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Thanks to Banca Monte dei Paschi di Siena
for hosting the international NIBIT M
eeting in its historical headquarter
Can
cer
Bio
-Im
mun
othe
rapy
XIII NIBIT
Banc
a Mo
nte
dei P
asch
i di
Sie
naRo
cca
Salim
beni
Piaz
za S
alim
beni
1, S
iena
12:00
Arriv
al/R
egis
tratio
n/Li
ght L
unch
14:00
Wel
com
e ad
dres
ses
SESS
ION
1. R
egul
ator
y m
echa
nism
s of
ant
i-tum
or
imm
une
resp
onse
sCh
airs
: M
atte
o Be
llone
(Mila
n, It
aly)
Vi
ncen
zo R
usso
(Mila
n, It
aly)
14:15
Vi
ncen
zo B
ront
e (V
eron
a, It
aly)
:
Mac
roph
ages
and
mye
loid
-der
ived
supp
ress
or c
ells
as
mod
ulat
ors
of a
nti-t
umor
imm
une
resp
onse
s.
14:40
Ba
rbar
a Se
liger
(Hal
le, G
erm
any)
:
Imm
unom
odul
ator
y m
icro
RNAs
as a
nov
el m
echa
nism
to re
vert
imm
une
es
cape
of t
umor
s.
15:05
Li
cia
Rivo
ltini
(Mila
n, It
aly)
:
pH re
gula
tors
in tu
mor
imm
unity
.
15:30
An
toni
o Si
ca (R
ozza
no, I
taly
):
Ta
rget
ing
mye
loid
cel
l diff
eren
tiatio
n
an
d fu
nctio
n in
can
cer.
Invi
ted
Abst
ract
:15:
55
Mar
io L
eona
rdo
Squa
drito
(Lau
sann
e, S
witz
erla
nd):
Di
cer c
ontro
l of m
acro
phag
e po
lariz
atio
n
an
d tu
mor
resp
onse
to im
mun
othe
rapy
16:10
Co
ffee
brea
ck
SESS
ION
2. M
utat
iona
l pro
file
of tu
mor
s an
d th
e id
entifi
catio
n of
neo
-ant
igen
sCh
airs
: Al
berto
Am
ador
i (Pa
dua,
Ital
y)
Gi
orgi
o Pa
rmia
ni (S
iena
, Ita
ly)
16:30
Ha
ns-G
eorg
Ram
men
see
(T
ubin
gen,
Ger
man
y):
Im
pact
of t
he im
mun
opep
tidom
ic la
ndsc
ape
of
can
cers
on
canc
er im
mun
othe
rapy
16:55
Ug
ur S
ahin
(Mai
nz, G
erm
any)
:
Indi
vidu
aliz
ed R
NA
vacc
ines
targ
etin
g
the
mut
anom
e.
17:20
Zl
atko
Tra
jano
ski (
Vien
na, A
ustri
a):
Im
mun
ophe
noty
pes
and
antig
enom
es
of
sol
id c
ance
rs.
Sele
cted
Abs
trac
t: 17:
45
Beat
rice
Schu
ler-T
hurn
er (E
rlang
en, G
erm
any)
:
Rand
omiz
ed, o
pen-
labe
l Pha
se II
I stu
dy to
eval
uate
the
adju
vant
vac
cina
tion
with
tu
mor
RN
A-lo
aded
aut
olog
ous
dend
ritic
cells
ver
sus
obse
rvat
ion
of p
atie
nts
with
rese
cted
mon
osom
y 3
uvea
l mel
anom
a.
18:00
Ge
nera
l Ass
embl
y of
the
NIB
IT 20
:00
Dinn
er
Thur
sday
Oct
ober
8
Frid
ay O
ctob
er 9
SESS
ION
3. T
umor
mic
roen
viro
nmen
tCh
airs
: En
rico
Proi
etti
(Rom
e, Ita
ly)
Pa
ola
Zano
vello
(Pad
ua, It
aly)
08:30
W
olf H
. Frid
man
(Par
is, F
ranc
e):
Cl
inic
al im
pact
of i
mm
une
mic
roen
viro
nmen
ts
in
diff
eren
t typ
es o
f hum
an c
ance
r.
08:55
Fr
anco
M. M
arin
cola
(Doh
a, Q
atar
):
Dete
rmin
ant o
f im
mun
e re
spon
sive
ness
amon
g di
ffere
nt c
ance
rs.
09:20
M
atte
o Be
llone
(Mila
n, It
aly)
:
The
rela
tions
hip
betw
een
TH17
and
mic
robi
ota
in m
ultip
le m
yelo
ma.
09:45
An
drea
Ani
chin
i (M
ilan,
Ital
y):
A
subs
et o
f CD8
+ ea
rly e
ffect
or T
cel
ls
at
tum
or s
ite in
NSC
LC.
