MiniSprayDryer en 1102 Low

7/30/2019 MiniSprayDryer en 1102 Low

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The Mini Spray Dryer B-290 is the la-boratory equipment of your choicefor the quick and gentle drying topowder of liquid end products. Theimpressive features of the SprayDryer include its efficient perfor-mance with very short set-up times,an effective integrated nozzle clea-ning mechanism and a high degreeof flexibility thanks to the different cy-linder geometries. Whether the re-quirement is the gentle drying of na-tural product dyestuffs, the isolation

of highly effective pharmaceuticalactive agents, or the micro-encapsu-lation of aromas the B-290s out-standing features greatly extends thenumber of applications that are pos-sible with a spray drying process.

Mini Spray Dryer B290

Efficient and safe Spray Drying of aqueous

and organic solutions

Areas of applicationMake sure you profit from the broadspectrum of applications: Spray drying from solutions

Structure modifications Drying of suspensionsAgglomeration Spray crystallization Micro-encapsulation and coating


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3Spray Drying

a fascinating Process with many Advantages

Many products are preferentially used in solid form. This simplifies storage and metering, and it may be essential forthe application for which the compound is to be used. Spray drying is a speedy, time-saving and gentle method ofobtaining even the smallest quantities of substances in powder form. The advantages compared with freeze dryingare the greater throughput rate and the short process times. The very short residence times and the cooling effectresulting from evaporation makes it possible to process even temperature-sensitive products in a gentle manner. Ifthe use of organic solvents is involved, the thermal load is reduced to a minimum.

The Mini Spray Dryer B-290 innovative solutions for spray drying in thelaboratory

Not only does the Mini Spray Dryer B-290make it possible to obtain powder directlyfrom a solution but many other pro-cesses can also be completed in a singlestage:

Modification of particle sizeAgglomeration of nanoparticles Drying suspensions Particle coatingImmobilization of liquids and solid ma-terials in a matrix

Manufacture of microcapsules

Variable gas flow control for optimaloperation

The standard method of operation for theMini Spray Dryer B-290 is in a suctionmode. The reduced-pressure environ-ment within the system prevents anypossible contamination in the case of aleakage. The system can be very easilyconverted to operate under pressurewhich prevents the aspirator from beingattacked by corrosive media. All partsthat come into contact with the productare readily accessible for cleaning.

The operating panel displays all the func-tions in a clear manner. In addition to thesettings of the spray parameters, the in-put- and output temperatures are dis-played. The integral nozzle-cleaning de-vice permits automatic or manual clean-ing at selected intervals, or allows themanual insertion of a needle through thenozzle to prevent blockages or to remedythem.

The two-fluid nozzle is a superb illustra-tion of what may be achieved by combi-nation of novel design functionality andhigh precision manufacturing. A ruby witha highly precise aperture is set in the tipof the nozzle cap. This guarantees repro-ducible and trouble-free spraying overlong periods. The nozzle may also bethermostatically controlled.

Two different versions of the glass cylin-ders make it possible to optimize the yielddepending on the process. The lateraloutlet cylinder is particularly suitable foraqueous products which are difficult todry, whilst the second type of cylinderwith a vertical outlet geometry is es-pecially useful for work involving organicsolvents.

The assembly of the glass parts is amaz-ingly fast, elegant and simple. The glasscylinder can be inserted with a single man-ual movement of a locking lever.

Two-uid nozzle, operated by compressed

air to disperse the solution into fne droplets

Electric heating o the drying medium

Spray cylinder or drying the droplets to

solid particles

Separation o the particles in the cyclone

Outlet flter to remove fne particles

Aspirator or generating the ow

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Inert Loop B295

Spray drying with organic solvents

At last it is possible to safely carry out laboratory scale spray drying of organic solvents by using the accessory InertLoop B-295! Previously, spray drying of inflammable solvents was associated with the risk of explosion and was con-sequently prohibited. However, important new areas of research and applications necessitate the use of spray dryingfrom an organic solvent base. To be able to respond to this challenge a new type of accessory has been developedwhich allows the user to work safely with almost all currently available solvents!

Inert Loop B-295 With the accent on safety

The cooling block is assembled as a mo-bile unit and is connected to the MiniSpray Dryer B-290 via two hose connec-tions and a communication cable. Twosignal lamps display the condition of theintegrated oxygen and pressure monitor-ing system. Should a fault develop, thecircuit automatically switches the equip-ment to a safe condition. The system hasbeen certified by the Swiss Institute of Sa-

fety.

