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SUPPORTING INFORMATION
Solution-Phase Synthesis of Pyrrole-Imidazole Polyamides
David M. Chenoweth, Daniel A. Harki, and Peter B. Dervan* Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125
Table of Contents for Supporting NMR Spectra
Compound Page 1H NMR of HCl•H2N-Py-CO2Me (10) S2 13C NMR of HCl•H2N-Py-CO2Me (10) S3 1H NMR of BocHN-PyPy-CO2Me (11) S4 13C NMR of BocHN-PyPy-CO2Me (11) S5 1H NMR of HCl•H2N-PyPy-CO2Me (12) S6 13C NMR of HCl•H2N-PyPy-CO2Me (12) S7 1H NMR of BocHN-PyPyPy-CO2Me (13) S8 13C NMR of BocHN-PyPyPy-CO2Me (13) S9 1H NMR of HCl•H2N-PyPyPy-CO2Me (4) S10 13C NMR of HCl•H2N-PyPyPy-CO2Me (4) S11 1H NMR of ImPyPyPy-CO2Me (14) S12 13C NMR of ImPyPyPy-CO2Me (14) S13 1H NMR of ImPyPyPy-CO2H (3) S14 13C NMR of ImPyPyPy-CO2H (3) S15 1H NMR of BocHN-(R) -CbzHN -Im-CO2Et (15) S16 13C NMR of BocHN-(R) -CbzHN -Im-CO2Et (15) S17 1H NMR of HCl•H2N-(R) -CbzHN -Im-CO2Et (5) S18 13C NMR of HCl•H2N-(R) -CbzHN -Im-CO2Et (5) S19 1H NMR of ImPyPyPy-(R) -CbzHN -Im-CO2Et (16) S20 13C NMR of ImPyPyPy-(R) -CbzHN -Im-CO2Et (16) S21 1H NMR of ImPyPyPy-(R) -CbzHN -Im-CO2H (17) S22 13C NMR of ImPyPyPy-(R) -CbzHN -Im-CO2H (17) S23 1H NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-CO2Me (2) S24 13C NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-CO2Me (2) S25 1H NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-CO2H (22) S26 13C NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-CO2H (22) S27 1H NMR of BocHN-(+)-BnOIPA (20) S28 13C NMR of BocHN-(+)-BnOIPA (20) S29 1H NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-(+)-BnOIPA (23) S30 13C NMR of ImPyPyPy-(R) -CbzHN -ImPyPyPy-(+)-BnOIPA (23) S31 1H NMR of ImPyPyPy-(R) -H2N -ImPyPyPy-(+)-IPA (1) S32 13C NMR of ImPyPyPy-(R) -H2N -ImPyPyPy-(+)-IPA (1) S33
S1
NH2•HCl
NMeO2C
S2
NH2•HCl
NMeO2C
S3
NHBoc
NO
HN
NMeO2C
S4
NHBoc
NO
HN
NMeO2C
S5
NH2•HCl
NO
HN
NMeO2C
S6
NH2•HCl
NO
HN
NMeO2C
S7
NHBoc
NO
HN
NO
HN
NMeO2C
S8
NHBoc
NO
HN
NO
HN
NMeO2C
S9
NH2•HCl
NO
HN
NO
HN
NMeO2C
S10
NH2•HCl
NO
HN
NO
HN
NMeO2C
S11
MeO2C
N
NO
HN
NO
HN
NO
HN
N
S12
MeO2C
N
NO
HN
NO
HN
NO
HN
N
S13
HO2C
N
NO
HN
NO
HN
NO
HN
N
S14
HO2C
N
NO
HN
NO
HN
NO
HN
N
S15
N
NEtO2C
HN
O
NHBocNHCbz
S16
N
NEtO2C
HN
O
NHBocNHCbz
S17
N
NEtO2C
HN
O
NH2•HClNHCbz
S18
N
NEtO2C
HN
O
NH2•HClNHCbz
S19
N
NEtO2C
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NHCbz
S20
N
NEtO2C
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NHCbz
S21
N
NHO2C
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NHCbz
S22
N
NHO2C
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NHCbz
S23
N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
MeO2C
NHCbz
S24
N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
MeO2C
NHCbz
S25
N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
HO2C
NHCbz
S26
N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
HO2C
NHCbz
S27
BocHN N NH
O
OBn
O
S28
BocHN N NH
O
OBn
O
S29
N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
HN
O
NHCbz
N
HN
O
O OBn
S30
dmso
N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
HN
O
NHCbz
N
HN
O
O OBn
S31
N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NH3
O
HNHN
HN
O
O O
CF3CO2H salt
S32
N
NO
HN
NO
HN
NO
HN
N
HN
O
NH
O
N
NO
NH
NO
NH
NO
NH
N
NH3
O
HNHN
HN
O
O O
CF3CO2H salt
S33