Multiple Types of Epithelia

Structure of the Intestinal Epithelial Cell

Acidification of an Extracellular Medium

Transport of Glucose from the Intestinal Lumen into the Blood

ORAL REHYDRATION THERAPY

1) REQUIRES BOTH NaCl AND GLUCOSE; NEITHER ALONE WORKS

THE Na+/ GLUCOSE SYMPORT PROTEIN MUST TRANSPORT Na+AND GLUCOSE TOGETHER

2) TRANSPORT OF NaCl AND GLUCOSE ACROSS THE INTESTINAL EPITHELIUM CAUSES OSMOTIC FLOW OF WATER FROM THE INTESTINAL LUMEN INTO THE BLOOD, LEADING TO REHYDRATION

Schematic overview of the types of molecules that bind cells to each other and to the extracellular matrix

Major families of cell-adhesion molecules

(CAMs).

Adhesion molecules in junctions involved in cell-cell adhesion

Structure of the Intestinal Epithelial Cell

Desmosomes

Desmosomes

Gap Junctions

Gap Junctions

Tight Junction in Thin Section

Model of a Tight Junction Between Two Epithelial Cells

Freeze Fracture Image of a Tight Junctionin the Plasma Membrane of One of the Two

Adjacent Epithelial Cells

The structure of fibrous collagen

Type IV collagen - a key component of the basal lamina

Type IV collagen - a key component of the basal lamina

Model of the basal lamina

The association of the plasma membrane of skeletal muscle with the basal lamina

Organization of the basal lamina in different tissues

Structure of laminin, a large heterotrimeric multiadhesive matrix protein found in all basal laminae

Three-dimensional structure of the type III repeat of fibronectin that contains the RGD

integrin-binding sequence

Structure of the glycosaminoglycan Heparan sulfate

Structure of the glycosaminoglycan Hyaluron (Hyaluronic Acid)

The cell-surface proteoglycan syndecan-4

Modulation of activity of fibroblast growth factor

(FGF) by heparan sulfate proteoglycans 

Structure of the FGF - FGR Receptor Complex