of a ketogenic diet on longevity and skeletal

University of California, Davis muscle maintenance with aging USA

12:20-12:24 Vita Sonjak Denervation-induced Modulation of Skeletal Muscle

McGill University Mitochondrial Function in Frail/Pre-frail Elderly Women Canada

12:25-12:29 Brittany Collins Estradiol Deficiency Impairs Satellite Cell Maintenance

University of Minnesota and Self-Renewal USA

12:30-2:00pm Poster Session II– Grand Ballroom

Beverages and boxed lunches provided

2:00pm Session Mitochondria and Redox Biology Chair Scott Powers 2:00-2:25 Stefano Schiaffino Mitochondrial specialization revealed by single muscle Venetian Institute of fiber proteomics

Molecular Medicine Italy 2:25-2:50 Robert Balaban The Mitochondrial Reticulum of Skeletal Muscle National Heart, Lung and Blood Institute

USA

2:50-3:15 Benjamin Miller Mitochondrial biogenesis in skeletal muscle with slowed Colorado State University aging: why cell proliferation matters USA

3:15-3:40 Aaron Russel MicroRNA inhibition to improve skeletal muscle health in Deakin University amyotrophic lateral sclerosis Australia Short talks selected from abstracts (4 min presentations with no questions)

3:40-3:44 Giulia Favaro The mitochondria fission protein Drp1 is required for University of Padova muscle mass maintenance

Italy

3:45-3:49 Yoshitake Cho Perm1 (PGC-1 and ERR-induced Regulator, Muscle 1) is

University of California, required for exercise–induced mitochondrial biogenesis San Diego and enhances oxidative capacity in skeletal muscle USA

3:50-3:54 Rebecca Wilson Mitochondria-targeted S-nitrosothiol, MitoSNO1, reduces

University of Virginia mitochondrial oxidative stress and preserves function of USA the sciatic nerve following hindlimb ischemia-reperfusion

Injury 3:55-3:59 Robert Standley Weight loss and Exercise Induced Improvement in Insulin

Florida Hospital, Sensitivity is Associated with Improved Mitochondrial Translational Research Respiration in Skeletal Muscle of Older Obese Subjects Institute for Metabolism and Diabetes USA

4:00pm Farewell Scientific Organizers

Andrew Judge, University of Florida Leonardo Ferreira, University of Florida

Lee Sweeney, University of Florida Karyn Esser, University of Florida

Scott Powers, University of Florida Sue Bodine, University of California, Davis

Scientific Advisory and Review Committee

Glenn Walter, University of Florida Elisabeth Barton, University of Florida

Stephen Dodd, University of Florida

Administrative Organizer

Christa Stout, Myology Institute, University of Florida

Please visit the UF Myology Institute website for more information about its mission and members:

Myology Institute

For information about various Graduate Programs at UF please visit the following sites:

Rehabilitation Sciences Applied Physiology & Kinesiology

Interdisciplinary Program in Biomedical Sciences

Thank you for attending the

Advances in Skeletal Muscle

Biology in Health and Disease

Conference and visiting the

University of Florida.

ABSTRACTS/POSTERS

Abstract numbers below refer to poster board numbers where they will be on display in the Grand Ballroom.

Muscle Diseases: Biology and Biomarkers

1. Natural Disease Progression of Upper Extremity Muscles in Boys with Duchenne Muscular Dystrophy, Cross-sectional Study Alabasi, Umar; Willcocks, Rebecca; Forbes, Sean; Triplett, Bill; Rooney, William; Wang, Dah-Jyuu; Lott, Donovan; Finkel, Richard; Tennekoon, Gihan; Finanger, Erika; Russman, Barry; Byrne, Barry; Walter, Glenn; Sweeney, Lee; Vandenborne, Krista.

2. MRI muscle T2 correlates with upper extremity functional ability in boys with DMD

Arora, H; Willcocks, RJ; Forbes, SC; Rooney, WD; Lott, DJ; Senesac, CR; Zilke, KL; Harrington, AT; Wang, DJ; Tennekoon, GI; Finanger, EL; Russman, BS; Finkel, RS; Triplett, WT; Byrne, BJ; Sweeney, HL; Walter, GA & Vandenborne, K

3. An MRI Investigation of Trunk Muscle Involvement and Effects on Expiratory Function in

Duchenne Muscular Dystrophy Alison Barnard; Donovan Lott; Rebecca Willcocks; Sean Forbes; William Triplett; Abhinandan Batra; Barbara Smith; Krista Vandenborne; Glenn Walter

4. Cardiac MRI to assess cardiac remodeling in Duchenne Muscular Dystrophy

Batra, Abhinandan; Lott, Donovan J; Willcocks, Rebecca W; Forbes, Sean C; Barnard, Alison; William, Triplett; Schmalfuss, Carsten M; Byrne, Barry J; Vandenborne, Krista; Walter, Glenn A

5. Peculiar behavior of fibroblasts from human fibrotic muscles.

Bensalah, Mona; Albert, Victorine; Cordova, Gonzalo; Oliver, Alison; Gidaro, Teresa; Duddy, William; Perié, Sophie; Lacau St-Guily, Jean; Butler-Browne, Gillian; Bigot, Anne; Mouly, Vincent; Negroni, Elisa; Trollet, Capucine

6. High-fat diets enriched with varying fatty acid compositions have differential effects on

skeletal muscle Troponin T pre-mRNA alternative splicing Black, Adam J; Schilder, Rudolf J; Kimball, Scot R

7. Aberrant Respiratory Control in the Mdx Mouse Model of Duchenne Muscular Dystrophy

Burns, David P.; Lucking, Eric; Roy, Arijit; McDonald, Fiona B.; Wilson, Richard; Edge, Deirdre; O’Halloran, Ken D.

