Ppt Semsol Feby n Mukti

8/16/2019 Ppt Semsol Feby n Mukti

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FORMULASI PEMBUATAN SEDIAANSTERIL INJEKSI INTRA MUSKULAR

KLORPROMAZIN HCl

TEKNOLOGI SEDIAAN SEMI SOLID



Nama Kelompok

Feby K!ma De"# $%%&&'()*+Mk,# Ka-.#a"a,# $%%&&'()/+



La,a- Belaka.0

U.,k mempe-ole1 e2ek ya.0 leb#1 3epa,4 5#ba,la1

!e5#aa. CPZ #.6ek!# 7/ m08ml9 Se5#aa. #.# 5apa,la.0!.0 5#5#!,-#b!#ka. 5# 5alam ,b1 ka-e.a5#!.,#kka. ke 5alam pembl1 5a-a1 !e1#.00a 3epa,me.#mblka. e2ek ,e-ap# 5#ba.5#.0ka. !e5#aa. ,able,ya.0 1a-! me.0alam# pe.01a.3-a. ,e-leb#1 5a1lkem5#a. 5#ab!o-p!# 5# 5alam 0a!,-o #.,e!,#.al9



T6a.

Me.0e,a1# 3a-a pemba,a. #.6ek!# Klo-p-oma:#. ya.0ba#k 5a. be.a-

Memba.5#.0ka. 2o-mla!# #.6ek!# Klo-p-oma:#. ya.0aka. 5#ba, 5e.0a. 2o-mla!# 5a-# bebe-apa 6-.al,e-5a1l9



Se5#aa. I.6ek!#

Me.-, Fa-makope I.5o.e!#a E5#!# III4 #.6ek!# a5ala1!e5#aa. !,e-#l be-pa la-,a.4 eml!#4 !!pe.!# a,a!e-bk ya.0 1a-! 5#la-,ka. a,a 5#!!pe.!#ka.,e-leb#1 5a1l !ebelm 5#0.aka.4 ya.0 5#!.,#kka.

5e.0a. 3a-a me-obek 6a-#.0a. ke 5alam kl#, a,amelal# kl#, a,a melal# !elap, le.5#-9$FI9III9%;(;+

Se5a.0ka. me.-, Fa-makope I.5o.e!#a E5#!# I<4#.6ek!# a5ala1 #.6ek!# ya.0 5#kema! 5alam "a5a1 %))mL a,a k-a.09 Umm.ya 1a.ya la-,a. oba, 5alam a#-ya.0 b#!a 5#be-#ka. !e3a-a #.,-a=e.a9 S!pe.!# ,#5ak b#!a5#be-#ka. ka-e.a be-ba1aya ya.0 5apa, me.yebabka.pe.ymba,a. pa5a pembl1 5a-a1 kap#le-9 $FI9I<9%;;/+



I.,-am!kla-

I!,#la1 #.,-am!kla- $IM+ a5ala1 mema!kka.!e6mla1 :a,83a#-a. ke 5alam o,o, 5e.0a. 6a-m

!.,#k9 Ca#-a. ya.0 5#0.aka. b#a!a.ya 5alam 6mla1 ke3#l4 a.,a-a )4/>%) 33 R,e #.,-am!kla-me.y#apka. ke3epa,a. ak!# o.!e, !e5#k#, leb#1.o-mal 5a-#pa5a -,e #.,-a=e.a4 ,e,ap# leb#1 be!a-5a-#pa5a -,e !bk,a.



Ca-a Pemba,a. Se5#aa. S,e-#l

Cara aseptik :

D#0.aka. kala ba1a. oba,.ya ,#5ak 5apa, 5#!,e-#lka.4ka-e.a aka. -!ak a,a me.0-a#9

Cara non-aseptik ( NASTERIL ).

D#lakka. !,e-#l#!a!# ak1#-



E=ala!# Se5#aa. I.6ek!#

E=ala!# F#!#ka

E=ala!# B#olo0#

E=ala!# K#m#a



Pe-1#,.0a. I!o,o.#!

Bebe-apa 3a-a 5apa, me.6a5#ka. la-,a. #!o,o.#! ?