The following solvents havebeen tested and can be usedwithout reservation: Methanol EthanolToluene HexaneAcetone Ethylacetate Dichloromethane*

For water, we recommend to use theB-296 (see next page)

* additional Cold Trap recommended

Schematic of the closed circuit:

1 Heat exchanger

2 Condensation units

3 Cooling aggregate

A Initial solution

B Product

C Waste gas

D Solvent

Adsorption columnIf mixtures of organic solvents and waterare used, we strongly recommend theadditional adsorption column in theclosed loop system. The separationprevents water from freezing in the InertLoop B-295 and potentially damaging theheat exchanger. The humidity is detectedby a sensor. As soon as a critical thresholdis exceeded as the column is saturated,

the feed pump is stopped and themolecular sieve has to be exchanged orregenerated.

To safely spray dry inflammable solvents,a new operating principle is employedwhich uses a combination of the SprayDryer B-290 and the Inert Loop B-295 toprovide a closed loop circulation underinert conditions. The absence of oxygenprevents the formation of a ignitable mix-ture. At the same time, the solvent con-tained in the gas stream is cooled andconsequently condensed. The regener-

ated flow is then returned again to thespray dryer.


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5Dehumidifier B296

Year round Reproducibility and closed loop operation

The Dehumidifier B-296 is a versatile instrumentfor different applications:

Inlet air ConditioningAir humidity changes occurring between different seasonsand regions affect the Spray drying process. By using the newDehumidifier B-296, the drying conditions are exactly definedand made reproducible by removing the water content witha cold trap at 5 C. The integrated hygrometer displays the airhumidity.

Closed loop with aqueous solutionsFor the use of aqueous solutions or mixtures with less than

50% organic solvents, we recommend the DehumidifierB-296 due to the risk of freezing causing damage in the In-ert Loop B-295. The additional pre-heat exchanger allows

the efficient condensation resulting in a dry product.

Inlet air chillerWhen using the spray chilling accessory (see next page) theinlet air can be cooled by the B-296 to produce optimalsolidification, making the Dehumidifier the right choice for thisapplication.

Instruments

Mini Spray Dryer B-290

For aqueous solutions; inclus-ive of nozzle, complete set ofglassware and all necessaryhosing.

Order number230 V, 50 60 Hz 44780200 V, 50 60 Hz 44781

Mini Spray Dryer B-290AdvancedFor aqueous and organic sol-utions (together with B-295).For the version to deal with or-ganic solutions a set of peris-taltic hosing for different sol-vents is provided. Both typesof spray cylinders are in-cluded, together with the feedswitch valve and the safetycurtain.

Order number230 V, 50 60 Hz 44699200 V, 50 60 Hz 44700

Inert Loop B-295

Closed circulation for safeoperation with solvents in as-sociation with the B-290 Ad-vanced unit; comprises a cool-ing unit, pressure control andoxygen monitoring elements,communication cables to theB-290.

Order number230 V, 50 Hz 44701230 V, 60 Hz 46344200 V, 50 Hz 44779

Dehumidifier B-296

The ideal instrument for in-let air conditioning, condens-ing of water in the closed loopor inlet air cooling for the spraychilling operation.

Order number230 V, 50 60 Hz 40188


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Accessories:

Spray Chilling World novelty in the lab-scale

When a melting is dispersed into a cold gas stream, the dropletsare solidified into particles and can thus be separated. Thematrix substance and the active ingredients are heated abovethe melting point. The nozzle is also heated to prevent anyblocking. No additional thermostat is required, as the existingheating control and peristaltic pump in the instrument are used.If the sample has a low melting point, then the inlet air is cooledto increase the temperature gradient. If lower temperatures than10C (provided by the B-296) are used, e.g. for hard fats, theinlet air can be cooled to 5C by using a specially developedrefrigeration unit. (Please contact your local distributor). Highest

melting point is 70 C.

Typical encapsulation examples are:Vitamins dissolved in fat Lypophilic active agents in glyceridesMicrocapsules for cosmetics

Taste masking

Remote Control Unit

Allows full control and the set-ting of all important parame-ters when the Spray Dryer isused in a fume hood.

Order number 44702

Nozzle

Replacement nozzle. Reducessystem down-time when thereis a change of product.

Order number 44698

Spray ChillingLiquifying bath, incl. heater,temperature probe and me-tering valve. Temperaturerange 20150 C, Batch vol-

ume 300 ml. Reverse compa-tibility for installed B-290 uponrequest.

Order number230 V, 5060 Hz 40351

Spray chilling can now be performed using this novel accessory to form particles directly from liquid samples by gas-phase solidification. Whether waxes, hard fats or glycerides as possible matrix substances profit from this inno vativeencapsulation method now also performed at laboratory scale!