Invi
ted
Abst
ract
:10:
10 Sa
mue
l Hub
er (H
ambu
rg, G
erm
any)
:
Diffe
rent
iatio
n an
d in
flam
mat
ion:
Role
of T
H17
cel
ls.
Sele
cted
Abs
trac
ts:
10:25
Ch
iara
Poz
zi (M
ilan,
Ital
y):
Th
e an
ti-EG
FR m
onoc
lona
l ant
ibod
y
ce
tuxi
mab
com
bine
d w
ith c
hem
othe
rapy
trigg
ers
imm
unog
enic
cel
l dea
th.
10:40
Gi
anfra
nca
Corn
a (M
ilan,
Ital
y):
H
IF-1a
indu
ces
24-H
ydro
xych
oles
tero
l-
depe
nden
t pan
crea
tic n
euro
endo
crin
e
tu
mor
ang
ioge
nesi
s.
10:55
Co
ffee
brea
ck
SESS
ION
4. T
he e
volv
ing
role
of i
mm
unot
hera
py
of c
ance
r Ch
airs
: Ch
risto
ph H
uber
(Mai
nz, G
erm
any)
Umbe
rto T
irelli
(Avi
ano,
Ital
y)
11:15
Pier
re C
oulie
(Bru
ssel
s, Be
lgiu
m):
Tum
or a
ntig
ens
and
imm
unos
timul
ator
y
an
tibod
ies.
11:40
Sold
ano
Ferro
ne (B
osto
n, U
SA):
Intra
cellu
lar t
umor
ant
igen
s as
a s
ourc
e
of
targ
ets
for a
ntib
ody-
base
d im
mun
othe
rapy
of
sol
id tu
mor
s.
12:05
Lu
ana
Cala
brò
(Sie
na, I
taly
)
Imm
unot
hera
py o
f tho
raci
c m
alig
nanc
ies.
12:30
Ch
risto
ph H
uber
(Mai
nz, G
erm
any)
:
An in
trodu
ctio
n to
the
Euro
pean
Allia
nce
for I
mm
uno-
Onco
logy
(EAI
O).
Invi
ted
Abst
ract
: 12:
45
Mar
iang
ela
Figi
ni (M
ilan,
Ital
y):
H
ooki
ng T
RAIL
-R2
to “e
duca
te” i
mm
une
sy
stem
to re
cogn
ize
canc
er c
ell.
Sele
cted
Abs
trac
ts:
13:00
Ca
rla B
ucci
one
(Rom
e, Ita
ly):
Com
bini
ng T
ype
I IFN
and
5-A
za-2
’-
Deox
yciti
dine
to im
prov
e an
ti-tu
mor
resp
onse
agai
nst m
elan
oma.
13:15
Mar
ia T
aglia
mon
te (N
aple
s, Ita
ly):
Nov
el m
etro
nom
ic c
hem
othe
rapy
and
canc
er v
acci
ne c
ombi
nato
rial s
trate
gy
fo
r hep
atoc
ellu
lar c
arci
nom
a.
13:30
Lu
nch
Frid
ay O
ctob
er 9
SESS
ION
5. N
ews
from
Com
pani
es
Chai
rs:
Mic
hael
Gio
rdan
o (N
ew Y
ork,
USA)
Robe
rto C
amer
ini (
Rom
e, Ita
ly)
14:15
Mic
hael
Gio
rdan
o (B
MS,
New
Yor
k, US
A):
Im
mun
Onco
logy
at B
MS.
14:40
Ra
my
Ibra
him
(Ast
ra Z
enec
a, G
aith
ersb
urg,
MD,
USA
):
Im
mun
Onco
logy
at A
stra
Zen
eca
15:05
El
liot C
harta
sh (M
SD, N
ew Y
ork,
USA)
Imm
unOn
colo
gy a
t MSD
15:30
M
oham
med
Aza
b
(A
stex
/Ots
uka,
Ple
asen
ton,
CA,
USA
):
Guad
ecita
bine
(SGI
-110
): a
nove
l epi
gene
tic
p
artn
er fo
r im
mun
othe
rapy
.
15:55
Je
an-M
arie
Cui
llero
t
(EM
D-Se
rono
, Bos
ton,
MA,
USA
):
Im
mun
Onco
logy
at E
MD-
Sero
no.
16:20
Co
ffee
brea
ck
SESS
ION
6. N
ew a
spec
ts o
f im
mun
e re
spon
ses
fo
r im
mun
othe
rapy
. Joi
nt s
essi
on N
IBIT
-SIIC
ACh
airs
: M
iche
le M
aio
(Sie
na, It
aly)
Ange
lo V
acca
(Bar
i, Ita
ly)
16:40
M
ario
Pao
lo C
olom
bo (M
ilan,
Ital
y):
M
yelo
id c
ells
in tu
mor
igen
esis
and
imm
unor
egul
atio
n
17:05
En
nio
Carb
one
(Cat
anza
ro, It
aly)
:
New
opp
ortu
nity
in m
elan
oma:
NK
cells
.
