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Pre Lab Session:Diseases of theRespiratory System
Jennifer J. Mananes, MDResidentDepartment of PathologyDLSUMC
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Diseases of the respiratory system
Alteration in lung expansion (Atelectasis) slide 107 Diseases of
vascular origin
Chronic Passive Congestion 79
Hemorrhagic infarction 104 ARDS 190 Pulmonary infections
Bronchopneumonia 70 Tuberculosis 72 Aspergillosis 185
Tumors Primary
Moderately differentiated squamous cell carcinoma 300
Bronchogenic carcinoma, large cell undiffiferentiated 109 Bronchial
carcinoid 213
Secondary Metastatic Choriocarcinoma, metastatic 165
Obstructive pulmonary disease (Bronchiectasis and Emphysema)
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Alteration in lung expansion
(Atelectasis)
Greek words ateles
and ektasis, ~incompleteexpansion.
Collapse/
compression of apreviously inflatedlung.
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Alteration in lung expansion
(Atelectasis) slide 107
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Atelectasis What x-ray finding differentiates obstructive from
compressive
atelectasis?
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Chronic Passive Congestion
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Chronic Passive Congestion
Brown induration
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Chronic Passive Congestion slide 79
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Hemorrhagic infarction slide 104
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Hemorrhagic infarction
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ARDS 190
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ARDS
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Bronchopneumonia slide 70
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Bronchopneumonia
Guide question:On the basis of themicroscopic pathology,explain
the occurrenceof rales inbronchopneumonia.
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Miliary tuberculosis
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Miliary tuberculosis (Slide no. 72)
Note the tubercles composed of
epithelioid cells, Langhans giantcells, and lymphocytes
Type of inflammation? Necrosis?Etiology?
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Aspergillosis
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Aspergillosis slide 185
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Squamous cell carcinoma
http://www.chinatraderonline.com/Lighters-Smoking-Accessories/Ashtrays/smokeless-ashtrays/Quit-Smoking-Ashtray-223149387.htmhttp://www.sciencephoto.com/image/253654/large/M1310688-Squamous_cell_carcinoma_lung_cancer-SPL.jpg
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Squamous cell carcinoma slide 300
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Squamous cell carcinoma
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Squamous cell carcinoma
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Undifferentiated large cell carcinoma (Slide 109)
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Bronchial carcinoid (Slide no. 213)
Note the nests of tumor cells surrounded by delicate
fibrocollagenized connective tissue stroma Cells are small and
uniform in size with scanty cytoplasm/ uniform cytologic pattern
What is the histogenesis of this tumor? What is carcinoid
syndrome?
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Metastatic choriocarcinoma (Slide 165)
Note the extensive hemorrhage
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Choriocarcinoma, metastatic
Cytotrophoblast vsSyncytiotrophoblast
Rounder with vesicularnuclei and prominentnucleoli
Spindlly, irregularly-shaped,and hyperchromatic nuclei
http://radiographics.rsna.org/content/22/1/189/F37.large.jpg
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Guide Question---Explain why the liver andthe lungs are the two
most frequentlyinvolved organs in hematogenous
metastaticcarcinoma.
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Obstructive pulmonary disease :
Emphysema
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Obstructive pulmonary disease :
Emphysema
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Obstructive pulmonary disease:
Emphysema
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Obstructive pulmonary disease:Bronchiectasis
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Bronchiectasis
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