Pathways Newsletter, Summer 2013

TULANE UNIVERSITY HEALTH SCIENCES CENTER

DEPARTMENT OF PATHOLOGY AND LABORATORY MEDICINE

PATHWAYS

MESSAGE FROM THE CHAIRMAN

NEWSLETTER VOLUME 4, ISSUE 1 SUMMER 2013

Dear Colleagues:

As we are entering the 2013-2014 academic year,

the Department warmly welcomes the new resi-

dents and fellows and wishes those who have just graduated

from the residency and fellowship programs continued success

in their learning and future endeavors. The recent departmen-

tal graduation ceremony was a memorable event to express

our congratulations and best wishes to the graduates and to

thank the faculty and staff for their commitment to excellence

in teaching and mentoring. With the excellent contributions

from all members of the department, including the faculty,

staff, fellows, residents and students, we have successfully

achieved our objectives in teaching, research and clinical ser-

vices during the past academic year. I believe that now we are

poised to an even more successful next academic year.

Have a great summer!

2013 COMMENCEMENT CEREMONY

Andrea’s Restaurant was the setting for the annual Depart-

ment of Pathology Residents-Fellows graduation reception held

May 6, 2013. The festivities also included an awards ceremony

that recognizes the achievements of the past school year attained

by both faculty and residents.

Dr. Tong Wu, Chairman of the Department of Pathology,

opened the ceremony by presenting the Outstanding Graduate

Student Award to Michael Strong who performs research work in

the lab of Dr. Erik Flemington. Dr. Kyoung-Sub Song, who works

in Dr. Wu’s lab, was given the Outstanding Post Doctoral Fellow

Award by Dr. Wu (see photo below).

Receiving certificates that marked

the successful end of their fellowship

were Cytopathology fellow Dr. Sharon

Hirsh; Dermatopathology fellows Drs.

Christine Lin and Nicholas Whitling;

and Dr. Kirk Bourgeois, the Hematopa-

thology fellow.

Drs. Van Vo and Jonathan Stone,

who were graduating from their resi-

dency, were presented certificates and

books by Residency Program Director,

Dr. Janet Schmid. Vice-Chairman of the Department, Dr. Byron

Crawford bestowed Chief Resident Dr. Stone with the Richard J.

Reed Award for excellence in the performance of his duties as a

resident.

PATHWAYS NEWSLETTER SUMMER 2013 Page 2


COMMENCEMENT

(continued)

The annual Philip J. Daroca Award for

Excellence in Residency Education was

awarded to Dr. Krzysztof Moroz by Dr.

Stone. Dr. Suzanne Meleg-Smith, Director

of Autopsy Service, presented the Roki-

tansky Award for Excellence in Autopsy to

first year resident, Dr. John Scopetta. The

festivities concluded with Dr. Schmid an-

nouncing the names of the new residents

and fellows who would join the Department at the beginning of the

new fiscal year (see Page 5 ).

Above left: (Left to right) Dr. Erik Flemington and graduate student Mi-

chael Strong. Below: Pathology Graduates (from left to right): Drs.

Kirk Bourgeois, HemePath Fellow; Sharon Hirsh, Cytopath Fellow;

Christine Lin, Dermpath Fellow; Residents Drs. Van Vo and Jonathan

Stone (Richard J. Reed Award for Excellence in Residency); Dr. Nicholas

Whitling, Dermpath Fellow (rear row).

COMMENCEMENT (continued)


Top Left: Drs. Christine Lin, Alun Wang (Director of Der-

matopathology Fellowship), and Nicholas Whitling.

Top Right: Dr. Janet Schmid, Director of Residency Pro-

gram and Hematopathology Fellowship, with Dr. Kirk

Bourgeois.

Bottom Left: Cytopathology Fellowship Director Dr.

Krzysztof Moroz with Dr. Sharon Hirsh. Bottom Right:

Dr. John Scopetta (Rokitansky Award Winner for Excel-

lence in Autopsy).

WELCOME NEW FELLOWS AND RESIDENTS

Pathways Newsletter SUMMER 2013 Page 5

Dr. Ronnie Self,

Chief Resident

2013-2014

First Year Residents (Left to right): Drs. Meggie Doucet, Eleanor Lewin and

Nathaniel McLaughlin.

Dr. Xianmin Meng,

Dermatopathology

Fellow

Dr. Janet McNaughton,

Hematopathology

Fellow

Dr. Janese Trimaldi

Cytopathology Fellow

GERBER LECTURE

Dr. Gregory Gores (seen right),

the Reuben R. Eisenberg Profes-

sor, Chair, Division of Gastroen-

terology and Hepatology at the

Mayo Clinic College of Medicine,

presented the 13th annual Dr. & Mrs. Michael A. Gerber

Memorial Lecture on April 3, 2013. Speaking on “Emerging

Therapeutic Concepts for Cholangiocarcinoma,” the lecture

was also a featured part of Tulane University HSC Research

Days.