17:30
An
na M
aria
Di G
iaco
mo
(Sie
na, It
aly)
:
The
NIB
IT c
linic
al s
tudi
es.
17:55
Ce
cilia
Gar
land
a (M
ilan,
Ital
y):
Th
e hu
mor
al p
atte
rn re
cogn
ition
mol
ecul
e
PTX3
act
s as
an
extri
nsic
onc
osup
pres
sor
by
regu
latin
g Co
mpl
emen
t-dep
ende
nt
tu
mor
-pro
mot
ing
infla
mm
atio
n.
Sele
cted
Abs
trac
ts18:
20
Pier
Fra
nces
co F
erru
cci (
Mila
n, It
aly)
:
Base
line
neut
roph
ils a
nd d
eriv
ed
ne
utro
phil-
to-ly
mph
ocyt
e ra
tio: u
pfro
nt
m
arke
rs fo
r ipi
limum
ab tr
eatm
ent
in
met
asta
tic m
elan
oma.
18:35
Pa
ola
Nist
icò
(Rom
e, Ita
ly):
Anti-
tum
or p
olyf
unct
iona
l CD8
T c
ells
elic
ited
by d
acar
bazi
ne tr
eatm
ent b
efor
e pe
ptid
e
va
ccin
atio
n de
pend
s on
AKT
act
ivat
ion
sust
aine
d by
ICOS
.
19:00
Gu
est L
ectu
re
Dani
ela
Min
erva
(Rom
e, Ita
ly):
Perc
hé l’i
mm
unon
colo
gia
piac
e ta
nto
ai m
edia
e c
hi s
ono
i suo
i nem
ici?
In
trodu
ces
Mic
hele
Mai
o (S
iena
, Ital
y).
20:30
So
cial d
inner
Frid
ay O
ctob
er 9
SESS
ION
7. A
dopt
ive
Cell
Ther
apy
Chai
rs:
Lore
nzo
Mor
etta
(Rom
e, Ita
ly)
Pi
er F
ranc
esco
Fer
rucc
i (M
ilan,
Ital
y)
08:30
Pe
r Tho
r Stra
ten
(Cop
enha
gen,
Den
mar
k):
AC
T in
mel
anom
a.08
:55
Giac
omo
Oliv
eira
(Mila
n, It
aly)
:
Editi
ng a
nd tr
acki
ng T
cel
ls fo
r can
cer
im
mun
othe
rapy
.09
:20
Lore
nzo
Mor
etta
(Rom
e, It
aly)
:
NK
cells
in th
e th
erap
y of
hig
h ris
k le
ukem
ias.
Sele
cted
Abs
trac
ts09
:45
Gaia
Zuc
colo
tto (P
adua
, Ita
ly):
CaveCAR
!Ahighaffin
ityscF
vincon
junc
tion
with
ahighlyeffic
ientCD2
8-CD
137sign
alling
dom
ain
can
be d
etrim
enta
l for
T c
ells
.
10:00
Da
rio S
angi
olo
(Tur
in, I
taly
):
Ta
rget
ing
soft
tissu
e sa
rcom
as b
y cy
toki
ne-
in
duce
d ki
ller (
CIK)
cel
ls re
dire
cted
with
anti-
CD44
v6 c
him
eric
ant
igen
rece
ptor
.
10:15
Co
ffee
brea
ck
SESS
ION
8. O
ngoi
ng a
nd p
rosp
ectiv
e N
IBIT
ac
tiviti
es a
nd c
olla
bora
tions
Chai
rs:
Mas
sim
o Di
Nic
ola
(Mila
n, It
aly)
Ru
gger
o Ri
dolfi
(Mel
dola
, Ita
ly)
10:35
Cr
istin
a M
acca
lli (S
iena
, Ita
ly):
The
NIB
IT tr
ansl
atio
nal s
tudi
es.
11:00
Paol
a Qu
eiro
lo (G
enoa
, Ita
ly):
IMI a
ctiv
ities
. 11:2
5 M
iche
le M
aio
(Sie
na, I
taly
):
Im
mun
Onco
logy
web
-site
.
Sele
cted
Abs
trac
t11:4
0 Gi
anlu
ca G
iaco
bini
(Sie
na, It
aly)
:
BRAF
inhi
bito
rs c
an e
ither
inhi
bit o
r pot
entia
te
an
ti-tu
mor
T c
ell r
espo
nses
in m
elan
oma
patie
nts
depe
ndin
g on
the
orig
ins
of T
lym
phoc
ytes
.
