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Miguel Concepción
Class of 2009
UMass Medical School
Educational Presentation for Middle & High School Students
What Do You Know?
Bone Marrow
It is a spongy matrix located in the center of many bones.
It contains stem cells. It is the factory where
all the cellular components of blood are made.
University Healthcare http://healthcare.utah.edu/healthinfo/pediatric/hemat/bonetran.htm
Problems with Bone Marrow
There are many diseases that affect the bone marrow such as:
Cancers (i.e. Leukemia & Lymphomas) Genetic Disorders ( i.e. SCID)
Many of these diseases are often fatal! BM transplant may be the last line of
defense.
BM Transplantation
A bone marrow transplant replaces a patient's unhealthy stem cells in the bone marrow with healthy stem cells from a volunteer donor.
Is Blood Transfusion the Same??
2 completely different things! Blood is a finished product that is constantly
replenished every 3 months. Only offers a temporary symptomatic fix. By providing stem cells, a BM transplant
gives one the ability to constantly renew blood cells.
Bone Marrow Registry Database
Ages 18-60 Buccal Swab obtained HLA cell type determined
Donors must have similar cell types as recipient in order to prevent bad reactions.
Information is confidentially put into the national registry.
Necessity of the Registry
There remains a low number of participants in the registry.
It is difficult for a recipient to find a complete match; the more people in the registry the higher the likelihood of matching.
Compounded Problem Patients are more likely to match with someone in
their ethnic group; however, there are even fewer underrepresented people in the registry.
NMDP Registry by Race
75,000
415,000
480,000
8,000
3,000,000
150,000
1,500,000
American Indian/AlaskaNative
Asian
Black or AfricanAmerican
Native Hawaiian or OtherPacific Islander
White
Multiple Race
Unknown*
Facts and Figures, The National Marrow Donor Program . Creating Connections. Saving Lives. http://www.marrow.org/MEDIA/facts_figures.pdf
The Process
Donor will be contacted if he/she matches the patient’s cell type and the process is explained.
Donor may still back out. If committed, the donor will meet the medical
team and the method of stem cell extraction is determined.
Bone Marrow Stem Cell or Peripheral Blood Stem Cell
Marrow Collection
Surgical day procedure Marrow extracted from
pelvis (hip) using a hollow needle
Anesthesia is used to minimize pain.
Copyright © 2005 Nucleus Communications, Inc. All rights reserved. www.nucleusinc.com
Marrow Collection
Most patients will go home the same day.
Many experience lower back pain and stiffness for several days.
The marrow stem cells will completely regenerate in 4-6 weeks.
Peripheral Blood Stem Cell (PBSC)
Allows collection of stem cells through the blood rather than bone
A drug must be taken a week prior to extraction to induce the stem cells
An apheresis process is used in extraction.
http://www.communitybloodservices.org/bone_marrow_donor_5_nmdp_steps.htm
PSBC Collection
The whole process may take several hours.
Side effects include headache and muscle aches during a week prior to collection.
Summary
The whole donation process will not cost the donor anything; it will be covered by the recipient’s insurance.
BM transplant is a life-saving procedure that offers hope to many afflicted with certain diseases.
Questions?
Contact Information
Caitlin Raymond International Registry 508 334 8969 http://www.crir.org/registerdonor.php Located Here In Worcester, Ma
National Marrow Donor Program 1-800-627-7692
http://www.marrow.org/HELP/Join_the_Registry/index.html