Safety Curtain

If no fume hood is availableand work is being carried outwith inflammable or toxic pro-ducts, the safety curtain is ahighly reliable alternative. It iseasy to unfold and the lamellapermit inspection and access

to the glass elements whilstthe spray drying process isunderway (incl. in B-290 Ad-vanced).Order number 44783

Feed Switch Valve

Allows the automatic swit-ching between pure solventand sample feed-stock elimi-nating the need for manualchangeover of hose connec-tions. It is recommended thatthe unit be used with the Re-

mote Control Unit (included inB-290 Advanced).

Order number 44725


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Outlet filter

Outlet filter with a polyester-

deep bed filter and display ofthe pressure drop. Providesoptimal protection for the as-pirator and whilst permittingcleaning of the aspirator. Theadditional filter, made of a po-rous PTFE-membrane, alsofacilitates the recovery of theproduct by means of com-pressed air counter-pulses. Afilter bag for each is included.

Order numberDischarge Filtercomplete 44754Replacement Filter(6 items) 35004PTFE-MembraneFilter 46316

Inlet Filter

Contaminants such as parti-

cles of dust, pollen or soot arefiltered out of the air enteringthe equipment. It is an ultra fil-ter made of glass fiber cloth,having an effective filteringsurface area of 2.3 m2.

Order number 11235

Complete set of Glassware

Complete set of glassware foralternating between cleaningand operational activities. In-cludes all connectors. Ver-sions also available in brownglass for photosensitive pro-ducts.

Complete setof glass elements 44680

Complete set ofbrown glass elements 44758

High-performance cyclone

Increased separation of fines;designed for small quantities.Complete with small collec-tion vessel.

Order number 46369

Adsorption column

Efficient water separation onthe surface of a molecularsieve, incl. humidity sensorand 2.5 kg molecular sievebag.

Adsorption column 46560Spare molecularsieve bag 46568

Scale-up of

Spray Drying Processes

Scale up is an important aspect in spray drying processes toeasily translating initial trials in the research lab to full-scale in-dustrial production. The two leading suppliers of spray dryingsystems, BCHI Labortechnik AG and Niro A/S are collabora-ting in offering customers their combined and comprehensive

know-how.

Based on decades of experience and thousands of installationsworldwide BUCHI and Niro simply help you scale your spraydrying operation to any level easily, efficiently and fast.

Cylinder Insulation

Less product loss and closer

to scale-up conditions.

Order number 40058

Pre-heat exchangerTo work in closed mode withthe Dehumidifier B-296

Order Number 40059

Pressure air supplyOilfree operated compressorfor the feeding ofthe two-fluid nozzle 27907

Air Maintenance Unitfor clear, anhydrouspressurized air 04366


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Technical data

Mini Spray Dryer B-290Power Rating 2900 W

Voltage 200/230 V, 50 60 HzEvaporative Capacity 1.0 l/hr H2O, higher for organic solvents

Air Flow Max. of 35 cu. m./hrMotor Control Frequency ConverterMax. Temperature Input 220 CHeating Capacity 2300 WHeating Control PT-100, Fuzzy Logic, Control Accuracy 3 CInterface Serial port RS-232 for all parametersSpray Gas Compressed air or nitrogen, 2001000 l/hr, 58 barNozzle Diameter 0.7 mm Standard, 1.4 and 2.0 mm as accessoriesNozzle Cap 1.4 mm and 1.5 mm diameter

Mean Dwell Time 1.01.5 secondsPossible particle diameter range 125 mMaterials in contact with product Acid-resistant stainless steel, 3.3 Borosilicate glass, FPM, SiliconeDimensions L xWx H 60 x 50 x 110 cmWeight 48 kg

Inert Loop B-295Power Rating 1 kWConnection Voltage 200/230 V, 5060 Hzmin. Outlet Temperature down to 20 CRate of Cooling 800 W at 10 CDimensions LxWxH 60 x 70 x 77 cm

Weight 95 kg

Dehumidifier B-296Power Rating 700 WConnection Voltage 200230 V, 50 60 Hzmin. Outlet Temperature +2 CRate of Cooling 600 W at 0 CDimensions LxWxH 35x 40x 60 cmWeight 36 kg

094019en1102/Technicaldataaresubjecttochangewithoutnotice/QualitySystemsISO

9001

TheEnglis

hversionistheoriginallanguageversionandservesasbasisforalltranslationsintootherlanguages.

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MiniSprayDryer en 1102 Low