11:55
Gues
t Lec
ture
Si
lvio
Mon
fard
ini (
Mila
n, It
aly)
:
An in
trodu
ctio
n to
can
cer i
n th
e el
derly
bef
ore
em
bark
ing
upon
imm
unot
hera
py tr
ials
.
Intro
duce
s Gi
orgi
o Pa
rmia
ni (S
iena
, Ital
y).
12:30
N
IBIT
AW
ARDS
NOM
INAT
ION
S 12:
45
NIB
IT E
lect
ions
- Re
sults
13:15
Lunc
h
14:00
Ad
jour
n
SESS
ION
5. N
ews
from
Com
pani
es
Chai
rs:
Mic
hael
Gio
rdan
o (N
ew Y
ork,
USA)
Robe
rto C
amer
ini (
Rom
e, Ita
ly)
14:15
Mic
hael
Gio
rdan
o (B
MS,
New
Yor
k, US
A):
Im
mun
Onco
logy
at B
MS.
14:40
Ra
my
Ibra
him
(Ast
ra Z
enec
a, G
aith
ersb
urg,
MD,
USA
):
Im
mun
Onco
logy
at A
stra
Zen
eca
15:05
El
liot C
harta
sh (M
SD, N
ew Y
ork,
USA)
Imm
unOn
colo
gy a
t MSD
15:30
M
oham
med
Aza
b
(A
stex
/Ots
uka,
Ple
asen
ton,
CA,
USA
):
Guad
ecita
bine
(SGI
-110
): a
nove
l epi
gene
tic
p
artn
er fo
r im
mun
othe
rapy
.
15:55
Je
an-M
arie
Cui
llero
t
(EM
D-Se
rono
, Bos
ton,
MA,
USA
):
Im
mun
Onco
logy
at E
MD-
Sero
no.
16:20
Co
ffee
brea
ck
SESS
ION
6. N
ew a
spec
ts o
f im
mun
e re
spon
ses
fo
r im
mun
othe
rapy
. Joi
nt s
essi
on N
IBIT
-SIIC
ACh
airs
: M
iche
le M
aio
(Sie
na, It
aly)
Ange
lo V
acca
(Bar
i, Ita
ly)
16:40
M
ario
Pao
lo C
olom
bo (M
ilan,
Ital
y):
M
yelo
id c
ells
in tu
mor
igen
esis
and
imm
unor
egul
atio
n
17:05
En
nio
Carb
one
(Cat
anza
ro, It
aly)
:
New
opp
ortu
nity
in m
elan
oma:
NK
cells
.
17:30
An
na M
aria
Di G
iaco
mo
(Sie
na, It
aly)
:
The
NIB
IT c
linic
al s
tudi
es.
17:55
Ce
cilia
Gar
land
a (M
ilan,
Ital
y):
Th
e hu
mor
al p
atte
rn re
cogn
ition
mol
ecul
e
PTX3
act
s as
an
extri
nsic
onc
osup
pres
sor
by
regu
latin
g Co
mpl
emen
t-dep
ende
nt
tu
mor
-pro
mot
ing
infla
mm
atio
n.
Sele
cted
Abs
trac
ts18:
20
Pier
Fra
nces
co F
erru
cci (
Mila
n, It
aly)
:
Base
line
neut
roph
ils a
nd d
eriv
ed
ne
utro
phil-
to-ly
mph
ocyt
e ra
tio: u
pfro
nt
m
arke
rs fo
r ipi
limum
ab tr
eatm
ent
in
met
asta
tic m
elan
oma.
18:35
Pa
ola
Nist
icò
(Rom
e, Ita
ly):
Anti-
tum
or p
olyf
unct
iona
l CD8
T c
ells
elic
ited
by d
acar
bazi
ne tr
eatm
ent b
efor
e pe
ptid
e
va
ccin
atio
n de
pend
s on
AKT
act
ivat
ion
sust
aine
d by
ICOS
.
19:00
Gu
est L
ectu
re
Dani
ela
Min
erva
(Rom
e, Ita
ly):
Perc
hé l’i
mm
unon
colo
gia
piac
e ta
nto
ai m
edia
e c
hi s
ono
i suo
i nem
ici?
In
trodu
ces
Mic
hele
Mai
o (S
iena
, Ital
y).
20:30
So
cial d
inner
Satu
rday
Oct
ober
10
ENDO
RSED
SPON
SOR
SUPP
ORTE
R
Endo
rsed
by
GOLD
Spo
nsor
SILV
ER S
pons
or
Logo
Fon
dazi
one
NIB
ITPR
OPO
STA
E
NIB
ITFO
ND
AZ
ION
E
Net
wor
k Ita
liano
per
la B
iote
rapi
a de
i Tum
ori
Spon
sor (
OTHE
R SU
PPOR
TERS
)
ONCO
LOGY
SUPP
ORTE
R
