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PRESSMEDDELANDE  Press release BOX 50005, SE-104 05 STOCKHOLM, SWEDEN TEL +46 8 673 95 00, FAX +46 8 15 56 70, [email protected] HTTP://KVA.SE BESÖK/VISIT: LILLA FRESCATIVÄGEN 4A, SE-114 18 STOCKHOLM, SWEDEN The Nobel Prize in Chemistry 2010 The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2010 to Akira Suzuki Hokkaido University, Sapporo, Japan Richard F. Heck University of Delaware, Newark, DE, USA, Ei-ichi Negishi Purdue University, West Lafayette, IN, USA Organic chemistry has developed into an art form where scientists produce marvelous chemical crea- tions in their test tubes. Mankind benets from this in the form of medicines, ever-more precise electronics and advanced technological materials. The Nobel Prize in Chemistry 2010 awards one of the most sophisticated tools available to chemists today. This year’s Nobel Prize in Chemistry is awarded to Richard F. Heck, Ei-ichi Negishi and Akira Suzuki for the development of palladium-catalyzed cross coupling. This chemical tool has vastly improved the possibilities for chemists to create sophisticated chemicals, for example carbon-based molecules as complex as those created by nature itself. Carbon-based (organic) chemistry is the basis of life and is responsible for numerous fascinating natural pheno- mena: colour in owers, snake poison and bacteria killing substanc es such as penicillin. Organic chemistry has allo- wed man to build on nature’s chemistry; making use of carbon’s ability to provide a stable skeleton for functional molecules. This has given mankind new medicines and revolutionary materials such as plastics. In order to create these complex chemicals, chemists need to be able to join carbon atoms together. However, carbon is stable and carbon atoms do not easily react with one another. The rst methods used by chemists to bind carbon atoms together were therefore based upon various techniques for rendering carbon more reactive. Such met- hods worked when creating simple molecules, but when synthesizing more complex molecules chemists ended up with too many unwanted by-products in their test tubes. Palladium-catalyzed cross coupling solved that problem and provided chemists with a more precise and efcient tool to work with. In the Heck reaction, Negishi reaction and Suzuki reaction, carbon atoms meet on a palladium atom, whereupon their proximity to one another kick- starts the chemical reaction . Palladium-catalyzed cross coupling is used in research worldwide, as well as in the commercial production of for example pharmaceuticals and molecules used in the electronics industry. Richard F. Heck , American citizen. Born 1931 in Springeld, MA, USA. Ph.D. 1954 from University of California Los Angeles (UCLA), CA, USA. Willis F. Harrington Professor Emeritus at University of Delaware, Newark, DE, USA. Ei-ichi Negishi , Japanese citizen. Born 1935 in Changchun, China (former Japan). Ph.D. 1963 from University of Pennsylvania, Philadelphia, PA, USA. Herbert C. Brown Distinguished Professor of Chemistry at Purdue University, West Lafayette, IN, USA. www.chem.purdue.edu/negishi/index.htm Akira Suzuki, Japanese citizen. Born 1930 in Mukawa, Japan. Ph.D. 1959, Distinguished Professor Emeritus, both at Hokkaido University, Sapporo, Japan. Prize amount: SEK 10 million to be shared equally between the L aureates. Further information: http://kva.se and http://nobelprize.org Contacts: Erik Huss, Press Of cer, Phone +46 8 673 95 44, +46 70 673 96 50, [email protected] Annika Moberg, Editor, Phone +46 8 673 95 22, +46 70 263 74 46, annika.moberg@k va.se The Royal Swedish Academy of S ciences, founded in 1739, is an independent organization whose overall objecti ve is to promote the sciences and strengthen their inuence in society. The Academy takes special responsibility for the natural sciences and mathematics, but endeavours to promote the exchange of ideas between various disciplines. Great art in a test tube “for palladium-catalyzed cross couplings in organic synthesis”. 6 October 2010 N o b e l  P r i z e ®  i s  a  r e g i s t e r e d  t r a d e m a r k  o f  t h e  N o b e l  F o u n d a t i o n .  and

