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NIC’s Pandemic influenza response and activities in New Zealand

Dr. Sue HuangHead, WHO National Influenza Centre

Institute of Environmental Science and ResearchWellington, New Zealand

The 3rd WHO National Influenza Centre meeting, Beijing18-20 August 2009

© ESR 2006

Outline

• Pandemic influenza & seasonal influenza situation

• NIC’s response & activities during early containment phase

• NIC’s response & activities during late containment phase

• NIC’s response & activities during management phase

© ESR 2006

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Epidemic curve of pandemic (H1N1) 2009 cases

As of 2 August:•Total cases: 2934•610 hospitalised•109 pneumonia•25 ARDS•39 fatal cases reported with10 being confirmed to have pandemic virus as the primary cause

© ESR 2006

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© ESR 2006

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© ESR 2006

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Influenza strain surveillance

© ESR 2006

NIC’s response & activities during early containment phase

(25 April-Mid May)

• NIC developed a nested PCR and sequencing method for NA gene with good sensitivity: confirmed 3 pandemic (H1N1) 2009 cases

• NIC did a contingency plan and identified 5 bottle necks: test result reporting; specimen reception; automation; testing algorithm; technical staff

© ESR 2006

NIC’s response & activities during late containment phase

(Mid May-21 June 2009)

•Highest sample volume: - For a week: ~1000

samples- For a day: ~350 samples

•High political commitment: mobilize resources from MAF IDC, AgResearch, ESR CD group;

•Test for Pacific Island countries: Cook Island, Samoa, Togan

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© ESR 2006

NIC’s response & activities during management phase(22 June-present)

• Viral culture and antigenic typing

• Tamiflu resistance monitoring

• Investigation of coinfection of pandemic A(H1N1) and seasonal A(H1N1) cases

• Full genome sequencing for fatal and ICU cases

• Potential sero-survey

© ESR 2006

Influenza Virus Seasonal AH1N1 Novel AH1N1

Year 2006 2007 2008 2009 2009

Number of viruses 17 138 4 25 20

Mean IC50* 1.84 0.83 728 1399 0.372

Std. dev. 0.71 0.63 136 2690 0.145

Min IC50 0.25 0.01 547 305 0.183

Max IC50 3.099 4.226 870 7912 0.745

Oseltamivir resistance monitoring

© ESR 2006

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