Pe.-.a. ,#,#k bek

@ $)4/7 a+ 8 b

@ 6mla1 $0+ ba1a. pemba., #!o,o.#3 5alam %)) ml la-,a.

a ,-..ya ,#,#k bek a#- ak#ba, :a, ,e-la-,4 5#1#,.0

5e.0a.mempe-ba.yak .#la# .,k la-,a.. % b8=9

b ,-..ya ,#,#k bek a#- ya.0 5#1a!#lka. ole1 % b8= ba1a.

pemba.,#!o,o.#!9

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.a,-#m klo-#5a map. ba1a. oba, be-a5a 5alam la-,a. be-=olme!ama9 Maka4 % 0-am ba1a. oba, ek#=ale. 5e.0a. ,eka.a. o!mo,#35a-# 0-am .a,-#m klo-#5a9 De.0a. ba.,a. ek#=ale.!# .a,-#m klo-#5a4k#,a5apa, me.01#,.0 =olme a#- ya.0 5#b,1ka. .,k memba, la-,a.ba1a.oba, #!o,o.#k9



Co.,#.e99

Ke!e,a-aa. =olme #!o,o.#39 Pe-1#,.0a. 5#5a!a-ka. pa5ake.ya,aa. ba1"a la-,a. #!o,o.#3 5#,amba1la-,a. #!o,o.#31a!#l.ya la-,a. #!o,o.#39

Rm! ? < " E %%%4%< =olme la-,a. ba1a. oba, #!o,o.#3 ya.0 5#3a-# $ml+

" ma!a ba1a. oba, $0+ 5a. la-,a. ya.0 5#ba,

E ek#=ale.!# .a,-#m klo-#5a

%%%4% =olme la-,a. #!o,o.#3 $ml+ ya.0 me.0a.5.0 %

0-am .a,-#mklo-#5a %%%4% ml



Pe-ba.5#.0a. Fo-mla

Nama Obat Formula 1 Formula Formula ! Formula " Fun#si

$lorproma%in

&Cl%) m0 7/ m0 7/ m0 7/ m0 Za, Ak,#2

Na' isulit > > % m0 % m0 A.,#ok!#5a.

NaCl > > m0 / m0 Pe.0#!o,o.#!

en%il Alko*ol > %/ m0 %/ m0 > Pe.0a"e,

As+orbi+ A+i, 7 m0 > 7 m0 > A.,#ok!#5a.

Aua .ro

In/e+tion

a5 %

mLa5 % mL a5 % mL A5 % mL Pela-,



Pemba1a!a.

Formula 1

Pa5a 2o-mla pe-,ama ba1a. ,amba1a. ya.0 5#0.aka.!a.0a, !e5#k#, ya#, a!3o-b#3 a3#5 ya.0 be-2.0!# !eba0a#a.,#ok!#5a. 5a. aab#5e!, !eba0a# pela-,9 Kek-a.0a.pa5a 2o-mla #.# ya#, ,#5ak me.00.aka. :a, pe.0#!o,o.#!a0a- ke,#ka :a, 5#!.,#kka. ke 5alam ,b1 ,#5ak ,e-lal!ak#,9



Co.,#.e99

Formula

Pa5a 2o-mla #.# ba1a. ,amba1a. ya.0 5#0.aka. 60a!e5#k#, ya#, be.:#l alko1ol ya.0 be-2.0!# !eba0a#

pe.0a"e, 5a. aab#5e!, !eba0a# pela-,9 Kek-a.0a.pa5a 2o-mla #.# ya#, ,#5ak me.00.aka. :a, pe.0#!o,o.#!a0a- ke,#ka :a, 5#!.,#kka. ke 5alam ,b1 ,#5ak ,e-lal!ak#,9 Hal #.# 5#ka-e.aka. 6#ka ko.!e.,-a!#.ya !ama be!a-5e.0a. ko.!e.,-a!# 5alam !el 5a-a1 me-a1 !e1#.00a ,#5ak,e-6a5# pe-,ka-a. 3a#-a. 5#a.,a-a ke5a.ya9 Pa5a 2o-mla

#.# 60a ,#5ak me.00.aka. a.,#ok!#5a. .,k me.6a0a!e5#aa. 5a-# -eak!# ok!#5a!#9



Co.,#.e99

Formula !

Pa5a 2o-mla #.# ba1a. ,amba1a. ya.0 5#0.aka.

