12

Ondansetron + dexamethasone controls cispIatin-induced emesis better than ondansetron alone

Ondansetron + dexamethasone therapy was shown ' ... to giJ1~ t"~ "ig"~st rat~ 0/ comp/~t~ protwioll ~J1~r /oulld ill II IIlrg~ double-blind comPilrati,~ study Oil prop"yltu:tic therllpy 0/ CDDP /cispllltillj-inducu ~muu.'

Ondansetron + dexamethasone provided significantly better control of cisplatin-induced nausea and vomiting than ondansetron alone, producing complete protection in 72/89 (80.9%) patients compared with 50/89 (56.2%) patients who received ondansetron monotherapy. Complete protection from vomiting and nausea, respectively, occurred in 81 and 79 patients during combination therapy, and in 57 and 59 patients during ondansetron monotherapy. Failure of treatment (~ 6 emetic episodes) occurred in 8 patients all of whom were receiving ondansetron only. Dexamethasone + ondansetron was preferred by 74% of those patients who expressed a preference, as it was significantly superior in reducing the intensity and duration of emesis.

89 evaluable patients received IV ondansetron 0.15 mg/kg + either dexamethasone 20mg or saline prior to cisplatin therapy, followed by a further 2 doses of ondansetron, in a crossover study. Roila F, Tonato M, Cognetti F, Cortesi E, Favalli G, et al. Prevention of cisplatin-induced emesis: a double-blind multicenter randomized crossover study comparing ondansetron and ondansetron plus dexamethasone. Journal of Clinical Oncology 9: 675-678, Apr 1991 .".

25 Mq 1991 INPHARMA- ISSN 0156-2703/91/0525-oo12/0J01.oo/0 c A.da I"""",t;olllll Ltd