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Innovation with Integrity LC-MS Simply Connect TM nanoElute ®

nanoElute - Simply Connect€¦ · Unique valve design and novel instrument configuration enable: software controlled flow paths for dynamic inclusion of trap column and backflushing

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Page 1: nanoElute - Simply Connect€¦ · Unique valve design and novel instrument configuration enable: software controlled flow paths for dynamic inclusion of trap column and backflushing

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Innovation with IntegrityLC-MS

Simply ConnectTM

nanoElute®

Page 2: nanoElute - Simply Connect€¦ · Unique valve design and novel instrument configuration enable: software controlled flow paths for dynamic inclusion of trap column and backflushing

nanoElute® - Simply Connect ...

Bruker nanoElute is designed with years of proteomics know-how and nano-UHPLC expertise to deliver robust and reliable operation from the moment of installation through years of OMICS knowledge generation.

The fully integrated unit delivers its intelligence and applied chromatographic understanding from an intuitive user interface that is both powerful and flexible to operate.

... knew what you wanted to achieve? came with quality control built right in? could expertly guide your maintenance? adapted to your experimental design? included years of expertise? worked perfectly out of the box?

What if your nano-UHPLC ...

What if your nano-UHPLC was a nanoElute?

Page 3: nanoElute - Simply Connect€¦ · Unique valve design and novel instrument configuration enable: software controlled flow paths for dynamic inclusion of trap column and backflushing

... Your Sample with Biology

Instant Expertise™ delivers:

LC-MS/MS method with intelligent self-optimizing. LC separation for higher productivity and expert-caliber results the first time.

Optimal experimental conditions are automatically calculated from column type and sample characteristics to suit all proteomics samples. Chromatographic resolution is preserved for best simultaneous ID and Quant capabilities.

Page 4: nanoElute - Simply Connect€¦ · Unique valve design and novel instrument configuration enable: software controlled flow paths for dynamic inclusion of trap column and backflushing

... Your Sample with Biology

The unique valve design also allows ”Direct Infusion” for fast runs of simple samples e.g. BSA at 2 µl/min

With trap column BSA, 6 runs

Infusion Mode

Base Peak Chromatogram, HeLa, 3 runs

Detailed view, HeLa

Without trap column

Detailed view, HeLa

BPC MS

Base Peak Chromatogram, HeLa, 3 runsBSA, 6 runs

Page 5: nanoElute - Simply Connect€¦ · Unique valve design and novel instrument configuration enable: software controlled flow paths for dynamic inclusion of trap column and backflushing

Intuitive Innovation

The system performance is secured through 3 layers of protection:

- Automatic initialization. - Built-in scheduling of preventive maintenance.

- Precise diagnostics where leaks and blockages are automatically detected and highlighted in the graphical user interface.

Unique valve design and novel instrument configuration enable: software controlled flow paths for dynamic inclusion of trap column and backflushing the sample for sharper peaks.

The ultra high-resolution, accurate mass QqTOF, the Bruker impact II, and the market proven CaptiveSpray ionization source are the perfect companions for the nanoElute system.

Large volume, single stroke piston pumps support both longer gradients and a wider flow range.

Page 6: nanoElute - Simply Connect€¦ · Unique valve design and novel instrument configuration enable: software controlled flow paths for dynamic inclusion of trap column and backflushing

IntelligentIntuitive IntegratedB

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836

467

Bruker Daltonik GmbH

Bremen · GermanyPhone +49 (0)421-2205-0

Bruker Scientific LLC

Billerica, MA · USA Phone +1 (978) 663-3660

[email protected] - www.bruker.com

For research use only. Not for use in diagnostic procedures.

nanoElute® - Simply Connect.

Professor Leonard Foster Director, Department of Biochemistry and Molecular Biology, University of British Columbia, Canada:“LC-MS experts and biologists alike require trouble-free operation and ease-of-use along with top performance. The integrated nanoElute system readily delivers through an intuitive, wizard-driven interface with intelligent diagnostics and built-in troubleshooting.”