3kp ba.yak ya#, komb#.a!# a.,#ok!#5a. .a,-#m b#!l2#,5a. a!3o-b#3 a3#54 be.:#l alko1ol !eba0a# pe.0a"e,4 NaCl!eba0a# :a, pe.0#!o,o.#!9 Kek-a.0a. pa5a 2o-mla #.#ya#, Na9 B#!l2#, 5apa, be-eak!# 5e.0a. be.:#l alko1ol9Se1a-!.ya :a,>:a, ,amba1a. ya.0 5#0.aka. ,#5akbe-eak!# ba#k ,e-1a5ap "a5a1 map. ,e-1a5ap ba1a.

,amba1a. la#..ya9



Co.,#.e99

Formula aru

Pa5a 2o-mla #.# ba1a. ,amba1a. ya.0 5#0.aka. 3kp!e5e-1a.a ya#, Na me,ab#!l2#, be-2.0!# !eba0a#a.,#ok!#5a. ka-e.a klo-p-oma:#. !a.0a, m5a1 ,e-ok!#5a!#

5a. pH -e.5a1 !e1#.00a 5#0.aka. pla a.,#ok!#5a. 5e.0a.pH -e.5a19 Na be.:oa, be-2.0!# !eba0a# pe.0a"e, ka-e.a!,e-#l#!a!# klo-p-oma:#. me.00.aka. me,o5e a!ep,#!4 ya#,!,e-#l#!a!# 5e.0a. 3a-a 2#l,-a!# memb-a. !e1#.00a 5#b,1ka.!a, pe.0a"e,9 S,ab#l#,a! klo-p-oma:#. HCl aka. ,e-ok!#5a!#ole1 ka-e.a #, 5#b,1ka. !a, a.,#ok!#5a. a.,a-a la#. ?

a!3o-b#3 a3#54 Na,-#m b#!l2#,e 5a. Na,-#m Sl2#,e9 Na,-#mB#!l2#,e !eba0a# a.,#ok!#5a. ka-e.a !,ab#l pa5a pH &>/ 5a.,#5ak OTT ,e-1a5ap Klo-p-oma:#. HCL 5a. 60a !eba0a# a.,#m#k-oba9 Ab#5e!, 5#0.aka. !eba0a# pela-,9



Ke!#mpla.

I.6ek!# a5ala1 !e5#aa. !,e-#l be-pa la-,a.4 eml!#4 !!pe.!# a,a!e-bk ya.0 1a-! 5#la-,ka. a,a 5#!!pe.!#ka. ,e-leb#1 5a1l!ebelm 5#0.aka.4 ya.0 5#!.,#kka. 5e.0a. 3a-a me-obek 6a-#.0a.ke 5alam kl#, a,a melal# kl#, a,a melal# !elap, le.5#-9

S,e-#l#!a!# me-paka. p-o!e! ya.0 5#-a.3a.0 .,k me.3#p,aka.

kea5aa. !,e-#l9 S,e-#l #.# !e.5#-# mem#l#k# mak.a ya.0 be-a-,# !a,kea5aa. 5# ma.a ,e-6a5# pa5a ko.5#!# ko.o,a!# -ela,#=e4a,ap. pa5ako.5#!# m,lak beba! 5a-# o-0a.#!me9 Se5#aa. !,e-#l 5apa, be-be.,kpa5a, !,e-#l4!em# pa5a,43a#-9

Klo-p-oma:#.e me-paka. oba, a.,#p!#ko,#k ,-.a. p1e.o,#a:#.e9P-#.!#p e2ek 2a-makolo0#.ya a5ala1 !eba0a# p!#ko,-op#k 5a. #a 60amemp.ya# e2ek !e5a,#2 5a. a.,#>eme,#k

S,e-#l#!a!# klo-p-oma:#. me.00.aka. me,o5e a!ep,#!4 ya#, !,e-#l#!a!#5e.0a. 3a-a 2#l,-a!# memb-a. !e1#.00a 5#b,1ka. !a, pe.0a"e,

Ca-a Pemba,a. Se5#aa. S,e-#l I.6ek!# Klo-p-oma:#. ya#, 5e.0a. 3a-aa!ep,#k 5a. 3a-a .o.>a!ep,#k $ Na!,e-#l +





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Ppt Semsol Feby n Mukti