8. Long non-coding RNAs modulate mitochondria morphology and functionality in skeletal

muscle Alessio, Enrico; Chemello, Francesco; Grespi, Francesca; Buson, Lisa; Martini, Paolo; Pacchioni, Beniamina; Millino, Caterina; Romualdi, Chiara; Massimino, Marilina; Bertoli, Alessandro; Sandri, Marco; Lanfranchi, Gerolamo; Cagnin, Stefano

9. Beclin 1 is required for skeletal muscle homeostasis and its deficiency leads to muscular

dystrophy Castagnaro, Silvia; Da Ros, Francesco; Sini, Antonella Emanuela; Chrisam, Martina; Grumati, Paolo; Bonaldo, Paolo

10. Novel methods in imaging and quantification of skeletal muscle fibrosis associated with

severe muscular dystrophy Coker, Cora; Hammers, David; Chen, Li; Petitjean, Mathieu; Barton, Elisabeth; Sweeney, Lee

11. BIN1 is a negative regulator of DNM2, and DNM2 haploinsufficiency rescues perinatal death due to loss of BIN1 Cowling, Belinda; Prokic, Ivana; Tasfaout, Hichem; Humbert, Frédéric; Nicot, Anne-Sophie; Kretz, Christine; Roux, Aurélien; Laporte, Jocelyn.

12. Hyperammonemia reduces skeletal muscle protein synthesis via β-catenin mediated

impaired ribosomal biogenesis Davuluri Gangarao; Guisto Michela; Kumar Avinash; Thapaliya Samjhana; Wessely Oliver; NagaPrasad Sathyamangla; Dasarathy Srinivasan.

13. MCF7 Breast Cancer Cells Treated with Exercised Condition Perfusate Media Attenuates

Anabolic Signaling and Cell Proliferation through mTOR signal transduction. Deaver, J William, Davis, Amanda R, Goodenough, Chelsea G, O’Reilly, Colleen L, Riechman, Steven E, Fluckey, James D.

14. Comparison of treatment efficacy in the hypoglossal motor system of AAV-DES-coGAA and

novel vector AAV-DES-IGFIIcoGAA in Gaa-/- mice Doyle, Brendan M; Turner, Sara MF; Poirier, Amy; Jorgensen, Marda L; Falk, Darin J; Doerfler, Phillip A; Byrne, Barry J; Fuller, David D

15. Physical activities are improved by hematopoietic cell transplantation and enzyme replacement therapy in MPS 1-H mice Galligan, Colleen; Gengyun, Le; Nardina, Nash L.; Lowe, Dawn A.; Lund, Troy C.

16. The role of mTOR in Breast Cancer cell signaling. Goodenough, Chelsea G, Deaver, J William, O’Reilly, Colleen L, Davis, Amanda R, Riechman, Steven E, and Fluckey, James D.

17. Breast cancer chemotherapy-induced muscle atrophy and mitotoxicity

Guigni B, Tourville TW, Dittus K, Toth MJ.

18. Molecular Mechanisms Behind Myosteatosis Following Muscle Injury Gumucio, Jonathan; McDonagh, Brian; Mendias, Christopher

19. Engineered synthetic hydrogel for skeletal muscle satellite cell delivery Han, Woojin; Shin, Eunjung; Jang, Young; García, Andrés

20. Nucleus-cytoskeleton coupling is altered in MDX muscle

Iyer, Shama R; Mauban, Joseph R; Shah, Sameer B; Valencia, Ana P; Schneider, Martin F; Hernandez-Ochoa, Erick O; Stains, Joseph P; Blemker, Silvia S; and Lovering, Richard M.

21. A tunable phenotypic FSHD-like mouse model

Jones, Takako; Jones, Peter 22. Sex differences and proteomic profiling of diaphragm weakness in chronic heart failure

Kelley, Rachel C; McDonagh, Brian; Hanna, Steven; Ferreira, Leonardo F 23. Clinical Studies of Biomarkers in Autosomal Dominant Inclusion Body Myopathy

Kimonis, Virginia; Surampalli, Abhilasha; Al-Tahan, Sejad; Al-Obeidi, Ebaa Omizo, Molly; Udd, Bjarne; Mozaffar, Tahseen

24. Robust Angiogenic Response to Endurance Training is Mismatched to Blunted

Mitochondrial Biogenesis Response in Skeletal Muscle of COPD Patients Compared to Healthy Controls Konokhova, Yana; MacMillan, Norah; Hepple, Russell; Taivassalo, Tanja

25. Dysregulation of miRNA biogenesis machinery, miRNA/RNA ratio and miRNA normalizing targets in skeletal muscle of ALS mice Lamon, Séverine; Ngo, Shyuan; Yerbury, Justin; Chung, Roger; Russell, Aaron

26. Mutation of an enhancer element in the pRL chimeric intron improves reliability as a

control for transient transfections with E-box binding transcription factors. LeBlanc, Mallory A., Zhang, Xiping, Riley, Lance A., Esser, Karyn A.

27. ACE-2494, a systemically-acting GDF ligand trap, attenuates muscle weakness in murine

models of neurodegeneration, muscular dystrophy, and disuse atrophy Li, Jia; Fredericks, Maureen; Li, Robert; Grinberg, Asya; Suragani, Rajasekhar NVS; Pearsall, R Scott; Kumar, Ravindra

28. Nebulin’s C-terminus is necessary for proper sarcomeric structure and function Li, Frank; Kiss, Balazs; Granzier, Henk

29. Spectrin repeat 2 through hinge 2 impacts functionality of miniaturized dystrophin constructs Lindsay, Angus; Lowe, Dawn A.; Duan, Dongsheng; Judge, Luke M.; Chamberlain, Jeffery S.; Ervasti, James M.

