LOW-DOSE HEPARIN PROTECTS AGAINST DEEP VEIN THROMBOSIS Among surgical patients receiving low-dose heparin prophylaxis, the incidence of deep vein thrombosis (13%) was significantly lower than in the control group (36%) undergoing similar surgical procedures. Heparin was given to 83 of 178 patients in general surgical and urological services. A single subcutaneous dose of heparin was given before surgery and administration was continued postoperatively in a dosage of S,OOOIU tid for at least 7 days, depending upon time of ambulation. The 125 !-fibrinogen test was performed daily in all patients to detect thrombosis. On the basis of these results and fmdings in other studies,low-dose heparin appears to be effective in preventing post-operative deep vein thrombosis in general surgical cases. Further data are needed in urological, gynaecological, and hip surgery. Administration of heparin did not appear to reduce the incidence of deep vein thrombosis in patients undergoing surgery for malignant diseases. Rem, J. et al.: Schweizerische Medizinische Wochenschrift 105: 827 (28 Jun 1975)

LOW-DOSE HEPARIN PROTECTS AGAINST DEEP VEIN THROMBOSIS

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LOW-DOSE HEPARIN PROTECTS AGAINST DEEP VEIN THROMBOSIS

Among surgical patients receiving low-dose heparin prophylaxis, the incidence of deep vein thrombosis (13%) was significantly lower than in the control group (36%) undergoing similar surgical procedures. Heparin was given to 83 of 178 patients in general surgical and urological services. A single subcutaneous dose of heparin was given before surgery and administration was continued postoperatively in a dosage of S,OOOIU tid for at least 7 days, depending upon time of ambulation. The 125 !-fibrinogen test was performed daily in all patients to detect thrombosis.

On the basis of these results and fmdings in other studies,low-dose heparin appears to be effective in preventing post-operative deep vein thrombosis in general surgical cases. Further data are needed in urological, gynaecological, and hip surgery. Administration of heparin did not appear to reduce the incidence of deep vein thrombosis in patients undergoing surgery for malignant diseases.

Rem, J. et al.: Schweizerische Medizinische Wochenschrift 105: 827 (28 Jun 1975)