Pharmacogenomic Approach Paving the Way for Personal is Ed Drugs

8/3/2019 Pharmacogenomic Approach Paving the Way for Personal is Ed Drugs

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PHARMACOGENOMIC APPROACH;

PAVING THE WAY FOR

PERSONALISED DRUGSFOR ASTHMA

BY

SAHITHI . GADDEK.V.S.R.SIDDARTHA COLLEGE OF PHARMACEUTICAL

SCIENCES ,

VIJAYAWADA.



DEFINITION OF ASTHMA

• Asthma is a chronic inflammatory disorder of the airways ofthe lungs.

• Many cells and cellular elements including mast cells,eosinophils, T-lymphocytes, macrophages, neutrophills andepithelial cells are involved in the process.

• It affects nearly 155 million individuals across the world.

• In India 10-15% of the population particularly women andchildren were found to be affected by atopic asthma.



CLASSIFICATION• It is classified as;

1. Atopic (symptoms are precipitated

by allergens)2. Non-atopic (symptoms are not

precipitated by allergens)





SYMPTOMS

• Wheezing (high pitched whistling soundswhen breathing out-especially in children)

•

Breathlessness • Chest tightness

• Coughing

- these symptoms are particularlyobserved in night and in early mornings.





Causes for asthma • The infiltration of leukocytes

particularly eosionphils in to the

lungs and release of vaso activemediators from mast cells set thestage for asthamatic inflammation.



Two functional alterations aretypically associated with

asthma;• These include variable air way obstruction of

bronchial hyper responsiveness. The narrowingof the airways is associated with smooth muscle

contraction, airway wall thickening, edema andincreased mucus secretion.

• Along with these there is a denudation of theair way epithelium and collagen deposition

beneath the basement membrane.



BIOCHEMICAL PATHWAYSINVOLVED IN THE

PATHOGENESIS OF ASTHMA



• Studies over last 25 years have clearlydemonstrated that both genetic and environmental factors determine the

phenotypic expression of asthma.



• Asthma is a complex disorder of multi

factorial origin.• Atopic asthma in children is found to be

strongly familial and genetic basis.

•

In addition to genes of asthmaenvironmental factors such as allergens,food, childhood viral infection, alsoplays a significant role in causingasthma.





Genes contributing to asthma



CURRENT MODE OF

ASTHMA THERAPY• Large number of drugs are available for

the treatment of asthma.

•

Theanti-leukotrienes

are the newest class ofanti asthmatic drugs available. They helpto control symptoms of asthma.

• Corticosteroids are the anti inflammatory

drugs of choice.





FUTURE PERSPECTIVE





ACKNOWLEDGEMENT • A.PRAMEELA RANI

• N.KANAKA DURGA DEVI

• K.NAVEEN BABU

• KVSR SIDDARTHA COLLEGE OF PHARMACEUTICALSCIENCES,

VIJAYAWADA.



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Pharmacogenomic Approach Paving the Way for Personal is Ed Drugs