30. Muscle ULK1 and ULK2 modulate different aspects of autophagy and are required for

atrophy during fasting Mere, Caleb; Fuqua, Jordan; Blomme, Jay; de Melo, Vitor; Kronemberger, Ana; Lira, Vitor

31. Cytokine secretory responses of MYD88 skeletal muscle specific knockout to pathogen

exposure in vitro Mattingly, Alex; Laitano, Orlando; Garcia, Christian; Robinson, Gerard; Van Steenbergen, David; & Clanton, Thomas.

32. Evidence for denervation-induced mitochondrial impairment in skeletal muscle following

a 16-week cigarette smoke exposure in adult mice Míguez, Kayla M.; Vuda, Madhusudanarao; Sonjak, Vita; Perez, Anna; Elkrief, Daren; de Souza, Angela R.; Baglole, Carolyn J.; and Hepple, Russell T.

33. Single-Stem Cell Imaging Analysis and Molecular Dysregulation of Muscle Stem Cells

Tichy, Elisia D; Oyster, Nicholas; Mourkioti, Foteini

34. Identification of a PYROXD1 mutation in an LGMD cohort from Saudi Arabia Reddy, Hemakumar M; Salih, Mustafa A; Jones, Michael D; Mitsuhashi, Satomi; Cho, Kyung-Ah; Estrella,Elicia; Lek, Monkol; Valkanas, Elise; Kunkel, Louis M; MacArthur, Daniel G; Kang, Peter B.

35. MMP Activity is Upregulated Following a Repeated Bout of Lengthening Muscle

Contractions Nelson, W. Bradley; Hyldahl, Robert D.

36. Chemotherapy and Cancer-Induced Cachexia Yield Distinct Metabolic Perturbations Thomas OConnell; Rafael Barreto; Marion Couch; Andrea Bonetto

37. In silico deimmunization of human dystrophin T-cell epitopes King Indigo, Crudelle Julie, Walker Christopher, Baker David, Chamberlain Jeffrey, and Odom Guy.

38. Loss of the skeletal muscle-specific protein Klhl31 causes non-dystrophic congenital

myopathy James B. Papizan, Glynnis Gary, Svetlana Brezprozvannaya, John R. McAnally, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson

39. Macrophage BACH1, a heme regulated transcriptional repressor, controls HMOX1 and skeletal muscle regeneration Patsalos, Andreas; Tzerpos, Petros; Varga, Tamas; Pap, Attila; Giannakis, Nikolas; Horvath, Attila; Lyroni, Konstantina; Koliaraki, Vasiliki; Pintye, Eva; Dezso, Balazs; Kollias, George; Spilianakis, Charalambos G.; Nagy, Laszlo

40. Neuromuscular pathology mediated by survival motor neuron deficiency in skeletal

muscle Reedich, Emily J.; Potter, Kyle A.; Coppola, Giovanni; Cox, Gregory A.; DiDonato, Christine J.

41. Investigation of the penultimate domain of titin using the CRISPR/Cas9 system:

implication for LGMD2A, TMD/LGMD2J and DM1 Charton, Karine; Suel, Laurence; Henriques, Sara F; Moussu, Jean-Paul; Bovolenta, Matteo; Taillepierre, Miguel; Becker, Céline; Lipson, Karelia; Richard, Isabelle

42. The Skeletal Muscle Molecular Clock Regulates Titin Isoform Expression

Riley, Lance A., Zhang, Xiping, Esser, Karyn A. 43. Consequences of pathogenic MEGF10 mutations on myoblast function and interactions

with Notch Saha, Madhurima; Mitsuhashi, Satomi; Jones, Michael; Manko, Kelsey; Reddy, Hemakumar M; Bruels, Christine; Cho, Kyung-Ah; Pacak, Christina A.;Draper, Isabelle and Kang, Peter B.

44. Impaired autophagic flux in dystrophic muscle augments extracellular autophagosome

release Spaulding, Hannah R., Kelly, Ellen M., Sheffield, Joel B., Quindry, John C., Hudson, Matthew B. and Selsby, Joshua T.

45. MCP-1 is a potential biomarker for pancreatic cancer-induced cachexia.

Talbert, Erin E.; Dillhoff, Mary E.; Lewis, Heather; Rajasekera, Priyani; Haverick, Ericka; Schmidt, Carl R.; Hart, Phil A.; Guttridge, Denis C.

46. Disruption of Prenatal RNA Splicing Patterns and Altered Myogenesis in Congenital

Myotonic Dystrophy

Thomas, JD; Sznajder, LJ; Aslam, F; Anastasiadis, Z; Scotti, MM; Nakamori, M; Wang, ET; Swanson,

MS

47. Agent-based models of muscle regeneration explore the roles of inflammation and satellite cell dynamics in Duchenne muscular dystrophy. Virgilio, Kelley M.; Martin, Kyle S.; Peirce, Shayn M.; Blemker, Silvia S.

