Drug Discovery Copia

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    PREINITIATIONexposure to

    cancerogenes

    INITIATIONmutations

    PROGRESSIONcancer in situ

    PROMOTIONcumulations of 

    mutations

    MALIGNANCYmetastasis

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    "#$ %&'()*+,-.,&./ 01+ "23,)'/*+3435&'()*+3

    #6&/.323,-.,#/./' )*5-.7)+.-&5'$

    CH3

    N

    CH3

    CH3

    O

    HCl

    "8$ 9)'/('-6&/' ": : 35&6'()*+,)'/'()*+#6&/' )*5-.7)+.-&5'$

    CH2C

    CH3

    CH3

    NH2

    HCl

     

    "7$ ;.,&-#6#(' "4::?3%&3O3

    &@.,-.,*+&5'/'33%3A-B7(.,*-#/.@'@B+A#6#('$

    O

    O

    O

    O

    CH3

    CH3

    CH3

    CH3

    CH2OSO

    2NH

    2

    O

     

    "5$ C./&@#6&5' "8'/D.E5F&@.G#D.+336'()*+3 ,'/(#/.&7 #7&5 "I$323EE"4I: 3

    5&7)+.-.3,)'/*+$3>36'()*+3 N 3",&,'-&5&/'323*+$31H 3,*-#D.+'3

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