INFEKSI VIRUS

MULTI-SISTEM

Riyani Wikaningrum

Bag. Mikrobiologi

Fakultas Kedokteran Univ. Yarsi

Penyakit Infeksi berdasar Sistem

Infeksi Multi-sistem

• Vector-borne

• Zoonosis

• Fever of Unknown Origin (FUO)

• Infection of the compromised host

Vector Borne Disease

• Arboviruses are arthropod-borne viruses

• Arbovirus replicate in: – Vascular endothelium

– CNS

– Skin and Muscle

• Arbovirus infection: – Yellow fever

– Dengue fever

– Arbovirus encephalitis

– Arbovirus and hemorrhagic fever

Yellow Fever

• Yellow fever virus is transmitted by mosquitoes and is restricted to Africa, Central and South America and the Caribbean

• Clinical features of yellow fever may be mild, but liver damage can prove fatal

• The diagnosis is usually clinical, there is no specific treatment, but there is a vaccine

Dengue Fever

• Dengue virus is transmitted by mosquitoes

and occurs in southeast Asia, the Pacific

area, India and the Caribbean

• Dengue fever may be complicated by

dengue hemorrhagic fever shock

syndrome

• There is no antiviral therapy or vaccine for

dengue fever

Arbovirus Enchephalitis

• The encephalitic arboviruses only

occasionally cause encephalitis

Arboviruses and hemorrhagic fevers

Zoonosis

• Some multisystem infections in man

are animal diseases (i.e. zoonoses)

• Viral Haemorrhagic Fever caused by:

– Arenaviruses

– Filoviruses

– Bunyaviruses

– Flaviviruses

ARENAVIRUS INFECTIONS

• Arenaviruses are transmitted to humans in rodent excreta

• Arenavirus infection is diagnosed by serology, virus isolation or viral genome detection

• Lymphocytic choriomeningitis virus occurs worldwide

• Lassa fever virus is an arenavirus that infects a bush rat in parts of west Africa

KOREAN HEMORRHAGIC FEVER

• The Hantaan virus causes Korean

hemorrhagic fever and infects rodents

MARBURG AND EBOLA

HEMORRHAGIC FEVERS

Viral Multi-System Infection – Mucocutaneous Lessions

Patogenesis

Infeksi HSV & VZV

Manifestasi Infeksi HSV

Manifestasi

Infeksi VZV

SMALLPOX atau VARIOLA

MORBILLI atau MEASLES (RUBEOLA)

Koplik’s spots

MORBILLI atau MEASLES (RUBEOLA)

• Measles outbreaks occur every few years in unvaccinated populations

• Clinical features of measles include respiratory symptoms, Koplik's spots and a rash

• Measles rash results from a cell-mediated immune response

• Complications of measles are particularly likely among children in developing countries

• Measles is usually diagnosed clinically; there is no antiviral treatment, but there is a vaccine

RUBELLA (GERMAN MEASLES)

• Rubella virus infection causes a

multisystem infection, but its main impact

is on the fetus

• Rubella is diagnosed serologically; there is

no treatment, but there is a vaccine