48. The Microtubule Network is a Disease Modifier in Striated Muscle Ward, Christopher; Shi, Guoli; Joca, Humberto; Khairallah, Ramzi

49. Targeted exon excision therapeutics in iPSC-derived patients’ myoblasts in vitro in VCP Inclusion body disease Weiss, Lan; Chan, Isabella; Llewellyn, Katrina; Nalbandian,Angele; Wilton,Steve; Kimonis, Virginia

50. Short-term unloading of myocytes reveals MuRF1’s novel role in Phenylalanine/Valine

metabolism and tRNA biosynthesis

Wei Tang, MD, PhD, Traci Parry, PhD, Monte S. Willis, MD, PhD, MBA

51. PERK is essential for satellite stem cell regenerative function during skeletal muscle

repair

Xiong, Guangyan; Hindi, Sajedah M; Gallot, Yann S; Bohnert, Kyle R; Whittemore,Scott R; Kumar,

Ashok

52. Degradation of a toxic RNA involved in Type I Myotonic Dystrophy

Bargsten, Annie J Zhang; Schneider, Mary; Wilusz, Carol J.

53. Molecular clock factors and MyoD1 synergistically regulate Tcap expression with

implications for a daily myogenic gene expression program

Zhang, Xiping; Hodge, Brian; LeBlanc, Mallory; Cao, Ximei; Du, Ping; Esser, Karyn.

Mechanism of Muscle Wasting

54. Harnessing cAMP Signaling to Promote Skeletal Muscle Regeneration Akhmedov D, Mendoza-Rodriguez MG, Wess J, Berdeaux R

55. The role of Raptor in skeletal muscle mass

Baraldo, Martina, Sandri, Marco, Blaauw, Bert.

56. Exercise-Induced Stress and the Role of the Immunoproteasome Baumann, Cory; Kwak, Dongmin; Ferrington, Deborah; Thompson, LaDora

57. IRE1/XBP1 arm of the UPR promotes skeletal muscle wasting during cancer cachexia Bohnert, Kyle; Kumar, Ashok

58. Mitochondrial Degeneration Precedes Muscle Atrophy in Cancer Cachexia Brown, Jacob. Rosa-Caldwell, Megan. Lee, David. Blackwell, Thomas. Perry Jr, Richard. Brown, Lemuel. Haynie, Wesley. Wiggs, Michael. Washington, Tyrone. Greene, Nicholas.

59. TRB3 Regulates Protein Turnover in Mouse Skeletal Muscle

Choi, Ran Hee, McConahay, Abigail, Hardee, Justin P., Carson, James A., Hirshman, Michael F., Goodyear, Laurie J., Koh, Ho-jin

60. Role of chaperone-mediated autophagy in skeletal muscle homeostasis and

pathophysiology

Coletto, Luisa; Cuervo, Ana Maria

61. miR-424: a potential regulator of muscle wasting and anabolic resistance in COPD and ICU-associated wasting Connolly, Martin; Farré Garrós, Roser; Wort, John; Kemp, Paul.

62. Resistance exercise prevents cancer-induced muscle wasting using two different animal models. Deminice R; Testa MTJ; Padilha CS; Frajacomo FT; Marinello PC; Cella PS; Guarnier FA; Cecchini, R; Duarte JA.

63. The mitochondria fission protein Drp1 is required for muscle mass maintenance

Favaro, Giulia; Romanello, Vanina; Varanita, Tatiana; Gherardi, Gaia; Desbats, Mariam; Canato, Marta; Albiero, Mattia; Blaauw, Bert; Reggiani, Carlo; De Stefani, Diego; Salviati, Leonardo; Scorrano, Luca; Sandri, Marco.

64. Progression of Cancer-Cachexia – A Transcriptomics View Nicholas P. Greene; Thomas A. Blackwell; Bhuwan Khatri; Jacob L. Brown; David E. Lee; Megan E. Rosa; Richard A. Perry Jr.; Lemuel A. Brown; Michael P. Wiggs; Tyrone A. Washington; Byung-Whi Kong

65. Supraphysiological levels of GDF11 induce severe striated muscle atrophy

Hammers, David W.; Merscham-Banda, Melissa; Ying Hsiao, Jennifer; Engst, Stefan; Hartman, James J.; Sweeney, H. Lee

66. Inflammatory Signaling Regulation of Eccentric Contraction–induced Protein Synthesis in Cachectic Skeletal Muscle Hardee, Justin P., Gao, Song, VanderVeen, Brandon N., Fix, Dennis K., Carson, James A.

67. Identification and Characterization of Tetratricopeptide 39c (Ttc39c) in Skeletal Muscle

Hayes, Caleb and Waddell, David

68. Pancreatic cancer patients display progressive skeletal muscle pathology Judge, SM; Nosacka, RL; Delitto, D; Gerber, M; Trevino, JG; Judge, AR 69. microRNA Expression Profile of Cancer Cachexia-Induced Muscle Atrophy

Lee, David E., Brown, Jacob, L., Rosa-Caldwell, Megan E., Blackwell, Thomas A., Perry, Richard A., Brown, Lemuel A., Khatri, Bhuwan, Seo, Dongwon, Bottje, Walter G., Washington, Tyrone A., Wiggs, Michael P., Kong, Byung-Whi, Greene, Nicholas P.

70. Cell cycle inhibitors function in muscle stem cells

Mademtzoglou Despoina; Alonso-Martin Sonia; Mourikis Philippos; Relaix Frédéric.

71. AMP Deaminase overexpression decreases activation of AMPK in response to mitochondrial uncoupling. Miller, Spencer, Brault, Jeffrey J.

72. Modeling Human Pancreatic Cancer Cachexia Using Mouse Avatars

Nosacka, Rachel L, Judge, Sarah M, Gerber, Michael , Trevino, Jose G and Judge, Andrew R

73. Novel lncRNAs Transcribed Near Contractile Protein-Coding Genes are Altered during Skeletal Muscle Unloading Resnick, Jessica D.; Gilbert, Carolyn A.; Theodore, Lindsey; Lowrey, Angela J.; Wiles, Amy M.; Pandorf, Clay E.

