Lecture 13 – Project selection & Signalling Cross Talk

Lecture 13 – Project selection & Signalling Cross Talk

BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy

Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

Module 7: Figure metabolic energy network


Module 7: Figure control of food intake


Module 7: Figure pancreas


Module 7: Figure β-cell signalling


Module 7: Figure α-cell signalling


Module 7: Figure liver cell signalling


CREB (Cyclic AMP response element-binding protein)

CREB (Cyclic AMP response element-binding protein) functions in the control of many different cellular processes:• The survival and proliferation of β-cells is regulated by glucose and by various hormones such as

• glucagon-like peptide-1 (GLP-1)• Which appear to act synergistically to activate the CREB co-activators called TORCs • Regulating the biosynthesis of Glucagon

• Activation of neuronal gene transcription responsible for learning and memory • Expression of clock genes • Expression of brain-derived neutrophic factor (BDNF) • Fast-spiking interneurons (Module 12: Figure schizophrenia).• The CREB/TORC transcriptional duo play a critical role in energy metabolism • peroxisome-proliferator-activated receptor γ (PPARγ) coactivator-1 (PGC-1)

• PPAR transcription factors - function in liver cell gluconeogenesis• Transcriptional regulation aquaporin AQP2 and AQP3 - vasopressin-induced antidiuresis• Melanogenesis • NMDA receptor hypofunction in schizophrenia.


Module 7: Figure wite fat cells


Module 7: Figure lipolysis and lipogenesis


Module 7: Figure brown fat cells




Module 7: Figure glycogenolysis and gluconeogenesis



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Lecture 13 – Project selection & Signalling Cross Talk