PATHWAYS Newsletter SUMMER 2013 Page 6

SPECIAL LECTURES

STERNBERG-REED LECTURE

Speaking on the topic, “Mesenchymal Le-

sions of the Gastrointestinal Tract—New

and Old Observations,” Dr. Elizabeth

Montgomery (seen right), Professor of Pa-

thology, Oncology and Orthopedic Surgery

at Johns Hopkins University, delivered the

third annual Sternberg-Reed Lecture on

October 19, 2012. Dr. Montgomery like-

wise conducted two resident slide reviews

with LSU and Tulane pathology services.

WINNER OF THE

2013 GERBER

AWARD

BEIBEI XU, MOR-

RIS LAB GRAD

STUDENT (SEEN

LEFT).


Bhandary YP, Shetty SK, Marudamuthu AS, Ji HL, Neuen Schwander PF, Boggaram V, Morris GF, Fu J, Idell S, Shetty S. Regulation of Lung Injury and Fibrosis by p53-Mediated Changes in Urokinase and

Plasminogen Activator Inhibitor-1. American Journal of Pathology 183,

May 8. pii: S0002-9440 (13)00283-6. PMID: 23665346.

Shackelford R, Hirsh S, Henry K, Abdel-Maged A, Kandil Coppola D.

Nicotinamide Phosphoribosyltransferase and SirT3 Expression are Increased in Well-Differentiated Thyroid Carcinomas. Anticancer

Research, in press.

Mayhall K, Ghayouri M, Henry K, Margin V, Coppola D,

Shackelford R. A Thirty-Five-Year-Old Woman with Gastric Signet Ring Cell Carcinoma Secondary to the Chernobyl Nuclear Accident: A Case

Report. Case Reports in Oncology, 2013; 6:158-162.

Shackelford R, Jackson K, Gocke CD. Liquid Bead Array Technology in the Detection of Common Translocations in Acute and Chronic Leuke mias, in press in the series of Methods in Molecular Biology,

edition on Hematological Malignancies, vol. 999, 2013, Chapter 6.

Abd Elmageed Zy, Moroz K, Srivastay SK, Fang Z, Crawford BE, Moparty K, Thomas R, Abdel-Mageed AB. High Circulating Estrogens

and Selective Expression of erβ in Prostate Tumors; Implications for Racial Disparity of Prostate Cancer.Carcinogenesis 2013 May.

PMID: 23658372

Lin Z, Wang X, Strong MJ, Concha M, Baddoo M, Xu G, Baribault, C Fewell C, Hulme W, Hedges D, Taylor CM, Flemington EK. Whole-genome sequencing of the Akata and Mutu Epstein-Barr virus strains.

J Virol. 2013 Jan;87(2):1172-1182. PMID: 23152513

PUBLICATIONS


Fang Z, Du R, Edwards A, Flemington EK, Zhang K. The sequence

structure of human micro-RNA molecules and their implications. PLoS

One. 2013; 8(1):e54215. PMID: 23349828

Wang Y, Han C, Lu L, Magliato S, Wu T. Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. 2013

Mar 16. Doi: 10.1002/hep.26394. PMID: 23504944

Song K, Han C, Zhang J, Lu D, Dash S, Feitelson M, Lim K, Wu T. Epi-

genetic Regulation of miR-122 by PPARγ and hepatitis B virus X protein in hepatocellular carcinoma cells. Hepatology. 2013 May 23. Doi:

0.1002/hep.26514. PMID: 23703729

Zhuang Y, Wang X, Nguyen HT, Zhou Y, Cui X, Flemington EK, Shan B.

Induction of long intergenic non-coding RNA HOTAIR in lung cancer by Type I collagen. J Hematol Oncol. 2013 May 13: 6:35. Doi:

10.1186/1756-8722-6-5-. PMID: 23668363.