74. Development of an aged mouse hindlimb immobilization model for the identification of novel skeletal muscle atrophy targets using RNAseq and connectivity mapping analysis Panigel, Jacqueline; Pandey, Ashutosh; Thomas, Elizabeth; Traini, Christopher; Kalyana Sundaram, Shanker; Halsey, Wendy; Sathe, Ganesh, Livi, George; Rajpal, Deepak; Hinken, Aaron; Russell, Alan; Kramer, Fritz

75. Non-targeted Metabolomics Analysis of Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo Traci Parry, PhD, Joe Kornegay, DVM, PhD, Monte S. Willis, MD, PhD, MBA

76. Adverse Ultrastructural Remodeling and Mitochondria Dysfunction of Skeletal Muscle during Heart Failure Rogowski, Michael; Fu, Lianwu; Butts, Brittany; Agnetti, Giulio; Powell, Pamela; Bamman, Marcas; Collawn, James; J. Dell’Italia, Louis

77. The Role of Androgens in the Exercise Induced Decrease in Protein Breakdown Rossetti, Michael L., Gordon, Bradley S.

78. Monitoring FoxO1-GFP and atrophy of adult mouse skeletal muscle fibers in culture: effects of altered FoxO1 regulation Russell, Sarah J.; Hernandez-Ochoa, Erick; and Schneider, Martin

79. SP1 mediated regulation of pancreatic cancer-induced muscle atrophy Shukla S.K, Dasgupta A, Gunda VG, Chaika N, Vernucci E, King R, Aberago J, Singh PK

80. Novel skeletal myopathy in dilated cardiomyopathy Song, Taejeong; Rubinstein, Jack; Sadayappan, Sakthivel

81. Exploring Muscle Transcriptional Networks Involved in the Energy Metabolic Response to Disuse Atrophy Trevino, Michelle B.; Zhang, Xiaolei; Pereira, Suzette; Tian, M.; Kelly, Owen; Coen, Paul M., Vega; Rick B., Goodpaster; Bret H., Kelly; Daniel P.

82. Diaphragm outcomes of hyperbaric oxygen treatment following mid-cervical spinal contusion injury Sara, Turner; Cassandra, Schuster; Aaron, B. Morton; J. Matthew, Hinkley; David, Fuller; and Ashley, J. Smuder.

83. A Novel Slow-Fatigable Skeletal Muscle Phenotype Develops During the Progression of Cachexia VanderVeen BN; Fix DK; Hardee JP; Mangum JE; Gao S; Carson JA

84. Thrombospondin-1 expression in myofibers causes muscle atrophy via the PERK-eIF2α-ATF4 pathway and regulates body adiposity by inducing FGF21. Davy Vanhoutte, Tobias Schips, Michelle A. Sargent, Jeffery D. Molkentin

85. Muscle-specific igf-1 gene deletion leads to deficient growth

Vassilakos, Georgios; Spradlin, Ray A.; Park, Soohyun; Barton, Elisabeth R.

86. Differential sensitivity to the lack of extracellular signal-regulated kinases 1/2 in murine fast- and slow-twitch muscles Wang, Shuo; Seaberg Bonnie; Paez-Colasante, Ximena; Rimer, Mendell

87. Lewis lung carcinoma induces muscle wasting by activating Toll-like receptor 4

Zhang, Guohua; Liu, Zhelong; Ding, Hui; Miao, Hongyu; Garcia, Jose; Li, Yi-Ping

Muscle Force Transmission and EC-Coupling 88. Localization of the adaptor protein Numb in the triad junction of skeletal muscle fibers

De Gasperi, Rita; Graham, Zachary A.; Harlow, Lauren; Bauman, William A.; Brotto, Marco; Cardozo, Christopher P.

89. New insights into collagen VI localization in human skeletal muscle: transverse tubule

location with fiber type differences

Fitzgerald, Jamie and Dietz, Paula

90. Muscle-specific knockdown of Numb and Numb-like protein reduces in situ tetanic and

twitch force production in mouse gastrocnemius muscle

Graham, Zachary A.; De Gasperia, Rita; Harlow, Lauren; Bauman, William A.; Brotto, Marco; Cardozo, Christopher P.

91. MicroRNA-31 and Aging: Impact on the force transfer apparatus in skeletal muscle

Hughes, David C., Ebert, Scott M., Marcotte, George R., Juo, Natalie., Adams, Christopher M. and Baar, Keith

92. Muscle and Tendon Contributions to Reduced Rate of Torque Development in Old Age

Narici Marco, Quinlan Jonathan, Franchi Martino, Atherton Philip, Smith Kenny, Szewczyk Nathalien, Greenhaff Paul, Maganaris Constantinos

93. Effects of Three Weeks of Wingate-Type High-Intensity Interval Training on Muscle Fatigue and Ryr1 Expression Neyroud Daria; Schlittler Maja; Tanga Christian; Andersson Daniel C.; Westerblad Håkan; Kayser Bengt; Place Nicolas

94. Oxidative stress induced dysregulation of excitation-contraction coupling contributes to muscle weakness Qaisar, Rizwan; Riddle, Kaitlyn; Bhaskaran, Shylesh; Ahn, Bumsoo; Premkumar, Pavithra; Ranjit, Rojina; Satara Natarajan, Kavithalakshmi; Van Remmen, Holly

Nutrition and Muscle Metabolism 95. Transcription Factor EB controls metabolic flexibility during exercise

