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FUNGAL DISEASES

dr erly SpMK 

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Principal function of MCI defence againstm.o survive and growth intracellular

Mediator of DTH

clinical test for fungalinfection

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CMI immunity against fungi Antifungal antibodies without protective

eect

!ungi

 prominent opportunistic pathogensendogenous micro"ora candida

Depression of the CMI response spread andgrowth of fungi commonly present in the

environment#Aspergillus$candida$mucor..%

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Mucocutaneous candidiasisgeneralisedinfection with C.albicans

& immunosuppressive drugs

  & infant

de'cient thymus function  & AID( immunode'ciency

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Mycoto)icoses

fungisecondary metabolitesto)iccompound

mushroomAspergillus "avus a"ato)in#carcinogen%

Hypersensitivity

*fungal spore count+air pollution

,hinitis$bronchial asthma

Diseases

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Pathogenic !ungal Immunocompetent humans high innate

resistance to fungi

Infection and disease occure whendisruptions in the barrier of the s-in andmucous membrane or defect immunesystem

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Dermatophytes

-eratinasehydrolied -eratin Candida

become 'lamentous whwn infade tissues Dimorphic fungi

systemic mycoses

Cryptococcus

neoformanscapsule#virulence factor%

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/. (uper'cial mycoses

(tratum corneum

 Tinea versicolor

0. Cutaneous mycosesDermatopytes

delicate balance host& parasite

& invasive properties

& in"matory reaction

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1. (ubcutaneous mycoses

traumatic in2ury

Infection deeper layer of the

dermis$subcutaneous tissue$or boneChronic infection

Agent in the soil on decaying vegetation

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3. (ystemic mycoses Histoplasmosis

inhalation of conidia4hypha

Histoplasma capsulatumsoil with high nitrogen content

Cryptococcosis

Cryptococcus neoformans#capsule%

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5. 6pportunistic mycoses

& Candidiasis

& Aspergillosis

Chronic mucocutaneous candidiasis#CMC%Disseminated candidiasis

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Aspergillosis

Allergic aspergillosis

*fungus ball+#in chronic clinical situation%

(ystemic aspergillosis

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 T7 , I M A 8 A ( I H