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Integrated Drug Discovery & Development JMLedidnal Chemistry ~*****T ^ Ricerca's unique integrated drug discovery program cost-effectively weeds out predictable failures and creates higher value optimal drug candidates for development. Give us your hits...and we'll utilize medicinal chemistry coupled with ADMET to provide optimized leads. • Medicinal chemistry In vitro ADMET In vivo ADMET • Metabolite ID • Bioavailability assessment & optimization* • Microbiology Chemical Development Our Chemical Development Group and pilot plant can make your drug, efficiently and scaleable for Phase I and Phase II testing. • CMC development • API preparations and manufacture • Process chemistry and scale-up • Peptide synthesis and manufacture* • Analytical development; Polymorph screening Drug Development Biology Our Drug Development Biology Group provides extensive services to assure the quality of material being used is acceptable to government regulations and patient safety. • IND-enabling toxicology and metabolism • Carcogenicity and reproductive tox • Bioanalytical method development and sample analysis • Regulatory support Twice the Power for Developing Drugs" Strategic Alliance Partners •/ Ricerca Biosciences 7528 Auburn Road • Concord, OH 44077 Tel: 888-763-4797 • Fax: 440-357-4939 E-mail: [email protected] • www.ricerca.com Discovery Lead Optimization : · J iJ i t : TTt-f-Jt 'Leati Hit Όί Άαι

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Integrated Drug Discovery & Development

JMLedidnal Chemistry

~*****T ^

Ricerca's unique integrated drug discovery program cost-effectively weeds out predictable failures and creates higher value optimal drug candidates for development. Give us your hits...and we'll utilize medicinal chemistry coupled with ADMET to provide optimized leads.

• Medicinal chemistry • In vitro ADMET • In vivo ADMET • Metabolite ID • Bioavailability assessment

& optimization* • Microbiology

Chemical Development

Our Chemical Development Group and pilot plant can make your drug, efficiently and scaleable for Phase I and Phase II testing.

• CMC development • API preparations and manufacture • Process chemistry and scale-up • Peptide synthesis and manufacture* • Analytical development; Polymorph screening

Drug Development

Biology

Our Drug Development Biology Group provides extensive services to assure the quality of

material being used is acceptable to government regulations and patient safety.

• IND-enabling toxicology and metabolism • Carcogenicity and reproductive tox • Bioanalytical method development and sample analysis • Regulatory support

Twice the Power for Developing Drugs"

Strategic Alliance Partners

•/ Ricerca B i o s c i e n c e s

7528 Auburn Road • Concord, OH 44077 Tel: 888-763-4797 • Fax: 440-357-4939 E-mail: [email protected] • www.ricerca.com

Discovery Lead

Optimization : · J iJ i t : TTt-f-Jt 'Leati Hit

ΌίΆαι