MTHFR & Genetic Basics - Doctor Doni...What is MTHFR? Gene and enzyme that turns folic acid into folate. “Folic acid” and “folate” are often used interchangeably, but they

By Dr. Doni Wilson

The Answers You Need to Take Control of Your Health

MTHFR & Genetic Basics

Genetics + Stress = Health

© 2017 Dr. Doni Wilson


Footnote


What are Stresses? Major Life Stresses

Daily StressesFood Sensitivities

InfectionsMedications

Physical TraumaLack of Sleep

Elevated Blood SugarLack of Nutrients

Toxins




How to Read a Genetic Report?

Letters, numbers and colors.Genes code for enzymes.

Genes have 2 strands and 2 possible SNPs.Heterozygous = 1 SNP (yellow)

Homozygous = 2 SNPs (red)

We all have some SNPs!


What Are SNPs? Genetic variations.

Potential traffic jams.



What are Cofactors?

Nutrient(s) required for enzyme to function.


What is MTHFR? Gene and enzyme that turns folic acid into folate.

“Folic acid” and “folate” are often used interchangeably, but they are different.

Folate is found in nature.Folic acid is synthetic.

MTHFR A1298CMTHFR C677T



Health Risks Associated with MTHFR? Migraines

Anxiety and DepressionMiscarriages and Neural Tube Defects

InsomniaCervical Dysplasia (abnormal pap smears)

Heart DiseaseDiabetesCancer

Alzheimer’s



How much does it affect me?

What is Methylation? “B Vitamin Cycle”

What our B vitamins are up to!

Folate and B12 come together with Homocysteine to make SAM (S-adenosyl methionine).

Then SAM recycles back around to Homocysteine.

Negatively Affected by Stress.


What is SAM?

Used in the body to do all sorts of good!

Protects our DNAHelps make healthy new cells

Makes and breaks down neurotransmittersand helps get rid of histamine (think of allergies).


What is Homocysteine? Recycling SAM.

Connects up with Folate and B12.

Can also go down the glutathione pathway.Glutathione is a major anti-oxidant in our bodies -

a cell protector.

Can be measured in blood work.


What can block Methylation?

InflammationMetalsAlcohol

LPS from gut bacteriaNitric Oxide (uncoupled)


What can I do to address MTHFR?

• Avoid Folic Acid.• Eat foods high in folate.• Find out if you need Folate.• What is blocking methylation?• Do you have enough cofactors?• Address YOUR stress!


What can I do to address MTHFR?


What tests do I need to do? Genetic panelRun software

Blood test for Homocysteine

May also need to test: SAM, sulfur, organic acids, cortisol, neurotransmitters, food sensitivities, metals, toxins, glutathione, stool/gut

bacteria, nutrient levels, methylmalonic acid



Methylation Panel


Organic Acids Panel


Urine Sulfur Strips


Cortisol & Neurotransmitter Panel


Food Sensitivity & Stool Panels

Footnote


Additional Panels

Will Supplements Help? Which?

Yes - Important to Individualize!

Vitamin B6, MagnesiumOther B vitamins

Minerals/Electrolytes

Methyl-Folate (5MTHF)Methyl-Cobalamin (B12)


Will Supplements Help? Which?


Dr. Doni’s 5-step Approach


Remove Blocks

By decreasing “stresses” in our bodies, we improve

methylation.


Stress

Inflammation

Decreased Methylation

Leaky Gut + Dysbiosis + Blood Sugar Issues

Oxidative Stress + Chronic Infection


Address Downstream Pathways


Sulfur & Glutathione

Nitric Oxideand

Histamine

Neurotransmitters© 2017 Dr. Doni Wilson

Support Cofactors First!


MagnesiumMinerals/Electrolytes

Vitamin B6 Other B vitaminsHydroxo B12 trial

Molybdenum (if needed)

Assess Methylation


Know your homocysteine level!

Add Methylation Supportonly IF needed !!


5MTHF +

Methyl B12 +

B6 (P5P)




Stress Remedy Program

https://doctordoni.com/pdfs/Dr-Doni-Wilson_MTHFR-and-Genetic-Profiling-

Solutions-Package.pdf


MTHFR 5 Step Approach Workshop

Dr. Doni’s 5-Step Approach


Workshop Sessions


1. Identify blocks and assess downstream pathways 2. Address blocks and cofactors 3. Assess progress 4. Implement methylation5. Assess progress6. Plan for continued success


MTHFR 5 Step Approach Workshop

Sign Up Here

https://www.drdonistore.com/MTHFR-5-Step-Approach-Workshop_p_974.html

THANK YOU!

www.DrDoni.comBlog and NewsletterMTHFR Consultation Package5 Step Approach Workshop

DrDoniStore.com The Stress Remedy Book The Stress Remedy Program


https://doctordoni.com/pdfs/Dr-Doni-Wilson_MTHFR-and-Genetic-Profiling-Solutions-Package.pdf

https://www.drdonistore.com/MTHFR-5-Step-Approach-Workshop_p_974.html

Documents

MTHFR & Genetic Basics - Doctor Doni...What is MTHFR? Gene and enzyme that turns folic acid into folate. “Folic acid” and “folate” are often used interchangeably, but they