Armani Andrea, Mansueto Gelsomina, Ballabio Andrea, Sandri Marco 96. Diaphragm alterations in a cardiometabolic obese rat model of heart failure with

preserved ejection fraction (HFpEF) are not reversed by exercise training Bowen, T. Scott; Brauer, Dominic; Rolim, Natale; Bakkerud, Fredrik; Fischer, Tina; di Silva, Gustavo; Wisloff, Ulrik; Adams, Volker

97. Stimulus-dependent Role Of Increasing NAD In Skeletal Muscle Via Nicotinamide

Phosphoribosyltransferase In Mice Brouwers Bram; Costford Sheila R.; Gabriel Meghan E.; Gardell Steven J.; Smith Steven R

98. Β2-Adrenoceptor Agonist Improves Mitochondrial Quality Control by Activating

Autophagy in Skeletal Muscle Weakness/Wasting Campos, Juliane C.; Andres, Allen M.; Baehr, Leslie M.; Bodine, Sue C.; Gottlieb, Roberta A.; Ferreira, Julio C.B.

99. Creatine supplementation prevents muscle wasting by attenuating Walker-256 tumor-

induced systemic pro-inflammatory condition and muscle oxidative stress in rats. Deminice R, Cella PS, Ribeiro DF, Borges FH, Marinello PC, Guarnier FA, Cechinni R, Duarte JA.

100. Skeletal muscle Ulk1 is required for metabolic adaptation to exercise training. Drake, Joshua; Wilson, Rebecca; Laker, Rhianna; Zhang, Mei; Yan, Zhen

101. Phenotypic properties of muscle in 18-mo-old mice are influenced by food intake between

birth and 11 d of age Fiorotto M L; Fleischman R; Belmont JW; Maity S; Coarfa C; Davis TA

102. Variable Clinical Features and Response to ERT in Pompe Disease

Kimonis, Virginia; Wencel Marie; Hall, Kathy; Alandy-dy, Jousef; Simon, Julie; Surampalli, Abhilasha; Yang, Jade; Goyal, Namita; Mozaffar, Tahseen.

103. Metal transporter ZIP14 (SLC39A14) is critical to inflammatory responses and atrophy

prevention in murine skeletal muscle Kim, Jinhee; Aydemir, Tolunay B.; Kim, Min-Hyun; and Cousins, Robert J.

104. Seven-days of hindlimb suspension in voluntary wheel running mice results in

substantial insulin resistance, soleus muscle atrophy and intramyocellular ceramide accumulation McKenzie, Alec I.; Reidy, Paul T.; Nelson, Daniel S.; Mulvey, Jade L.; Brunker, Preston T.; Lindsay, Catherine C.; Yonemura, Nikol M.; Drummond, Micah J.

105. Functional overload-induced muscle hypertrophy and glucose uptake occurs independent of glucose transporter 4 (GLUT4) Shawna McMillin, Denise Schmidt, Barbara Kahn and Carol Witczak

106. Effect Of Resistance Exercise Training On Nutrient Sensing And Protein Synthesis In

Skeletal Muscle Of Older Adults Moro Tatiana, Brightwell Camille, Deer Rachel R, Fry Christopher S, Graber Theodor G, Galvan Elfego, Volpi Elena and Rasmussen Blake B

107. Pharmacological inhibition of mTOR and ERK ½ results in altered anabolic signaling of differentiated C2C12 myoblasts similar to that of in vivo Rat studies. O'Reilly, Colleen L., Deaver, J William, Fluckey, James D

108. Single Muscle Fiber Analysis Reveals a Fiber Type Selective Effect of a High Fat Diet on Glucose Uptake in Insulin-Stimulated Rat Epitrochlearis Muscle Pataky, Mark; Arias, Edward; Yu, Carmen; Ploutz-Snyder, Robert; Cartee, Gregory

109. Designing relevant in vitro models of muscle metabolism with inclusion of energy expenditure Snidow, Madeleine; Taylor, Caroline; Paton, Chad M.

110. 20-hydroxyecdysone and anabolic signaling following in vivo eccentric skeletal muscle

damage Rice, Tyler; Zwetsloot, Kevin A.; Shanely, R. Andrew

111. Insulin resistance does not impair functional overload-induced increases in muscle

hypertrophy or glucose uptake in mouse skeletal muscle Weyrauch, Luke; McMillin, Shawna; Turner, Kristen; Witczak, Carol

112. Lipidomics Associated Signaling Pathways In VCP Myopathy

Weiss, Lan; Llewellyn, Katrina; Nalbandian, Angele; Yu, Howard; Jung, Kwang; Piomelli, Daniele; Kimonis, Virginia.

Skeletal Muscle Aging: Metabolism and Function 113. Muscle Hypertrophy as a Novel Buffer against Obesity-Derived Hypertension

Butcher, Joshua T.; Larion, S.; Mintz, J.; Fulton, David J.; Stepp, David W. 114. A novel cage of weightlifting induces transcriptional, biochemical, cellular, contractile

and metabolic adaptations in mice Cui, Di; Wilson, Rebecca; Zhang, Mei; Yan, Zhen

115. Optogenetic therapy for skeletal muscle Todd, AG; Vaught, LA; Mahajan, B; Maruniak, S; Duncanson, L; Falk, DJ

116. Regional muscle architectural adaptations to concentric and eccentric training reflect different activation of mechanosensitive focal adhesion kinase Franchi, Martino

117. MyD88 promotes myoblast fusion during myogenesis

Yann S. Gallot, Sajedah M. Hindi, Jonghyun Shin, Guangyan Xiong, Ashok Kumar

118. Short term Regulation of myotube protein synthesis by IL-6 related cytokines Song Gao; James Carson

119. Castration Suppresses the Absolute Anabolic Response following High Frequency Muscle Contractions Gordon, Bradley S.; Steiner, Jennifer L.; Fukuda, David H.; Hoffman, Jay R.

