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Pre Lab Session:Diseases of theRespiratory System

Jennifer J. Mananes, MDResidentDepartment of PathologyDLSUMC

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Diseases of the respiratory system

Alteration in lung expansion (Atelectasis) slide 107 Diseases of vascular origin

Chronic Passive Congestion 79

Hemorrhagic infarction 104 ARDS 190 Pulmonary infections

Bronchopneumonia 70 Tuberculosis 72 Aspergillosis 185

Tumors Primary

Moderately differentiated squamous cell carcinoma 300 Bronchogenic carcinoma, large cell undiffiferentiated 109 Bronchial carcinoid 213

Secondary Metastatic Choriocarcinoma, metastatic 165

Obstructive pulmonary disease (Bronchiectasis and Emphysema)

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Alteration in lung expansion

(Atelectasis)

Greek words ateles

and ektasis, ~incompleteexpansion.

Collapse/

compression of apreviously inflatedlung.

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Alteration in lung expansion

(Atelectasis) slide 107

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Atelectasis What x-ray finding differentiates obstructive from compressive

atelectasis?

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Chronic Passive Congestion

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Chronic Passive Congestion

Brown induration

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Chronic Passive Congestion slide 79

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Hemorrhagic infarction slide 104

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Hemorrhagic infarction

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ARDS 190

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ARDS

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Bronchopneumonia slide 70

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Bronchopneumonia

Guide question:On the basis of themicroscopic pathology,explain the occurrenceof rales inbronchopneumonia.

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Miliary tuberculosis

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Miliary tuberculosis (Slide no. 72)

Note the tubercles composed of

epithelioid cells, Langhans giantcells, and lymphocytes

Type of inflammation? Necrosis?Etiology?

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Aspergillosis

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Aspergillosis slide 185

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Squamous cell carcinoma

http://www.chinatraderonline.com/Lighters-Smoking-Accessories/Ashtrays/smokeless-ashtrays/Quit-Smoking-Ashtray-223149387.htmhttp://www.sciencephoto.com/image/253654/large/M1310688-Squamous_cell_carcinoma_lung_cancer-SPL.jpg

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Squamous cell carcinoma slide 300

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Squamous cell carcinoma

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Squamous cell carcinoma

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Undifferentiated large cell carcinoma (Slide 109)

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Bronchial carcinoid (Slide no. 213)

Note the nests of tumor cells surrounded by delicate fibrocollagenized connective tissue stroma Cells are small and uniform in size with scanty cytoplasm/ uniform cytologic pattern What is the histogenesis of this tumor? What is carcinoid syndrome?

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Metastatic choriocarcinoma (Slide 165)

Note the extensive hemorrhage

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Choriocarcinoma, metastatic

Cytotrophoblast vsSyncytiotrophoblast

Rounder with vesicularnuclei and prominentnucleoli

Spindlly, irregularly-shaped,and hyperchromatic nuclei

http://radiographics.rsna.org/content/22/1/189/F37.large.jpg

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Guide Question---Explain why the liver andthe lungs are the two most frequentlyinvolved organs in hematogenous metastaticcarcinoma.

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Obstructive pulmonary disease :

Emphysema

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Obstructive pulmonary disease :

Emphysema

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Obstructive pulmonary disease:

Emphysema

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Obstructive pulmonary disease:Bronchiectasis

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Bronchiectasis

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