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PRESSMEDDELANDE

  Press release

BOX 50005, SE-104 05 STOCKHOLM, SWEDEN

TEL +46 8 673 95 00, FAX +46 8 15 56 70, [email protected] HTTP://KVA.SE

BESÖK/VISIT: LILLA FRESCATIVÄGEN 4A, SE-114 18 STOCKHOLM, SWEDEN

The Nobel Prize in Chemistry 2010The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2010 to

Akira SuzukiHokkaido University, Sapporo,Japan

Richard F. HeckUniversity of Delaware, Newark, DE, USA,

Ei-ichi NegishiPurdue University, West Lafayette,IN, USA

Organic chemistry has developed into an art form

where scientists produce marvelous chemical crea-tions in their test tubes. Mankind benets from this in

the form of medicines, ever-more precise electronics

and advanced technological materials. The Nobel

Prize in Chemistry 2010 awards one of the most

sophisticated tools available to chemists today.

This year’s Nobel Prize in Chemistry is awarded toRichard F. Heck, Ei-ichi Negishi and Akira Suzuki for thedevelopment of palladium-catalyzed cross coupling. Thischemical tool has vastly improved the possibilities forchemists to create sophisticated chemicals, for examplecarbon-based molecules as complex as those created by

nature itself.

Carbon-based (organic) chemistry is the basis of life andis responsible for numerous fascinating natural pheno-mena: colour in owers, snake poison and bacteria killingsubstances such as penicillin. Organic chemistry has allo-wed man to build on nature’s chemistry; making use of carbon’s ability to provide a stable skeleton for functionalmolecules. This has given mankind new medicines andrevolutionary materials such as plastics.

In order to create these complex chemicals, chemistsneed to be able to join carbon atoms together. However,

carbon is stable and carbon atoms do not easily react withone another. The rst methods used by chemists to bindcarbon atoms together were therefore based upon varioustechniques for rendering carbon more reactive. Such met-

hods worked when creating simple molecules, but when

synthesizing more complex molecules chemists ended upwith too many unwanted by-products in their test tubes.

Palladium-catalyzed cross coupling solved that problemand provided chemists with a more precise and efcienttool to work with. In the Heck reaction, Negishi reactionand Suzuki reaction, carbon atoms meet on a palladiumatom, whereupon their proximity to one another kick-starts the chemical reaction.

Palladium-catalyzed cross coupling is used in researchworldwide, as well as in the commercial production of for example pharmaceuticals and molecules used in theelectronics industry.

Richard F. Heck, American citizen. Born 1931 in Springeld, MA,

USA. Ph.D. 1954 from University of California Los Angeles (UCLA),

CA, USA. Willis F. Harrington Professor Emeritus at University of

Delaware, Newark, DE, USA.

Ei-ichi Negishi, Japanese citizen. Born 1935 in Changchun, China

(former Japan). Ph.D. 1963 from University of Pennsylvania,

Philadelphia, PA, USA. Herbert C. Brown Distinguished Professor

of Chemistry at Purdue University, West Lafayette, IN, USA.

www.chem.purdue.edu/negishi/index.htm

Akira Suzuki, Japanese citizen. Born 1930 in Mukawa, Japan.

Ph.D. 1959, Distinguished Professor Emeritus, both at HokkaidoUniversity, Sapporo, Japan.

Prize amount: SEK 10 million to be shared equally between the L aureates.

Further information: http://kva.se and http://nobelprize.org

Contacts: Erik Huss, Press Of cer, Phone +46 8 673 95 44, +46 70 673 96 50, [email protected]

Annika Moberg, Editor, Phone +46 8 673 95 22, +46 70 263 74 46, annika.moberg@k va.se

The Royal Swedish Academy of Sciences, founded in 1739, is an independent organization whose overall objecti ve is to promote the sciences andstrengthen their inuence in society. The Academy takes special responsibility for the natural sciences and mathematics, but endeavours to promote

the exchange of ideas between various disciplines.

Great art in a test tube

“for palladium-catalyzed cross couplings in organic synthesis”.

6 October 2010

Nobel P

rize® is a registered trademark of the Nobel Foundation. 

and