120. Essential role of TAK1 signalosome in skeletal muscle growth and maintenance Hindi, Sajedah; Sato,Shuichi; Xiong,Guangyan; Kumar, Ashok

121. Locomotor Training with Adjuvant Testosterone Promotes Activity-Mediated Neuromuscular Plasticity in Spinal Cord Injured Rats Kok, Hui Jean; Yarrow, Joshua F; Phillips, Ean G; Conover, Christine F; Bassett, Taylor E; Vasconez, Andrea; Alerte, Jonathan; Prock, Hannah; Flores, Micah; Borst, Stephen E; Ye, Fan.

122. Post-eccentric exercise alcohol ingestion and LPS-stimulated cytokines in resistance-trained women Levitt, Danielle E.; Luk, Hui-Ying; Duplanty, Anthony A.; Hill, David W.; McFarlin, Brian K.; and Vingren, Jakob L.

123. Effect of the transient resistance exercise-induced hormonal response on satellite cell

activity: A Pilot Study. Hui-Ying Luk, Danielle E. Levitt, James C. Boyett, Sharon Rojas, Shawn M. Flader, Jakob L. Vingren

124. Impact of Mechanical Unloading and Subsequent Eccentric Contractions on Protein Synthesis and Anabolic Signaling in Rat Soleus Muscle Mirzoev Timur, Tyganov Sergey, Petrova Irina, Shenkman Boris

125. Muscle IGF-I Production is Critical for Functional Recovery of Skeletal Muscle Following Disuse Atrophy Ray A. Spradlin, George Vassilakos, Michael Matheny, Hanqin Lei, Matan Ozery, Elisabeth R. Barton

126. Gender Differentially Regulates Glucose Uptake And Glucose Transporter Protein Levels In Mouse Skeletal Muscle Turner, Kristen; McMillin, Shawna; Schmidt, Denise; Kahn, Barbara; and Witczak, Carol

127. Diaphragm hypertrophy following passive stretch: a role for titin-based

mechanosensing? Van der Pijl, Robbert-Jan; Lindqvist, Johan; Strom, Joshua; Granzier, Henk; Ottenheijm, Coen

Nutrition and Muscle Metabolism 128. LAT1 muscle-specific knockout impairs signaling responses to fasting and refeeding of

whey protein Aguirre, Nicholas; Wallace, Marita; Baar, Keith

129. Age-Related Changes in Muscle Mass: Evidence For A Common Aging Signature?

Baehr, Leslie M., Marcotte, George M., Marshall, Andrea G., West, Daniel W.D., Baar, Keith, and Bodine, Sue C.

130. Effects of Female Sex Hormones and Estrogen Receptors on Physical Activity in Mice Cabelka, Christine A., Collins, Brittany C., Spangenburg, Espen, Lowe, Dawn A.

131. The Impact of Chronological Age and Physical Activity on Mitochondrial Energetics,

Exercise Efficiency and Skeletal Muscle Performance

DiStefano, Giovanna; Standley, Robert A.; Zhang, Xiaolei; Carnero, Elvis A.; Cornnell, Heather H.;

Goodpaster, Bret H.; Coen, Paul M.

132. Estradiol Deficiency Impairs Satellite Cell Maintenance and Self-Renewal

Brittany C. Collins; Robert W. Arpke; Vineesha Kollipara; Espen E. Spangenburg; Michael Kyba; and

Dawn A. Lowe.

133. Mitochondrial respiratory capacity of skeletal muscle is related to physical function in

older adults with obesity

Distefano, Giovanna; Standley, Robert A.; Coen, Paul M.; and Goodpaster, Bret H.

134. Notch: A Regulator of Protein Synthesis?

Huot, Joshua; Lawrence, Marcus; Peck, Bailey; Marino, Joseph and Arthur, Susan

135. Redox regulation of muscle stem cell and its microenvironment Han, W., Anderson, S., Shin, E., Nakhai, S. Tran, T., Mohiuddin, M, Garcia, A.J., Willet, N., Wagers, A.J., Jang, Y.C.

136. Aged Skeletal Muscle Growth after Overexpression of an Enhanced-activity Mutant Glycogen Synthase Lawrence, Marcus M., Huot, Josh R., Shields, Michael, Skurat, Alex V., Roach, Peter J., Kane, Eric G., Reitzel, Adam M., Arthur, Susan T., and Gordon, Scott E.

137. Lower mitochondrial density in skeletal muscle from aged American Quarter Horses

Li, Chengcheng; White, Sarah; Warren, Lori; Wohlgemuth, Stephanie

138. Regulation of collagen expression in skeletal muscle following resistance exercise in young and aged rats. Marcotte, George. Hughes, David. West, Daniel. Baar, Keith.

139. Restitution of in vivo myofilament ultrastructure strengthens relationships between age-related molecular contractile dysfunction and decreased muscle power output Foster, Aurora D.; Ades, Philip A.; Maughan, David W.; Toth, Michael J.; Miller, Mark S.

140. A study of longitudinal and intermittent autophagy induction to increase function of dystrophic muscle. Pruzinsky Elizabeth, Panigel Jacqueline, Russell Alan, Kramer Fritz

141. Denervation-induced Modulation of Skeletal Muscle Mitochondrial Function in Frail/Pre-frail Elderly Women Sonjak, Vita; Vuda, Madhusudanarao; Miguez, Kayla; Spake, Carole; Wright, Kathryn J.; Perez, Anna; Morais, Jose A.; Taivassalo, Tanja; and Hepple, Russell T.