Zhang J, Han C, Zhu H, Song K, Wu T. MicoRNA-101 Inhibits

Cholangiocarcinoma Angiogenesis through Targeting Vascular Endothelial Growth Factor (VEGF). Am J Pathol. 2013 May;182(5):1629-1639. PMID: 23608225

Onyeagucha BC, Mercado-Pimentel ME, Hutchison J, Flemington EK,

Nelson MA. S100P/RAGE signaling regulates microRNA-155 expression via AP-1 activation in colon cancer Exp Cell Res. 2013 May 18. doi:pii: S0014-4827(13) 00215-2. 0.1016/j.yexcr.2013.05.009. [Epub

ahead of print] PMID: 23693020

Palacios E, Quiroz-Casian A, Garaza Garcia L, Daroca PJ, Neitzchman

HR. Adult case of large sinonasal embryonal rhabdomyosarcoma with intracranial extension.Ear Nose Throat J. 2013 Apr-May;92-(4-5):177-

178.PMID: 23599096

PUBLICATIONS (Continued)


Lu D, Han C, Wu T. 15-PGDH inhibits hepatocellular carcinoma growth

through 15-keto-PGE2/PPARγ-mediated activation of p21WAF1/Cip1.Oncogene. 2013 Apr 1. Doi: 10.1038/onc.2013.69. PMID:

23542179

Lu D, Han C, Wu T. 15-hydroxyprostaglandin dehydrogenase (15-PGDH)-derived 15-keto-PGE2 inhibits cholangiocarcinoma cell growth through interaction with PPARу, SMAD2/3 and TAP63. J Biol Chem.

2013 May 16. PMID: 236837300

Alraiyes AH, Kheir F, Hirsh S, Salerno S, Bernal-Green Ly, Daroca P. A 40-Year-Old Woman With Multiple Lung Nodules. Chest. 2013; 143 (6):

1826-1829. doi: 10.1378/chest. 12-1795.

Kutty RK, Nagineni CN, Samuel W, Vijayasarathy C, Jaworsky C, Dun can T, Cameron JE, Flemington EK, Hook JJ, Redmond TM.

Differential regulation of microRNA-146a and microRNA-146b-5p in human retinal pigment epithelial cells by interlukin-1β tumor necrosis factor-α and interferon-gamma. Mol. Vis. 2013 Apr 3; 19:737-50. Print

2013. PMID: 23592910

Sides MD, Sosulski ML, Luo F, Lin Z, Flemington EK, Lasky JA. Co- treatment with arsenic trioxide and ganciclovir reduces tumor volume in a murine xenograft model of naso-pharyngeal carcinoma. Virol J.

2013 May 16;10:152. doi: 10.1186/1743-422X-10-152. PMID:

23680002

Strong MJ, Xu G, Coco J, Baribault C, Vinay DS, Lacey MR, Strong AL, Lehman TA, Seddon MB, Lin Z, Concha M, Baddoo M, Ferris M,

Swan KF, Sullivan DE, Burow ME, Taylor CM, Flemington E. . Differences in Gastric Carcinoma Microenvironment Stratify According to EBV Infection Intensity: Implications for Possible Immune Adjuvant

Therapy. PLoS Pathog.2013 May;9(5):e1003341. d o i : 1 0 . 1 3 7 1

Journal.ppat.1003341. Epub 2013 May 9. PMID: 223671415



Marsolier J, Pineau S, Medjkane S, Perichon M, Yin Q, Flemington E, Weitzman MD, Weitzman JB. OncomiR addiction is generated by a MiR

155 feedback loop in Theileria-transformed leuokocytes. PLos Pathog. 2013 Apr; 9(4):e100322. doi: 10.1371/journal.ppat.103222.

Epub 2013 Apr 18.

Whitling NA, Shanesmith RP, Jacob L, McBurney E, Siby S, Wang E,

Wang AR. Composite lymphoma of mycosis fungoides and cutaneous small B-cell lymphoma in a 73-year-male patient. Human Pathology.

2013; 44(4):670-675

Zhan Y, Cao B, Qi Y, Liu S, Zhou W, Xu D, Lu H, Sartor O, Kong W,

Zhang H, Dong Y. Methylselenol pro-drug enhances MDV3100 efficacy for treatment of castration-resistant prostate cancer. Int J Cancer 2013

Apr 11. Doi: 10>1002/ ijc.28202. PMID: 23575870

Cao B, Liu X, Li J, Qi y, Ziong Z, Zhang A, Wiese T, Fu X, Gu J, Rennie

PS, Sartor O, Lee BR, Ip C, Zhao L, Zhang H, Dong Y. 20(S)-proto panazadiol-aglycone downregulation of the f full-length and splice variants of androgen receptor. I Int J Cancer. 2013

Mar 15; 132 (6):1277-87. doi: 10.1002/ijc.27754


Tong Wu, M.D., Ph.D,

Chairman

Byron Crawford, M.D.,

Vice-Chairman

The Department of Pathology

1430 Tulane Avenue

Room 6519, SL-79

New Orleans, LA

70112

Phone: 504-988-5224

Fax: 504-988-7862

Editor: Jeanne Frois

Documents

Pathways Newsletter, Summer 2013