142. Examining the transitional extracellular matrix in aged and young human skeletal muscle

following lengthening contractions Sorensen, Jacob R., Holland, Alex, Sutton, Chris, Parcell, Allen C., Hyldahl, Robert D.

143. The influence of a ketogenic diet on longevity and skeletal muscle maintenance with aging

Wallace, MA; Hall, MH; López-Domínguez, JA; Marcotte, GR; Aguirre, NW; Marshall, AM; Perez, G; Tran, D; Gutiérrez-Casado, E; Zhou, Z; Kim, K; Knotts, TA; Tomilov, AA; Hagopian, K; Baar, K; Cortopassi, GA; Ramsey, JJ.

Mitochondria and Redox Biology 144. MnSod deficiency causes significant mitochondrial abnormalities and contractile

dysfunction in skeletal muscle but does not result in muscle atrophy Ahn, Bumsoo, Pharaoh, Gavin, Ranjit Rojina, Bhaskaran, Shylesh, Van Remmen, Holly

145. Attenuation of Mitophagy Exacerbates the Deleterious Effects of Statins on Skeletal Muscle Ramesh, Mridula; Campos, Juliane C.; Lee, Pam; Hernandez, Genaro; Tucker, Kyle C.; Islam, Moutusee J.; Sin, Jon; Gurney, Michael; Linton, Phyllis-Jean; Ferreira, Julio C.B.; Gottlieb, Roberta A.; Andres, Allen M.

146. Perm1 (PGC-1 and ERR-induced Regulator, Muscle 1) is required for exercise–induced

mitochondrial biogenesis and enhances oxidative capacity in skeletal muscle Cho, Yoshitake; Tachibana, Shizuko; Hazen, Bethany C.; Ross, Robert S.; Russell, Aaron P.; Kralli, Anastasia

147. gp130 Regulation of Muscle Mitochondrial Dynamics During Cancer Cachexia

Dennis K. Fix, Justin P. Hardee, Song Gao, Brandon N. VanderVeen, James A. Carson 148. Selective deletion of Nrf2 in skeletal muscle impairs exercise performance in mice

Gao, Lie; Hackfort, Bryan T; Zucker, Irving H; Schultz, Harold D 149. Diaphragm Muscle Adaptation and Antioxidant Levels in Heart Failure

Hackfort, Bryan T; Lewis, Robert; Gao, Lie; Zucker, Irving H; and Schultz, Harold D. 150. Deep Tissue Heating Increases Mitochondrial Respiratory Capacity of Human Skeletal

Muscle Hafen, Paul S.; Hancock, Chad R.; Hyldahl, Robert D.

151. Mitochondrial signaling facilitates repair of injured muscle fibers Horn, Adam; Van der Meulen, Jack H.; Defour, Aurelia; Hogarth, Marshall; Sreetama, SenChandra; Reed, Aaron; Scheffer, Luana; Chandel, Navdeep S.; Jaiswal, Jyoti K.

152. Weight loss and Exercise Induced Improvement in Insulin Sensitivity is Associated with Improved Mitochondrial Respiration in Skeletal Muscle of Older Obese Subjects Standley, Robert A.; DiStefano, Giovanna; Coen, Paul M.; Goodpaster, Bret H.

153. Mitochondrial Myopathy in Murine Sepsis Survivors with Long-Term Muscle Weakness

Steele, Allison M; Starr, Marlene E; Patel, Samirkumar P; Smith, Jeffrey D; Kaneki, Masao; Esser, Karyn; Rabchevsky, Alexander G.; Peterson, Charlotte A.; Saito, Hiroshi.

154. Mitochondria-targeted S-nitrosothiol, MitoSNO1, reduces mitochondrial oxidative stress

and preserves function of the sciatic nerve following hindlimb ischemia-reperfusion injury Wilson, Rebecca; Zhang, Mei; Murphy, Michael; Yan, Zhen

Monday, June 25- Thursday, June 28, 2018

The 2018 New Directions in Biology and Disease of Skeletal Muscle

Conference will be held in New Orleans, LA at the Westin New Orleans-Canal

Place. The eight biennial meeting is being organized by H. Lee Sweeney and

Elizabeth McNally. The conference will highlight current developments in

muscle biology, disease, and therapy with presentations by leading

international researchers.

Join us for a steamboat cruise down

the Mississippi River!

Visit our website at: http://myology.institute.ufl.edu/new-directions/

Email: NewDirections@health.ufl.edu

Save the Date: 2018 New Directions in Biology and Disease

of Skeletal Muscle Conference in New Orleans, LA!

T R A N S F O R M A T I O N ,

W I T H I N R E A C H T M

D I S C O V E R S A R E P T A . C O M

Sarepta Therapeutics is a

commercial-stage biopharmaceutical

company focused on discover y and

development of unique RNA-targeted

therapeutics for the treatment of rare

neuromuscular diseases . Our Company is

focused on rapidly advancing our

exon-skipping platform for the development of

treatments for Duchenne muscular dystrophy.

©2016 Sarepta Therapeutics, Inc. 215 First Street, Cambridge, MA 02142. All rights reserved.

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Sarepta, Sarepta Therapeutics, and the Sarepta logo are registered trademarks of Sarepta Therapeutics, Inc. “Transformation, Within Reach” is a trademark of Sarepta Therapeutics, Inc.

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17-RSRCH-00965 TRI Myology Conference Program Ad.indd 1 2/17/17 12:58 PM

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